• Clinical and Experimental Pediatrics
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• v.53 no.3
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• pp.397-407
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• 2010

Purpose : The F9 gene is known to be the causative gene for hemophilia B, but unfortunately the detection rate for restriction fragment length polymorphism-based linkage analysis is only 55.6%. Direct DNA sequencing can detect 98% of mutations, but this alternative procedure is very costly. Here, we conducted multiplex polymerase chain reactions (PCRs) and conformation sensitive gel electrophoresis (CSGE) to perform a screened DNA sequencing for the F9 gene, and we compared the results with direct sequencing in terms of accuracy, cost, simplicity, and time consumption. Methods : A total of 27 unrelated hemophilia B patients were enrolled. Direct DNA sequencing was performed for 27 patients by a separate institute, and multiplex PCR-CSGE screened sequencing was done in our laboratory. Results of the direct DNA sequencing were used as a reference, to which the results of the multiplex PCR-CSGE screened sequencing were compared. For the patients whose mutation was not detected by the 2 methods, multiplex ligation-dependent probe amplification (MLPA) was conducted. Results : With direct sequencing, the mutations could be identified from 26 patients (96.3%), whereas for multiplex PCRCSGE screened sequencing, the mutations could be detected in 23 (85.2%). One patient's mutation was identified by MLPA. A total of 21 different mutations were found among the 27 patients. Conclusion : Multiplex PCR-CSGE screened DNA sequencing detected 88.9% of mutations and reduced costs by 55.7% compared with direct DNA sequencing. However, it was more labor-intensive and time-consuming.

• Proceedings of the Korean Society of Computer Information Conference
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• 2014.07a
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• pp.15-16
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• 2014

본 논문은 음악 치료 전문가들로부터 수집한 음악 치료 프로그램에 관한 지식과 규칙을 수집하여 구성된 전문가 시스템을 도입하여 자동으로 우울증 환자를 위한 추천 음악 치료 시스템을 설계하는 것을 목표로 한다. 제안한 시스템은 음악 치료 전문가들로부터 수집한 수많은 음악 치료 프로그램 중 뇌파 측정을 통해 환자에게 가장 효과적인 치료 프로그램을 선별하고 환자에게 제공하여 치료 효과를 극대화하는 것을 목표로 한다. 제안 시스템은 우울증 환자들의 치료를 위해 뇌파 측정을 입력 받아 분석하여 환자의 증상을 완화하고 치료 효과가 가장 좋은 음악 치료 프로그램을 선별하기 위해 인공 지능 기술들인 전문가 시스템(Expert System) 기법에 기반 한 음악 치료 시스템을 설계하고 제안한다.

• Journal of the Korean Society of Radiology
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• v.83 no.1
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• pp.54-69
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• 2022

Early detection of potential asymptomatic coronary artery disease is very important, as patients with sudden cardiac death often do not show symptoms such as chest pain or motor dyspnea. Coronary CT angiography (CCTA) has long been unjustified as a screening tool for asymptomatic patients because of the risks posed by radiation exposure. However, there are still various opinions regarding the usefulness of CCTA for screening for coronary artery disease (CAD) in asymptomatic healthy individuals or patients. This review investigated the usefulness of coronary artery calcium score and CCTA as screening tests for CAD in asymptomatic healthy individuals or patients through various literature reviews. With the development of CT technology, recent studies have been conducted in asymptomatic CAD patients with a reduced radiation dose of less than 1 mSv. A total of 2.6% of asymptomatic subjects on CCTA found significant CAD over 70%, and it was concluded that screening CCTA for CAD showed prognostic power in predicting the future occurrence of CAD in asymptomatic people. However, after the completion of the current NIH SCOT-HEART 2 study, it may be possible to determine whether CCTA is appropriate as a screening tool for CAD in asymptomatic healthy individuals.

• 재활복지
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• v.21 no.2
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• pp.217-231
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• 2017

We have to consider two parts of the evaluation and treatment for the patients with head and neck burns. The primary consideration is swallowing function for nutrition supply for them and the next is speech function for efficient communication and aesthetic impression of them. The purpose of this study is to summarize the preliminary questions of Communication Screening Protocols which can help understand comprehensively on swallowing disorder, motor speech disorder and voice disorder of patients with head and neck burns. We divided the evaluation into 4 evaluation areas including 'oral mechanism', 'respiration/voice', 'articulation', and 'swallowing' by referring to overseas studies dealing with various communication disorders caused by burns, and prepared the final questionnaires by conducting the content validity verification by five expert (speech & language pathologist). The range of Content Validity Index was shown relatively appropriate with .50~.84. There was a conflict of opinions in experts whether the items in the areas of respiration/voice and swallowing may be appropriate, whereas there was no different view of the oral mechanism and articulation area. Through the different characteristics of communication difficulties of patients with head and neck burns, we expect it will be modified appropriately according to the patients through evaluation of burn patients by type and severity.

• The Monthly Diabetes
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• s.288
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• pp.12-20
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• 2013

• Korean Journal of Psychosomatic Medicine
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• v.26 no.2
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• pp.127-134
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• 2018

Objectives : This study aimed to identify the group with high risk of suicide in general hospital inpatient by comparing the depression, anxiety, and distress and their clinical characteristics. Methods : The study included all patients admitted to a general hospital between January 2016 and December 2017, and the final 41,249 patients were analyzed. Distress thermometer (DT) and hospital anxiety-depression scale (HADS) were used for emotional state evaluation. Group with high risk of suicide was defined as showing more than 4 in the DT and more than 8 in one of the two subscales (anxiety and depression) of the HADS. Results : Among the subjects, 3,603 patients (8.7%) met the high-risk criteria for suicide. The group with high risk of suicide experienced more severe pain than the control patient group, and it was found that there was more underlying disease. Patients who reported pain showed higher scores than those who reported no pain on the DT and HADS subscales. Conclusions : Group with high risk of suicide showed more severe pain and more underlying disease. Therefore, suicide prevention program specifically targeted for the group with high risk of suicide should be developed according to the risk of the patient evaluated at the time of the admission.

• Journal of Korean Ophthalmic Optics Society
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• v.5 no.1
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• pp.165-171
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• 2000

The purpose of this study is to determine the prevalence of cataracts in a rural area of Kyung-Buk province. Cataract is the main cause of blindness and visual impairment in the world. Recently, the number of age-related cataract surgeries has increased remarkably. In spite of such an increase in the number of patients, there are still many cataract patients with highly deteriorated visual function who have had no occasion to receive an ocular examination. In order to screen such patients the author assessed 636 individual(1272 eyes) aged 50 years or more who had wanted to be examined generally in two area. Chilgok and Munkyung, Kyung-Buk province using a simplified cataract screening system recently proposed by Sasaki et al. Kanazawa Medical University in Japan. The results obtained are as follows. The number of visual impairment patients in this study group was 493(77.5%). They were screened by cataract screening system. Primary screening examination detected 448 subjects to be suspected of cataract while the subsequent secondary examination narrowed this number of subjects to 308(48.4%). Final number of subjects to be diagnosed of cataract was 421(66.2%). The rate of incidence, according to the age, was 27.5% in the 50 year-olds age group, 62.5% in the 60's age group, 86.1% in the 70's age group and 94.3% in the 80's age group and upwards. This results concluded that cataract is the main cause of blindness and visual impairment and is an important public eye health care problem of aged population in rural Korea. Methods of tackling the cataract problem(both backlog and incident), and other eye health needs are recommended. The need to extend eye health service to the rural areas is emphasized.

• Korean Journal of Psychosomatic Medicine
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• v.21 no.2
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• pp.122-131
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• 2013

Objectives: This study aimed to examine the point prevalence of anxiety, depression and the associated risk factors in hospitalized patients with cancer. Methods: A total of 114 patients with cancer who admitted to the Cancer Center in St. Mary's Hospital were enrolled for a day. The patients were asked to complete Hospital Anxiety and Depression Scale(HADS). Sociodemographic and cancer related clinical variables were also evaluated. Results: The point prevalence of anxiety and depression was 10.5% and 34.2%, respectively, as assessed with HADS. Logistic regression models revealed that distant metastasis was significantly associated with anxiety in patients with cancer and previous chemotherapy and Low socioeconomic status were significantly associated with depression. Conclusions: Our results indicate that more than one third of patients with cancer suffer from either anxiety or depression. In addition, previous chemotherapy as well as low socioeconomic status and distant metastasis were associated risk factors of anxiety and depression, respectively. These findings suggest the need for screening and systematized psychosocial intervention for psychological distress in hospitalized patients with cancer.

• Annual Conference of KIPS
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• 2024.05a
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• pp.652-655
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• 2024

COPD(Chronic Obstructive Pulmonary Disease)는 장기간에 걸쳐 기도가 좁아지는 폐질환으로, 규칙적 운동은 호흡을 용이하게 하고 증상을 개선할 수 있는 주요 자가관리 중재법 중 하나이다. 건강정보 데이터와 인공지능을 사용하여 규직적 운동 이행군과 불이행군을 선별하여 자가관리 취약 집단을 파악하는 것은 질병관리 측면에서 비용효과적인 전략이다. 하지만 많은 양의 데이터를 확보하기 어렵고, 규칙적 운동군과 그렇지 않은 환자의 비율이 상이하기 때문에 인공지능 모델의 전체적인 선별 능력을 향상시키기 어렵다는 한계가 있다. 이러한 한계를 극복하기 위해 본 연구에서는 국민건강영양조사 데이터를 사용하여 머신러닝 모델인 XGBoost와 딥러닝 모델인 MLP에 오버샘플링, 언더샘플링, 가중치 부여 등 불균형 데이터 처리 기법을 적용 후 성능을 비교하여 가장 효과적인 불균형 데이터 처리 기법을 제시한다.

• The Monthly Diabetes
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• s.205
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• pp.28-29
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• 2006

고지혈증을 갖고 있는 사람의 대부분은 뚜렷한 임상 증상이 없기 때문에 조기에 선별 검사를 해야 하고 당뇨병환자는 콜레스테롤 수치에 관계없이 적어도 1년에 한번 이상은 고지혈증에 대한 검사를 해야 한다.