• Journal of the Korean Vacuum Society
• /
• v.13 no.1
• /
• pp.39-45
• /
• 2004

Ultraviolet-nanoimprint lithography (UV-NIL) is a promising method for cost-effectively defining nanoscale structures at room temperature and low pressure. A 5${\times}$5${\times}$0.09 in. quartz stamp is fabricated using the etch process in which a Cr film was employed as a hard mask for transferring nanostructures onto the quartz plate. FAS(Fluoroalkanesilane) is used as a material for anti-adhesion surface treatment on the stamp and a thin organic film to improve adhesion on a wafer is formed by spin-coating. The low viscosity resin droplets with a nanometer scale volume are dispensed on the whole area of the coated wafer. The UV-NIL experiments have been performed using the EVG620-NIL. 370 nm - 1 m features on the stamp have been transferred to the thin resin layer on the wafer using the multi-dispensing method and UV-NIL process. We have measured the imprinted patterns and residual layer using SEM and AFM to evaluate the potential of the process.

• Journal of Life Science
• /
• v.5 no.2
• /
• pp.14-14
• /
• 1995

The effect of lipoxygenase (LOX) on the oxidation and co-oxidation of lipid fraction was studied in the model system of rainbow trout. For the reaction in model system 1 g of lipid fraction and 50mL of enzyme extract(LOX, 140 unit in 50mL phosphate buffer solution at pH 7,4)), which were obtained from rainbow trout, were homoginized in the presence of Tween 20 and kept at 23$\circ$C for 3 days. The activity of LOX was decreased to 43% of initial level during the reaction in the model system. The initial composition of rainbow trout lipid was showed to be consisted of trigliceride(TG;82%) and free fatty acid(FFA;0.1%), while this converted to 59% of TG and 20% of FIFA, respectively after reaction in model system. Change of fatty acid composition was also observed and the content of linoleic acid, one of the major fatte acids, was decreased to 13% from 54% in the content of total fatty acids after reaction. The carotenoids in rainbow trout were composed of 0.4% $\alpha$-carotene, 1.6% $\beta$ -carotene, 80% canthaxanthin, 7% lutein and 11% zeaxanthin, thus the canthaxanthin was the major component. This canthaxanthin was the most degraded carotenoid by lipoxygenase catalyzed co-oxidation during the reaction. On the other hand the tocopherol isomers found in the rainbow trout were $\alpha$ and $\beta$ -tocopherol, and $\alpha$-tocopherol had a higher degradation rate by the lipoxygenase catalyzed co-oxidation than of $\beta$-tocopherol in the reaction of model system.

• Advances in Traditional Medicine
• /
• v.6 no.3
• /
• pp.237-244
• /
• 2006

Samultang has been believed for prevention and remedy various blood diseases such as menstrual irregularity, anemia, and metrorrhagia. However, the mechanism that accounts for anti-inflammatory effects of the Samultang is still not fully understood. This study was designed to evaluate whether and how the Samultang could modulate the production of pro-inflammatory cytokines in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 treated-human mast cell line, HMC-1. Samultang inhibited the production of tumor necrosis factor $(TNF)-\alpha$, interleukin (IL)-6, granulocyte macrophage colony stimulating factor (GM-CSF), and vascular endothelial growth factor (VEGF) in HMC-1. Maximal inhibition rate of $TNF-\alpha$, IL-6, GM-CSF, and VEGF by 0.1 mg/ml Samultang was about $70.73{\pm}3.0%,\;51.49{\pm}4.14%,\;54.03{\pm}2.09%$, and $47.95{\pm}7.86%$, respectively. Samultang partially blocked PMA plus A23187-induced cyclooxygenase (COX)-2 expression. In addition, Samultang inhibited activation of nuclear factor (NF)-kB, and extracellular signal-regulated kinase (ERK) activation. These results suggest that anti-inflammatory effect of Samulatng may be mediated by the suppression of cytokine production and COX-2 activation via down-regulation of NF-kB and ERK activation.

• Journal of Korean Physical Therapy Science
• /
• v.13 no.3
• /
• pp.55-64
• /
• 2006

Despite well-known benefits of physical activity for older adults, most older adults remain significantly underactive. The purpose of this study was to examine the effects of an inclusive, choice-based physical activity promotion program to increase lifetime physical activity levels of seniors on physical activity & health-related quality of life outcomes in older adults. The physical activity promotion program guided participants to choose activities that took into account their health, preferences, and abilities. It offered information on ways for them to exercise safely, motivate themselves, overcome barriers, and develop a balanced exercise regimen. A six-month comparison-group trial was conducted with older adults in community senior center. Changes in self-reported physical activity & health-related quality of life(SF-36) by group & within group were evaluated using t-test. Of 30 subjects, 22(73%) completed the trial. Subjects were aged 63 to 75 years(mean=$68.36{\pm}4.02$); 86% were female. The intervention group increased estimated caloric expenditure by 1975 calories/week in moderate intensity activities(MET${\geq}3.0$; p=.008), and by 2312 calories/week in physical activities of any intensity(p=.005). Between-group analyses showed that the changes were significantly different in both measures(p=0.17; p=032). The intervention group also significantly better scores on general health perception(p=.031) & vitality(p=.002). Individually tailored programs to encourage lifestyle changes in seniors may be effective and applicable to health care and community settings.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.25 no.1B
• /
• pp.183-192
• /
• 2000

In this paper, the dual looped CMOS PLL with 3-250MHz input locking range at a single 13.3V is designed. This paper proposed a new PLL architecture with a current pumping algorithm to improve voltage-to-frequencylinearity of VCO(Voltage Controlled Oscillator). The designed VCO operates at a wide frequency range of75.8MHz-lGHz with a high linearity. Also, PFD(Phase frequency Detector) circuit preventing voltage fluctuation of the charge pump with loop filter circuit under the locked condition is designed. The simulation results of the PLL using 0.6 um N-well single poly triple metal CMOS technology illustrate a locking time of 3.5 us, a power dissipation of 92mW at 1GHz operating frequency with 125MHz of input frequency. Measured results show that the phase noise of VCO with V-I converter is -100.3dBc/Hz at a 100kHz offset frequency.

• Environmental Analysis Health and Toxicology
• /
• v.13 no.1_2
• /
• pp.43-53
• /
• 1998

Ambient air levels of polycyclic aromatic hydrocarbons(PAHs) are of concern because of their potential for adverse health effects including transformation of some of these substances to mutagens and carcinogens by mammalian microsomal enzyme system. Airbone particulate samples were collected by a conventional high-volume sampler and by an Anderson cascade impactor on 2 to 3 days in each month over a period of 1 year at a representative site of the heavy traffic area of Seoul from beptember 1994 to August 1995. Ten individual PAHs in sizable air particulates of each stage of two months were separated and analyzed by gas chromatography/mass spectrometry. As a results of analysis, the gross concentrations of PAHs in the fine and coarse particles were higher in the winter month than in the spring, followed in descending order by in the fall and summer. In a study of dependency of 10 PAHs compounds on size distribution of particles at heavy traffic area found that about 85% of the total PAHs content was associated with particles less than 2.0um (fine particles) in diameter of winter sampling period. while 79% were associated with this size fraction during summer period. In according to the mean concentrations of the 10 PAHs in 7 size classification from < 0.38 to> 10.1, the 'size was the smaller, PAHs concentration was the higher. Thus it was found that PAHs concentration was greatly affected by air particle size. Annual mean benzo(a)pyrene equivalents was 5.88ng/m$^3$ and obtained by applying, toxic equivalency factor developed by Nisbet and Lagoy.

• Journal of the Korean Magnetics Society
• /
• v.5 no.5
• /
• pp.778-781
• /
• 1995

The mixed ferrite $Ni_{x}Co_{1-x}Fe_{2}O_{4}$ have been investigated by X-ray and $M\"{o}ssbauer$ spectoscpy. From the results of X-ray diffraction measurement the structure for this system is spinel, and the lattice constant is in accord with Vegard's law. $M\"{o}ssbauer$ spectra of $Ni_{x}Co_{1-x}Fe_{2}O_{4}$ have been taken at various temperature ranging from 13 to 800 K. The isomer shifts indicate that the valence states of the irons at both A(tetrahedral) and B(octahedral) sithe are found to be in ferric high-spin states. The variation of magnetic hyperfine fields at the A and B sites are explained on the basis on A-B and B-B supertransferred hyperfine interactions. It is found that Debye temperatures for the A and B sites of $CoFe_{2}O_{4}$ and $NiFe_{2}O_{4}$ are found to be ${\theta}_{A}=734{\pm}5K,\;{\theta}_{B}=248{\pm}5K,\;and\;{\theta}_{A}=378{\pm}5K,\;{\theta}_{B}=357{\pm}5K$, respectively. Atomic migration of $Ni_{0.3}Co_{0.7}Fe_{2}O_{4}$ starts near 450 K and increases rapidly with increasing temperature to such a degree that 61 % of the ferric ions at the A site have moved over to the B site by 700 K.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.33 no.5
• /
• pp.511-517
• /
• 2007

Purpose: The aim of this study is to determine whether a difference in the amount of bone graft material is needed between edentulous patients and dentulous patients and to calculate the amount of augmentation for a sinus lift procedure. Methods: 19 patients(20 sinuses) were included to measure maxillary sinus volume. Facial CT scanning was performed using MX 8000 IDT CT devices(Philips, USA). And it was used for IDLvm(The IDL Virtual Machine) 6.0, CT Volume Analyzer Ver 2.3 program to measure maxillary sinus volumes Results: At edentulous patients, volumes(mean${\pm}SD$) of the inferior portion of the sinuses were $0.56{\pm}0.13cm^3$(5mm height), $2.35{\pm}0.57cm^3$(10mm height), $4.85{\pm}1.10cm^3$(15mm height). At dentulous patients, volumes(mean${\pm}SD$) of the inferior portion of the sinuses were $0.41{\pm}0.18cm^3$(5mm height), $1.76{\pm}0.42cm^3$(10mm height), $3.80{\pm}0.84cm^3$ (15mm height). A significant correlation was found between augmentation height(5mm, 10mm, 15mm) and the calculated sinus volume.(p=0.027, p=0.018, p=0.044) Conclusions: A significant correlation was found between augmentation height(5mm, 10mm, 15mm) and the calculated sinus volume. Detailed preoperative knowledge of sinus lift augmentation volume is helpful in determining the appropriate amount of the bone graft material.

• Journal of Nutrition and Health
• /
• v.53 no.2
• /
• pp.175-189
• /
• 2020

Purpose: This study was conducted to develop, validate, and assess the reliability of a questionnaire for nutritional literacy among young Korean adults. Methods: The draft questionnaire contained 65 items in 7 domains (i.e., dietary guideline, nutrition and health, nutrients, 5 food groups [food bicycle], nutrition labeling, portion size, and nutrition management for disease prevention). The authors developed a draft questionnaire based on a literature review. After multiple drafts, 52 items were retained and 13 were eliminated in the 7 domains according to professional advice from 5 nutrition experts. A panel of experts (n = 20) comprised of clinical dietitians and nutrition professors completed the content validity assessment, including quantitative and qualitative feedback. As the results, all items of the portion size were eliminated from the questionnaire. A sample of 211 young adults completed the test-retest reliability assessment. Test-retest reliability was evaluated using intra-class correlation coefficient (ICC) and inter-item reliability by Cronbach α coefficient. Results: The final questionnaire contained 30 items with 5 questions each on the dietary guideline, nutrition and health, nutrients, 5 food groups (food bicycle), nutrition labeling, and nutrition management for disease prevention. The Lawshe content validity ratio for domains ranged from 0.60 to 1.00. The ICC scores for questions ranged from 0.64 to 0.86. Cronbach's α for domains ranged from 0.83 to 0.90 and for the overall questionnaire was 0.87. Conclusion: The questionnaire showed strong content validity, test-retest reliability, and high inter-item reliability, indicating that it is a useful tool for assessing nutritional literacy of young adults.

• 대한예방의학회:학술대회논문집
• /
• 1994.02b
• /
• pp.169-179
• /
• 1994

B-mode ultrasound is being used to assess carotid atherosclerosis in epidemiological studies and clinical trials. Recently the interpretation of measurements made from ultrasound images has been questioned. This study examines the anatomical correlates of B-mode ultrasound of carotid arteries in vitro and in situ in cadavers. Twenty-seven segments of human carotid artery were collected at autopsy. pressure perfusion fixed in buffered 2.5% gluteraldehyde and 4% paraformaldehyde and imaged using an ATL UM-8 (10 MHz single crystal mechanical probe). Each artery was then frozen, sectioned and stained with van Gieson or elastin van Gieson. The thickness of the intima. media and adventitia were measured 'to an accuracy of 0.01 mm from histological sections using a calibrated eye graticule on a light microscope. Shrinkage artifact induced by histological preparation was determined to be 7.8%. Digitised ultra sound images of the artery wall were analysed off-line. The distance from the leading edge of the first interface ($LE_{1}$) to the leading edge of the second interface ($LE_2$) was measured using a dedicated programme. $LE_{1}$-$LE_{2}$ measurements were correlated against histological measurements corrected for shrinkage. Mean values for the far wall were: ultra sound $LE_{1}$-$LE_{2}$ (0.97 mm, S.D. 0.26), total wall thickness (1.05 mm, S.D. 0.37), adventitia (0.35 mm, S.D. 0.16), media (0.61 mm, S.D. 0.18). intima (0.09 mm, S.D. 0.13). Ultrasound measurements corresponded best with total wall thickness, rather than elastin or the intima-media complex. Excision of part of the intima plus media or removal of the adventitia resulted in a corresponding decrease in the $LE_{1}$-$LE_{2}$ distance of the B-mode image. Furthermore. increased wall thickness due to intimal atherosclerotic thickening correlated well with $LE_{1}$-$LE_{2}$ distance of the B-mode images. B-mode images obtained from the carotid arteries in situ in four cadavers also corresponded best with total wall thickness measured from histological sections and not with the thickness of the intima plus media. In conclusion, the $LE_{1}$-$LE_{2}$ distance measured on B-mode images of the carotid artery best represents total wall thickness of intima plus media plus adventitia and not intima plus media alone.