• Journal of the Korean Society of Food Science and Nutrition
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• 제34권3호
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• pp.356-360
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• 2005

The maintenance of intestinal health is complex and relies on a delicate balance between the diet, the normal microflora and mucosa, including the digestive epithelium and overlying mucus layer. The colorectal mucosa is protected by a visco-elastic mucus gel formed by high molecular mass glycoproteins referred to as mucins. Abnormality of mucin have been identified with colorectal disease. Constipation increases with age, and is more common among women than men in all age groups, e.g. 10% of men and 20% of women in the USA. The aim of the present study was conducted to investigate that the effects of formulation KTG075 from edible plants on intestinal function on mucus secretion, were examined by loperamide-induced constipation method using Sprague Dawley male rats. Epithelial cells of colonic crypt contained more mucus in the KTG075 group compared with those of the control group and the thickness of the mucus layer stained with alcian blue was significantly thicker in KTG075 treated rats compared with in control rats. Mucus production of epithelial cells of crypt and mucus contents at fecal and mucosa surfaces were reduced by loperamide-induced constipation. These results indicates that a poly herbal formulation KTG075 accelerates evacuation and activated intestines.

• Journal of the Korean Applied Science and Technology
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• 제40권2호
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• pp.258-267
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• 2023

In this study, to investigate the possibility of using ethanol extract of Petasites japonicus (PJE) as a functional material, we investigated the activity of improving skin barrier and inflammation through UVB-induced human keratinocyte (HaCaT cell). As a result of confirming the antioxidant effect through DPPH radical scavenging activity, ABTS⁺ radical scavenging activity, and hydrogen peroxide scavenging activity, it was confirmed that it had an antioxidant effect similar to that of ascorbic acid, a control, at a concentration of 1 mg/ml. As a result of confirming the mRNA expression of the production ability of filaggrin and aquaporin-3 in HaCaT cells induced by UVB, it was confirmed that the reduced expression level by UVB stimulation increased in a concentration-dependent manner when the PJE was treated. It was confirmed that the mRNA expression of TNF-𝛼 and IL-1𝛽 were increased by UVB stimulation and decreased when the PJE was treated. As a result of the migration assay, it was confirmed that the proliferation of skin keratinocytes and the recovery rate of wounds were increased in a concentration-dependent manner. Based on the experimental results, it suggests that Petasites japonicus can be used as a functional cosmetic product that can improve skin moisturizing and skin barrier function.

• Journal of the Society of Cosmetic Scientists of Korea
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• 제40권1호
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• pp.21-28
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• 2014

In this study, Eucommia ulmoides Oliver extracts was studied in order to see any effects on the ${\beta}$-hexosaminidase release suppression of RBL-2H3 cells and on the expression of filaggrin, transglutaminase-1 (TGase-1) and cornified cell envelope (CE) related to the recovery of HaCaT keratinocyte skin barrier. Results showed that Eucommia ulmoides Oliver extracts reduced ${\beta}$-hexosaminidase release in RBL-2H3 cells and increased the effects of Eucommia ulmoides Oliver extract on the expression of filaggrin, transglutaminase-1 (TGase-1) and cornified cell envelope (CE) in HaCaT keratinocytes. Taken together, these results suggested that Eucommia ulmoides Oliver extract may be applicable for keratinocyte differentiation.

• The KIPS Transactions:PartD
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• 제10D권6호
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• pp.949-960
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• 2003

Main memory database systems use the different implementation techniques to sturucture and organize the user dta and system catalogs, since traditional database systems are optimized for the characteristics of disk storage environment. We present, in this paper, the design considerations for our main memory database system $ALTIBASE^{TM}$ that is currently applied to the time-critical applications. We focus on the design issues of storage manager in $ALTIBASE^{TM}$. The major components are introduced, and features and characteristics of transaction management and recovery method are described. We also present the database replication mechanism and its conflict resolution mechanism for high availability and performance. In order to evaluate our transaction performance, we show various experimental reports as measured by the TPS.

• YAKHAK HOEJI
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• 제49권2호
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• pp.168-173
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• 2005

Alzheimers disease (AD) is the most prevalent form of neurodegenerations associated with aging in the human population. This disease is characterized by the extracellular deposition of beta-amyloid (A ${\beta}$) peptide in cerebral plaques. The A ${\beta}$ peptide is derived from the ${\beta}$-amyloid precursor protein ( ${\beta}$APP). Photolytic processing of ${\beta}$APP by ${\beta}$-secretase(beta-site APP-cleaving enzyme, BASE) and ${\gamma}$-secretase generates the A ${\beta}$ peptide. Several lines of evidence support that A ${\beta}$-induced neuronal cell death is major mechanisms of development of AD. Accordingly, the ${\beta}$-and ${\gamma}$-secretase have been implicated to be excellent targets for the treatment of AD. We previously found that sesaminol glucosides have improving effect on memory functions through anti-oxidative mechanism. In this study, to elucidate possible other mechanism (inhibition of ${\beta}$-and ${\gamma}$-secretase) of sesaminol glucosides, we examined the improving effect of sesaminol glucosides in the scopolamine (1 mg/kg/mouse)-induced memory dysfunction using water maze test in the mice. Sesaminol glucosides (3.75, 7.5 mg/kg/6ml/day p.o., for 3 weeks) reversed the latency time, distance and velocity by scopolamine in dose dependent manner. Next, ${\beta}$-and ${\gamma}$-secretase activities were determined in different regions of brain. Sesaminol glucosides dose-dependently attenuated scopolamine-induced ${\beta}$-secretase activities in cortex and hippocampous and ${\gamma}$-secretase in cortex. This study therefore suggests that sesaminol glucosides may be a useful agent for prevention of the development or progression of AD, and its inhibitory effect on secretase may play a role in the improving action of sesaminol glucosides on memory function.

• Korean Journal of Microbiology
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• 제28권3호
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• pp.192-198
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• 1990

To determine whether the muc region of pKM101 and its mutant pSL4 is sufficient for the expression of these phenotypes, muc regions of pKM101 and pSL4 were subcloned onto the highcopy number vector pKB354 and were selected the cloned pJB200 and pJB210. The recombinant plasmids pJB200 and pJB210 were introduced into umu $C36^{-}$ uvr $A6^{-}$ (TK610) strain and determined the protection effect and mutagenecity for UV and MMS. The protection effect and mutagenecity of umu $C36^{-}$ uvr $A6^{-}$ (TK610) were supressed by muc gene of the recombinant plasmids. The muc gene of pSL4 has higher effect than that of pKM101. The recombiant plasmid pJB210(inclued muc gene of pKM101) did not affect uv-mutagenesis in the $recA^{-}$ (JC2926) mutant.

• Proceedings of the Korea Water Resources Association Conference
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• 한국수자원학회 2021년도 학술발표회
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• pp.59-59
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• 2021

최근 기후변화에 따른 가뭄의 상습화와 농촌용수 수요증가에 대비할 수 있는 가뭄대책의 수립을 통한 용수부족 문제에 대한 근본적인 해소의 필요성 증가하고 있는 가운데 기존 수자원을 효율적으로 활용하기 위한 4차 산업기술을 적용한 순환형 농업용수 관리시스템의 개발이 요구되고 있다. 본 연구는 2017년 가뭄이 극심하였던 충청남도 대사저수지, 풍전저수지와 경기도 마둔저수지에 대하여 기상분석, 관개분석, 수리분석 등을 수행하여 이수관리, 관개만족도, 회귀수의 재이용 등을 예측 관리할 수 있는 순환형 농업용수 관리 시스템을 개발하여 적용하고자, 선제적으로 가뭄 발생 들녘의 용수공급을 위한 농업용 저수지 소유역 순환용수 가용수량을 추정하였다. 2010년부터 2019년까지의 강우유출 모형을 적용하기 위하여 수원, 천안, 이천관측소의 강우, 최고/최저기온, 상대습도, 풍속, 일사량자료를 일자료로 활용하였고, 10년 평균 유출량을 순별로 산정하여 기본자료로 구축하여 주요 취입보 유입수량을 산정하였다. 주요 취입보 유입수량 산정과 취입보의 용적을 산출하기 위하여 시설별 높이차와 하천의 길이 및 폭을 측정하였으며 물수지는 보유용수량과 유입량의 합에서 공급수량을 제외한 값으로 정의하였고, 내용적을 초과하는 경우에는 범람되는 것으로 구현하여 마둔, 대사, 풍전저수지의 임의 지점(하천)별로 순환용수 가용을 위한 모의를 실시하였다. 공간 범위는 평야부 말단부로 선정하였고, 가상으로 약 2m 높이의 임시보를 적용하여 관개기 강우유출수 및 퇴수에 의한 가용수량을 산정하였다. 이를 위하여 하천의 폭과 표고를 이용하여 길이를 산출하여, 내용적을 산출하였다. 소유역별로 TANK 모형적용 결과를 입력자료로 활용하여 일 공급 양수량을 내용적 최대로 하였을 때 회복 기간에 대한 모의를 수행하였다. 강우유출수에 의한 소유역별 가용수량을 4월부터 모의 분석한 결과 유역별로 차이는 발생하지만 만수위에 도달하는 기간은 특이 유역을 제외하고는 약 50일 이상 걸리는 것으로 분석되었고, 관개기가 계속되면서 회복되는 기간이 짧아지는 경향을 보였다. 이를 통해 소유역별 농업용수 부족분 투입을 위한 위치선정과 용수량 판단이 가능할 것으로 예상된다.

• Journal of Korean Ophthalmic Optics Society
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• 제18권3호
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• pp.347-356
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• 2013

Purpose: To evaluate the visual acuity and visual performance after implantation of a aspheric multifocal (ReSTOR$^{(R)}$ SN6AD3) intraocular lens (IOL). Methods: Nineteen cataract patients (30 eyes) implanted with an aspheric multifocal IOL (ReSTOR$^{(R)}$ SN6AD3) either unilaterally or bilaterally were participated. Visual acuity (VA) and objective optical performance were evaluated at the time of preoperation, 1 week, 1 month, and 3 month after operation. At 3 month of post-operation, objective visual performance were measured and compared with the 38 eyes of 20 age-matched normal control. Distance VA was measured by using the ETDRS LCD chart and intermediate and near visual acuity were measured using Jaeger chart. Objective visual performance was assessed preoperatively and 1 week, 1 month and 3 month postoperatively using a double-pass system (Optical Quality Analysis System) with a 4-mm pupil diameter, the OSI (objective scatter index), MTF (modulation transfer function) cut off and strehl ratio. At 3 month of post-operation, visual acuity and visual performance compared with age matched normal control. Results: The uncorrected distance VA, OSI, MTF cut off and strehl ratio were significantly improved (p<0.05) until 1 month postoperatively. Visual performance of MTF cut off and strehl ratio after 3 month of operation were significantly improved compared to the normal control (p=0.063, p=0.103 respectively), however, OSI was higher than normal control. Patients implanted with aspheric multifocal IOL were satisfied with distance and near VA however, were unsatisfied with intermediate VA and reported glare and halos. Conclusions: The visual performance reaches to a stable condition in 1 month of implantation of aspheric multifocal IOL and improved to the level of age-mated normal patients. Also patients were satisfied with their quality of vision, however, intermediate VA, glare and halos were reported as complications.

• Journal of Chest Surgery
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• 제29권8호
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• pp.844-849
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• 1996

During the 2 years period, we hav performed acute peritoneal dialysis in twenty two children after cardiopulmonary bypass among 198 patients who underwent surgery due to complicated congenital heart diseAses . were fluid over- load (10 cases), oliguria (9 cases) and hyperkalemia (3 cases). Bypass time greAter than 90 minutes was a predictor of the need for dialysis(p< 0.05). Five neonates (38 %) operated on instituted peritoneal dialysis but it was insignificant determinant factor (p 08). Sixteen patients recovered their renal suction, but 4 patients died due to respirAtory fAilure or sepsis. All the patients which could not recover their renal function, expired although the renal failure was not re- sponsible for the mortality. We think that early peritoneal dialysis is helpful in cases of oliguia, fluid overload or hyperkalemia after cradiopulmonary bypass.

• Childhood Kidney Diseases
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• 제9권2호
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• pp.231-236
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• 2005

Juvenile rheumatoid arthritis(JRA) is the most common major connective tissue disease in children. Renal involvement in JRA is rare. Among the renal lesions that have been reported in JRA, amyloidosis and drug-induced nephropathy are the most common. Crescentic glomerulonephritis in JRA has rarely been reported. We report a case of ANCA-associated pauci-immune crescentic glomerulonephritis in JRA. The patient was a 15-year old boy with a 3-year history of JRA. He presented with gross hematuria, proteinuria, positive p-ANCA and elevation of BUN and creatinine. Pathologic findings revealed focal necrotizing and crescentic glomerulonephritis. There were no significant immunoglobulin or complement deposits. His renal function recovered after intravenous methylprednisolone pulse therapy and oral steroid use. In Korea, this is the first reported case of pauci-immune crescentic glomerulonephritis in JRA. (J Korean Soc Pediatr Nephrol 2005;9:231-236)