• Journal of Life Science
• /
• v.22 no.2
• /
• pp.266-280
• /
• 2012

Agar is a cell wall component of macro red algae that can be hydrolyzed by agarase. Agarases are classified into ${\alpha}$-agarase (E.C. 3.2.1.158) and ${\beta}$-agarase (E.C. 3.2.1.81), in accordance with their cleavage pattern, and can be grouped in the glycoside hydrolase (GH)-16, -58, -86, -96, and -118 family according to the amino acid sequences of the proteins. Many agarases and/or their genes have been detected, isolated, and recombinantly expressed from bacteria, and metagenomes have their origins in sea and terrestrial environments. Products of agarases, agarooligosaccharides and neoagarooligosaccharides, represent wide functions such as antitumor, immune stimulation, antioxidation, prebiotic, hepa-protective, antibacterial, whitening, and moisturizing effects; hence, broad applications would be possible in the food industry, cosmetics, and medical fields. In addition, agarases are also used as a tool enzyme for research. This paper reviews the sources, purifications and detection methods, and application fields of agarases. The role of agarases in agar metabolism and the function of their enzymatic products are also surveyed.

• Korean Journal of Pharmacognosy
• /
• v.44 no.2
• /
• pp.154-160
• /
• 2013

Ceramium boydenii belongs to euphorbia humitusa of red algae, and is distributed along the coast of Jeju island. This study was conducted to examine the anti-inflammatory effect and action mechanism of C. boydenii in the human keratinocyte cell line HaCaT. The 80% EtOH extract of C. boydenii inhibits the production of MDC (macrophage derived chemokine), an inflammatory chemokine, induced by IFN-${\gamma}$ and TNF-${\alpha}$ in a concentration dependent manner. It also suppressed the phosphorylation and nuclear translocation of STAT1, a key transcription factor in IFN-${\gamma}$ and TNF-${\alpha}$ signaling pathway, at the effective concentrations. These results suggest that C. boydenii demonstrates the anti-inflammatory activity via the suppression of STAT1 activation and has the significant value as an anti-inflammatory source.

• Journal of the Korea Institute of Building Construction
• /
• v.17 no.2
• /
• pp.199-209
• /
• 2017

The measurement of business performance is important to secure the competitiveness of construction companies. Therefore, the purpose of this study is to analyze what is needed to increase the competitiveness of small & medium construction companies. In order to analyze efficiently, this study reconfirms the effectiveness of Key Performance Indicators(KPI) of construction companies selected from previous studies. The empirical analysis to find differences of KPI between small & medium construction companies and big construction companies is performed using the 4,286 construction company samples extracted by 'KIS-Value Data Base'. The results of the empirical analysis show that there are significant differences in characteristics of KPI between small & medium construction companies and big construction companies. Particularly, small & medium construction companies are relatively insufficient to invest for the purpose of preparation for future and long-term growth. Additionally, empirical tests reconfirm that most of the KPIs from previous survey studies are suitable as a performance indicators. The contribution of this study is to analyze empirically small & medium construction company's strong & weak points and the effectiveness of KPIs derived from previous studies.

• Journal of the Korean Society of Marine Environment & Safety
• /
• v.15 no.3
• /
• pp.173-177
• /
• 2009

A total of 3 epiphytic macroalgae were collected from eelgrass bed in Jindong Bay, and Scytosiphon lomentaria and Colpomenia sp. in Phaephyta, Gracilaria sp. in Rhodophyta occurred during study periods. For epiphytic microalgae (diatoms), Cocconeis scutellum and Cocconeis placentula were common species. Seasonal variations of epiphytic algal biomass were marked: the higher epiphytic macroalgae was 3.3 g $DW/m^2$ in November 2003; whereas epiphytic diatoms were 43,153 $cells/m^2$ in June 2003. Diversity and number of epiphytic macroalgae species were the lowest in the study area, compared with those of in other areas such as Koongyang Bay, Dongdae Bay, and Aenggang Bay. These results were therefore likely due to the severe physical characteristics of the intertidal mudflat eelgrass biological characteristics, and the deterioration of water quality.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.20 no.4
• /
• pp.123-131
• /
• 2007

Purpose: To find the correlation between ambient temperature change and the efficacy of acupuncture on the postmenopausal hot flash. Methods: 52 patients entered a randomized clinical trial which was to verify the efficacy of acupuncture on postmenopausal hot flash. Participants were treated with optimal/minimal acupuncture in the course of 13 weeks. 34 of 52 visited for the temperature-rising period(Group 1), while 18 of 52 for the temperature-falling period(Group 2), 100mm hot flash VAS and average temperature were taken 18 times from each person. Linear mixed effects model was used to find the correlation between temperature and hot flash VAS score(p-value<0.05). Group1/2, optimal/minimal acupuncture, age, age of menarche, height, weight, percent body fat, BMI, waist-hip ratio, past history of hysterectomy and HRT were also examined. Results: Period of treatment had influence on the hot flash VAS. As time went by, hot flash decreased(p<.0000). Participants who underwent minimal acupuncture showed higher hot flash VAS(p=0.0479) and as waist-hip ratio rose, hot flash increased(p<.0000). As the temperature rose, hot flash VAS score became lower(p=0.0143) and it was because 34 of 52 participants were treated for the temperature-rising period. Group 1/2 had no interrelation with hot flash(p=0.5741). Conclusion: Hot flash diminished as participants were treated with acupuncture, independently of whether the ambient temperature rises or falls.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.20 no.4
• /
• pp.148-159
• /
• 2007

Purpose: Vasomotor symptoms including hot flash are very common to postmenopausal women. Estrogen therapy was regarded as the best option for relieving menopausal symptoms until 2002, when the Women#s Health Initiative(WHI) reported the side effect of the therapy. Consequently, studies on the complementary and alternative medical herbs and therapy for the management of menopausal symptoms have followed. And so we have reviewed some international clinical studies about the management of postmenopausal symptoms with acupuncture therapy. Methods: "Menopause and acupuncture" was designated as a key word in the search site. Pub Med, and nine papers dealing with hot flash among the relevant RCTs were selected, and then, the effect of acupuncture on hot flash and the way the researches had been done was examined. Results : The intensity of hot flash reduced significantly and the frequency of hot flash was inclined to reduce, but not significantly, compared to the controlled group. Conclusion: Each clinical test has its limitations in point of the number of the required samples. However, it still shows the possibility that acupuncture itself will be effective enough to reduce the intensity of hot flash to a certain degree. It is believed that extensive clinical tests on the effect of acupuncture on hot flash will need to be done hereafter. And when the tests are carried out, it is required to exclude placebo effect, do blind test, and carefully select and control the methods.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.19 no.4
• /
• pp.205-215
• /
• 2006

Purpose : To identify factors related to the severity and frequency of hot flush of postmenopausal women who participated in a clinical trial. Methods : A cross-section study of 34 postmenopausal women between 40 and 60 years of age was done. VAS(visual analog scale) was used to evaluate the hot flush degree. Statistical analysis was performed with multiple linear regression analysis. Results : Hot flush VAS was proportional to the percent body fat with 1.467 regression coefficient (p-value= 0.010). It implies that the symptom of hot flush becomes worse as the percent body fat increases. Some hormones also have effects on hot flush. We found that LH might cause increment of hot flush VAS(i.e., the corresponding regression coefficient is 0.912). Sasang constitution was not relevant to the hot flush degree. Hot flush VAS seemed to increase as the vascular aging degree by SA-2000 getting worse, but it was not statistically significant (p-value= 0.594). Conclusion : This study is a part of a prospective clinical trial. For more accurate result, larger-scale cross-section study or clinical trial are necessary.

• Journal of Plant Biology
• /
• v.34 no.2
• /
• pp.165-173
• /
• 1991

Subtidal algal communities of lnchon Dock, an enclosed artificial dock in the western coast of Korea, were investigated qualitatively and quntitatively. Assessments of species composition, biomass rlominant species, and vertical distribution were conducted from January to December, 1990. Duf"16 the study, benthic marine algal community was disturbed completely by water blooming in June, and was recolonized from July. Forty-five species of marine algae, 18 blue green. 13 green. 6 brown, and 8 red algae, were identified as results. Mean biomass was in ranges of $53.50-118.00\;g-dry\;wt/m^2$ in community before disturbance and $0.57-2.62\;g-dry\;wt/m^2$ after it. Dominant species determined by biomass and frequency were Polysiphonia m0\ulcorner7owii and Ceramium fastigiramosum before disturbance, while Lyngbya semiplena, Lyngbya lutea and Lyngbya rivulariarum after disturbance as pioneer colonizers.nizers.

• Korean Journal of Medicinal Crop Science
• /
• v.10 no.5
• /
• pp.366-374
• /
• 2002

Pen-tsao-kang-mu(Bon-cho-kang-mok), chinese medicinal plant book, was written by Lee sijin(1578), China. The subject of this study were 158 articles of vegetable part in Pen-tsao-kang-mu. Among them only 139 articles were able to be identified by authority of several references. By Engler's system they were classified into 8 divisions, 10 classes, 6 subclasses, 31 orders, 22 suborders, 52 families, 85 genera, 99 species, 12 varieties and 2 forma, and were confirmed 113 kinds of original plants. Among the divisions, Angiospermae was the most numerous division with 92 kinds(80.70%) and the second division was Fungi with 12 kinds(10.53%). The next was Rhodophyta with 4(3.51%) kinds. Other 19 articles were unable to be classified because of their ambiguous name.

• Korean Journal of Construction Engineering and Management
• /
• v.16 no.4
• /
• pp.30-40
• /
• 2015

Two-dimensional drawings are widely used as a communication tool in the construction industry, but they are still hard to be understood by engineers with less experience. A four dimensional CAD drawing is presented based on marker-based augmented reality, for visual assistance, detailed information, and prevention of misunderstanding among users. The developed drawing enables the users to easily understand its contents through the functions augmenting components, providing detailed construction information, and simulating construction process, using the marker in a 2D drawing. A questionnaire-based survey validates the capability of the developed drawing that it improves inexperienced engineers' understanding of the drawings.