• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.11 no.2
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• pp.122-129
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• 2008

Purpose: Patients with chronic gastrointestinal disease are at risk for trace element deficiency due to impaired absorption and gastrointestinal loss. The aim of this study was to evaluate the trace element status of patients with gastrointestinal disease by blood and hair analysis, and to determine the usefulness of hair mineral analysis for diagnosing trace element deficiency not detected by a blood test. Methods: An analysis of hair minerals was performed and compared with blood mineral analysis in 13 patients with chronic gastrointestinal disease. The concentration of each element in the hair and blood was compared in the subgroups based on parenteral nutritional support or clinical symptoms. Results: Almost all patients had trace element deficiency. The trace elements deficient in the blood or hair analysis included zinc, selenium and copper. The hair zinc concentration was significantly lower in the group receiving parenteral nutritional support. The hair selenium concentration was statistically associated with the clinical symptoms of hair loss, brittle hair and loss of hair pigmentation. Conclusion: The results of this study suggest that patients with chronic gastrointestinal disease should receive adequate zinc and selenium replacement to avoid trace element deficiency especially when treated with long-term parenteral nutrition. Hair mineral analysis is useful as a complementary tool for the detection of a trace element deficiency.

• Journal of Yeungnam Medical Science
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• v.9 no.2
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• pp.211-217
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• 1992

망막분지정맥폐쇄는 안저출혈을 일으키는 중요한 질환의 하나로서 합병성 황반부 부종 및 망막신생혈관에 의한 초자체출혈로 인하여 시력장애를 유발하는 질환으로 전신질환중 고혈압과 가장 흔히 동반되나 당뇨병 혹은 혈액성 질환과도 동반되는 것으로 알려져있다. 초자체출혈의 경우 다른 원인에 의한 경우보다 초자체절제술에 의한 시력개선의 효과가 현저한 질환으로 심한 초자체출혈이 동반된 망막분지정맥폐쇄의 경우 평면부를 통한 초자체절제술 및 안저광응고술에 의한 수술적 처치가 필요할 것으로 사료된다.

• Clinical and Experimental Pediatrics
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• v.52 no.10
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• pp.1153-1160
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• 2009

Purpose:To evaluate the risk factors for mortality and prognostic factors in pediatric hemato-oncology patients admitted to the pediatric intensive care unit (PICU). Methods:We retrospectively reviewed the medical records of pediatric hemato-oncology patients admitted at the PICU of the Asan Medical Center between September 2005 and July 2008. Patients admitted at the PICU for perioperative or terminal care were excluded. Results:Total 88 patients were analyzed. Overall ICU mortality rate was 34.1%. Mean age at PICU admission was $7.0{\pm}5.7$ years and mean duration of PICU stay was $18.1{\pm}22.2$ days. Hematologic diseases contributed to 77.3% of all the primary diagnoses, and the primary cause of admission was respiratory failure (39.8%). The factors related to increased mortality were C-reactive protein level (P<0.01), ventilation or dialysis requirement (P<0.01), and hematopoietic stem cell transplantation (P<0.05). In all, 3 scoring systems were investigated [Number of Organ System Failures (OSF number), the Pediatric Risk of Mortality III (PRISM III) score, and the Sequential Organ Failure Assessment (SOFA) score]; higher score correlated with worse outcome (P<0.01). The Oncological Pediatric Risk of Mortality (O-PRISM) scores of the 21 patients who had received hematopoietic stem cell transplantation were higher among the non-survivors, but not statistically significant (P=0.203). Conclusion:The PRISM III and SOFA scores obtained within 24 hours of PICU admission were found to be useful as early mortality predictors. The highest OSF number during the PICU stay was closely related to poor outcome.

• The KIPS Transactions:PartB
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• v.17B no.6
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• pp.437-444
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• 2010

In this paper, we propose a method of analysing the relation between the patient's face color and his(her) kidney disease using image processing technology. This method is based on the ocular inspection which is one of the most famous diagnosis methods used in the oriental medical system. The way of processing and analysing the face image, which is for visualization and objectification of the color difference, is included. The objects are selected from the patients who suffer the kidney disease and use the hemodialyzer. Their facial images and clinical data are collected. From these data, we propose a hypothesis that the color of the patient's face is changed according to the patient's kidney state. At the same time, we present two algorithms of extracting the specific part of face which can identify the state of the patient's kidney and tracing the history of the color's change. This proposed method is evaluated through the practical experiments and their analysis.

• Proceedings of the Korean Information Science Society Conference
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• 2006.06a
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• pp.85-87
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• 2006

압타머칩은 (주)제노프라에서 개발한 새로운 개념의 바이오칩으로서, 압타머(aptamer)를 이용하여 혈액중의 특정 단백질군의 상대적인 양의 변화를 측정할 수 있으며, 질병 진단에 바로 응용할 수 있는 도구이다. 본 논문에서는 압타머칩 데이터 분석을 통해 심혈관 질환 환자의 질병 진행 단계를 예측할 수 있음을 보인다. 정상, 안정/불안정성 협심증, 심근경색의 네 단계로 표지된 환자의 혈액 샘플로부터 제작한 (주)제노프라의 3K 압타머칩 데이터를, 일반 DNA 마이크로어레이 분석과 동일한 과정을 거쳐 분류한 결과, 각 단계별 환자샘플이 확연히 구분되는 것을 확인하였다. 분산분석 결과 P-Value를 이용하여 자질 선택을 수행하고, 분류 알고리즘으로는 신경망, 결정트리, SVM, 베이지안망을 적용한 결과. 각 알고리즘별로 50대 남성환자 31개의 샘플에 대하여 $77{\sim}100%$의 정확도로 심혈관 질환의 단계를 구분해내었다.

• Journal of Digital Convergence
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• v.11 no.1
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• pp.431-439
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• 2013

This thesis is to research the before and after changes of physical configurations, blood components and physical strength for normal and geriatric diseased senior citizens at the end of 24 week of combined exercises constructed of aerobic and muscular strength training to create most suitable and effective complex exercise program for geriatric diseased patients. For this experiment 20 normal and 20 geriatric diseased patients in the age of 65 residing in "K" city were selected to carry out the 24 weeks of combined exercises in regularly. The result of the research showed that geriatric patients increased significantly in everything, but normal group showed significant change in only WHR. There was a slight improvement in the blood components for the average participants but it only differed slightly from the diseased participants so there were no major changes reflecting the outcomes from both before and after. After concluding the program both groups displayed positive improvements in stamina but no significant alterations in physical strength., agility, muscle endurance and balance. The positive factors for each groups could be that the norms were able to maintain their health and enhancement in stamina and diseased were able to prevent their condition from worsening. Additionally, over 50 percent of all senior citizens have one or more geriatric diseases but the participation of any physical activity is in the decrease. Henceforth, this is a field that still needs a lot of work and combined exercise programs should be created and followed through so it may enhance in the improvement of health and quality of life as well.

• Annual Conference of KIPS
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• 2019.10a
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• pp.1080-1081
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• 2019

만성간질환의 조기 발견과 적절한 관리는 중증 질환으로 진행을 차단하거나 완치하는데 큰 역할을 할 수 있다. 만성간질환을 진단하는 Gold Standard는 조직검사이지만 시간적·비용적인 측면에서 제한점이 있다. 현재 만성간질환 진단을 위해 최우선 시행하고 있는 검사는 혈액검사이며 진단정확도가 낮은 것으로 보고된다. 영상진단검사는 검사비용 측면에서 혈액검사보다 비싸며 진단정확도 측면에서 조직검사를 대체하기에는 정확도 향상이 요구된다. 본 연구에서는 획득된 의료영상을 활용하여 간세포 이질성과 결정성을 신속하게 정량 분석할 수 있는 소프트웨어를 개발하고 만성간질환 환자를 대상으로 정량 평가함으로서 임상활용 가능성을 확인하고자 한다.

• The Korean Journal of Blood Transfusion
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• v.29 no.3
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• pp.229-239
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• 2018

The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood, which affect blood flow, are called hemorheologic factors. Hemorheologic factors, such as blood viscosity and erythrocyte aggregation, are influenced mainly by hematocrit. A higher hematocrit level results in an increase in blood viscosity, erythrocyte aggregation, which impedes the circulation itself, and tissue oxygenation. An excess of serum ferritin causes injury to vascular endothelial cells and erythrocytes via oxygen free radicals. In addition, an excess of blood can aggravatee the adverse effects of the hemorheologic parameters and induce atherogenesis, microcirculatory disturbances, and major cardiovascular events. A preventive and therapeutic approach with a phlebotomy or blood donation has been stimulated by the knowledge that blood loss, such as regular donations, is associated with significant decreases in key hemorheologic variables, including blood viscosity, erythrocyte aggregation, hematocrit, and fibrinogen. Major cardiovascular events have been improved in regular blood donors by improving blood flow and microcirculation by decreasing the level of oxidative stress, improving the hemorheologic parameters, and reducing the serum ferritin level. Confirmation of the positive preventive and therapeutic effects of blood donations on cardiovascular disease by a well-designed and well-controlled Cohort study may be good news to patients with cardiovascular disease or at risk of these diseases, as well as patients who require a transfusion.

• 방재와보험
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• s.110
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• pp.69-71
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• 2005

암, 심장병과 더불어 우리나라 3대 사망 원인질환의 하나인 뇌졸중. 단일 질환으로서는 가장 중요한 사망원인 암에도 불구하고 올바른 인식부족으로 돌이킬 수 없는 결과를 초래하기도 하다. 뇌에 혈액을 공급하는 혈관이 막히거나 터져서 뇌의 일부가 망가지는 뇌졸중은 정기적인 운동과 신선한 음식을 섭취하고, 갑작스런 추위에 노출되거나, 심한 스트레스 및 과로를 피하는 것이 최상의 예방책이다.

• The Monthly Diabetes
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• s.220
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• pp.10-11
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• 2008

당뇨병은 혈액 내 포도당 농도가 증가되어, 여러 장기에 합병증을 초래하여 사망률과 이환율을 증가시키고 삶의 질을 저하시키는 만성 대사 질환이다. 당뇨병과 간기능의 효소 수치를 높이는 질환들인 비알코올성 간질환, B형 및 C형 간염, 알코올성 간질환 등은 종종 병존하는 것으로 알려지고 있으나, 원인 및 임상적 의의에 대한 연구는 많지 않다.