• Journal of the korean academy of Pediatric Dentistry
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• v.29 no.3
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• pp.450-454
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• 2002

Laceration of soft palate and oropharynx is relatively common in children. Soft palate laceration has been reported patients of all ages, ranging from new born to geriatric patients. However, young children often place objects their mouth, they may fall on the object or receive a direct force on the object which then perforates the soft palate tissue. Most frequently affected site is the left supra-tonsillar area. Lesions are predominately in the soft palate with-out perforation. Linear and superficial wounds are frequent. A typical injury is the flat- U-, or V-shaped with apex directed anteriorly. In those cases without any through-and-through lacerations or any tissue loss, suture is not necessary. Furthermore, suture of the affected site may hinder wound healing. Healing of the wound should be complete by three weeks with minimal scarring. There have been reports of carotid artery injury due to soft palate laceration causing neurologic complications. For such reasons, traumatized child must be in close observation for 2-3days, and if symptoms of complication are noticed consultation with oromaxillofacial surgeons, E.N.T., or neurologist is required. These are two reports of boys 2 and 3 years of age who had soft palate laceration caused by a falling-down-in jury with an object in their mouth. They were treated non-surgically and neurologic evaluation was carried out for 1 week with complete healing.

• Korean Journal of Animal Reproduction
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• v.25 no.4
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• pp.399-407
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• 2001

The microinjection of retroviral vectors into the perivitelline spaces of MII-stage oocytes increased production of transgenic bovine embryos. However, oocytes have various sizes of perivitelline space, and there is the tendency that the oocyte membranes are damageable by micropipettes during the injection of retroviral vectors into perivitelline spaces or oocytes. Thus, it was not always possible to stably inject retroviral vector into perivitelline spaces of oocytes. Here we used sucrose to minimize the damage of the oocyte membrane. When the oocytes were suspended in 0.5% sucrose, poor quality oocytes showed rough cytoplasmic membranes, while good quality oocytes maintained smooth membranes. However, when the tatters were subjected to in vitro fertilization, no significant differences were observed in cleavage rates (82% of control Vs. 84% of sucrose treated oocytes). The Same trends were obtained from the oocytes fertilized after microinjection of LN$\beta$-EGFP and LNC-hGH genes into the perivitelline spares. The rates of cleavage and blastocyst from microinjection of LN$\beta$-EGFP genes were 81 and 25%, and from microinjection of LNC-hGM genes were 53 and 30%, respectively. The result indicated that microinjected oocytes could develop to the blastocyst stages after in vitro fertilization with no significant difference from control group. Moreover, the integration of hGH-gene (by PCR analysis) was detected in 52% of infected cleaved embryos and the expression of EGFP-gene (under a fluoresrence microscope) was also observed in 34% of infected blastocyst. These results indicated that 0.5% sucrose treatment could be an efficient method not only to select good quality embryos but also to inject retroviral vectors into perivitelline spares without any harm and hence improving developmental rates.

• Journal of Korean Tunnelling and Underground Space Association
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• v.9 no.1
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• pp.19-28
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• 2007

Tunnel management is a time-consuming and expensive task. In particular, visual analysis of tunnel inspection often requires extended time and cost and shows problems on data gathering, storage and analysis. This study proposes a new approach to extract information for tunnel management by using a laser scanning technology. A prototype tunnel laser scanner developed was used to obtain point clouds of a railway tunnel surface. Initial processing of laser scanning data was to separate those laser pulses returned from the installations attached to tunnel liner using radiometric and geometric characteristics of laser returns. Once the laser returns from the installations were separated and removed, physically damaged parts on tunnel lining are detected. Based on the plane formed by laser scanner data, damaged parts are detected by analysis of proximity. The algorithms presented in this study successfully detect the physically damaged parts which can be verified by the digital photography of the corresponding location on the tunnel surface.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.3
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• pp.479-484
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• 2000

흰쥐에 에탄올을 투여해 간 손상을 유도한 후 굼벵이를 투여해 굼벵이가 혈청과 간의 지진대사에 어떠한 영향을 미치는가를 조사하였다. 혈청지질 중 에탄올에 의해 증가된 triglyceride, 총 cholesterol은 굼벵이를 섭취시킴으로써 이의 수치를 감소시켰으며 HDL-cholesterol은 굼벵이의 섭취로 triglyceride 함량은 감소되었다. GOT와 GPT의 활성은 에탄올 투여시 정상식이에 비해 유의적인 증가를 보인 반면, 굼벵이의 섭취로 유의적인 감소를 나타내었다. (p<0.05). 에탄올 추여군의 간조직 세포는 세포질에 지방소적의 축적으로 세포질의 부분적인 괴사현상이 나타났으며 조면소포체와 mitochondria의 형태적 변형이 관찰되었다. 에탄올과 굼벵이의 병용투여군은 지방소적의 크기 및 양적 감소와 세포질의 괴사현상이 약간 회복 되었으나 조면소포체와 mitochondria의 수적인 증가는 미미하였다.

• Korean Journal of Food Science and Technology
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• v.47 no.1
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• pp.87-94
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• 2015

High voltage pulsed electric fields (PEF) treatment is one of the more promising nonthermal technologies to fully or partially replace thermal processing. The objective of this research was to investigate the microbial inactivation mechanisms of PEF treatment in terms of intra- and extracellular changes in the cells. Saccharomyces cerevisae cells treated with PEF showed cellular membrane damage. This resulted in the leakage of UV-absorbing materials and intracelluar ions, which increased with increasing treatment time and electric fields strength. This indicates that PEF treatment causes cell death via membrane damage and physical rupture of cell walls. We further confirmed this by Phloxine B staining, a dye that accumulates in dead cells. Using scanning and transmission electron microscopy, we observed morphological changes as well as disrupted cytoplasmic membranes in PEF treated S. cerevisae cells. In addition, PEF treatment led to damaged chromosomal DNA in S. cerevisiae.

• Journal of the Korean Arthroscopy Society
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• v.7 no.2
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• pp.127-136
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• 2003

Posterolateral instability of the knee occurs more commonly in association with an injury to anterior and posterior cruciate ligament and combined injuries are severe injuries that result in significant functional instability and articular cartilage degeneration. Reconstruction of the anterior and posterior cruciate ligament without an appropriate treatment of posterolateral corner injury result in failure of the reconstructed cruciate ligaments. Meticulous physical examinations, imaging studies, lower limb alignment and gait pattern should be evaluated. Acute grade III isolated or combined injury of the posterolateral corner is best treated within three weeks by direct repair, or augumentation, or reconstruction. The appropriate surgical method or combined methods are selected among the several methods of posterior and posterolateal reconstruction, and all injuried posterolateral and cruciate ligament structures are anatomically reconstructed simultaneously or by stages. If a varus alignment and varus thrust is disclosed in chronic posterolateral instability of knee, soft tissue reconstructions laterally are highly unlikely to be able to correct tile problem. It is appropriate that valgus osteotomy should be done before soft tissue reconstruction and reevaluate the posterolateral instability about 6 months later.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.400-400
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• 2022

관로 내 빈번히 발생하는 수격압의 발생은 관망 구조물에 피로가 누적되고 관벽에 손상을 발생시켜, 관로 내 누수가 다양한 형태로 생성된다. 관 내 누수가 발생되는 경우 관 내부의 수격압의 발생 시 생성되는 부압으로 인하여 외부 물질이 관으로 흡수되거나 혼합되어 스케일과 미생물의 생성되는 등 관 내의 수질에 악영향을 끼치며 마찰을 증가시켜 통수능이 감소하고 관리에 추가적인 비용을 발생시킨다. 이러한 영향을 방지하기 위해 관 내에서 생성되는 누수를 탐지하기 위하여 수격압을 발생시켜 압력파를 분석하거나 추적을 수행하는 여러 가지 연구들이 수행되었다. 본 연구에서는 현장 관망과 연결된 100A 대구경 관로에 관로 수압 발생장치를 연결하여 기존의 수격압을 발생시켜 분석하는 방법 대신 안전하고 용이한 방법인 압력파를 주입하여 실험을 수행하였다. 실험을 통해 획득한 데이터를 시간상에서 분석하고 Fourier 변환을 통한 빈도상 분석과 Wavelet 분석으로 신호주기에서 누수가 미치는 영향을 파악하였다. 실험 결과에서는 누수에 의한 영향으로 반사파가 직접적으로 변형되는 형태보다 시스템 전체에서 반영되어 수두가 감쇠되는 형태로 나타났다. Fourier 변환을 통해 무누수 조건과 누수조건의 비교에서 누수의 유무에 따른 신호의 형태가 차이를 보였다. 앞선 연구들에서의 누수의 특정한 위치를 찾아내는 형태 대신 신호처리 후 분석을 통해 시스템 전체에서 일어나는 감쇠를 통해 누수 존재 유무를 판별하고자 한다.

• Journal of Korean Physical Therapy Science
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• v.9 no.3
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• pp.7-17
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• 2002

편마비 환자의 인지 기능과 운동 및 신체적 기능에 관련된 변인을 분석하고자 하였다. 본 연구는 인지 기능이 편마비 환자에게 미치는 영향과 인지 영역의 손상이 편마비 환자의 독립적 기능 및 수준 향상의 예언 인자로서의 고려해야 할 개념을 검사나 평가 척도로 비교, 분석 하였다. 연구 대상은 전라북도에 소재한 한방병원에 입원 및 통원하고 있는 52-73세의 연령 범위에 있는 편마비환자 20명 이다. 편마비 환자의 기능적 능력, 운동 회복, 신체적 기능 그리고 인지적 상태를 평가하기 위해 편마비 환자를 위한 임상적 결과 변인 척도, 운동 평가 척도와 바델 척도 그리고 기능적 독립성 측정 척도를 평가도구로 사용하였다. 편마비 환자의 신체적, 운동 그리고 기능적 능력 상태를 평가도구에 의해 측정된 결과를 분석한 바 운동, 신체적 그리고 인지적인 영역과 기능적 독립 측정 척도 및 바델 척도와 관련성이 있음을 보여주고 있다. 편마비 환자의 신체적, 인지적 결함이나 손상 부위, 손상의 본질에 따른 대상의 선정과 운동 조절 형태에 관한 지식 그리고 인지와 신경학적 결함 정도를 심도있게 다루어 기능적 능력 향상의 임상적 효과를 높이고자 하는데 연구의 의의가 있다.

• Proceedings of the Korea Information Processing Society Conference
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• 2005.05a
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• pp.819-822
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• 2005

본 연구는 MDCT 영상을 이용하여 인체의 장기인 간을 추출하고 그 간 내부의 혈관을 추출하는 알고리즘을 제안하였다. 간에는 2개의 주요혈관이 있는데 생체 간 이식 수술시 필수적인 간의 절개 비율 및 간 내의 혈관 모습들을 제공하여 의료진에게 수술 전 혈관 형태에 대한 정확히 정보를 파악하도록 함으로써 혈관의 손상을 최대한으로 줄일 수 있도록 하여 수술 성공률을 높이는데 중요한 역할을 할 수 있다. 간을 이식 할 때 기증자와 수혜자가 동시에 생존하기 위해서는 기증자의 간으 크기가 중요하며 둘다 생존하기 위해서는 기증자는 자신의 간의 35% 이상을 남겨야 하며 수혜자 또한 생존을 위해 자신의 간의 40% 이상에 해당하는 간을 이식 받아야 하는데 간 이식에 있어서 절단 부분을 결정하는데 중요한 중간 정맥을 찾아내어 보여 줌으로써 중간 정맥을 중심으로 3가닥의 굵은 혈관과 주변혈관의 손상을 최소화하고 비율을 잘 맞추어 절단 할 수 있도록 수술하는데 도움을 줄 수 있다. 각 혈관은 원형성과 다양한 각도를 갖는 막대형의 형태를 가지고 있다는 특징을 이용해 morphological filtering을 통해 추출한 후 조합하여 재구성을 하여 혈관의 모습으로 생성해 낼 수 있었다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.1 no.1
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• pp.45-55
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• 1998

Purpose: To make objective standards of small intestinal mucosal changes in cow's milk-sensitive enteropathy (CMSE) we analyzed histological changes of endoscopic duodenal mucosa biopsy specimens from normal children and patients of CMSE. Methods: We review the medical records of patients who had been admitted and diagnosed as CMSE by means of gastrofiberscopic duodenal mucosal biopsy following cow's milk challenge and withdrawal. Thirteen babies with CMSE, ranging from 14 days to 56 days of age, were studied. Five non-CMSE patients were used as control, ranging from 22 days to 72 days of age. The morphometric parameters under study were villous height, crypt zone depth, ratio of villous height to crypt zone depth, total mucosal thickness and length of surface epithelium by using H & E stained specimens under the drawing apparatus attached microscope. In addition, the numbers of lymphocytes in the epithelium and eosinophil cells in the lamina propria and epithelium were measured. Results: In the duodenal mucosal biopsy specimens in CMSE we found partial and subtotal villous atrophy with an increased number of interepithelial lymphocytes. The mean villous height($135{\pm}59\;{\mu}m$), ratio of villous height to crypt zone depth ($0.46{\pm}0.28$), total mucosal thickness ($499{\pm}56\;{\mu}m$), length of surface epithelium of small intestinal mucosa ($889{\pm}231\;{\mu}m$) in CMSE was significantly decreased compared with the control (p<0.05). The mean crypt zone depth ($311{\pm}65\;{\mu}m$) was significantly greater than the control ($188{\pm}24\;{\mu}m$)(p<0.05). Infiltration of interepithelial lymphocytes ($34.1{\pm}10.5$) were significantly greater than the control ($13.6{\pm}3.6$)(p<0.05). The number of eosinophil cells in both lamina propria and epithelium was no significant differences between groups (p>0.05). The small intestinal mucosa in treated CMSE showed much improved enteropathy of villous height, crypt zone depth, interepithelial lymphocytes compared with the control as well as untreated CMSE. Conclusion: Quantitation of mucosal dimensions confirmed the presence of CMSE. It seems to be a limitation in the capacity of crypt cells to compensate for the loss of villous epithelium in CMSE. Specimens obtained by gastrofiberscopic duodenal mucosal biopsy were suitable for morphometric diagnosis of CMSE. Improvement of CMSE also can be confirmed histologically after the therapy of protein hydrolysate.