• Applied Biological Chemistry
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• 제39권4호
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• pp.309-314
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• 1996

2-Furyltriisopropoxytitanium은 chlorotaniumtriisopropoxide를 이용하여 2-furyllithium을 금속 전이(transmetallation)시킴으로써 합성되었다. 이 화합물은 실온에서 분리되고 수 주일 동안 $-10^{\circ}C$에서 보존할 수 있었다. 카르보닐 화합물에 대한 2-furyltriisopropoxytitanium의 반응성이 높다는 것을 알았다. 알데히드와 케톤 1:1 혼합물과의 경쟁 반응에서 이 화합물은 완벽한 알데히드 선택성을 나타내었다. 또한, 케톤과 케톤 1: 1 혼합물과의 경쟁반응에서도 이 화합물은 케톤-케톤 구별정도가 상당했다. 케톤-에스테르 작용기에 대한 반응에서 이 화합물은 단지 케톤기와만 반응하였다.

• Bulletin of the Korean Chemical Society
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• 제11권3호
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• pp.241-244
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• 1990

The photochemistry of 1-Methyl-2-cyclohexenyl aryl ketones (phenyl ketone 7a, p-toluyl ketone 7b, biphenyl ketone 7c and -naphthyl ketone 7d) is reported. The aryl ketone 7a, 7b and 7c undergo photo-racemization with efficiencies of 0.75, 0.79 and 0.76 respectively on direct irradiation. Direct irradiation of the ketone 7d, however, undergoes 1,3-shift with an efficiency of 0.02. Triplet states are responsible for the racemizations and singlet state is responsible for 1,3-shift as in general. The ketone 7a, 7b and 7c are good example of a few ${\beta},{\gamma}$-unsaturated ketones which undergo efficient intersystem crossing on direct irradiation.

• Bulletin of the Korean Chemical Society
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• 제18권8호
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• pp.824-827
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• 1997

Bis(ethylene)rhodium(Ⅰ) chloride dimer reacted with vinylcyclopropane to give σ,η3-allylrhodium(Ⅲ) complex 3. Complex 3 underwent C-C bond cleavage of 8-quinolinyl ethyl ketone 11, to form η3-1,3-dimethylallylrhodium(Ⅲ) complex 8, which was reductively eliminated by trimethyl phosphite to give 8-quinolinyl-1-methylbut-2-enyl ketone (10). More sterically hindered 8-quinolinyl alkyl ketones were allowed to react with complex 3 to afford corresponding alkenes as well as a mixture of complex 8 and η3-1-ethylallyl rhodium(Ⅲ) complex 19, identified as 10 and 8-quinolinyl-pent-2-enyl ketone (20) after reductive elimination. 8-Quinolinyl alkyl ketone bearing a sterically hindered alkyl group showed less reactivity for C-C bond cleavage and higher 20/10 ratio compared with those having a less sterically hindered alkyl group, such as 8-quinolinyl ethyl ketone (11).

• 대한화학회지
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• 제26권2호
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• pp.99-106
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• 1982

1-아세틸-1-메틸-2-시클로펜텐 화합물의 케톤 Chromophore를 나트릴, 카르보시산, 아미드 등의 group으로 대치하여 이들의 광화학반응을 검토한 결과 케튼 Chromophore에서 볼 수 있는 1,3-Acyl shift나 ODPM 반응은 일어나지 않았고 광화학적 중합 및 환원반응등 Chromophore를 변화시키므로서 광화학반응에 큰 변화를 보여주었다. 1-Cyano-1-methyl-2-cyclohexene의 경우도 Ketone chromophore와 비교하여 광화학 반응을 검토하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제23권1호
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• pp.37-45
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• 2019

To study the effect of nicorandil pretreatment on ketone body metabolism and Acetyl-CoA acetyltransferase (ACAT1) activity in hypoxia/reoxygenation (H/R)-induced cardiomyocytes. In our study, we applied H9c2 cardiomyocytes cell line to evaluate the cardioprotective effects of nicorandil. We detected mitochondrial viability, cellular apoptosis, reactive oxygen species (ROS) production and calcium overloading in H9c2 cells that exposed to H/R-induced cytotoxicity. Then we evaluated whether nicorandil possibly regulated ketone body, mainly ${\beta}$-hydroxybutyrate (BHB) and acetoacetate (ACAC), metabolism by regulating ACAT1 and Succinyl-CoA:3-ketoacid coenzyme A transferase 1 (OXCT1) protein and gene expressions. Nicorandil protected H9c2 cardiomyocytes against H/R-induced cytotoxicity dose-dependently by mitochondria-mediated anti-apoptosis pathway. Nicorandil significantly decreased cellular apoptotic rate and enhanced the ratio of Bcl-2/Bax expressions. Further, nicorandil decreased the production of ROS and alleviated calcium overloading in H/R-induced H9c2 cells. In crucial, nicorandil upregulated ACAT1 and OXCT1 protein expressions and either of their gene expressions, contributing to increased production of cellular BHB and ACAC. Nicorandil alleviated cardiomyocytes H/R-induced cytotoxicity through upregulating ACAT1/OXCT1 activity and ketone body metabolism, which might be a potential mechanism for emerging study of nicorandil and other $K_{ATP}$ channel openers.

• 대한화학회지
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• 제38권11호
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• pp.833-840
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• 1994

8-Quinolinecarboxaldehyde (1)와 1,5-hexadiene (2)을 월킨슨 촉매(3)와 $AgBF_4(8)$의 혼합 촉매에서 반응시키면 8-quinolinyl 5-hexenyl ketone(4)와 8-quinolinyl 5-hexen-2-yl ketone (9)이 높은 수율로 반응초기에 생성된다. 가지달린 alkenyl 케톤인 9가 생성되는 이유는 월킨슨 촉매와 $AgBF_4(8)$의 반응에서 촉매에 빈 배위공간이 만들어져 1,5-hexadiene의 하이드로메탈레이션반응에서 $AgBF_4(8)$를 넣지 않았을 때보다는 입체장애가 적은 5.5각형의 중간체를 만들 수 있기 때문으로 설명된다. $AgBF_4(8)$의 사용량이 많으면 많을수록 9가 4보다 많은 비율로 생성되며, 장시간과 고온에서는 생성된 9와 4의 혼합물이 10과 5의 내부올레핀을 함유한 alkenyl 케톤으로 이성질화반응이 진행됨을 관찰할 수 있었다. 특히 고온으로 반응을 진행시킬수록 8-quinolinyl cyclopentylmethyl ketone (11)의 생성이 눈에 띄게 높아짐을 알 수 있었다.

• 대한화학회지
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• 제17권4호
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• pp.247-255
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• 1973

$Li^{+},\;Na^{+},\;K^{+}, Ca^{2+},\;Ni^{2+},\;Al^{3+}$, 과 $F^{3+}$의 陽이온을 포화시킨 Wyoning montmorillonite에 acetone, methyl-ethyl ketone. diethyl ketone을 加熱用 i.r. gas cell 內에서 各各 다른 壓力아래 吸着시켜 $4000{\sim}1200cm^{-1}$에서spectra를 얻었다.두가지 형태의 C=O결합변화가$1713cm^{-1}$과 $1690cm^{-1}$ 나타났으며 이들은 陽이온의 水酸基 및 吸着水와 그리고 表面水酸基와 水素結合을 일으키는 결과로 나타났다. OH 吸收 spectra의 强度는 陽이온의 水酸基의 resonance 理論을 뒷받침해 주었다. coordinate bond를 일으키는 경향은 計算한 C=O기의 酸素의 formal charge의 크기와 잘 맞았다.

• 대한한의학회지
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• 제19권1호
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• pp.19-26
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• 1998

The purpose of present study is to clarify the differences between EIslwitzia Ciliata (Thunb.) Hylander(향유) and Elsholtzia splendens Nakai ex F. Maekawa (꽃향유) for standardization and the proper usage as medicinal herbs. The major ingredients of both species were isolated by distillation and extraction. The qualitative and quantitative analyses of major distillates were carried out by the use of GC/MS. There was a significant difference between the components of Elsholtzia ciliata and Elsholtzia splendens in the aspects of major components. Several common ingredients were identified as linalool, cumene, elsholtzia ketone, naginata ketone isomer, naginata ketone, myristicin, and sesquiterpene alcohol. Comparison between Elsholtzia. ciliata and Elsholtzia splendens was done in the aspect of major compounds. Myristicin (33.7%) has been shown to be the major component in Elsholtzia ciliata whereas naginata ketone isomer (26.1%) was believed to be a major ingredient in Elsholtzia splendens. The elsholtzia ketone was also one of the major differentiating factors between Elsholtzia splendens and Elsholtzia ciliata, and the quantity is 15.1% in Elslwltzia splendens compared to 2.87% in Elsholtzia ciliata. Moreover, in the Elsholtzia splendens, 4- vinylguaiacol and isoosmorhizole were absent, but both compounds were present in the EIsholtzia ciliata.

• 한국가스학회지
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• 제8권4호
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• pp.50-54
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• 2004

Methyl Ethyl Ketone Peroxide의 분해폭발로 인한 폭발의 위험성을 평가하기 위하여 소형압력용기 시험기(MCPVT)를 사용하여 실험을 하였다. 그 결과 최대폭발 압력은 MEKPO와 MEKPO에 $98\%H_2SO_4$의 첨가량이 $1\%,\;3\%$ 및 $5\%$로 증가할 수록 증가하였으며, 최대폭발압력상승 속도도 증가하였다. 또한 분해개시 압력하에서의 온도는 $H_2SO_4$의 첨가량이 증가할수록 $168.16^{\circ}C,\;126.76^{\circ}C,\;91.21^{\circ}C$ 및 $81.25^{\circ}C$로 낮아졌다.

• Archives of Pharmacal Research
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• 제15권3호
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• pp.191-195
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• 1992

Two 6'-substituted dobutamine analogues (1, 2) were synthesized from the coupling reaction of dopamine with the corresponding ketones. The ketone (8) was obtained from 4-nitrosalicyladehyde via 6 synthetic steps while the ketone (12) was prepared from 2-methyl-5-nitrobenzoic acid via 7 synthetic steps. Another synthetic attempts were also reported.