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Effect of Bulnesia sarmienti Ethanol Extract on Plasma Levels of Glucose and Lipid in Streptozotocin Induced Diabetic Rats  

Park, Chang-Ho (Daegu Technopark Bio Industry Center)
Kim, Dae-Ik (Daegu Technopark Bio Industry Center)
Shin, Eun-Ji (Daegu Technopark Bio Industry Center)
Lee, Gee-Dong (Daegu Gyeongbuk Institute for Oriental Medicine Industry)
Kim, Jung-Ok (Daegu Gyeongbuk Institute for Oriental Medicine Industry)
Kim, Kil-Soo (College of Veterinary Medicine, Kyungpook National University)
Hong, Joo-Heon (Daegu Technopark Bio Industry Center)
Publication Information
Korean Journal of Food Science and Technology / v.40, no.4, 2008 , pp. 455-459 More about this Journal
Abstract
This study examined the effects of Bulnesia sarmienti ethanol extract on lipid metabolism in streptozotocin (STZ)-induced diabetic rats. Sprague Dawley rats were induced with diabetes mellitus by injecting STZ (45 mg/kg) into the tail vein, and were then divided into 5 groups: normal, STZ-control, and three experimental diabetic groups. The rats were fed a basal diet along with B. sarmienti ethanol extract for 8 weeks. According to the results, after 8 weeks of consuming the experimental diets, the body weights and food efficiency ratios of the B. sarmienti ethanol extract-fed groups were not different from those of the control group. However, the concentrations of plasma total-cholesterol, LDL-cholesterol, and triglycerides were significantly lower in the B. sarmienti ethanol extract groups as compared to those of the control group. Although a blood glucose control effect was not observed after the eight weeks of B. sarmienti ethanol extract treatment in this type-l diabetes model, it was discovered that the experimental diets were highly effective at lowering levels of serum lipids, including triglycerides, total-cholesterol, and LDL-cholesterol.
Keywords
Bulnesia sarmienti; serum lipid; cholesterol; streptozotocin; triglyceride;
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Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By SCOPUS : 4
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