• 한국식품영양학회지
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• 제25권1호
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• pp.1-8
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• 2012

The purpose of this study was to compare convenience food purchasing behaviors and food habits. The study, which asked surveyed 131 female college students in Daejeon, in 2011, on how they used nutrition labels. The subjects were divided into two groups, in terms of the way they checked examined nutrition labels: a "Check" group(n=62, 47.3%) and a "No check" group(n=69, 52.7%). Reasons given for not reading nutrition labelings were "a habit of buying" for 72.2%, and "too small or rude" for 19.1%. The "Check" group reported higher interest in nutrition(p<0.001) and hygiene(p<0.01) than the "No check" group. Those who used the labels had higher cereal(p<0.01) and vegetable(p<0.01) consumption and a lower intake of fast foods(p<0.05). But however, most of the subjects(65.6%) chose by taste, at the time they purchased the convenience foods. The subjects considered "expiry date"(n=87, 66.4%) to be more important information on food labels than "nutrient composition"(n=11, 8.4%). The number of products whose nutrition labels were checked by over 50% was five out of 12. In conclusion, our study suggests that proper use of nutrition labeling may improve food choices and enable healthy dietary practices. Further efforts are needed to provide the public with nutrition education programs on how to read nutrition labeling. Modifying nutrition labels to make them easier for the public to understand should also be considered.

• 한국학교보건학회지
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• 제1권2호
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• pp.50-65
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• 1988

This study was conducted in order to grasp the condition of about the school nurse's service and to offer the basic materials of improving the school health service. The objects were comprised of 98 volunteered school nurses who take service in the elementary school. The material of this study was the questionaire suited to the purpose of this research which has been made through studying references and this questionaire has been corrected and revised three times. All the questionaire written by school-nurses. The results are as follows; 1. General features of the objects of study Average age was 35.9 and average career was 9.2 years. Except working as school-nurse, the past career was that average clinical-field was 3.4 years and health service was 4 months. Their educational level was as high as 72.4% of the objects were graduated from above 3 years college and 89.8% were married. 76.5% have religions and 94.8% were working at with national and public schools. 99.0% were doing only nursing service. 2. The conditions of the school health resources. The ratio of school-nurse to students was one to 2630. School-nurse to classes, one to 49.3, and school-nurse to teachers, one to 54. For total amount of a year budget of school health, from three hundred thousands to fifty nine hundred thousands won was most common. Expenses for purchasing medicine were used most. 58.2% of school-nurses hasn't known a year budget. There was an organization for school health in 74.2% of schools. 42.9% of nursing rooms were in the center of school and 88.8% were on first floor. Nursing room were used alone without being used by another purpose and the room size of 71.6% was below 10 pyong. 3. The conditions of school health service Average users of nursing room were 413 a month. The most of them had digestive trouble. Sending letters to home was 15.9 times a year. The most contents of letters was about health education. Object spent much time managing nursing room. 4. The degree of school health service When 2 points was given to "perform" and 1 point was to "not perform" the total average was 1.75, health education 1.89, environmental management 1.86, plan of project and evaluation 1.83, management of nursing room 1.82, health management 1.78, run of school health organization 1.32. 5. Correlation between the school health services and variables (1) The part of project plan and evaluation of school health service has relationship to existence or none-existence of school health organization (P<0.01), past health service career (P<0.05), number of classes (P<0.01), number of students (P<0.01), sending letters to home about health education (P<0.01) and number of users (P<0.05). (2) The part of nursing room management has relationship to ages (P<0.05) past clinical career (P<0.05), number of classes (P<0.05), number of students (P<0.05) and sending letters to home about health education (P<0.01). (3) The part of health education has relationship to existence or none-existence of school health organization (P<0.05), past clinical career (P<0.05), the ratio of health management to school nurse's all work (P<0.05) and the ratio of health education to school nurse's all work (P<0.01). (4) The part of environmental management to ages (P<0.01), career as a school-nurse (P<0.01), salary step(P<0.01), sending letters to home about health education (P<0.01), sending all letters to home (P<0.001), the ratio of health management to school nurse's all work (P<0.05), the ratio of health education to school nurse's all work (P<0.05) and area of school-nurse's room to be used. (5) The part of school health organization management to number of classes (P<0.05). (6) The part of health management to number of classes (P<0.05), sending letters to home about health education (P<0.001), sending all of letters to home (P<0.01) and the ratio of health management to school nurse's all work (P<0.05). (7) The part of school health service to ages (P<0.05), past clinical career (P<0.05), past health career (P<0.01), number of classes (P<0.05), number of student (P<0.05), sending letters to home about health education (P<0.05), sending all letters to home (P<0.05), the ratio of health management to school nurse's all work (P<0.05), the ratio of health education to school nurse's all work (P<0.01) and area of school - nurse's room to be used (P<0.05). ## Suggestion for further studies are as follows. 1. School-nurse should exert herself to advance a quality to take care of school population's health. 2. It is necessary that systematic support required to keep school population's health. 3. Home, school and community should make efforts cooperatively and the proper roles of students, teachers, health team members and parents must be achieved.

• Biomolecules & Therapeutics
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• 제15권2호
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• pp.102-107
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• 2007

Cimetidine, a substrate for P-glycoprotein (P-gp), is a well known drug interacting with a variety of drugs and results in alteration of pharmacokinetic parameters by concomitant administration. The aim of present study was to investigate whether cimetidine affects the transport of various quinolone antibiotics in human colorectal cancer cell line (Caco-2) system which has been typically used to investigate drug transport via P-gp. The apparent permeability coefficients (P$_{app}$) value of 9 quinolone antibiotics in the co-treatment with cimetidine was examined. Apical to basolateral (AP-to-BL) transport of fleroxacin in the co-treatment with cimetidine was increased to 1.5-fold (p<0.01) compared with that of fleroxacin alone, whereas basolateral to apical (BL-to-AP) transport of fleroxacin was decreased to 0.83-fold significantly (p<0.05). Ofloxacin was decreased to 0.8-fold (p<0.01) and 0.72-fold (p<0.01) significantly in AP-to-BL and BL-to-AP direction, respectively by cimetidine cotreatment. The P$_{app}$ values of gatifloxacin, moxifloxacin, ciprofloxacin and rufloxacin also were changed by cimetidine. These results have a potential that cimetidine influences on the pharmacokinetics of quinolone antibiotics. It suggests that careful drug monitoring and dosage adjustment may be necessary during the co-administration of quinolone antibiotics with cimetidine.

• 생명과학회지
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• 제15권4호
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• pp.657-663
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• 2005

Collagnase는 천연 collagen의 triple-stranded helix를 분해할 수 있는 protease로서 조직의 수복과 재생 과정에서 collagen의 재형성과 세포의 이동에 아주 중요한 역할을 하고, 숙주 감염시에는 collagen 기질을 빠르게 분해함으로써 감염을 돕는다. 본 연구에서는 일반가정에서 식용하는 김치로부터 collagenase를 생산하는 균주를 분리하여 Bacillus subtilis로 동정하였으며 이를 Bacillus subtilis JS-17이라 명명하였다. Bacillus subtilis JS-17이 생산하는 collagenase의 최적 생산 조건은 $1.5\%$ fructose, $1\%$ yeast extract, $0.5\%\;K_2HPO_4,\;0.4\%\;KH_2PO_4,\;0.01\%\;MgSO_4{\cdot}4H_2O,\;0.1\%\;citrate,\;0.1\%\;CaCl_2(pH\;7.0)$의 배지에서 $30^{\circ}C$, 200 rpm으로 72시간 동안 배양하는 것이다. 최적 조건에서 Bacillus subtilis JS-17이 생산하는 collagenase를 Amberlite IRA-900 column chromatography, Sephacryl S-300 HR column chromatography, DEAE-Sephadex A-30 column chromatography를 거쳐 분리 정제하고, 얻어진 정제 효소의 특성에 대하여 검토하였다. 정제된 collagenase의 비활성은 growth medium에서 192.1 units/mg였고, $1.1\%$의 수율로 얻어졌으며 분자량은 28 kDa이었다. 정제된 collagenase는 $55^{\circ}C$까지는 $100\%$의 활성을 유지하였고 $65^{\circ}C$에서도 $60\%$ 정도의 활성을 유지하였다. 또한 pH $6.0\~9.8$에서 $60\%$ 이상의 활성을 유지하였다. 정제된 collagenase는 metalloprotease inhibitor인 EDTA와 O-phenanthroline에 의해 효소 활성이 감소하였을 뿐만 아니라 Ammoninum persulfate, L-cysteine, N-ethylmaleimide, SDS, $NaN_3$, NaF, $KMnO_4$, PMSF에 대해서도 활성이 감소하였다. 정제된 collagenase를 여러 가지 기질에 대해 효소 활성을 비교한 결과 collagen (type I)에 대해 기질 특이성을 가지고 있었다.

• 대한지역사회영양학회지
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• 제9권2호
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• pp.151-160
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• 2004

The purpose of this study was to evaluate the intake of antioxidant vitamins and plasma concentrations of those in 60 maternal-infant pairs (30 in normal term delivery group, NT; 30 in preform delivery group, PT). We also investigated the relationship between vitamin levels of maternal-umbilical cord plasma and pregnancy outcome. Mean energy intakes of NT and PT pregnant women were 93.2% and 85.4%, and their protein intakes were 113.3% and 110.9% of the recommended dietary allowance (RDA), respectively. While vitamin A intakes were only 51.2% and 39.6% of the RDA in NT and PT pregnant women. The vitamin E intake was about 50% of the RDA (NT 6.27 mg, PT 7.78 mg). The levels of retinol in maternal plasma of NT and PT were $1.51\mumol/\ell\;and\;1.43\mumol/\ell$, respectively. The retinol levels in umbilical cord plasma in NT and PT were $0.72\mumol/\ell\;and\;0.61\mumol/\ell$, respectively. The level of $\beta-carotene$in maternal plasma of NT was 0.49 $\mu$mol/$\ell$, significantly (p ＜ 0.01) higher than that of PT ($0.31\mumol/\ell$).The $\beta-carotene$ of umbilical cord plasma of NT and PT were $0.702\mumol/\ell\;and\;0.01\mumol/\ell$, respectively. The plasma $\alpha$-tocopherol of maternal of NT and PT were $0.72\mumol/\ell\;and\;0.01\mumol/\ell\;29.51 /mumol/\ell\; and 27.17\mumol/\ell,\;respectively.\; The $\alpha$-tocopherol of umbilical cord plasma of NT and PT were $4.16\mumol/\ell\;and\;3.80\mumol/\ell$, respectively. The antioxidant vitamin levels (retinol, $\beta-carotene,\;and\;\alpha$-tocopherol) in maternal plasma were significantly higher (p＜0.0001) than those in umbilical cord plasma. However, there was no correlation between the vitamin levels in maternal plasma and those in umbilical cord plasma. The maternal plasma $\beta$-carotene level showed a positive correlation to gestational age. Also Apgar score at 1 min produced a positive correlation to maternal plasma $\beta$-carotene level.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1603-1609
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• 2014

Background: The response to treatment and overall survival (OS) of patients with acute myeloid leukemia (AML) is variable, with a median ranging from 6 months to 11.5 years. TP53 is associated with old age, chemotherapy resistance, and worse OS. Using genetic sequencing, we set out to look at our own experience with AML, and hypothesized that both TP53 mutations and SNPs at codon 72 would mimic the literature by occurring in a minority of patients, and conferring a worse OS. Materials and Methods: We performed a pilot study of randomly selected, newly diagnosed AML patients at Mount Sinai Medical Center, diagnosed from 2005-2008 (n=10). TP53 PCR sequencing was performed using DNA from bone marrow smears. Analysis was accomplished using Mutation Surveyor software with confirmation of the variants using the COSMIC and dbSNP databases. Results: Fewer than half of the patients harbored TP53 mutations (40%). There was no significant difference in OS based on gender, AML history, risk-stratified karyotype, or TP53 mutation. There were possible trends toward improved survival among patients less than 60 (11 vs 4 months, p=0.09), Hispanics (8 vs 1 months, p=0.11), and those not harboring SNP P72R (8 vs 2 months, p=0.10). There was a significant improvement in survival among patients with better performance status (28 vs 4 months, p=0.01) and those who did not have a complex karyotype (8 vs 1 months, p=0.03). The most commonly observed TP53 mutation was a missense N310K (40%) and the most commonly observed SNP was P72R (100.0%). Conclusions: Our study confirms previous reports that poor PS and the presence of a complex karyotype are associated with a decreased OS. In our cohort, TP53 mutations were relatively common, occurring more frequently in male patients with an adverse karyotype. Although there was no significant difference in survival between TP53 mutated and un-mutated patients, there was a possible trend toward worse OS among patients with SNP P72R. Larger studies are needed to validate these findings.

• 대한통합의학회지
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• 제6권3호
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• pp.113-121
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• 2018

Purpose : The purpose of this study was to understand the correlations between ego-resilience, self-efficacy and Satisfaction of Department on Nursing Students. Method : The subjects of this study were 352 nursing students in K college. The data collection period was from April 3, 2017 to April 20, 2017. The collected data was processed using SPSS 21.0 and were analyzed using frequency, means, standard deviation, t-test, ANOVA, Scheffe's test and pearson's correlation coefficient. Result : The mean scores for ego-resilience, self-efficacy and department satisfaction of the nursing students were 2.75 (${\pm}1.00$), 2.86 (${\pm}0.95$) and 3.72 (${\pm}0.92$) respectively. The ego-resilience score of the nursing students was significantly differed according to their religion (F=4.39, p=.002), choice motivation (F=3.99, p=.004), and relationship with friends (F=13.53, p=.015). The self-efficacy of the nursing students was significantly different by religion (F=3.18, p=.014). The department satisfaction of the nursing students also differed according to choice motivation (F=7.54, p= .007), and relationship with friends (F=11.66, p=.001). There was a positive correlation between ego-resilience and self-efficacy (r=.608, p<.01), between ego-resilience and department satisfaction (r=.342, p<.01), between self-efficacy and department satisfaction (r=.256, p<.01). Conclusion : The results of this study suggest the following: It is necessary to repeat the study with expanded number and scope of subjects in order to increase nursing a students' interest in Satisfaction of Department. It is necessary to develop programs for enhancing nursing students ego-resilience and self-efficacy which will result in a higher degree of department satisfaction.

• 한국산업보건학회지
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• 제22권1호
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• pp.61-72
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• 2012

Background: The purpose of this study was to analyze the associations between physical therapists' work-related musculoskeletal pain, quality of life (QoL), and presenteeism. Methods: Self-reported questionnaires were given to 402 physical therapists in Korea. Variables examined included the prevalence of pain sites related to work, pain intensity, pain pattern, pain frequency, pain duration, pain rating score (PRS), general characteristics, QoL, and presenteeism. Results: Of the 314 physical therapists who responded, 251 (79.9%) reported work -related musculoskeletal pain in at least one body part. The most affected regions included the wrist and hand (21.0%), shoulder (19.6%), and lower back (19.1%). On average patients, QoL and presenteeism differed significantly between physical therapists who reported pain and those who did not (P < 0.05). QoL showed a negative correlation with the work-related musculoskeletal pain (P < 0.01) and presenteeism (P < 0.01), while the presenteeism and work-related musculoskeletal pain showed positive one(P < 0.01). Factors influencing a physical therapist's QoL included presenteeism, Working venues (Convalescent hospital), Work status (Contra ct worker) and professional experience, while the presenteeism included QoL, work status (Intern), PRS, working venues (Convalescent hospital), Area of specialty (Pediatrics), age, sex and working hour. Conclusions: Results show that physical therapists appear to be at a higher risk for work-related musculoskeletal pain. Therefore, administrators need to use the intervention strategies to manage the presenteeism and QoL of physical therapists.

• Journal of Nutrition and Health
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• 제47권1호
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• pp.77-88
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• 2014

본 연구는 기숙사 생활을 하는 제주지역 고등학생을 대상으로 기숙사급식 만족도와 급식에서 제공되는 메뉴에 대한 기호도를 조사 분석함으로써 기숙사 학생들의 다양한 요구와 필요에 부합하고 기숙사 급식의 질적 향상을 모색하기 위한 기초자료로 활용하고자 실시하였다. 조사대상 고등학생의 성별은 남자가 71.1%, 학년은 2학년 46.0%, 기숙사 거주기간이 2~3학기인 학생이 45.3%, 월평균 용돈은 3만원 미만이 39.0%, 동지역에 거주하는 학생이 68.3%로 나타났다. 방학 중 외식횟수는 한 달에 1~2회가 51.4%, 부모가 맞벌이를 하는 학생은 73.7%, 어머니의 학력은 고졸이 46.9%, 본인이 건강하다고 생각하는 학생은 60.3%로 나타났다. 조사대상의 기숙사급식 만족도에 있어서는 메뉴 품질에 대한 만족도 (3.26)보다 서비스 및 위생에 대한 만족도 (3.46)가 높았고, 메뉴 품질에 있어서는 주식 (밥)의 양 (3.70), 음식의 온도 (3.50), 음식의 신선도 (3.42), 음식의 맛 (3.14)의 순으로, 서비스 및 위생에 있어서는 급식 정보 제공 (3.66), 식당 분위기(3.53), 급식 위생 (3.48), 식사질서 지도 (3.43), 원활한 배식 (3.34), 조리종사자의 친절도 (3.33)의 순으로 나타났다. 조사대상 고등학생의 끼니별 급식 만족도는 저녁식사 (3.70), 점심식사 (3.50), 아침식사 (3.14)의 순으로 나타났으며, 성별에 있어서는 아침식사의 경우 여학생의 만족도 (3.36)가 남학생의 만족도 (2.93)보다 유의적으로 높게 나타났다 (p < .01). 조사대상이 기숙사급식에서 제공받은 음식의 섭취량을 끼니별로 분석한 결과 저녁식사 (3.70), 점심식사 (3.50), 아침식사 (3.14)의 순으로 나타났고 점심식사와 저녁식사는 남학생의 섭취량 (각 4.12, 4.17)이 여학생 (각 3.72, 3.76) 보다 유의적으로 많았다 (p < .001). 조사대상 고등학생의 기숙사급식에 대한 개선점에 있어서는 맛의 향상 (43.4%), 메뉴의 다양성 (31.0%), 배식량 증가 (17.4%), 급식위생 (3.8%), 급식환경 (3.3%)의 순으로 응답율을 보였고 남학생의 경우 맛의 향상 (49.2%), 메뉴의 다양성 (28.7%), 배식량 증가 (14.9%), 급식환경 (4.6%), 급식위생 (1.3%)의 순으로, 여학생은 메뉴의 다양성 (36.6%), 맛의 향상 (29.3%), 배식량 증가 (23.6%), 급식위생 (8.1%), 급식환경 (1.6%)의 순으로 나타났다 (p < .001). 조사대상의 주식류에 대한 기호도는 면류 (4.06), 일품음식류 (3.92), 밥류 (3.66)의 순으로 높게 나타났고 밥류에 있어서는 검정쌀밥 (3.80), 일품음식류는 볶음밥 (4.05), 면류에 있어서는 스파게티 (4.21)의 기호도가 가장 높게 나타났다. 국 및 찌개류에 대한 기호도는 갈비탕 (4.10), 김치찌개 (3.99), 된장찌개 (3.92), 순두부찌개 (3.79), 육개장 (3.78)의 순으로 나타났고 동태찌개 (2.72)와 북어국 (2.61)은 보통 이하의 기호도를 보였다. 조사대상의 부식류에 대한 기호도에 있어서는 찜류 (3.95), 튀김류 (3.87), 볶음류 (3.57), 김치류 (3.54), 구이류 (3.49), 조림류 (3.27)의 순으로 나타났고 무침류는 3점 미만인 2.89를 나타내 보통 이하의 기호도를 보였다. 메뉴 아이템에 있어서는 갈비찜 (4.24), 닭튀김 (4.23), 닭볶음 (4.19), 돈까스 (4.17), 탕수육 (4.10), 돼지고기볶음 (4.04)의 순으로 높은 기호도를 보였고, 5점 만점에 대해 4점 이상을 나타냈으며, 콩조림 (2.94), 시금치무침 (2.94), 애호박무침 (2.89), 느타리버섯볶음 (2.84), 생선구이 (2.81), 마늘쫑무침 (2.69), 취나물무침 (2.67), 청경채 겉절이 (2.71), 톳무침 (2.65), 생선조림 (2.63), 건파래 무침 (2.59)은 5점 만점에 대해 3점 미만을 나타내 보통 이하의 기호도를 보여 생선이나 채소류보다 육류를 이용한 음식에 대한 기호도가 높음을 알 수 있었다. 후식류에 있어서는 쥬스류의 기호도 (4.52)가 가장 높았고 요구르트 (4.50), 생과일 (4.42), 빵류 (4.33), 우유 (4.08), 떡류 (4.01)의 순으로 나타났으며 빵류 (p < .05) 와 떡류 (p < .01)에 대해 남학생보다 여학생의 기호도가 유의적으로 높게 나타났다. 조사대상의 메뉴 기호도는 기숙사급식 만족도 (r = 0.369), 메뉴 품질 (r = 0.348), 서비스 및 위생 (r = 0.344), 끼니별 급식 만족도 (r = 0.418), 제공된 음식 섭취량 (r = 0.220)과 정 (+)의 상관관계를 (p < .01), 기숙사급식 만족도는 메뉴품질 (r = 0.944), 서비스 및 위생 (r = 0.931), 끼니별 급식 만족도 (r = 0.707)와 다소 높은 정 (+)의 상관관계를 (p < .01), 메뉴품질은 서비스 및 위생 (r = 0.758), 끼니별 만족도 (r = 0.717)와 다소 높은 정 (+)의 상관관계를 (p < .01), 서비스 및 위생은 끼니별 급식 만족도 (r = 0.604)와 정 (+)의 상관관계를 나타냈다 (p < .01). 이상의 연구결과를 토대로 살펴볼 때, 기숙사급식에의 의존도가 높은 기숙사생들이 영양적으로 균형 있는 음식을 섭취하고 올바른 식습관을 형성할 수 있도록 다각적이고 체계적인 영양교육이 병행되어야 하며 배식량 및 배식방법 등을 개선하고 다양한 조리법 및 이벤트 메뉴 등을 개발하는 등 학생들이 성장기에 필요한 영양소를 충분히 섭취할 수 있도록 다양한 방안이 모색되어야 할 것으로 사료된다.

• Journal of Nutrition and Health
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• 제50권4호
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• pp.361-375
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• 2017

2010년, 2014년 3~5세의 국민건강영양조사 자료를 이용하여 유치원 및 보육시설을 이용하는 원아 509명을 대상으로 분석한 결과는 다음과 같다. 2014년 원아들의 조사 전날 결식률은 16.2%로, 2010년 원아의 결식률에 비해 5.5%p 증가하였다. 원아들의 연도별 영양상태를 살펴본 결과, 2014년도 원아들의 칼슘 섭취량은 권장량 대비 가장 적게 섭취한 영양소로, 2010년도 원아들에 비해 1일 39.78 mg (3세), 54.78 mg (4세) 35.78 mg (5세) 적게 섭취하였다. 영양소 적정섭취비의 경우, 2014년 4세와 5세 원아는 2010년 4, 5세에 비해 철과 티아민의 NAR이 유의하게 높았다. 영양 밀도지수에서 2014년 5세 원아의 칼슘과 인 INQ는 2010년 5세에 비해 유의하게 낮은 반면, 티아민의 INQ는 2010년 5세에 비해 높았다. 과잉섭취 대상자 비율에서는 2014년 3~5세 원아들은 2010년 원아들에 비해 철과 티아민 과잉섭취 대상자 비율이 높았다. 또한 원아들의 연령별 영양상태를 살펴본 결과에서는, 평균 영양소 적정섭취비에서 3세의 MAR은 4세와 5세에 비해 유의하게 낮았고, 평균필요량 미만으로 섭취한 영양소의 개수는 4세 (2.14개)와 5세 (1.92개)에 비해 3세에서 2.72개로 유의하게 많았다.