• KIEAE Journal
• /
• 제12권6호
• /
• pp.77-84
• /
• 2012

The current architectural design of unit modular has been based on 2D of CAD program, so unit modular character which needs unit information management, as a dried-member system, has no effect on design process. The purpose of this study is We have developed a suitable BIM design process, according to various works of construction, then tried to contribute to supply and activation of the urban-life-housing based on unit modular. The BIM modeling process based on unit modular has been in order of unit combination with preparing manual classification, and, it has been constructed, at construction site, from housing foundation to roof finish by Bottom-up method. At a manufacturing factory, it has been produced in order of 1) grouping materials and parts, 2) fabricating unit boxes, and 3) interference examination of unit boxes, and each order has been classified as housing structure, architecture, plumbing process separately. At a construction site, the fabrication has been done in order of, like as a real housing construction scenario, 1) RC foundation work 2) unit module job-site-fabrication work, 3) roof truss work, 4) plumbing and HVAC work, and 5) housing interior finish work. After modeling process, the interference examination on each work of construction has finally completed modeling. The Unit modular utilizing BIM modeling can make easy housing maintenance through systematic control with preparing manual of unit module information, and securing accurate and speedy construction information. And it will promote design credibility and create maximum effect of unit modular construction method, such as construction period reduction and upgrade of construction quality, etc., through the computer simulation as real as construction environment in cyber space, and with the interfering examination.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권4호
• /
• pp.1903-1907
• /
• 2016

Background: Studies of effects of IL-1 polymorphisms, CYP2C19 genotype together with antibiotic resistance for H. pylori eradication are rare worldwide. The present study was designed to evaluate efficacy of 10-day sequential therapy (SQT) and 14-day standard triple therapy (STT) with four- times-daily dosing of amoxicillin for H. pylori eradication related to these important host and bacterial factors in Thailand. Materials and Methods: This prospective randomized study was performed during March 2015 to January 2016. H. pylori infected gastritis patients were randomized to receive 10-day sequential therapy and 14-day standard triple therapy. CYP2C19 genotyping, IL1 polymorphism (IL-1B and IL-1RN genotypes) and antibiotic susceptibility tests were performed in all patients. 13C-UBT was conducted to confirm H. pylori eradication at least 4 weeks after treatment. Results: A total of 100 patients (33 males and 67 females, mean age=51.1 years) were enrolled. Eradication rate by PP analysis was 97.9% (47/48) with the 10-day SQT regimen and 87.8% (43/49) with 14-day STT regimen (97.9% vs 87.8%; p-value=0.053). Antibiotic susceptibility testing demonstrated 45% resistance to metronidazole, 14.8% to clarithromycin, and 24.1% to levofloxacin. CYP2C19 genotyping revealed 44.9% RM, 49% IM and 6.1% PM. IL-1B and IL-1RN genotypes were demonstrated as 21.4% for CC, 48.1% for TC, 36.8% for TT, 72.7% for 1/1, and 21.2% for 1/2 genotypes, respectively. The 10-day SQT regimen provided 100% eradication in patients with clarithromycin or dual clarithromycin and levofloxacin H. pylori resistant strains. Moreover, the 10-day SQT regimen resulted in a 100% eradication rate in all patients with CYP2C19 genotype RM and almost type of IL-1B (TC and TT) and IL1-RN genotypes ( 1/2 and other). Conclusions: Treatment with 10-day sequential therapy is highly effective for H. pylori eradication regardless of the effects of clarithromycin resistance, dual clarithromycin and levofloxacin resistance, CYP2C19 genotype, IL-1B and IL1-RN genetic polymorphisms and can be used as effective first line therapy in Thailand.

• 물과 미래
• /
• 제25권1호
• /
• pp.93-100
• /
• 1992

Abstract A study on the Derivation of the Unit Hydrograph using Multiple Regression Moe이. The purpose of this study is to deriver an optimal unit hydrograph suing the multiple regression model, particularly when only small amount of data is available. The presence of multicollinearity among the input data can cause serious oscillations in the derivation of the unit hydrograph. In this case, the oscillations in the unit hydrograph ordinate are eliminated by combining the data. The data used in this study are based upon the collection and arrangement of rainfall-runoff data(1977-1989) at the Soyang-river Dam site. When the matrix X is the rainfall series, the condition number and the reciprocal of the minimum eigenvalue of XTX are calculated by the Jacobi an method, and are compared with the oscillation in the unit hydrograph. The optimal unit hydrograph is derived by combining the numerous rainfall-runoff data. The conclusions are as follows; 1)The oscillations in the derived unit hydrograph are reduced by combining the data from each flood event. 2) The reciprocals of the minimum eigen\value of XTX, 1/k and the condition number CN are increased when the oscillations are active in the derived unit hydrograph. 3)The parameter estimates are validated by extending the model to the Soyang river Dam site with elimination of the autocorrelation in the disturbances. Finally, this paper illustrates the application of the multiple regression model to drive an optimal unit hydrograph dealing with the multicollinearity and the autocorrelation which cause some problems.

• Journal of Microbiology and Biotechnology
• /
• 제7권1호
• /
• pp.49-51
• /
• 1997

In order to obtain a hybrid synthetic peptide with a more potent antifungal activity than magainin-2 but without hemolytic activity, four hybrid peptides were designed from the sequences of magainin 2 and cecropin A and their antifungal activities against Trichosporon beigelii were investigated. The result showed that analogue 2 and 4 exhibited better antifungal activity against T. beigelii than magainin-2 but no hemolytic activities. The peptides, therefore, could be used as models for the development of potent antifungal peptides.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권7호
• /
• pp.3131-3138
• /
• 2016

Several studies have addressed the possible role of hepatitis C virus genotype-4 (HCV GT4) in apoptosis. However, this still not fully understood. In the current study a re-constructed clone of E1/E2 polyprotein region of the HCV GT4 was transfected into the Huh7 cell line and a human apoptotic PCR array of 84 genes was used to investigate its possible significance for apoptosis. Out of the 84 genes, only 35 showed significant differential expression, 12 genes being up-regulated and 23 down-regulated. The highest-up regulated genes were APAF1 (apoptotic peptidase-activating factor 1), BID (BH3 interacting domain death agonist) and BCL 10 (B-cell CLL/lymphoma protein 10) with fold regulation of 33.2, 30.1 and 18.9, respectively. The most down-regulated were FAS (TNF receptor super family), TNFRSF10B (tumor necrosis factor receptor super-family member 10b) and FADD (FAS-associated death domain) with fold regulation of -30.2, -27.7 and -14.9, respectively. These results suggest that the E1/E2 proteins may be involved in HCV-induced pathogenesis by modulating apoptosis through the induction of the intrinsic apoptosis pathway and disruption of the BCL2 gene family.

• Archives of Pharmacal Research
• /
• 제22권4호
• /
• pp.428-431
• /
• 1999

Seven known oleanolic acid glycosides (1-7) were isolated form the MeOH extract of Tiarella polyphylla. The structures were identified to be 3-O-($\beta$-glucopyranosyl) oleanolic acid (1), 3-O-[$\beta$-D-glucopyranosyl-(1 3)-$\beta$-D-glucopyranosyl] oleanolic acid (2), 3-O-D-[$\beta$-D-glucopyranosyl-(1 2)-$\beta$-D-glycopyranosyl] oleanolic acid (3), 3-O-[$\beta$-D-glucopyranosyl-(1 3)-$\beta$-D-glucopyranosyl] oleanolic acid 28-O-$\beta$D-glucopyranosyl ester (4), 3-O-[$\beta$-D-glucopyranosyl-(1 2)-$\beta$-D-glucopyranosyl] oleanolic acid 28-O-$\beta$-D-glucopyranosyl ester (5), 3-O-[a-L-rahmnopyranosyl-(1 3)-$\beta$-D-glucururonopyranosyl] oleanolic acid (6), and 3-O-[$\alpha$-L-rhamnopyranosyl-(1 3)-$\alpha$-D-glucuronopyranosyl] oleanolic acid 28-O-$\alpha$-D-glucopyranosyl ester (7) on the basis of physicochemical and spectral data. These triterpene glycosides were tested for the anti-complement activity and hemolytic activity. Bisdesmosidic saponins, 4, 5, and 7, showed anti-complement activity; in contrast, monodesmosidic saponins, 1-3, and 6, showed direct hemolytic activity. Methyl esterified monodesmosidic saponins showed anti-complement activity at a low concentration and hemolytic activity at a high concentration.

• 한국식품영양학회지
• /
• 제14권1호
• /
• pp.46-51
• /
• 2001

마쇄한 무를 30%사용하여 당질을 가하지 않은 동치미, 전분을 1% 가한 동치미, 설탕을 1% 가한 동치미를 담가 4$^{\circ}C$에서 30일간 발효시켰다. HPLC 및 TLC 분석결과 전분을 가하지 않은 동치미에는 글루코오스, 프룩토오스, 수크로오스가 있었고, 발효진행에 따라 이들이 함량이 낮아졌다. 전분을 가한 동치미는 아밀라아제의 작용으로 이들 당 외에 말토오스, 말토트리오스, 말토테트라오스가 생성되었다. 수크로오스를 가한 동치미는 글루코오스, 프룩토오스, 수크로오스가 나타났다. 당질을 가하지 않은 동치미는 30일 발효후 환원당 53 $\mu$g/ml, 아밀라아제 활성 0.012unit/ml, pH 3.84, 산도 1.8을 나타냈다. 전분 1%를 가한 동치미는 환원당 173$\mu$g/ml, 아밀라아제 활성 0.019unit/ml, pH 3.87, 산도 2.1을 나타냈다. 수크로오스 1%를 가한 동치미는 환원당 211$\mu$g/ml, 아밀라아제 활성 0.015unit/ml, pH 3.36, 산도 2.4를 나타냈다.

• 한국주거학회논문집
• /
• 제18권5호
• /
• pp.11-22
• /
• 2007

The purpose of this study is to propose prototypical plans for a dwelling unit applying the concepts of 'open housing' and 'aging in place' for senior citizens living in cities focusing on specific life patterns with chronic disease. Especially, a unit was designed for diabetes patients because diabetes, a representative disease of elderly people, often accompanies complications such as arthritis and Alzheimer disease. A unit design suitable for the convenient life of the elderly people with diabetes will provide a guideline for the similar unit designs of the senior citizens with other diseases. In this study, three types of unit plan are proposed. A-type plan is for type-1 diabetes patients, B-type alt.1 for the independent seniors of type-2 diabetes patients, and B-type alt.2 for the dependant seniors of type-2 diabetes patients. And a support design for a unit plan with the exclusive area of $60\;m^2$ is proposed. The same support design is used for all three unit types. Although the locations of bathroom and storage room are fixed and the location of the kitchen is changeable only in wet-zone. In conclusion, senior residents with diabetes can choose one of three unit types before occupation and the chosen unit type can be renovated by replacing infill systems as the health condition or life style changes.

• 전자공학회논문지SC
• /
• 제38권1호
• /
• pp.27-34
• /
• 2001

[ $GF(2^m)$ ]의 기약 3항식인 $x^m+x+1$을 이용한 승산기 알고리즘은 Mastrovito에 의해 제안되었다. 본 논문에서는 기약 3항식 $x^m+x+1$에서 1$GF(2^m)$상의 원시 기약 3 항식을 전개하여 회로를 간략화 하였으며, 제안된 승산기 설계는 규칙적이며 모듈러 구조, 그리고 간단한 제어신호를 요하기 때문에 VLSI 실현이 용이하다고 사료된다.

• Journal of Gastric Cancer
• /
• 제20권1호
• /
• pp.106-114
• /
• 2020

Breast metastases of extramammary malignant neoplasms are rare, with an incidence of 0.3%-2.7% among all malignant mammary tumors. Breast metastases from gastric carcinoma are very rare (<0.1%), and this event is even rarer during pregnancy. Herein, we describe a 39-year-old Caucasian woman with a history of an Epstein-Barr virus-associated gastric carcinoma (EBVaGC) that was characterized by prominent tumor infiltrating lymphocytes. Three years after undergoing radical surgery, the patient developed bilateral breast nodules during her pregnancy. A breast biopsy was performed, and histology confirmed a diagnosis of EBVaGC; tumor cells showed positivity for cytokeratin 8/18 and E-cadherin, and negativity for cytokeratin 7, cytokeratin 20, cytokeratin 5/6, caudal type homebox 2, androgen receptor, mammaglobin, gross cystic disease fluid protein-15, and estrogen and progesterone receptors. We also discuss the main diagnostic pitfalls. To our knowledge, this is the first report of an EBVaGC with lymphoid stroma that developed breast metastases during pregnancy.