• Journal of Life Science
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• v.33 no.5
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• pp.429-435
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• 2023

Epidemiological studies suggest that maternal infection, maternal stress, and environmental risk factors during pregnancy increase the risk of brain development abnormalities associated with cognitive impairment in the offspring and increase susceptibility to schizophrenia and autism spectrum disorder. Several animal models have demonstrated that maternal immune activation (MIA) is sufficient to induce abnormal brain development and behavioral defects in the fetus. When polyinosine:polycytodylic acid (poly I:C) or lipopolysaccharide (LPS), which is commonly used in maternal immune activation animal models, was introduced into a pregnant dam, an increase in pro-inflammatory cytokines and microglial activity was observed in the offspring's brain. Microglia are brain-resident immune cells that play a mediating role in the central nervous system, and they are responsible for various functions, such as phagocytosis, synapse formation and branching, and angiogenesis. Several studies have reported that microglia are activated in MIA offspring and influence offspring behavior through interactions with various cytokines. In addition, it has been reported that they play an important role in brain circuits through interactions with neurons and astrocytes. However, there is controversy concerning whether microglia are essential to brain development or lead to behavioral defects, and the exact mechanism remains unknown. Therefore, for the potential diagnosis and treatment of brain developmental disorders, a functional study of microglia should be conducted using MIA animal models.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.4A
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• pp.281-290
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• 2009

In this study, an analysis technique of hybrid girder considering nonlinearity of steel-concrete contact surface is presented. Steel-concrete hybrid girder shows partial-interaction behavior due to the deformation of shear connectors, slip and detachment at the interface, and cracks under the applied loads. Therefore, the partial-interaction approach becomes more reasonable. Contact surface is modeled by interface element and analyzed nonlinearly because of cost of time and effort to detailed model and analysis. Steel and Concrete are modeled considering non-linearity of materials. Material property of contact surface is obtained from push-out test and input to interface element. For the constitutive models, Drucker-Prager and smeared cracking model are used for concrete in compression and tension, respectively, and a von-Mises model is used for steel. This analysis technique is verified by comparing it with test results. Using verified analysis technique, various analyses are performed with different parameters such as nonlinear material property of interface element and prestress. The results are compared with linear analysis result and analysis result with the assumption of full-interaction.

• Journal of Life Science
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• v.32 no.8
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• pp.601-610
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• 2022

P. tenebrifer (PT) belongs to the Diptera order and Stratiomyidae family. Recently, insect industry have been focused as food, animal feed and environmental advantages. γ-aminobutyric acid (GABA) and melatonin have been associated with regulating sleep and depression. GABA is the primary inhibitory neurotransmitter and is synthesized via biotransformation of monosodium glutamate (MSG) to GABA by lactic acid bacteria. In this study, we first used a GABA-enhanced PT extract, wherein GABA was enhanced by feeding MSG to PT. The underlying mechanisms preventing stress and insomnia were investigated in a corticosterone (CORT)-induced endoplasmic reticulum (ER) stress and chronic restraint stress (CRS)-exposed mouse model, as well as in pentobarbital (45 mg/kg)-induced sleep behaviors in mice. In the present study, the GABA peak was detected in high-performance liquid chromatography-evaporative light scattering detector (HPLC-ELSD) analysis and showed in Ptecticus tenebrifer water extract (PTW) but not in non-PTW extract. The results showed that PTW and Ptecticus tenebrifer with 70% ethanol extract (PTE) exerted neuroprotective effects by protecting against CORT-induced downregulation of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and cAMP-response element binding protein (CREB) expression. In addition, PTW (300 mg/kg) significantly reduced CORT levels in CRS-exposed mice. Furthermore, PTW (100 and 300 mg/kg) significantly reduced sleep latency and increased total sleep duration in pentobarbital (45 mg/kg)-induced sleeping behaviors, which was related to serum melatonin levels. In conclusion, our results suggest that PTW exerts anti-stress and sleep-enhancing effects by regulating serum CORT and melatonin levels.

• Korean Journal of Remote Sensing
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• v.39 no.6_2
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• pp.1635-1650
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• 2023

Under global warming, the steadily increasing sea surface temperature (SST) severely impacts marine ecosystems,such as the productivity decrease and change in marine species distribution. Recently, the catch of Todarodes Pacificus, one of South Korea's primary marine resources, has dramatically decreased. In this study, we analyze the marine environment that affects the formation of fishing grounds of Todarodes Pacificus and develop seasonal habitat suitability index (HSI) models based on various satellite data including Geostationary Ocean Color Imager (GOCI) data to continuously manage fisheries resources over Korean exclusive economic zone. About 83% of catches are found within the range of SST of 14.11-26.16℃,sea level height of 0.56-0.82 m, chlorophyll-a concentration of 0.31-1.52 mg m^-3, and primary production of 580.96-1574.13 mg C m^-2 day^-1. The seasonal HSI models are developed using the Arithmetic Mean Model, which showed the best performance. Comparing the developed HSI value with the 2019 catch data, it is confirmed that the HSI model is valid because the fishing grounds are formed in different sea regions by season (East Sea in winter and Yellow Sea in summer) and the high HSI (> 0.6) concurrences to areas with the high catch. In addition, we identified the significant increasing trend in SST over study regions, which is highly related to the formation of fishing grounds of Todarodes Pacificus. We can expect the fishing grounds will be changed by accelerating ocean warming in the future. Continuous HSI monitoring is necessary to manage fisheries' spatial and temporal distribution.

• Journal of Digital Contents Society
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• v.15 no.1
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• pp.19-27
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• 2014

In order to estimate the life of 2,5 inch HDD which is adopted by PC environment, make the test plan which reflect the failure mode of market, make the test model of accelerated life test which reflect the stress of temperature. after an analysis of the environment of PC using, test procedure was decided that operation was write 50 % and read 50 %, and then access method was sequential 50 % and random 50%. The acceleration life test was executed on condition that temperature was $50^{\circ}C$ and $60^{\circ}C$, performance was 95 % in max performance, test time was 1000 hours. by the test of goodness of fit of anderson-darling of the failure data during test, it was confirmed that the distribution of failure fellow weibull. test for shape and scale was equal, and shape parameter was 0.7177, characteristic life was 429434 hours at normal user condition($30^{\circ}C$) by the analysis of weibull-arrhenius modeling. It made no difference about the statistics when equality test was executed. The activation energy was 0.2775eV. In analyzing between the failure samples of acceleration test and the samples of market return even though there is detail difference about the share of failure mode, the rank of share was almost same. This study suggest the test procedure of acceleration test of 2.5 inch HDD in PC using environment, and help the life estimation at manufacture and user.

• Journal of the Korean Society of Marine Environment & Safety
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• v.26 no.6
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• pp.634-643
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• 2020

Because of the continuous increase in the demand for and importance of marine space, marine exploration and survey activities are being actively conducted in Korea actively. Because the marine survey vessels used for these activities have special operational patterns depending on the purpose and probe vessels, research on maritime traffic risk is required. In this study, an attempt was made to determine the correlation of each factor with the effect of marine exploration and survey vessel operation on maritime traffic. The status of ocean exploration and survey vessels in operation in Korea was identified, as well as the special operational conditions of some of the ocean physical probes. Generally, the number of exploration and survey vessels involved per hour, total vessel length(including exploration equipment), operation, interval distance of exploration as per plan, and marine traffic conditions(traffic volume and speed) can be classified as operating factors. To compare the results of the environmental stress, a maritime traffic flow simulation based on the "ES" Model was performed with each of the identified operating factors as independent variables. The results of the analysis confirmed that the environmental stress significantly changed in the order of traffic volume, ship length and speed. In addition, it was confirmed that the environmental stress is reduced when the operation course is set at an angle with the nearby maritime traffic flow. Accordingly, it can help reduce the operator's burden if the survey vessel operator understands nearby maritime traffic conditions and reflects them in the operation method when setting the operation plan.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.2 no.3
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• pp.10-17
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• 1999

In order to confirm the effectiveness of the natural river improvement technique, the analysis of vegetation was carried out in Yangjae stream between 1996 and 1998. The results of this study showed the numbers of riparian plants had increased from 41 species to 53 species, and the dominant species had changed from annual and biannual(Humulus japonicus, Persicaria thunbergii, Persicaria hydropiper, Panicum dichotomiflorum, Echinochloa crus-galli) to perennials (Phragmites communis). The variation in biomass and biodiversity index were measured and calculated according to the rehabilitation method. Biomass were varied 302 to $828g/m^2$ and biodiversity index was varied 1.53 to 1.52 at point bar plots(A treatment plots) from 1996 to 1998. In conclusion, the natural river improvement technique which has operated in Yanjaecheon for three years has contributed to restoration of riparian plants. Additionally, subsequent study using this technique should be followed in the near future.

• Journal of Advanced Navigation Technology
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• v.13 no.4
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• pp.577-585
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• 2009

Various studies on individual health-care application services have been lively going on due to recent development of information and communication technology and improvement of life quality. Moreover, U-health care area is emerging as a new growth industry as the demand of U-health care service for a quality life grows with the development of medical technology and ubiquitous environment. U-health care system for crew members on ships, who need to spend much time on sea far from their families, is especially needed because they find their job much more stressful not only physically but also mentally than any other people in different jobs do and have less chance to get proper medical services in time. In this paper, we suggested how to get more accurate and objective U-health wellbeing index by complementing SF-36, the general heath care index model in order to managing health of crew. Also we designed the U-health wellbeing index service system which can provide appropriate sports programs or diet contents according to health index.

• Journal of Navigation and Port Research
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• v.41 no.3
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• pp.93-102
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• 2017

When VTSOs (Vessel Traffic Service Operator) determine the degree of collision risk for two vessels, they consider comprehensive information about each vessel's course, speed, DCPA, TCPA, and encountering situation. In this study, we proposed a utility function based on the risk attitudes of VTSOs toward the Risk Index (RI). The RI was calculated using the risk of encounter, the risk of approach, and the risk of time for two vessels in order to predict each ship's collision risk from the VTS viewpoint. We obtained each coefficient of the RI and the risk attitude through a survey of collision risks among VTSOs of Korea. In order to verify whether the proposed utility is reasonable, we validated by applying the degree of collision risk to some historical cases of accidents in Busan port along with the Ship of ES value($ES_S$) of ES(Environmental Stress) model.

• Journal of the Microelectronics and Packaging Society
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• v.15 no.2
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• pp.55-61
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• 2008

This paper shows quantitative reliability evaluations of a Bluetooth module through extending previous qualitative methods limited to structure reliability tests and solder joint reliability tests for Bluetooth modules. Accelerated Life Testing (ALT) of the modules using temperature difference in temperature cycling as an accelerated stress was conducted for quantitative reliability evaluation under field environment conditions. Lifetime distribution parameters were estimated using the failure times obtained through the ALT, and then Coffin-Manson model was implemented. Results of the ALT showed that the failure mode of the modules was open and the failure mechanisms are both crack and delamination. The ALT reproduced the failure mode and mechanisms of failed Bluetooth modules collected from the field. Further, a quantitative reliability evaluation method with respect to various temperature differences in temperature cycling was proposed in this paper. $B_{10}$ lifetime of the module for the temperature difference $70^{\circ}C$ using the proposed method would be estimated as about 4 years.