• Biomolecules & Therapeutics
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• v.16 no.1
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• pp.28-33
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• 2008

Atorvastatin calcium salt (1) was obtained through the preparation of lactone compound (8) from 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-ethyl)-2-phenyl-1,3,2-dioxaborinan-4-yl)acetic acid tert-butyl ester (9) by hydrolysis in basic condition. Efficient hydrolysis of boronate compound 9 aimed at the viable synthesis for commercial production and purification of Atorvastatin calcium is reported. Detail studies of evaluation procedure are also reported.

• Journal of Korean Institute of Industrial Engineers
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• v.41 no.1
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• pp.86-96
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• 2015

A lot of research works in the BPM area focuses on the development of new techniques in process mining. Even though the application of process mining to analyze real life process logs is important, only few case studies are available. Thus, in this paper, we conduct a case study on how to analyze a real life process log which comes from a Korean company in the heavy industry area. We analyze a customer service process that consists of a series of activities to enhance the level of customer satisfaction. In this case study, five research questions are derived based on collected questions from the company. Then we focus on bottleneck analysis, basic performance analysis and pattern analysis that are selected in order to answer the research questions. The analysis shows some abnormal behaviors in the process and possible ways to improve current processes are suggested.

• Ocean Systems Engineering
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• v.2 no.1
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• pp.49-68
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• 2012

In this paper, an offshore process front end engineering design (FEED) method is systematically introduced and reviewed to enable efficient offshore oil and gas production plant engineering. An integrated process engineering environment is also presented for the topside systems of a liquefied natural gas floating production, storage, and offloading (LNG FPSO) unit, based on the concepts and procedures for the process FEED of general offshore production plants. Various activities of the general process FEED scheme are first summarized, and then the offshore process FEED method, which is applicable to all types of offshore oil and gas production plants, is presented. The integrated process engineering environment is presented according to the aforementioned FEED method. Finally, the offshore process FEED method is applied to the topside systems of an LNG FPSO in order to verify the validity and applicability of the FEED method.

• Communications for Statistical Applications and Methods
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• v.14 no.1
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• pp.155-167
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• 2007

Knowing the time of the process change could lead to quicker identification of the responsible special cause and less process down time, and it could help to reduce the probability of incorrectly identifying the special cause. In this paper, we propose the maximum likelihood estimator (MLE) for the process change point when a control chart is used in monitoring the mean of a process in which the observations can be modeled as an AR(1) process plus an additional random error. The performance of the proposed MLE is compared to the performance of the built-in estimator when they are used in EWMA charts based on the residuals. The results show that the proposed MLE provides good performance in terms of both accuracy and precision of the estimator.

• Research in Mathematical Education
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• v.19 no.1
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• pp.61-79
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• 2015

This study discussed about how pseudo-thinking process actually occurs in the mind of the students, used Piaget's frame work of the assimilation and accommodation process. The data collection is conducted using Think-Out-Loud (TOL) method. The study reveals that pseudo thinking process of covariational reasoning occurs originally from incomplete assimilation, incomplete accommodation process or both. Based on this, three models of incomplete thinking structure constructions are established: (1) Deviated thinking structure, (2) Incomplete thinking structure on assimilation process, and (3) Incomplete thinking structure on accommodation process.

• Progress in Superconductivity and Cryogenics
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• v.8 no.1
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• pp.23-25
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• 2006

Optimization of process variables, including oxygen and water partial pressure and also an nesting temperature, was performed in batch-type process to fabricate YBCO films on LaAlO3 single crystal. In this work, YBCO oxide powder was used as a starting precursor for metal-organic deposition(MOD)method. The precursor films were fabricated in batch furnace and they were converted to the epitaxial YBCO films at the same furnace with varying the process variables. The oxygen partial pressure was varied from 100ppm to 2000ppm and the water partial pressure from 1.2% to 12.2%. The window for optimal P(O2) was narrow about 700ppm for batch-type process. YBCO films in bathc-thype MOD process were optimized at 740-770oC and P(H2O) of 2.3%-7.3%.

• Journal of Environmental Science International
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• v.8 no.6
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• pp.725-730
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• 1999

The advanced oxidation process (AOP) using ozone combined with hydrogen peroxide and ultraviolet treatment were evaluated for biodegradable dissolved organic carbon (EDOC) formation and dissolved organic carbon (DOC) removal. Oxidation treatment were conducted alone or combination with ozone, hydrogen peroxide and ultraviolet processes. Ozone dosage of ozone process was varied from $0.5mg/l{\ell}\cdot}min$ to $5mg/{\ell}{\cdot}min$. Ozone/hydrogen peroxide process was done using $20mg/{\ell}{\cdot}min$ of hydrogen peroxide concentration. Ozone/ultraviolet process was irradiated with $12mW/cm^2$ of density and 254nm. Ozone dosage was varied from $0.5mg/{\ell}{\cdot}min$ to $5mg/{\ell}{\cdot}min$ at the ozone/hydrogen peroxide and ozone/ultraviolet processes too. Contact time of all the process was 20 minutes. Oxidation treatment were performed on microfiltration effluent samples. BDOC formation was reached to an optimum at ozone dosage of $1.5mg/{\ell}{\cdot}min$ in the ozone/hydrogen peroxide process and $1mg/{\ell}{\cdot}min$ in ozone/ultraviolet process, after which BDOC formation was decreased at higher ozone dosages. But BDOC formation was increased with ozone dosages increasing in ozone process. The efficiency of DOC removal was higher AOPs than ozone process. Ozone/ultraviolet proces was the highest for DOC removal efficiency in each process. THMFP. removal efficiency by ozone/ultraviolet process was higher than that by each of ozone process and ozone/hydrogen peroxide process.

• Communications for Statistical Applications and Methods
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• v.16 no.3
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• pp.429-436
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• 2009

This paper considers the integrated process control procedure for detecting special causes in an IMA(1,1) process that is being adjusted automatically after each observation using a minimum mean squared error adjustment policy. When the control chart signals after the occurrence of a special cause, the special cause will be detected and eliminated from the process by the rectifying action. However, when the elimination of the special cause costs high or is not practically possible, an alternative action is to readjust the process with appropriately modified adjustment scheme. In this paper, we propose the readjustment procedure after having a true signal, and show that the use of the readjustment can reduce the deviation of a process from the target.

• Journal of Korea Foundry Society
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• v.40 no.1
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• pp.1-6
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• 2020

Many studies involving a thermal stress analysis using computational methods have been conducted, though there have been relatively few experimental attempts to investigate thermal stress phenomena. Casting products undergo thermal stress variations during the casting process as the temperature drops from the melting temperature to room temperature, with gradient cooling also occurring from the surface to the core. It is difficult to examine thermal stress states continuously during the casting process. Therefore, only the final states of thermal stress and deformations can be detemined. In this study, specimens sensitive to thermal stress, were made by a casting process. After which the residual stress levels in the specimens were measured by a hole drilling method with Electron Speckle-Interferometry technique. Subsequently, we examined the thermal stresses in terms of deformation during the casting process by means of a numerical analysis. Finally, we compared the experimental and numerical analysis results. It was found that the numerical thermal stress analysis is an effective means of understanding the stress generation mechanism in casting products during the casting process.

• Journal of Powder Materials
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• v.29 no.1
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• pp.1-7
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• 2022

This study investigates the effect of process stopping and restarting on the microstructure and local nanoindentation properties of 316L stainless steel manufactured via selective laser melting (SLM). We find that stopping the SLM process midway, exposing the substrate to air having an oxygen concentration of 22% or more for 12 h, and subsequently restarting the process, makes little difference to the density of the restarted area (~ 99.8%) as compared to the previously melted area of the substrate below. While the microstructure and pore distribution near the stop/restart area changes, this modified process does not induce the development of unusual features, such as an inhomogeneous microstructure or irregular pore distribution in the substrate. An analysis of the stiffness and hardness values of the nano-indented steel also reveals very little change at the joint of the stop/restart area. Further, we discuss the possible and effective follow-up actions of stopping and subsequently restarting the SLM process.