• Food Industry And Nutrition
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• v.7 no.2
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• pp.45-50
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• 2002

본 연구는 성인 남자의 식생활 형태가 혈중지질 농도에 미치는 영향을 연구하기 위한 기초적인 연구로 영남의료원의 건강피검진자를 대상으로 식습관, 영양소 섭취량, 혈중지질농도를 조사하였다. 전체 조사대상자 220명중에 정상인 133명(60.5%), 경계수준군과 고콜레스테롤환자군은 각각 62명(28.2%)과 25(11.3%)를 차지하였다. 조사대상의 평균연령은 $48.4\pm9.5$세이었고, 체중은 $67.7\pm10.2kg$이었다. 평균 Broca's 지수(RBM)와 체질량지수(BMI)는 각각 $109\pm14.3$, $23.6\pm3.0$이었다. 식습관이 좋은 사람이 12명(5.4%)이고 보통인 사람이 130명(59.1%)에 해당하였으며 나쁜 사람이 78명(35.5%)으로 나타났으며, 식사형태와 식품의 배합에 대한 인식이 부족한 것으로 나타났다. 조사대상자의 혈중 중성지질의 평균농도는 약 115.8mg/dL이었고, $90\sim120mg/dL$인 사람이 대상자 220명중에 131명으로 전체의 59.9%를 차지하였다. 조사 대상자의 혈중 콜레스테롤 농도의 평균은 192.4mg/dL이었고, 혈중 콜레스테롤의 농도에 따른 대상자의 분포는 $180\sim210mg/dL$인 대상자가 73명으로 전체의 33.2%를 차지하여 가장 많았고 $150\sim210mg/dL$사이 포함되는 사람이 전체의 60.5%로 133명인 것으로 나타났다.

• Journal of the East Asian Society of Dietary Life
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• v.9 no.4
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• pp.421-426
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• 1999

This study was performed to evaluate the effect of persimmon vinegar on serum lipid components in the hypercholesterolemic Sprague-Dawley male rats. Forty rats were divided into four groups and fed diets containing l% cholesterol for 4 weeks. Experimental diets added to distilled water, 1.5%, 3%, and 7% persimmon vinegar(PV) as drinking water. Concentration of total cholesterol, LDL and HDL cholesterol, triglyceride in serum and activity of AST, ALT in serum were assayed. Average food intake, weight gain and FER of experimental rats were not significantly different by contents of persimmon vinegar. Concentration of total cholesterol and LDL cholesterol in serum were lowest in 7% persimmon vinegar group. However concentration of HDL cholesterol in serum was highest in 3% persimmon vinegar group. Concentration of triglyceride in serum was significantly lower in persimmon vinegar group than control group. Activities of AST and ALT in serum were lowest in 7% persimmon vinegar group. The results in this study suggest that persimmon vinegar is effective in lowering serum triglyceride level.

• Korean Journal of Food Science and Technology
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• v.40 no.4
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• pp.455-459
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• 2008

This study examined the effects of Bulnesia sarmienti ethanol extract on lipid metabolism in streptozotocin (STZ)-induced diabetic rats. Sprague Dawley rats were induced with diabetes mellitus by injecting STZ (45 mg/kg) into the tail vein, and were then divided into 5 groups: normal, STZ-control, and three experimental diabetic groups. The rats were fed a basal diet along with B. sarmienti ethanol extract for 8 weeks. According to the results, after 8 weeks of consuming the experimental diets, the body weights and food efficiency ratios of the B. sarmienti ethanol extract-fed groups were not different from those of the control group. However, the concentrations of plasma total-cholesterol, LDL-cholesterol, and triglycerides were significantly lower in the B. sarmienti ethanol extract groups as compared to those of the control group. Although a blood glucose control effect was not observed after the eight weeks of B. sarmienti ethanol extract treatment in this type-l diabetes model, it was discovered that the experimental diets were highly effective at lowering levels of serum lipids, including triglycerides, total-cholesterol, and LDL-cholesterol.

• Journal of the Korean Data and Information Science Society
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• v.23 no.4
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• pp.649-656
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• 2012

The present study was carried out to summarize the effect of caffeine in the lipid metabolic by meta-analysis. The association measure to test effect of caffeine was the Hedges's standardized mean difference (HG). In this particular fixed-effect model of Hedges's standardized mean difference, weight gain, heart weight, serum total lipid, serum triglycerides and liver triglycerides were significantly decreased (p < 0.05). Also, serum HDL cholesterol and serum LDL cholesterol were significantly increased. In this case of heterogeneous variable, random effect model was applied. In this model, weight gain, heart weight, serum total lipid, serum triglycerides, serum LDL cholesterol and liver triglycerides were significantly decreased in caffeine treated group. Also HDL-cholesterol was significantly increased in caffeine treated group.

• Proceedings of the KAIS Fall Conference
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• 2003.06a
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• pp.317-319
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• 2003

영양소의 충분한 섭취는 혈중 연농도의 체내 흡수 및 보유에 영향을 미치며, 혈중 연농도 또한 채내 영양상태에 영향을 미치는 것으로 알려져 왔다. 본 연구는 연사업장 근로자들의 영양소 섭취상태를 조사하고, 각 영양소와 채내 혈중 연농도와의 상관성을 분석함으로써 혈중 연농도 조절을 위한 식사중재연구의 기초사료를 제공하고자 실시되었다. 대상자는 직장인 건강진단을 위해 순천향 천안 병원 건강증진센터에 방문한 김진자 95명(남자 63명, 여자 32명)과 산업체 직장 건강검진에 참여한 부평 및 구미의 연사업장 근로자 135명(남자 118명, 여자 17명)등 총 230명이었다. 영양소 섭취량을 비교한 곁과, 콜레스테롤 섭취량을 제외하고 전반적으로 대조군에 비해 근로자군에서 영양소 섭취량이 낮았다. 영양소 섭취량과 혈중 연함량과의 상관관계는 비타민 B₁, B₂ 콜레스테롤을 제외하고 모두 음의 상관관계를 보였으며, 특히 식이 단백질, 식이 섬유소, 칼슘, 철분, 인, 나트륨, 칼륨, 비타민 C, 나이아신에서 유의한 음의 상관성을 나타내었다. 따라서 연사업장 근로자들에서 혈중 연농도를 저하시키기 위한 가능한 중재방법으로 식사를 통한 충분한 영양소 선취의 긍정적 효과가 제시되었다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.4
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• pp.485-490
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• 2014

The aim of this study was to investigate the hypocholesterol effects of Opuntia humifusa extract in hypercholesterolemic rats. Rats (8-week-old, male) were randomly divided into four groups (n=4) as follows: N-control, normal diet; H-control, hypercholesterolemic diet; OH-1, 2% O. humifusa extract-supplemented hypercholesterolemic diet; OH-2, 4% O. humifusa extract-supplemented hypercholesterolemic diet. After 4 weeks, we observed that hypercholesterolemia induced significant increases in serum lipids (total cholesterol and LDL-cholesterol), hepatic lipids (total cholesterol and triglyceride), and hepatic function parameters (ALT, alanine aminotransferase; AST, aspartate aminotransferase) (P<0.05). Treatment with O. humifusa extract for 2 weeks normalized these indexes up to the levels of normal rats. O. humifusa extract tended to increase fecal lipid (H-control: 142.74 mg/day vs. OH-1: 214.05 mg/day; OH-2: 200.95 mg/day, P<0.05) and bile acid (H-control: 37.07 ${\mu}M/day$ vs. OH-1: 47.23 ${\mu}M/day$, OH-2: 47.93 ${\mu}M/day$, P<0.05) contents of hypercholesterolemic rats. We concluded that oral administration of O. humifusa extract effectively improved cholesterol metabolism in a hypercholesterolemic animal model induced by hypercholesterol diet.

• Journal of the Korean Society of Food Science and Nutrition
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• v.31 no.1
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• pp.98-103
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• 2002

The serum lipid-lowering effect of garlic was examined in hypercholesterolemic rats. The food intake was not significantly different by garlic powder supplementation. The inclusion of 1% garlic powder in a diets containing 1% cholesterol brought a reduction in the serum cholesterol and triglyceride. Liver lipids were not affected by the addition of l% garlic Powder in hypercholesterolemic rats. Earlier studies have suggested that the effect of garlic on serum cholesterol may be related to the sulfur-containing amino acids of products released during protein digestion. However, our results in rats fed garlic powder diet showed no specific effect on plasma free amino acid concentrations. In conclusion. this study clears shows that garlic intake is able to reduce the levels of serum cholesterol in hypercholesteroolemic rats. However, further studies have to be done in order to elucidate the mechanism underlying this phenomenon.

• Journal of the Korean Society of Food Science and Nutrition
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• v.34 no.8
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• pp.1175-1181
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• 2005

The purpose of this study was to investigate the effects of green vegetable (kale) juice powder supple-mentation on lipid profiles, plasma homocysteine, folate and vitamin $B_{12}$ in rats fed cholesterol (Chol. ) or Chol. free diet. 7-week old male Sprague Dawley rats (n=40) were divided into 4 groups, and experimental diets containing control diet group (CO), control diet plus 0.5 wt$ \% $ Chol. (CC), control diet added with 5 wt$ \% $ kale (KO), control diet added with 5 wt$ \% $ kale plus 0.5 wt$ \% $ Chol. (KC) were fed for 8 wks. Plasma homocysteine level was examined by amino acid analyzer and serum folate and vitamin $B_{12}$ level were measured by com-petitive radioimmunoassay methods. In various serum lipid profiles, TG level was lower in kale juice powder groups (KO, KC) compared to the corresponding groups (CO, CC) (p<0.001). In Chol. supplemented groups (CC, KC), HDL-Chol. level was lower (p<0.001) and LDL-Chol. level was higher (p<0.05) than Chol. free diet. HDL-Chol. level was higer (p<0.05) in kale juice powder groups. HDL/LDL ratio was lower in Chol. supplemented groups (CC, KC) and tended to be higher in kale juice powder groups (KO, KC) Serum folate and vitamin $B_{12}$ levels were not affected by dietary Chol. and kale juice powder supplementation. Plasma homocysteine level was not affected by dietary Chol. and kale juice powder supplementation, too. Serum folate level was positively correlated with serum vitamin $B_{12}$ level (r=0.5632, p<0.001), but plasma homocysteine level was not significantly correlated with any serum folate, vitamin $B_{12}$ and Chol. levels, respectively. In summary, kale juice powder supplementation have improved serum lipid profiles by increasing the HDL level and decreasing the TG level and have not altered homocysteine level under the sufficient supply of folate and vitamin B complex relating with the homocysteine metabolism.

• KAPE Magazine
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• s.201
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• pp.16-16
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• 2013

• Proceedings of the Korean Nutrition Society Conference
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• 2000.06a
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• pp.116-116
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• 2000