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Effects of Music Therapy on Cognitive function and Agitation, Anxiety and Depression in Dementia Elderly: a Systematic Review and Meta-analysis of Randomized Controlled Trials (음악요법이 치매노인의 인지기능, 초조행동, 불안 및 우울에 미치는 효과: 체계적 고찰 및 메타분석)

  • Chai, Gong Ju;Lee, Mi-Kyung;Nam, Eun Sook;Lee, Ho Yeon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.1
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    • pp.520-530
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    • 2021
  • Objectives: This study aimed to identify the effects of music therapy on cognitive function, agitation, anxiety and depression in the elderly with dementia. Method: A comprehensive literature search was performed on PubMed, EMBASE, Cochrane Library, CINAHL, Web of Science, Google scholar and PsycINFO, for the period 2010 to 2019. In the meta-analysis, the standardized mean difference (Hedges' g) and 95% confidence interval were calculated as summary measure, and the random effect model and inverse variance method were applied using the RevMan 5.4 program. A total of 13 studies were included; all were determined to be acceptable, based on the Cochrane collaboration's tool for assessing risk of bias. Results: The effect size (Hedges' g) was 0.31 (95% CI: -0.02, 0.65) for cognition and -0.03 (95% CI: -0.17, 0.11) for agitation behavior as the primary outcomes, and 0.61 (95% CI: -1.17, -0.05) for anxiety and -0.44(95% CI: -0.88, 0.00) for depression as the secondary outcomes. Subgroup analysis by type of music intervention revealed that combined music therapy has a significantly increasing beneficial effect on cognition of dementia patients (g=0.45[95% CI: 0.03, 0.87]). Conclusion: Music therapy was determined to exert beneficial effects in reducing anxiety and depression, and combined music therapy demonstrated improved cognitive functions in elderly patients with dementia.

Comparison of rectum fecal bacterial community of finishing bulls fed high-concentrate diets with active dry yeast and yeast culture supplementation

  • Kai, Gao;Chunyin, Geng
    • Animal Bioscience
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    • v.36 no.1
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    • pp.63-74
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    • 2023
  • Objective: The objective of this study was to investigate the effects of feeding active dry yeast (ADY) and yeast culture (YC) on fecal bacterial community in finishing bulls fed high-concentrate diets in the same experimental environment. Methods: Forty-five healthy finishing cattle (Simmental×Chinese Luxi yellow bulls; 24 months; 505±29 kg) were randomly divided into three groups: i) CON group (control group, only fed basal diet), ii) ADY group (fed basal diet + active dry yeast), and iii) YC group (fed basal diet + yeast culture). At the end of the trial, nine rectum fecal samples were randomly selected from each group for bacterial DNA sequencing. Results: There was no difference among groups about alpha diversity indices (all p>0.05), including ACE, Chao 1, Shannon, and Simpson indices. Principal component analysis and non-metric multidimensional scaling analysis showed a high similarity among three groups. Compared with CON group, ADY and YC groups had greater relative abundance of c_Clostridia, o_Oscillospirales, and f_Oscillospiraceae, but lesser relative abundance of g_Megasphaera, and s_Megasphaera_elsdenii (all p<0.01). And, the relative abundances of p_Firmicutes (p = 0.03), s_Prevotella_sp (p = 0.03), o_Clostridiales (p<0.01), g_Clostridium (p<0.01), f_Caloramatoraceae (p<0.01), and f_Ruminococcaceae (p = 0.04) were increased in the ADY group. The PICRUSt2 prediction results showed that the metabolic pathways had no significant differences among groups (p>0.05). Besides, the relative abundance of c_Clostridia (r = 0.42), and f_Oscillospiraceae (r = 0.40) were positively correlated to average daily gain of finishing bulls (p<0.05). Conclusion: Both of ADY and YC had no effect on diversity of fecal bacteria in finishing bulls, but the supplementation of ADY and YC can improve the large intestinal function in finishing bulls by increasing the abundance of cellulolytic bacteria and altering the abundance of lactic acid-utilizing bacteria.

Anti-inflammatory Effects of Lemon Myrtle (Backhousia citriodora) Leaf Extracts in LPS-induced RAW 264.7 Cells (LPS로 유도된 RAW 264.7 세포에 대한 레몬 머틀 잎 추출물의 항염증 효과)

  • Kim, Pan Kil;Jung, Kyung Im;Choi, Young Ju;Gal, Sang Wan
    • Journal of Life Science
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    • v.27 no.9
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    • pp.986-993
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    • 2017
  • Lemon myrtle (Backhousia citriodora) has been identified as one of the plants that are likely to undergo important commercial exploitation. This study was carried out to investigate the anti-inflammatory activities and nitric oxide synthase (iNOS) expression of hot water (LMW) and 80% ethanol (LME) extracts from lemon myrtle leaf in lipopolysaccharide-induced (LPS) RAW 264.7 cells. The total phenol content of LMW and LME was 207.44 and $331.54{\mu}g$ tannic acid equivalents (TAE)/mg, respectively (p<0.01). DPPH radical scavenging activities of LMW and LME were remarkably increased in a dose-dependent manner, and were about 90.69% and 92.50% at 0.5 mg/ml, respectively. Superoxide dismutase (SOD) activities of LMW and LME were 106.22% and 103.58% at 1 mg/ml, respectively. The highest activity (91.03%) of nitrite-scavenging was observed for LME at 1 mg/ml at pH 1.2, while the activity for LMW was about 81.03% under the same conditions (p<0.05). Anti-inflammatory effect was examined in LPS stimulated RAW 264.7 cells. Nitric oxide (NO) production were reduced to 35.41% and 78.39% by addition of LMW and LME at 0.5 mg/ml, respectively (p<0.05). LMW and LME reduced protein expression of inducible nitric oxide synthase (iNOS) in a dose-dependent manner (p<0.05). These results, we conclude that lemon myrtle may be a highly valuable natural product owing to its high-quality functional components as well as its anti-oxidant and anti-inflammatory activities.

A Study on the Fracture Strength of the Cement Gap (Cement Gap에 따른 Zirconia Crown의 파절강도 비교)

  • Kim, Nam-Joong;Lee, Chung-Jae;Kwak, Woon-Seon
    • Journal of Technologic Dentistry
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    • v.38 no.4
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    • pp.299-304
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    • 2016
  • Purpose: This research is conducted for better clinical test of Zirconia as we find out the fracture strength difference of Zirconia on cement gaps of full Crown that made use of Zirconia which is somewhat being used in recent dental technology. Methods: We produced each nine of Zirconia Crown of Zirconia fracture cement gaps A group(0.03 mm), B group(0.05 mm), C group(0.08 mm) on cement gaps by use of CAD/CAM, and compared the results. We could end up getting conclusions as following. Results: There was fracture strength difference per cement gaps but no impact(P<0.05). There was difference between $1.962{\pm}0.259$ from group A and $2.005{\pm}0.367$ from group B, but no impact(P<0.05). There was difference between $1.962{\pm}0.259$ from group A and $2.478{\pm}0.331$ from group C, but it's hard to be considered as an impact(P<0.05). Conclusion: Because of the hight pressure 0.08 mm is fractured and Margin has a lot of empty space due to gap for 0.08 mm. To identify the difference between 0.08 mm and 0.05 mm, 0.08 mm is selected as a gap. Therefore when it comes to using 0.05 mm authentically 0.05 mm is quite practical to use as a gap.

Relationship between Bone Mineral Density and Bone Metabolic Biochemical Markers and Diet Quality Index-International(DQI-I) in Postmenopausal Obese Women (폐경비만여성의 골밀도와 골대사 지표 및 식사의 질 상관성 조사)

  • Jeong, Yeonah;Kim, Misung;Shin, Saeron;Han, Ahreum;Seo, Geomsuk;Sohn, Cheongmin
    • Korean Journal of Community Nutrition
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    • v.21 no.3
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    • pp.284-292
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    • 2016
  • Objectives: This study compared the differences of postmenopausal women's bone mineral density in relation to the degree of obesity, metabolism index and dietary factors that affect bone mineral density. Methods: The subjects included in the study are 39 postmenopausal women of normal weight with body mass index less than $25kg/m^2$ and 32 postmenopausal who are obese. Anthropometry and biochemical analysis were performed and nutrient intakes and DQI-I were assessed. Results: Normal weight women were $56.03{\pm}3.76years$ old and obese women were $58.09{\pm}5.13years$ old and there was no significant difference in age between the two groups. The T-score of bone mineral density was $0.03{\pm}1.06$ in normal weight women and $-0.60{\pm}1.47$ in obese women and this was significantly different between the two groups (p<0.05). Blood Leptin concentration was significantly lower in normal weight women ($6.09{\pm}3.37ng/mL$) compared to obese women in ($9.01{\pm}4.99ng/mL$) (p<0.05). The total score of diet quality index-international was $70.41{\pm}9.34$ in normal weight women and $64.93{\pm}7.82$ in obese women (p<0.05). T-score of bone mineral density showed negative correlations with percentage of body fat (r = -0.233, p=0.05), BMI (r = -0.197, p=0.017), triglyceride (r = -0.281, p=0.020) and leptin (r = -0.308, p=0.011). The results of multiple regression analysis performed as the method of entry showed that with 22.0% of explanation power, percentage of body fat (${\beta}=-0.048$, p<0.05), triglyceride (${\beta}=-0.005$, p<0.05) and HDL-cholesterol (${\beta}=0.034$, p<0.01), moderation of DQI-I (${\beta}=-0.231$, p<0.05) affected T-score significantly. Conclusions: The results of the study showed that obese women have less bone density than those with normal weight women. In addition, the factor analysis result that affect bone mineral density showed that intake of fat is a very important factor. Therefore, postmenopausal women need to maintain normal weight and manage blood lipid levels within normal range. They also need to take various sources of protein and reduce consumption of empty calorie foods that have high calories, fat, cholesterol and sodium.

The Effect of Swiss Ball Exercise on Lower Extremity Function of Elderly Women with Mild Cognitive Impairment (스위스볼 운동이 경도인지장애 여성노인의 하지기능에 미치는 효과)

  • Shin, Hyung-Soo
    • Journal of the Korean Society of Physical Medicine
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    • v.6 no.2
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    • pp.119-126
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    • 2011
  • Purpose: The purpose of this study was to confirm whether the Swiss Ball exercise program is effective to improve lower extremity function and activity of daily living of elderly women with mild cognitive impairment (MCI). Methods: This study was a double blind control study. Subjects participated 34 female elderly women who were assigned to exercise group (n=17) and control group (n=17). The Swiss Ball exercise program was performed 2 times a week during the 12 weeks. Pre-and post-exercise various measurements were made: lower extremity function (OLS, TUG, STS). Results: In exercise group, There showed statically significance improve between pre-and post-exercise in OLS (7.29${\pm}$1.10 and 7.64${\pm}$1.32), TUG (10.47${\pm}$2.03 and 10.05${\pm}$2.04), STS (7.71${\pm}$1.04 and 7.94${\pm}$.82)(p<.05). ADL also showed statically significance improve between pre-and post-exercise (13.76${\pm}$3.54 and 12.82${\pm}$3.39, p<.05). There showed statically significance difference between two groups (p<.05). Conclusion: The Swiss Ball exercise program improved lower extremity function and ADL of elderly women with MCI. Further studies are required to examine the significance of the assessment of motor function of lower extremities.

Effect of Flexi-bar Exercise on Postural Alignment and Balance in Asymmetric Posture

  • Um, Ki Mai;Kim, Hyun Sook;Lim, In Hyuk
    • Journal of International Academy of Physical Therapy Research
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    • v.6 no.1
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    • pp.809-814
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    • 2015
  • This study was conducted to identify how a flexi-bar exercise influences body alignment and balance in adults who have asymmetry in their right or left body. In total, 20 participants were separated into the experimental group and the comparison group. Those in the experimental group participated in a flexi-bar exercise for 6 weeks and based on the coronal plane before and after exercise, their body alignment and balance were measured behind the body. The result was those who had participated in a flexi-bar exercise significantly improved their angle of acromion on both sides, the difference in the angle and height of the posterior superior iliac spine on both sides(p<.05), and the balance of the center sagittal plane(p<.05). Through this study, it could be said that participating in a flexi-bar exercise would improve postural alignment and balance of the shoulder and pelvis in adults with asymmetric posture.

Influence of Ca-Si Addition on Anodic Polarization Chgaraqcteristics of Al-Zn-In Anodes (海水中 Al-Zn-In 合金陽極의 分極特性에 미치는 Ca-Si 添加의 影響)

  • Seo, Chang-Je
    • Journal of the Korean institute of surface engineering
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    • v.12 no.1
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    • pp.3-10
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    • 1979
  • Many excellent Al-Zn-In anode have been developed up to the present. But for the purpose of the better performance of Al-Zn-In anodes in sea water the effect of calcium silicon addition on anodic polarization and current capacity of Al-Zn-In anodes was measured and analysed in sea water and artificial sea water. The results and conclusions obtained are summarized as follows. 1) Being compared with Al-Zn-In anodes, Al-Zn-In anodes containing 0.05% calcium silicon had superior characteristics in both anodic polarization and current capacity. 2) Corrosion patterns of the anodes containing calcium silicon were much more uniform than those of Al-Zn-In anodes. 3) In this experiment the most useful anode was Al-4% Zn-0.03% In-0.05% (Ca-Si). It had a capacity of 2.60Amp-hr of current/g and a voltage of 1.13(SCE reference) at anodic current density 1,000 4{\mu}A/cm^2$.

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Leukoaraiosis on Magnetic Resonance Imaging Is Related to Long-Term Poor Functional Outcome after Thrombolysis in Acute Ischemic Stroke

  • Choi, Jae-Hyung;Bae, Hyo-Jin;Cha, Jae-Kwan
    • Journal of Korean Neurosurgical Society
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    • v.50 no.2
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    • pp.75-80
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    • 2011
  • Objective : Leukoaraiosis (LA) has been suggested to be related to the poor outcome or the occurrence of symptomatic intracerebral hemorrhage (sICH) after acute ischemic stroke. We retrospectively investigated the influences of LA on long-term outcome and the occurrence of sICH after thrombolysis in acute ischemic stroke (AIS). Methods : In this study, we recruited 164 patients with AIS and magnetic resonance image (MRI)-detected thrombolysis. The presence and extent of LA were assessed using the Fazekas grading system. The National Institutes of Health Stroke Scale score was used to assess the baseline measure of neurologic severity, and the modified Rankin Scale score assessment was used up to 1 year after thrombolysis. Results : Of 164 subjects, 56 (34.2%) showed LA on MRI. Compared to the 108 patients without LA, the patients with LA were of much older age (p<0.01), had a higher prevalence of hypertension (p<0.01), and had a much poorer outcome at 90 days (p=0.05) and 1 yr (p=0.01) after thrombolysis. There were no significant differences in sICH between patients with and without LA on MRI. In univariate analysis for the occurrence of poor outcome at 90 days after thrombolysis, the size of ischemic lesion on diffusion weighted images (DWI), [odds ratio (OR), 1.03; 95% confidence interval (95% CI), 1.01-1.04; p<0.01], recanalization (OR, 0.03; 95% CI, 0.01-0.10; p<0.01), sICH (OR, 12.2; 95% CI, 1.54-95.8), neurologic severity (OR, 1.17; 95% CI, 1.09-1.25; p<0.01), blood glucose level (OR, 1.01; 95% CI, 1.00-1.02; p=0.03), and the presence of LA on MRI (OR, 2.01; 95% CI, 1.04-3.01; p=0.04) were statistically significant. In multivariate analysis, neurologic severity (OR, 1.14; 95% CI, 1.04-1.24; p<0.01), recanalization (OR, 0.03; 95% CI, 0.01-0.11; p<0.01), lesion size on DWI (OR, 1.02; 95% CI, 1.01-1.03; p=0.02), serum glucose level (OR, 1.01; 95% CI; 1.01-1.02; p=0.03), and the presence of LA on MRI (OR, 3.2; 95% CI, 1.22-8.48; p<0.01) showed statistically significant differences. These trends persisted up to 1 yr after thrombolysis. Conclusion : In this study, we demonstrated that the presence of LA on MRI might be related to poor outcome after use of intravenous tissue plasminogen activator in AIS.

Effect of a Training Programme on Knowledge of Nurses from a Missionary Hospital in India Regarding Breast Cancer and its Screening

  • Khokhar, Anita
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.12
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    • pp.5985-5987
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    • 2012
  • A cross-sectional study was conducted among nursing staff of a missionary hospital of Delhi in June 2009. All the nurses were invited to participate in the training programme on breast cancer and techniques of breast self examination (BSE). A questionnaire was administered to all 259 participants seeking information on their level of awareness regarding breast cancer and relevant screening guidelines. With the help of 5 training workshops all the nurses were imparted training regarding the most appropriate technique of doing breast self exams. The mean age of the participants was 35.8 years. Out of a total of 259 nursing staff members 77.2% correctly answered all the 10 questions regarding high risk factors for breast cancer and after the training programme this increased to 100% (p<0.05). Only 65.2% of the participants gave correct responses to all the 8 questions regarding correct technique of performing a BSE, which after the training programme increased to 99.3% (p<0.05). At the baseline only 56.8% knew all the three screening methods correctly and after the intervention 98.7% could correctly mark the responses regarding screening (p<0.05). The actual practice of following the screening guidelines amongst the nursing staff was poor. Only 26 (10.03%) had ever done a BSE, none performed it monthly, 58 (22.4%) had ever gone themselves for a CBE and 18 (6. 94%) had ever undergone mammography.