• Journal of Yeungnam Medical Science
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• 제8권2호
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• pp.95-105
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• 1991

This study was designed to investigate the effect of GABA and related substances on the spontaneous contraction of rat small intestine. The rats(Sprague-Dawley), weighing 200-250g, were sacrificed by cervical dislocation, and the small intestine was isolated. Longitudinal muscle strips from duodenum, jejunum and ileum were suspended in Biancani's isolated muscle chambers and myographied isometrically. GABA and muscimol, a GABA A receptor agonist relaxed the duodenum and jejunum significantly, but baclofen-induced relaxation in those muscle strips was negligible. The effectiveness of GABA and muscimol in various regions were the greatest on duodenum, and greater on jejunum than on ileum The effect of GABA and muscimol was antagonized by bicuculline, a compeptitive GABA A receptor antagonist and picrotoxin, a noncomptitive GABA A receptor antagonist. Duodenal relaxation induced by GABA and muscimol was unaffected by hexamethonium, but was prevented by tetrodotoxin. These results suggest that GABA inhibit the contractility of smooth muscle with distinct regional difference of efficacy, and the site of inhibitory action is the GABA A receptor existing at the presynaptic membrane of postganglionic excitatory nerves.

• Korean Journal of Veterinary Research
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• 제40권2호
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• pp.247-256
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• 2000

The regional distributions and relative frequencies of endocrine cells were studied histochemically (Grimelius and Masson-Hamperl (M-H) silver methods) in the alimentary tract of the red-eared slider, Trachemys scripta elegans. Samples were taken from the esophagus, fundus, pylorus, duodenum, jejunum, ileum and large intestine. Argyrophil (Grimelius-positive) cells and argentaffin (M-H-positive) cells were found in the whole alimentary tract in this study. Spherical to spindle and/or oval to round-shaped argyrophil or argentaffin cells were located in the gastric glands of the stomach regions, in the basal portion of the epithelium of intestinal tract or the esophagus with variable frequencies. Argentaffin cells were more numerously detected in the whole alimentary tract compared with those of argyrophil cells in this study. Argyrophil cells were observed in the whole alimentary tract including the esophagus and the most predominant region was the rectum with moderate frequency. The relative frequency of these cells was rare in the esophagus, fundus, duodenum, jejunum and ileum, respectively and a few frequency in the pylorus. Argentaffin cells were also observed in the whole alimentary tract including the esophagus and the most numerously demonstrated region was the rectum with numerous frequency. They were observed with a few frequencies in the remaining regions of the alimentary tract except for the rectum, respectively. However, to know the exact type of the argyrophil cells and argentaffin cells that were observed in this study, more developmental methods such as immunohistochemistry were needed.

• Journal of the Mineralogical Society of Korea
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• 제21권4호
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• pp.397-413
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• 2008

In Gaya area, the Boseong kaolin deposits exhibit locally unusual occurrences such as downward enrichment of kaoin minerals, characteristic hydrothermal alterations (illite and stilbite), and phase relations among kaolin minerals in addition to the extensive weathering of anorthositic country rocks. This indicates that the kaolin deposits seem to be genetically formed as a mixed hydrothermal and residual model. The kaolin ores can be divided into five types on the basis of differences in occurrence, mineral composition and characters. These consist of two types of high-grade ores ranging above 80% in grade and low-grade ores as low as less than 80% including feldspar residuals or the peculiar impurity phase of illite-vermiculite-stilbite. Halloysite and kaolinite are mostly coexisted in the Boseong kaolin, and these kaolin minerals exhibit diverse appearances in crystallinity and morphology. Such a diversity in mineral phase and crystallinity seems to be originated from the complexity in genesis. In addition to these diverse characters of the kaolin, its applied-mineralogical characteristics such as chemical composition, thermal properties, whiteness, viscosity, and etc. made it disadvantageous in terms of ore quality.

• Korean Journal of Fisheries and Aquatic Sciences
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• 제32권2호
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• pp.232-237
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• 1999

The relationship between structure and contractile activity was studied on the three neuropeptide $\gamma$ (mammalian-, bowfin-, shark-NP$\gamma$) that were synthesized by the solid-phase method. Circular dichroism spectra showed that mammalian-, bowfin- and shark-neuropeptide $\gamma$ took an unordered structure in buffer solution and artificial liposome. The intestinal motility response was investigated with guinea-pig ileum, rat duodenum and carp intestine. In case of carp intestine, contractile activity was as follows; bowfin-NP$\gamma$> shark-NP$\gamma$>mammalian-NP$\gamma$, On the other hand, the contractile activity of mammalian-neuropeptide $\gamma$ was more potent than those of bowfin-, shark-neuropeptide $\gamma$ in the guinea-pig ileum and rat duodenum. These results suggest that NP$\gamma$ show the species-specific activity.

• Journal of the Korean Society of Food Science and Nutrition
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• 제20권6호
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• pp.519-526
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• 1991

This study was designed to investigate the effects of dietary glycosyl-sucrose on blood glucose and serum lipids concentrations and carbohydrate hydrolysing enzyme activities in rats. Male Sprague-Dawley rate were divided into 3 experimental groups, cornstarch group(68% cornstarch diet), sucrose group (20% sucrose + 48% cornstarch diet) and glycosyl-sucrose group(20% glycosyl sucrose + 48% cornstarch diet). After 6 weeks, the mean values of food efficiency ratio of 3 groups were not significantly different. There were no significant differences in mean fasting blood glucose levels of three groups, while the glucose response at 30 and 60 minutes and the group as compared with sucreose area showed a tendency to decrease in glycosyl-sucrose group as compared with sucrose group. Serum lipids (T. G., phospholipids, HDL-cholesteol and total lipid) contents showed no significant differences among 3 groups but a tendency of jejunum and ileum were significantly reduced in glycosyl-sucrose group as compared with cornstarch group. The maltose hydrolysing enzyme activity, especially in jejunum was lower in glycosyl-sucrose group than in sucrose group.

• The Journal of the Petrological Society of Korea
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• 제26권4호
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• pp.385-398
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• 2017

Jiri Mountain lies in the southwestern portion of the Yeongnam massif, which is one of the Precambrian basement massifs of the Korean Peninsular, consisting essentially of high-grade metamorphic rocks. The geology of the area mainly consists of Paleoproterozoic metasedimentary migmatitic gneisses, granitic gneisses which are classified into granitic gneiss, (K-feldspar porphyroblastic) granitic gneiss and quartzo-feldspathic gneiss, charnockite and anorthosite based on their occurrence and petrographic characteristics. The ages obtained from these rocks mainly span a narrow range between ca. 1,876 and 1,856 Ma although inherited cores of zircons from massive granite gneiss yielded much older age spectrum (>2,029 Ma). The age of major metamorphism is ca. 1850-1840 Ma and the metamorphic condition obtained from mineral assemblages and geothermobarometers is about 4-6 kb and up to $700-750^{\circ}C$. These results indicate that in the area intense granitic magmatism and metamorphism occurred in the deep crust during Paleoproterozoic orogeny. Some younger age of charnockite (1,856-1,865 Ma) and anorthosite (1,861-1,862 Ma) might indicate the beginning of intraplate rifting leading to felsic and mafic magmatism just after the orogeny. In conclusion, the rocks in the Jiri Mountain area which formed at a mid to deep crustal zone provide us windows into the deep crust.

• 발명특허
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• 제10권10호통권116호
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• pp.18-24
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• 1985

한국발명특허협회는 기업의 적극적인 참여와 관계당국의 지원을 받아 지난 73년 10월 18일 창립, 그간 발명 및 공업소유권관계 제위의 아낌없는 성원에 힘입어 금년 10월 18일로 12주년을 맞게 되었다. 창립당시 우리나라는 선진국으로 도약하기 위하여 경제개발과 수출드라이브 정책을 추구하기 위해 창조적 자주기술 개발과 선진기술을 도입, 소화흡수하는 것의 시급한 문제로 대두되었으며 더욱이 앞으로 다가올 본격적인 국제화 시대와 자유경쟁시대에 대비하여 외국과의 경쟁에서 이길 수 있는 산업기반의 구책이 절실했다. 이러한 시대적 요청에 부응하기 위하여는 공업소유권 제도의 확립을 통한 신기술 개발의 촉진 및 발명풍토조성이 선결 문제였으며 이를 해결코자 본회가 창립되었던 것이다. 이에 창립과 동시 공업소유권 제도의 수용태세를 갖추도록 하기 위하여 그 인식제고와 보급$\cdot$확산을 통한 제도 정착에 노력해 왔다. 그 결과 동제도의 불모지였던 우리나라 산업계에서도 공업소유권 제도에 눈을 뜨기 시작했으며 ${\ulcorner}$66발기회원${\lrcorner}$으로 출발하였던 본회는 이제 320회원에 이르게 되었다. 또 공업소유권 제도에 대한 인식을 바탕으로 발명$\cdot$신기술개발을 적극적으로 유도하기 위해 발명특허 정보의 보급에 힘써 왔으며 이에따라 기업 및 발명인들이 우수한 발명품들을 창안하여 기업화함으로써 국내 공급은 물론 수출까지 하는 사례도 많이 늘게 되었다. 그러나 무엇 보다도 획기적인 전환점은 지난 82년 한국특허협회를 한국발명특허협회로 확대 개편한데있다. 전경환 명예회장$\cdot$구자경 회장$\cdot$이태섭 상근부회장을 주축으로 재출범한 본회는 지난 4년동안 기술국립으로 지향하는 국가시책에 부응하는 기술혁신의 요체가 되는 공업소유권제도의 정착과 발명환경 조성을 위한 사업기본방향을 공업소유권 인식제고$\cdot$발명진흥장려$\cdot$특허관리체제확립 등 3대 목표에 두고 발명특허의식고양사업$\cdot$공업소유권관리요원양성배출사업$\cdot$발명진흥행사 및 전시사업$\cdot$발명지원사업$\cdot$발명보호계도사업$\cdot$공업소유권제도조사연구사업$\cdot$공업소유권관리자료발간 보급사업$\cdot$각종 공보발간사업$\cdot$발명특허자료(책자)판매선터운영 등 중점사업을 전개하여 이제 명실상부한 국내 유일의 공업소유권 단체로 도약해가고 있다. 발명의 날 부활에 따른 기념행사를 통한 발명유공자 및 우수특허관리기업체 포상, 전국우수발명품 전시회 개최, 발명시작품제작보조, 발명장려관 설치운영, 해외출원비용 및 해외발명전 출품지원등 발명진흥장려사업에 새로운 전기를 마련한 것이다. 한 마디로 ${\ulcorner}$0년이면 강산도 변한다${\lrcorner}$는 속언을 실감하게 한다. 창립 12주년! 이제 또다시 변해가는 시점에서 지난 12년사를 20대 뉴스를 중심으로 소개한다.

• Korean Journal of Poultry Science
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• 제29권2호
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• pp.117-124
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• 2002

Betaine functions as an osmoregulators in the cells and its inclusion in diet can spare the choline and carcass fat reduction in chicken. Thus, two hundred eighty eight laying hens were fed with 0, 500, 1,000, 2,000 ppm of betaine from seventy eight to eighty six weeks of age during the environmentally high temperature stress. Com and soybean basal diets contained 2,800 kcal/kg ME and 16% CP. Egg production, feed intake, and feed conversion were examined for eight weeks. Egg quality characters, serum cholesterol, liver betaine, and lower ileal osmolality were measured at the end of experiment. Egg Production rates of hens fed with 500 or 2,000 ppm of betaine were 75.06 and 75.02%, respectively and tended to increase compared to the control. The feed conversion(FCR) of these treatments was significantly(P<0.05) improved compared to that of control although it did not significantly differ in the e99 Production rates between 500 and 2,000 ppm of betain groups. Eggshell breaking strength of hens fed betaine was significantly(P<0.05) higher than those of control. However, betaine supplements did not influence to improving the albumen height and Haugh unit. Liver betaine in hens fed with betaine was linearly increased unto 2,000 ppm. The birds fed with 2,000 ppm betaine showed significantly(P<0.05) higher in the liver betaine than the control birds. Total cholesterol and triglyceride tended to be increased by dietary betaine supplement. The lower ileal osmolality in betaine supplement group tended to be slightly decreased. As a result, dietary betaine supplement tended to improve the egg Production and eggshell Quality in laying hens during heat stress.

• Journal of the Korean Child Neurology Society
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• 제26권4호
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• pp.284-287
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• 2018

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutation of one of two genes, TSC1 (encoding hamartin, 9q34) and TSC2 (encoding tuberin, 16p13). It invades the central nervous system and various parts of the body, causing various symptoms. Crohn's disease (CD) is a chronic immune-mediated disease that has not been clearly elucidated. It is thought to be caused by an excessive immune response of the body to bacteria that normally exist in the digestive tract with genetic factors. No cases have been reported in which both of the above-mentioned diseases occurred simultaneously. We report a case of CD in a patient with TSC. A 12-year-old boy was brought to our hospital because of abdominal pain. Skin lesions were observed in the TSC. Fundus examination revealed a hamartoma in the right retina. Brain magnetic resonance imaging revealed a subendothelial giant cell astrocytoma (SEGA). On the basis of these findings, he was diagnosed as having TSC. Blood test results showed increased levels of inflammatory markers. On abdominal ultrasonography, his colon walls were observed to be thickened with increased vascularity of the proximal ascending colon, ileocecal valve, and terminal ileum. Colonoscopy revealed discontinuous ulcerations and inflammations of the ileum, IC valve, and cecum, similar to those found in CD. Everolimus was administered orally for the SEGA but was discontinued frequently owing to the exacerbation of CD. The possibility of CD should be kept in mind in patients with TSC considering to undergo treatment for SEGA.

• Korean Journal of Mineralogy and Petrology
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• 제35권3호
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• pp.199-214
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• 2022

The Yeongnam Massif is one of representative basement provinces in the Korean Peninsula, which has experienced high-temperature, low-pressure (HTLP) regional metamorphism and partial melting. Here we reviewed recent developments in Paleoproterozoic (1.87-1.84 Ga) hot orogenesis of the Yeongnam Massif, typified by the granulite-facies metamorphism and partial melting recorded in the HTLP rocks. In particular, spatiotemporal linkage between the metamorphic and magmatic activities, including the Sancheong-Hadong anorthositic magma as a heat source, provides a key to understand the widespread HTLP metamorphism and partial melting in the Yeongnam Massif. Crustal anatexis, resulting from the fluid-present melting and muscovite/biotite dehydration melting, has yielded various types of leucosomes and leucogranites. Zircon and monazite petrochronology, using in-situ U(-Th)-Pb data from the secondary ion mass spectrometry, indicates that the HTLP metamorphism and anatexis lasted over a period of ~15 Ma at ca. 1870-1854 Ma. In addition, a fluid influx event at ca. 1840 Ma was locally recognized by the occurrence of incipient charnockite. Taken together, the Yeongnam Massif preserves a prolonged evolutionary record of the HTLP metamorphism, partial melting, and fluid influx diagnostic for a hot orogen. Such an orogen is linked to the Paleoproterozoic orogeny widespread in the North China Craton, and most likely represents the final phase of crustal evolution in the Columbia/Nuna supercontinent.