• Tuberculosis and Respiratory Diseases
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• v.46 no.5
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• pp.697-708
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• 1999

Background : Leukotriene (LT) $C_4$, $D_4$, and $E_4$, the main components of slow-reacting substance of anaphylaxis (SRS-A), have been suggested to play an important role in bronchial asthma such as antigen-induced bronchoconstriction, airway hyperreactivity, and pulmonary eosinophil accumulation. The purpose of this study was to evaluate the effects of treatment with the cysteinyl-LTs (cys-LTs) antagonist, pranlukast on allergen-induced guinea pig asthma model. Methods : Guinea pigs of treatment and placebo groups were sensitized by subcutaneous injection of ovalbumin(OVA) and challenged by inhalation of aerosolized OVA (1% weight/volume OVA). Normal control group did not sensitize with OVA. Oral ingestion of pranlukast and normal saline to the treatment and placebo groups was performed. In the treatment and placebo groups, airway resistance was measured before and after oral ingestion. Serum $LTC_4$ and eosinophilic infiltration of the bronchiolar and peribronchiolar tissues were measured after ingestion in the treatment and placebo groups. Results : Allergen-induced airway constriction developed in 20 (8 in treatment group, 12 in placebo group) among 35 guinea pigs. Airway resistance was significantly decreased at 3 and 6 minutes after OVA challenge in the pranlukast treatment group. In the placebo group, there was no difference of airway resistance between before and after saline ingestion. Serum $LTC_4$ levels showed 348.4 pg/ml in the treatment group, 373.9 pg/ml in the placebo group, and 364.4 pg/ml in the control group. There were no statistically significant difference between treatment and placebo group (p=0.232), and treatment and control group (p=0.501). Eosinophilic infiltrations in the peribronchiolar region per one-microscopic field ($\times$400 high power fields) demonstrated 7.06 in the treatment group, 19.2 in the placebo group, and 4.50 in the control group. There was significant decrement of eosinophilic infiltration in the treatment group which was compared with placebo group (p=0.001). Conclusion : These results demonstrate that pranlukast, a cys-LTs receptor antagonist, can attenuate allergen induced early-phase bronchoconstriction and eosinophilic infiltration in the bronchiolar tissues.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.20 no.5
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• pp.661-669
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• 2007

Eyer since the Prandtl's experiment in 1934 and X-21 airjet test in 1950 both attempting to reduce drag, it was found that controlling the velocities of surface for extremely fast-moving object in the air through suction or injection was highly effective and active method. To obtain the right amount of suction or injection, however, repetitive trial-and error parameter test has been still used up to now. This study started from an attempt to decide optimal amount of suction and injection of incompressible Navier-Stokes by employing optimization techniques. However, optimization with traditional methods are very limited, especially when Reynolds number gets high and many unexpected variables emerges. In earlier study, we have proposed an algorithm to solve this problem by using step by step method in analysis and introducing SQP method in optimization. In this study, we propose more effective and robust algorithm and techniques in solving flow optimization problem.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2002.04a
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• pp.62-63
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• 2002

램젯 엔진을 장착한 미사일은 기존의 터보젯 이나 터보팬 엔진에 비해 압축기와 터빈과 같은 엔진 구성품이 없어 무게가 가볍고 초음속에서 저항도 적으며 고속의 비행영역에서 연료효율과 생존성능이 뛰어나기 때문에 차세대 미사일 추진 시스템으로서 세계 여러 국가에서 개발 및 운용이 이루어지고 있다. 하지만 램젯 엔진은 충분한 램 효과를 얻어야 초기 점화가 가능하기 때문에 현재 개발되고 있는 대부분의 시스템은 최초 발사시 로켓 부스터에 의해 가속하고 로켓연료를 모두 소모하고난 후에 흡입구가 개방되어 램젯 엔진이 점화하는 방식을 취하고 있다.

• Journal of the korean Society of Automotive Engineers
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• v.12 no.1
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• pp.6-9
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• 1990

본 고에서는 녹킹현상과 녹킹 발생의 결과, 그리고 녹킹과 연료와의 관계등에 대해 개략적으로 설명하려 한다. 녹킹 발생 유무는 흡입공기상태, 스로틀 열림정도, 연소실 형상, 스파크 점화시기, 화염 전파속도 및 연료의 자연 발화 특성에 관계되며 화염 전파속도와 end-gas에 있는 연로의 반응속도와의 경쟁이라 볼수 있다. 연료의 녹킹 발생에 대한 저항성을 나탄내는 척도가 옥탄가이며 옥탄가가 높을 수록 자연 발화하기 어려우므로 녹킹이 잘 일어나지 않는다.

• Proceedings of the KAIS Fall Conference
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• 2011.12b
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• pp.525-528
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• 2011

1400cc급 발전용 엔진 트로틀 바디의 최적화 및 성능 향상을 위하여 유동해석을 수행하였다. 베르누이 정리를 기본으로, 성능을 발휘하는 주요 설계인자인 트로틀 바디 내부의 트로틀 밸브 각도 및 흡기부 곡률 등을 설계 변수로 유동해석을 수행하였다. 벤튜리관 흡입부의 곡률을 증가시켜 트로틀 바디에서 소모되는 흡기저항을 줄였다. 감소된 흡기저항은 펌핑로스를 저감하여 연비향상에 도움이 될 것으로 기대된다. 결과적으로 해석결과 분석을 통하여 최적화된 모델을 제시하였다.

• Journal of Advanced Marine Engineering and Technology
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• v.33 no.8
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• pp.1144-1151
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• 2009

Refrigeration systems can be incorporated with non-adiabatic capillary tubes to improve their efficiency. The non-adiabatic capillary tube is constructed by joining the capillary tube with suction pipe to allow heat transfer between them, which is called capillary tube-suction line heat exchanger(SLHX). There are various joining methods and they may influence the characteristics of the refrigeration cycle. The present work aims to analyze the effect of widely-used two joining methods on the refrigeration cycle. The results show that soldered SLHX has much less thermal resistance than tapered SLHX but slightly outperforms in terms of coefficient of performance(COP) and cooling capacity. The soldered SLHX increased COP and cooling capacity of a refrigerator by 5.09% and 14.77% while the tapered SLHX did by 5.05% and 14.75%, respectively.

• Clinical and Experimental Pediatrics
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• v.45 no.2
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• pp.192-198
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• 2002

Purpose : It is important to select and use kinds of Inhaler appropriate to the age of the patient and severity of symptoms. Several kinds of Inhaler have been developed and recommended according to each inhaler's resistance and usage method. We evaluated the usable age of 4 inhalers (turbulent flow inhalers, multi unit dose inhalers, breath actuated MDI, and autohalers) by measuring peak inspiratory flow(PIF) using $In-Check^{(TM)}$ Inspiratory Flow Meter. Methods : Ninety three patients aged from 3 to 7 years(mean $57{\pm}12.9$ mo.) who had admitted to CHA hospital from July 2000 to April 2001 were enrolled. Study patients were divided into 4 groups according to age : 3-4 years of age(group A, n=31), 4-5 years of age(group B, n=32), 5-6 years of age(group C, n=18), and 6-7 years of age(group D, n=12). Results : Out of total 93 patients, 23(71%), 27(84%), 17(94%) patients of each group A, B, C and all 12 patients of group D could use the 4 types of inhaler through adequated education. In all four groups, height, body weight and age were significantly correlated(P<0.05). Usable age, height and weight of children who can use turbulent flow inhaler(TFI) were each 8 year 7 month old, 144 cm, 32.0 kg, and those of multi unit dose inhaler(MUD) were 2 year 10 month old, 92 cm, 12.0 kg. Also that of breath-actuated MDI were 1 yr 8 months, 83 cm, 8.5 kg and that of autohaler were 2 yr 8 months, 91 cm, 11.0 kg Conclusion : We concluded that the ability to use inhalers correlated with height, weight and age of the patients. Multi unit dose inhalers, Breath actuated MDI and Autohaler are useful after 3 years of age through adequate education.

• The Journal of Engineering Geology
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• v.22 no.2
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• pp.145-155
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• 2012

The matric suction and volumetric water content of Jumunin standard sand with a relative density of 60% were measured using an Automated Soil-Water Characteristic Curve (SWCC) apparatus during both drying and wetting processes. The test time for the drying process was longer than that for the wetting process, because the flow of water is likely to be protected by air trapped in voids within the soils during the drying process. Based on the matric suction and volumetric water content, the SWCC was estimated using the model proposed by van Genuchten (1980). For the drying process, the unsaturated fitting parameters ${\alpha}$, n, and m were 0.399, 8.586, and 0.884, respectively; for the wetting process, the values were 0.548, 5.625, and 8.220, respectively. The hysteresis phenomenon occurred in the SWCCs, which means the SWCC of the drying process is not matched with the SWCC of the wetting process. Using these unsaturated parameters, we estimated the Suction Stress Characteristic Curve (SSCC), based on the relationship between suction stress and the effective degree of saturation. The suction stress showed a rapid decrease when the matric suction exceeds the Air Entry Value (AEV). Therefore, the effective stress of unsaturated soils is different from that of saturated soils when the matric suction exceeds the AEV. The suction stress of the drying process exceeds that of the wetting process for a given effective degree of saturation. The hysteresis phenomenon was also recognized in SSCCs. The hysteresis phenomenon of SSCCs arises from that of SWCCs, which is induced by the ink bottle effect and the contact angle effect. In the case of a sandy slope, the suction stress is positive and acts to enhance the slope stability as the water infiltrates the ground, but is negative when the suction stress exceeds the AEV. The results obtained for the wetting process should be applied in analyses of slope stability, because the process of water infiltration into ground is similar to the wetting process.

• Journal of the Society of Naval Architects of Korea
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• v.34 no.4
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• pp.21-30
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• 1997

This paper describes the experimental method of a pod-type waterjet propulsion system in a towing tank and shows the experimental analysis and test results of a designed waterjet propulsion system to be used for a hybrid high speed craft. The cruising performance of this craft is estimated from the results of the hull resistance test and waterjet test under the assumption that the interaction between the hull and the inlet pod is very small. A pod-type waterjet system with an axial pump was designed and a stand-alone waterjet experimental system was developed. Useful data such as the pump performance, the jet efficiency, the losses of inlet duct and nozzle were obtained. Test results show a good agreement with the design requirement.

• Journal of the korean academy of Pediatric Dentistry
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• v.42 no.1
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• pp.75-79
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• 2015

Pulmonary arterial hypertension (PAH) is a common complication of Congenital heart defects (CHD) with left-to-right shunts, and PAH with increased pulmonary vascular resistance (PVR) is associated with considerable morbidity and mortality. General anesthesia (GA) can be life-threatening in patients with PAH, because the positive pressure ventilation during GA increases pulmonary arterial pressure and decreases pulmonary blood flow. This may also lead to hypoxia. Therefore, spontaneous ventilation may be safer than positive pressure ventilation in patients with PAH. A five-year-old male child, weighing 11 kg, with medical history showing a total correction of Tetralogy of Fallot (TOF) in 2009 and ongoing treatment with hypertension (HTN) medicine since 2007, visited the Dankook University Dental Hospital. He had multiple dental caries, and the treatment was completed under sevoflurane insufflation sedation via nasal cannula. The patient remained sedated throughout the operation while maintaining normal vital signs and spontaneous respiration. In conclusion, sevoflurane insufflation sedation may be a safer alternative to GA for the dental treatment of patients with PAH.