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http://dx.doi.org/10.3746/jkfn.2014.43.4.485

Hypocholesterol Effect of Opuntia humifusa Extract on High Cholesterol Diet-induced Hypercholesterolemic Rats  

Jung, Eun Young (Dept. of Home Economic Education, Jeonju University)
Yeon, Seong Ho (Dept. of Food Science and Technology, Chungbuk National University)
Suh, Hyung Joo (Dept. of Food and Nutrition, Korea University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.43, no.4, 2014 , pp. 485-490 More about this Journal
Abstract
The aim of this study was to investigate the hypocholesterol effects of Opuntia humifusa extract in hypercholesterolemic rats. Rats (8-week-old, male) were randomly divided into four groups (n=4) as follows: N-control, normal diet; H-control, hypercholesterolemic diet; OH-1, 2% O. humifusa extract-supplemented hypercholesterolemic diet; OH-2, 4% O. humifusa extract-supplemented hypercholesterolemic diet. After 4 weeks, we observed that hypercholesterolemia induced significant increases in serum lipids (total cholesterol and LDL-cholesterol), hepatic lipids (total cholesterol and triglyceride), and hepatic function parameters (ALT, alanine aminotransferase; AST, aspartate aminotransferase) (P<0.05). Treatment with O. humifusa extract for 2 weeks normalized these indexes up to the levels of normal rats. O. humifusa extract tended to increase fecal lipid (H-control: 142.74 mg/day vs. OH-1: 214.05 mg/day; OH-2: 200.95 mg/day, P<0.05) and bile acid (H-control: 37.07 ${\mu}M/day$ vs. OH-1: 47.23 ${\mu}M/day$, OH-2: 47.93 ${\mu}M/day$, P<0.05) contents of hypercholesterolemic rats. We concluded that oral administration of O. humifusa extract effectively improved cholesterol metabolism in a hypercholesterolemic animal model induced by hypercholesterol diet.
Keywords
Opuntia humifusa extract; hypercholesterolemia; cholesterol; LDL-cholesterol;
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Times Cited By KSCI : 4  (Citation Analysis)
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