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http://dx.doi.org/10.5720/kjcn.2016.21.3.284

Relationship between Bone Mineral Density and Bone Metabolic Biochemical Markers and Diet Quality Index-International(DQI-I) in Postmenopausal Obese Women  

Jeong, Yeonah (Department of Nutrition Services, Wonkwnag University Hospital)
Kim, Misung (Department of Food and Nutrition, Wonkwang University)
Shin, Saeron (Department of Family Medicine, Wonkwang University Hospital)
Han, Ahreum (Department of Family Medicine, Wonkwang University Hospital)
Seo, Geomsuk (Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University College of Medicine)
Sohn, Cheongmin (Department of Food and Nutrition, Wonkwang University)
Publication Information
Korean Journal of Community Nutrition / v.21, no.3, 2016 , pp. 284-292 More about this Journal
Abstract
Objectives: This study compared the differences of postmenopausal women's bone mineral density in relation to the degree of obesity, metabolism index and dietary factors that affect bone mineral density. Methods: The subjects included in the study are 39 postmenopausal women of normal weight with body mass index less than $25kg/m^2$ and 32 postmenopausal who are obese. Anthropometry and biochemical analysis were performed and nutrient intakes and DQI-I were assessed. Results: Normal weight women were $56.03{\pm}3.76years$ old and obese women were $58.09{\pm}5.13years$ old and there was no significant difference in age between the two groups. The T-score of bone mineral density was $0.03{\pm}1.06$ in normal weight women and $-0.60{\pm}1.47$ in obese women and this was significantly different between the two groups (p<0.05). Blood Leptin concentration was significantly lower in normal weight women ($6.09{\pm}3.37ng/mL$) compared to obese women in ($9.01{\pm}4.99ng/mL$) (p<0.05). The total score of diet quality index-international was $70.41{\pm}9.34$ in normal weight women and $64.93{\pm}7.82$ in obese women (p<0.05). T-score of bone mineral density showed negative correlations with percentage of body fat (r = -0.233, p=0.05), BMI (r = -0.197, p=0.017), triglyceride (r = -0.281, p=0.020) and leptin (r = -0.308, p=0.011). The results of multiple regression analysis performed as the method of entry showed that with 22.0% of explanation power, percentage of body fat (${\beta}=-0.048$, p<0.05), triglyceride (${\beta}=-0.005$, p<0.05) and HDL-cholesterol (${\beta}=0.034$, p<0.01), moderation of DQI-I (${\beta}=-0.231$, p<0.05) affected T-score significantly. Conclusions: The results of the study showed that obese women have less bone density than those with normal weight women. In addition, the factor analysis result that affect bone mineral density showed that intake of fat is a very important factor. Therefore, postmenopausal women need to maintain normal weight and manage blood lipid levels within normal range. They also need to take various sources of protein and reduce consumption of empty calorie foods that have high calories, fat, cholesterol and sodium.
Keywords
bone mineral density; bone metabolic markers; diet quality index-international; postmenopausal; obesity;
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Times Cited By KSCI : 6  (Citation Analysis)
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1 Lee MY, Kim JH. Comparison of serum insulin, leptin, adiponectin and high sensitivity C-reactive protein levels according to body mass index and their associations in adult women. Korean J Community Nutr 2011; 16(1): 126-135.   DOI
2 Baik IK, Shin C. Association of daily sleep duration with obesity, macronutrient intake, and physical activity. Korean J Community Nutr 2011; 16(3): 315-323.   DOI
3 Ministry of Health and Welfare and Korea Centers for Disease Control and Prevention. Korea Health Statistics 2014: Korea National Health and Nutrition Examination Survey [KNHANES VI-2] [internet]. 2015 [cited 2016 May 01]. Available from: https://knhanes.cdc.go.kr/knhanes/index.do.
4 Yeo JK, Lee SJ, Joo IW, Kim JA, Oh HJ. Age-related changes of serum bone turnover marker (osteocalcin, bone specific alkaline phosphatase and cross-linked C telopeptides of type I collagen) and the relationship with bone mineral density in Korean women. Osteoporosis 2008; 6(1): 43-50.
5 Christenson RH. Biochemical markers of bone metabolism: an overview. Clin Biochem 1997; 30(8): 573-593.   DOI
6 Neeland IJ, Turer AT, Ayers CR, Powell-Wiley TM, Vega GL, Farzaneh-Far R et al. Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults. JAMA 2012; 308(11): 1150-1159.   DOI
7 Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 2004; 50(9): 1511-1525.   DOI
8 Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89(6): 2548-2556.   DOI
9 Sipila S, Narici M, Kjaer M, Pollanen E, Atkinson RA, Hansen M et al. Sex hormones and skeletal muscle weakness. Biogerontology 2013; 14(3): 231-245.   DOI
10 Kim S, Haines PS, Siega-Riz AM, Popkin BM. The Diet Quality Index-International (DQI-I) provides an effective tool for crossnational comparison of diet quality as illustrated by China and the United States. J Nutr 2003; 133(11): 3476-3484.   DOI
11 Czarkowska-Paczek B, Milczarczyk S. Age-related muscle mass loss. Przegl Lek 2006; 63(8): 658-661.
12 Christenson RH. Biochemical markers of bone metabolism: an overview. Clin Biochem 1997; 30(8): 573-593.   DOI
13 Ho-Pham LT, Nguyen ND, Lai TQ, Nguyen TV. Contributions of lean mass and fat mass to bone mineral density: a study in postmenopausal women. BMC Musculoskelet Disord 2010; DOI:10.1186/1471-2474-11-59.   DOI
14 Ijuin M, Douchi T, Matsuo T, Yamamoto S, Uto H, Nagata Y. Difference in the effects of body composition on bone mineral density between pre- and postmenopausal women. Maturitas 2002; 43(4): 239-244.   DOI
15 Choi YH, Sung CJ. Effects of physiological factors and lifestyles on bone mineral density in postmenopausal women. Korean J Nutr 2007; 40(6): 517-525.
16 Yang R, Ma X, Pan X, Wang F, Luo Y, Gu C et al. Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women. Menopause 2013; 20(5): 548-553.
17 Bae SJ, Choe JW, Chung YE, Kim BJ, Lee SH, Kim HY et al. The association between serum osteocalcin levels and metabolic syndrome in Koreans. Osteoporos Int 2011; 22(11): 2837-2846.   DOI
18 Ministry of Health and Welfare and Korea Centers for Disease Control and Prevention. Korea Health Statistics 2010: Korea National Health and Nutrition Examination Survey [KNHANES V-1] [internet]. 2012 [cited 2016 May 01]. Available from: https://knhanes.cdc.go.kr/knhanes/index.do.
19 Park JY, Choi MY, Lee SH, Choi YH, Park YK. The association between bone mineral density, bone turnover markers and nutrient intake in pre- and postmenopausal women. Korean J Nutr 2011; 44(1): 29-40.   DOI
20 Filip R, Raszewski G. Bone mineral density and bone turnover in relation to serum leptin, alpha-ketoglutarate and sex steroids in overweight and obese postmenopausal women. Clin Endocrinol 2009; 70(2): 214-220.   DOI
21 Oh HJ, Lim CH, Chung HY, Han KO, Chang HC, Yoon HK et al. Effect of obesity on BMD in postmenopausal women. Korean J Obes 2000; 9(2): 122-127.
22 Compston JE, Watts NB, Chapurlat R, Cooper C, Boonen S, Greenspan S et al. Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med 2011; 124(11): 1043-1050.   DOI
23 Cui LH, Shin MH, Chung EK, Lee YH, Kweon SS, Park KS et al. Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea. Osteoporos Int 2005; 16(12): 1975-1981.   DOI
24 Reid IR, Ames R, Evans MC, Sharpe S, Gamble G, France JT et al. Determinants of total body and regional bone mineral density in normal postmenopausal women-a key role for fat mass. J Clin Endocrinol Metab 1992; 75(1): 45-51.   DOI
25 Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z et al. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr 2006; 83(1): 146-154.   DOI
26 Hu FB. Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 2002; 13(1): 3-9.   DOI
27 Zeng FF, Xue WQ, Cao WT, Wu BH, Xie HL, Fan F et al. Diet-quality scores and risk of hip fractures in elderly urban Chinese in Guangdong, China: a case-control study. Osteoporos Int 2014; 25(8): 2131-2141.   DOI
28 Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q et al. Plasma lipids and osteoporosis in postmenopausal women. Endocr J 2002; 49(2): 211-217.   DOI
29 Luegmayr E, Glantschnig H, Wesolowski GA, Gentile MA, Fisher JE, Rodan GA et al. Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol/lipoproteins. Cell Death Differ 2004; 11(Suppl 1): S108-118.   DOI
30 Parhami F, Demer LL. Arterial calcification in face of osteoporosis in ageing: can we blame oxidized lipids? Curr Opin Lipidol 1997; 8(5): 312-314.   DOI
31 Burguera B, Hofbauer LC, Thomas T, Gori F, Evans GL, Khosla S et al. Leptin reduces ovariectomy-induced bone loss in rats. Endocrinology 2001; 142(8): 3546-3553.   DOI
32 Park SJ, Ahn YJ, Min HS, Oh KS, Park C, Cho NH et al. Osteoporosis prevalence of radius and tibia and related factors using multiple bone sites quantitative ultrasound measurement of the Korean health and genome study cohort women. Korean J Community Nutr 2005; 10(4): 536-545.
33 Koo JO, Park SY. Analysis of BMI menopose, blood pressure and dietary habits affecting born mineral density of 30-60 years women. Korean J Community Nutr 2010; 15(3): 403-414.
34 Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000; 100(2): 197-207.   DOI
35 Holloway WR, Collier FM, Aitken CJ, Myers DE, Hodge JM, Malakellis M et al. Leptin inhibits osteoclast generation. J Bone Miner Res 2002; 17(2): 200-209.   DOI