• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.128-128
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• 1998

Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteases that degrade extracellular matrix and basement membrane. These enzymes are play important roles in tumor cell invasion and metastasis, as well as angiogenesis and other connective tissue diseases. In our screening program for inhibitors of MMP-2 from fungal metabolites, we have isolated novel non-peptidic inhibitors of MMPs, designated gelastatin A and B from the culture broth of Westerdykella multispora F50733. The structures of gelastatin A and B were determined to be 3-(5E-hexa-2E,4E-dienylidene-2-oxo-5,6-dihydro-2H-pyran-3yl)-propanoic acid and 3-(5Z-hexa-2E,4E-dienylidene-2-oxo-5,6-dihydro-2H-pyran-3yl)-propanoic acid, respectively. Gelastatin A and B exist as a mixture of two stereoisomers in a ratio of 2: 1. The 2: 1 mixture of gelastatin A and B inhibited activated MMP-2 and MMP-9 with an IC$\sub$50/ value of 0.63, 5.29 ${\mu}$M, respectively. They inhibited the invasion of B16F10 melanoma cells through basement membrane Matrigel with dose dependent.

• Analytical Science and Technology
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• v.16 no.5
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• pp.375-390
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• 2003

A single crystal of fully indium-exchanged zeolite A (In-A) was brought into contact with antimony in a fine Pyrex capillary at $350^{\circ}C$ for 6 days. The reaction was monitored by electron-probe X-ray microanalysis (EPXMA). The crystal structure of antimony-sorbed indium-exchanged zeolite A has been determined by single-crystal X-ray diffraction techniques at $21^{\circ}C$ in the cubic space group Pm ${\bar{3}}m$. The crystal structure of $In_8Si_{12}Al_{12}O_{48}{\cdot}(In)_{1.35}(Sb)_{0.7}$ ($a=12.111(2){{\AA}}$, $R_1=0.071$, and $R_2=0.067$) has 8 indium cations, 1.35 indium atoms, and 0.7 antimony atoms per unit cell. Unit cell 1 ($In_8-A{\cdot}In$, 65% of unit cells) contain the $(In_5)^{8+}$ cluster. In unit cell 2 ($In_8-A{\cdot}(In)_2(Sb)_2$, 35% of unit cells), two $(In_3)^{2+}$ cluster and one $(In_3Sb_2)^{7+}$ cluster are found in the large cavity.

• Bulletin of the Korean Mathematical Society
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• v.54 no.2
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• pp.705-714
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• 2017

Let $A^2_{{\alpha},{\beta}}(\mathbb{B}_n)$ denote the space of holomorphic functions that are $L^2$ with respect to a weight of form ${\omega}_{{\alpha},{\beta}}(z)=(1-{\mid}z{\mid}^{\alpha}e^{-{\frac{\beta}{1-{\mid}z{\mid}}}}$, where ${\alpha}{\in}\mathbb{R}$ and ${\beta}$ > 0 on the unit ball $\mathbb{B}_n$. We obtain some results for the boundedness and compactness of $Ces{\grave{a}}ro$ operator on $A^2_{{\alpha},{\beta}(\mathbb{B}_n)$.

• Kyungpook Mathematical Journal
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• v.45 no.3
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• pp.395-404
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• 2005

Let α be a complex number with 𝕽α > 0. Let the functions f and g be analytic in the unit disc E = {z : |z| < 1} and normalized by the conditions f(0) = g(0) = 0, f'(0) = g'(0) = 1. In the present article, we study the differential subordinations of the forms $${\alpha}{\frac{z^2f^{{\prime}{\prime}}(z)}{f(z)}}+{\frac{zf^{\prime}(z)}{f(z)}}{\prec}{\alpha}{\frac{z^2g^{{\prime}{\prime}}(z)}{g(z)}}+{\frac{zg^{\prime}(z)}{g(z)}},\;z{\in}E,$$ and $${\frac{z^2f^{{\prime}{\prime}}(z)}{f(z)}}{\prec}{\frac{z^2g^{{\prime}{\prime}}(z)}{g(z)}},\;z{\in}E.$$ As consequences, we obtain a number of sufficient conditions for star likeness of analytic maps in the unit disc. Here, the symbol ' ${\prec}$ ' stands for subordination

• Journal of Korean Society of Rural Planning
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• v.24 no.1
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• pp.1-10
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• 2018

This study is to evaluate the per capita accessibility to child care facilities using road map in rural village unit considering the supply and demand of child care facilities in municipal (Si-Gun) units. Using these estimated accessibility, the most accessible regions to child care facilities was identifies using Moran's index. Assuming establish a new child care facility in the most accessible region, the sensitivity of child care environment was analyzed. The number of regions are 71 si-gun-gu where supply of child care facilities is insufficient. The average accessibility per capita is 1.09 km to child care facilities and the average accessibility in Myeon unit is approximately 2.2 times higher than accessibility in Eup unit (Eup unit 0.54 km, Myeon unit 1.21 km). Approach tendency from village to child care facilities has positive relationship as 0.451 global Moran's index. The high-high (H-H) accessibility regions are wide as Gangwon-do, Gyeongsangbuk-do, Gyeongsangnam-do, Jeollanam-do and Chungcheongbuk-do. Assumed to be established the new child care facilities in Yangyang-gun (Ganwon-do), accessibility changes of child care environment are up to 2.7 times greater and the recipient population is 77% of Yangyang-gun.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.21 no.2
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• pp.134-140
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• 2018

Chylomicron retention disease, also known as Anderson's disease, is a rare hereditary hypocholesterolemic disorder, recessive inherited, characterized by nonspecific symptoms as abdominal distension, steatorrhea, and vomiting associated with failure to thrive. We describe a patient with failure to thrive, chronic diarrhea and steatorrhea who the diagnosis of chylomicron retention disease was established after several months of disease progression. The genetic study confirmed a homozygosity mutation in SAR1B gene, identifying a mutation never previous described [c.83_84delTG(p.Leu28Argfs*7)]. With this case report the authors aim to highlight for this very rare cause of failure to thrive and for the importance of an attempting diagnosis, in order to start adequate management with low fat diet supplemented with fat-soluble vitamins, reverting the state of malnutrition and avoiding possible irreversible and desvantating complications.

• Korean Institute of Interior Design Journal
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• v.16 no.3 s.62
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• pp.66-75
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• 2007

In this study, by comparing the development and the space types of local and foreign flexible apartments, basic data will be derived for the development of various flexible types of apartments in Korea. A total of 60 unit plans, including 30 domestic cases and 30 overseas cases of flexible apartments, are analyzed for this study. In terms of the unit plan types, Korean apartments usually had a wide front bay with shallow depth, placing more rooms on the front bay; whereas foreign apartments tend to have various unit plan types: (1) a narrow front bay with deep depth, (2) a wide front bay with shallow depth, and (3) variegated open-plan types. Many apartments in foreign countries had a double-layered structure with the. upstairs and downstairs areas. In terms of the flexible types, many Korean apartments achieved interior flexibility using non-bearing wall or sliding doors; whereas foreign apartments had a flexible space by separating the support elements and the infill elements. There was found to be a close relationship between the location of support elements and the variability of unit plans. Support elements can be placed largely into three locations: (1) Between the front side bay and the rear side bay, (2) in the center bay of a unit plan, and (3) others. Depending on the location of support elements, various types of flexible unit plans can be created. Through a comparative analysis of domestic and foreign apartments, basic data that can be used for developing various flexible unit plans was derived.

• Journal of The Geomorphological Association of Korea
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• v.26 no.1
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• pp.59-78
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• 2019

The physical and chemical characteristics of more than 5 m sandy deposits behind the beach in Sinji-do Island are investigated and its burial ages are estimated using Optically Stimulated Luminescence. By the estimated burial ages of the sandy deposits, this section is divided into four sub-units: Unit I (6.2 ka), Unit II (23.2 ka), Unit III (115.9 ka), and Unit IV (115.9 to 127.5 ka). It can be proposed that the Unit I of a coarse sand deposited during the Holocene Climatic Optimum. Unit II, supposed to be the aeolian sediments, formed during the Last Glacial Maximum (LGM). It can be supposed that the study area was not affected by the marine processes during the LGM, directly. Unit III is more consolidated deposits of coarse silt to fine sand and deposited during the Last Interglacial Period. Unit IV mainly consist of beach gravels with sandy matrix deposited during the Marine Isotope Stage 5e (MIS 5e), and thus indicates that the sea level of the southwest sea had risen 3 to 5 m above present sea level during the MIS 5e.

• Journal of the Korean Chemical Society
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• v.28 no.4
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• pp.205-209
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• 1984

The crystal and molecular structure of thiosinamine, $H_2NCSNHCH_2CHCH_2$, has been determined by X-ray diffraction method. The crystals are monoclinic, space group $P2_1/a$ with four molecules in a unit cell of dimensions, a = 9.819(3), b = 8.553(3), c = 9.170(2)${\AA}$, ${\beta}$ = 127.3(1)$^{\circ}$, and z = 4. Intensity data for 814 reflections were collected with a Rigaku-Denki automatic four circle diffractometer. The structure was solved by direct and Fourier methods. Refinements were carried out by full matrix least-squares method to a final R value of 0.046. The thiourea unit is planar, and the bond lengths and angles in that unit agree well with those in the compounds which contain a thiourea moiety. The molecules are linked together by the two patterns of N-H${\cdots}$S hydrogen bonds along the b-axis.

• KIPS Transactions on Software and Data Engineering
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• v.7 no.4
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• pp.121-128
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• 2018

A Korean morphological analyzer adopts sequence-to-sequence (seq2seq) model, which can generate an output sequence of different length from an input. In general, a seq2seq based Korean morphological analyzer takes a syllable-unit based sequence as an input, and output a syllable-unit based sequence. Syllable-based morphological analysis has the advantage that unknown words can be easily handled, but has the disadvantages that morpheme-based information is ignored. In this paper, we propose a reranking model as a post-processor of seq2seq model that can improve the accuracy of morphological analysis. The seq2seq based morphological analyzer can generate K results by using a beam-search method. The reranking model exploits morpheme-unit embedding information as well as n-gram of morphemes in order to reorder K results. The experimental results show that the reranking model can improve 1.17% F1 score comparing with the original seq2seq model.