• Archives of design research
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• v.19 no.4 s.66
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• pp.205-208
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• 2006

This work is a interactive digital art work which used the multiplex of jitter. It is an work which used a cross concept of two images. This work shows two kinds of images. One is on the wall through the gap of fluorescent lamp screen, and the other is on the fluorescent lamp screen. Two images are intercepted and comes out to the length as the multiplex of the jitter. The appearance of the spectator be recognized on the fluorescent lamp screen or on the wall, by two branch image which comes out intersecting of a length with multiplex function of the jitter. Two branch features of the image which it produces and the spectator which is input at real-time is equally divided, or in impression of juxtaposition goes in the spectator. It expresses the duplicity of the human being, with physical existence space divides the time space which we feel and there is a governing grammar which is different with each other and to express the thing it becomes. It used the image of the screen which it produces with the fluorescent lamp and cross concept.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2012.05a
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• pp.916-919
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• 2012

Bioimaging that can be imaging phenomena within cells of a molecular size have been advanced in technology. We can observe clearly DNA and proteins using a confocal microscope. Currently biological fluorescent imaging area is used essentially for diagnosis and treatment in health and clinical care field. In this paper, we developed an integration management system of analyzing fluorescence images on smart phone. It can support a user to analyse fluorescence images anytime anywhere. And our system is based on client-server configuration and has functions that can figure intensity of fluorescence images and manage many imaging data. Proposed system can be a mean of ubiquitous health because it helps a doctor diagnose by analyzing fluorescence images of emergency patients without time and space restrictions.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.04b
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• pp.81-84
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• 2004

본 논문은 스크린 프린트 방식을 이용하여 두께 $18{\mu}m$의 ZnS:(Cu,Al) 필름을 제조하여 미세구조와 결정성을 분석하고 형광체로써의 특성을 평가하였다. 영상획득에는 포항 가속기 연구소의 싱크로트론을 이용하였으며 CMOS 영상 센서를 사용하여 DR의 간접방식을 구현하였다. 특성 평가를 위해 SEM 측정, 발광 강도 측정을 하였고, 단색광(Beam size $5mm{\times}2mm$)을 사용하여 test phantom 영상과 물고기 영상을 획득하였다. 획득한 영상의 평가를 위해서 test phantom 영상의 MTF 측정을 하였다 제조된 ZnS:(Cu,Al) 필름의 표면은 육방정계 구조를 가졌으며, 5lp/mm는 73.8%, 10lp/mm는 38.9%, 15lp/mm는 15.4%, 20lp/mm는 12.2%의 MTF를 가졌다. 물고기 영상을 통하여 ZnS:(Cu,Al) 필름을 이용한 고해상도 미세구조영상 획득의 가능성을 확인하였다.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.04b
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• pp.68-71
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• 2004

본 연구는 싱크로트론 방사광의 단색광 (monobeam)을 이용한 영상을 획득하였다. 영상센서로서 CMOS를 사용하였으며 센서 앞단에는 형광체 (phosphor)를 이용하여 방사광에 대한 빛의 신호로서 영상을 획득하였다. 사용된 싱크로트론 방사광의 beam size는 $5mm{\times}2mm$ 이며 ion chamber를 통한 beam intensity 는 $10{\times}10^{-7}$이다. 형광체는 각각 ZnS(Cu:Al), ZnS(Ag,Al), $BiTiO_3$, $Y_2O_2S(Tb)$로서 4가지를 사용하였으며 여기에 사용된 형광체는 기계식 스크린 프린팅 (Screen Printing) 방식으로 직접 제조하였다. 두께는 모두 동일하게 $10{\mu}m$이며 각각에 대한 PL(Photoluminescence)을 측정하여 분석하였다. object로는 물고기와 20linepair를 사용하였으며 CMOS센서를 이용하여 각각의 phosphor에 대하여 영상을 획득하였다. 영상의 평가는 20line pair 영상의 MTF를 이용하였다. 각각의 형광체에 대한 MTF는 5 lp/mm 에서는 0.5650, 0.2150, 0.7890, 0.3840 이며 10 lp/mm 은 0.4500, 0.0900, 0.2510, 0.1500이고 15 lp/mm 는 0.1900, 0.0300, 0.1430, 0.0500이며 마지막으로 20 lp/mm 은 0.0810, 0.004, 0.0500, 0.0320의 MTF 값을 나타내었다. $10{\mu}m$ 두께에 대하여 ZnS(Cu:Al)이 가장 좋은 MTF의 값을 나타내었다.

• Journal of the Korean Society of Radiology
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• v.8 no.3
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• pp.123-136
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• 2014

In this paper, we study to classify molecular imaging and applications to predict future. Molecular imaging in vivo at the cellular level and the molecular level changes taking place to be imaged, that is molecular cell biology and imaging technology combined with the development of the new field. Molecular imaging is used fluorescence, bioluminescence, SPECT, PET, MRI, Ultrasound and other imaging technologies. That is applied to monitoring of gene therapy, cell tracking and monitoring of cell therapy, antibody imaging, drug development, molecular interaction picture, the near-infrared fluorescence imaging of cancer using fluorescence, bacteria using tumor-targeting imaging, therapeutic early assessment, prediction and therapy. The future of molecular imaging would be developed through fused interdisciplinary research and mutual cooperation, which molecular cell biology, genetics, chemistry, physics, computer science, biomedical engineering, nuclear medicine, radiology, clinical medicine, etc. The advent of molecular imaging will be possible to early diagnosis and personalized treatment of disease in the future.

• The Journal of the Acoustical Society of Korea
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• v.42 no.5
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• pp.429-440
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• 2023

This study explores recent research trends and potential applications of ultrasound optical imaging-based multimodal technology. Ultrasound imaging has been widely utilized in medical diagnostics due to its real-time capability and relative safety. However, the drawback of low resolution in ultrasound imaging has prompted active research on multimodal imaging techniques that combine ultrasound with other imaging modalities to enhance diagnostic accuracy. In particular, ultrasound optical imaging-based multimodal technology enables the utilization of each modality's advantages while compensating for their limitations, offering a means to improve the accuracy of the diagnosis. Various forms of multimodal imaging techniques have been proposed, including the fusion of optical coherence tomography, photoacoustic, fluorescence, fluorescence lifetime, and spectral technology with ultrasound. This study investigates recent research trends in ultrasound optical imaging-based multimodal technology, and its potential applications are demonstrated in the biomedical field. The ultrasound optical imaging-based multimodal technology provides insights into the progress of integrating ultrasound and optical technologies, laying the foundation for novel approaches to enhance diagnostic accuracy in the biomedical domain.

• Journal of the Korean Society of Radiology
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• v.5 no.5
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• pp.283-287
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• 2011

In this study, fine $Gd_2O_2S$:Tb powder was synthesized by using a low temperature solution-combustion method for a high-resolution digital x-ray imaging detector. From the fabricated phosphor power, the fine scintillator films was fabricated by particle sedimentation method and was investigated the luminescent property. From the experimental results of relative light output as a function of terbium concentration, the highest luminescent efficiency has at 5 wt% Tb concentration, and luminescent intensity decreased rapidly according to quenching effect about higher Tb concentration. Also, the relative light output of $270{\mu}m$-$Gd_2O_2S$:Tb film has 2945 pC/$cm^2$/mR. And light intensity was saturated at higher film thickness. Finally, to evaluate an image acquisition performance of fabricated phosphor, images were obtained by using commercial CMOS sensor and measured the MTF, NPS, and DQE. DQE(0 lp/mm) of fine phosphor film has 37%. But, DQE improvement of fine phosphor film is possible by resolving problem of film fabrication process and has a significant potential in the application of digital radiation imaging system later.

• The KIPS Transactions:PartB
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• v.17B no.6
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• pp.445-458
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• 2010

A Cold Cathode Fluorescent Lamp(CCFL) is used as a LCD Monitor's backlight widely. The most common way to check CCFL's defects is an examination with the naked eye. This naked eye examination can cause examination inconsistencies and industrial disasters. A shooting environment and detection algorithms are important for finding CCFL defects automatically. This paper presents CCFL defect detection algorithms using images captured under the shooting environment with sidelight which is one of the shooting environment we have suggested. The experimental result shows 4.65% of overdetection and 5.37% of unsuccessful defect detection of CCFL.

• Nuclear Medicine and Molecular Imaging
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• v.41 no.3
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• pp.226-233
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• 2007

Purpose: Dual reporter gene imaging has several advantages for more sophisticated molecular imaging studies such as gene therapy monitoring. Herein, we have constructed hepatoma cell line expressing dual reporter genes of sodium iodide symporter (NIS) and enhanced green fluorescence protein (EGFP), and the functionalities of the genes were evaluated in vivo by nuclear and optical imaging. Materials and Methods: A pRetro-PN vector was constructed after separating NIS gene from pcDNA-NIS. RSV-EGFP-WPRE fragment separated from pLNRGW was cloned into pRetro-PN vector. The final vector expressing dual reporter genes was named pRetro-PNRGW. A human hepatoma (HepG2) cells were transfected by the retrovirus containing NIS and EGFP gene (HepG2-NE). Expression of NIS gene was confirmed by RT-PCR, radioiodine uptake and efflux studies. Expression of EGFP was confirmed by RT-PCR and fluorescence microscope. The HepG2 and HepG2-NE cells were implanted in shoulder and hindlimb of nude mice, then fluorescence image, gamma camera image and I-124 microPET image were undertaken. Results: The HepG2-NE cell was successfully constructed. RT-PCR showed NIS and EGFP mRNA expression. About 50% of cells showed fluorescence. The iodine uptake of NIS-expressed cells was about 9 times higher than control. In efflux study, $T_{1/2}$ of HepG2-NE cells was 9 min. HepG2-NE xenograft showed high signal-to-background fluorescent spots and higher iodine-uptake compared to those of HepG2 xenograft. Conclusion: A hepatoma cell line expressing NIS and EGFP dual reporter genes was successfully constructed and could be used as a potential either by therapeutic gene or imaging reporter gene.

• Proceedings of the KAIS Fall Conference
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• 2011.05a
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• pp.389-392
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• 2011

본 논문에서는 영상의 색 항등성을 달성하기 위해 본질 영상의 핵심인 불변 방향을 K-means 클러스터링을 이용해 검출하는 개선된 알고리즘을 제안한다. 우선, RGB 영상을 K-means 클러스터링 기법에 의해 다수의 클러스터로 분할한다. 이 때, 클러스터 간의 거리 측정은 유클리드 거리이다. 그리고 분할된 클러스터 중 가장 많은 색을 가진 클러스터만을 x-색도 공간으로 도시하여 해당되는 후보 불변 방향을 계산한다. 검출된 후보 불변 방향은 방향별로 프로젝션된 히스토그램에서 3개 이상의 프로젝션된 데이터를 가진 bin들의 개수가 가장 적은 방향이다. 그 후, 분할된 다른 여러 클러스터에 해당되는 후 보 불변 방향을 계산하여 가장 많은 빈도로 나타나는 방향을 영상의 최종 불변 방향으로 결정한다. 실험에서 Ebner에 의해 제안된 데이터집합을 실험 영상으로 사용하였고, 색항등성 측도를 평가 척도로 사용하였다. 실험 결과, 제안한 기법은 형광성 표면을 가진 형광 데이터집합에 보다 적합하였으며, 엔트로피 기법보다 색항등성이 1.5배 이상 높았다.