• Journal of Biomedical Engineering Research
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• v.22 no.1
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• pp.59-68
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• 2001

유체-고체 상호작용을 고려하여 다양한 복부대동맥류 모델에 대해서 맥동유동 및 구조를 동시에 해석하였다. 동맥류의 확장부 크기와 혈관벽 두께에 따라서 총 여덟 개의 축대칭 동맥류 모델을 선정하였다. 유한체적법 및 압력기반의 유한차분법을 이용하여 유동을 해석하였으며, 유한요소법을 이용하여 구조해석을 수행하였다. 동맥류의 확장부위가 클수록 최대응력은 최대확장부위와 변곡점에 해당하는 동맥류의 입구 및 출구 부분에 집중되었으며, Von Mises 응력은 최대확장부위 뿐만 아니라 동맥류의 근위부와 원위부($\pm$1D)에서도 현저하게 증가하였다. 또한 더욱 확장된 모델일수록 혈관벽은 직경방향의 변위보다 축방향의 변위가 지배적이었으며, 동맥류 원위부보다 근위부에서 큰 축방향 변위를 나타냈다. 동맥류 입구부의 미약한 와류는 한 주기동안 그 크기와 강도를 더해가며 동맥류 원외부로 이동하였고, 동맥류의 내부 유동은 압력차이가 감소하는 기간동안 더 큰 영향을 받았다. 확장정도가 심할수록 동맥류 내부에 더 크고 강한 와류가 관찰되었다. 압력차이가 최소가 된 직후 동맥류의 근위부와 원위부동맥 벽 근처에서의 역방향 유동이 관찰되었다. 대체로 혈관벽 두께가 감소한 모델과 더욱 확장된 모델일수록 벽전달률은 감소하였다. 혈관벽의 탄성에 의하여 압력차이와 벽전달률 사이에 위상차가 존재함이 확인되었다. 유체-고체의 상호작용을 고려한 연구는 다른 심혈관계를 이해하는데도 매우 유익할 것으로 생각된다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.9
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• pp.4009-4017
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• 2012

This study was conducted to test the effects of participation in 12-week program of boxing aerobics by obese middle-aged women on their body composition, blood constituents, and vascular compliance The samples are the middle-aged women in their forties or more, who has 30% or more body fat percentage, but has no medical history in cardiovascular disorders or metabolic diseases. The samples are divided into 8 of exercising group, and 8 of control group by random assignment. The intensity of boxing aerobics was HRmax 50% for the initial 4 weeks, HRmax 60% for the 5th to 8th week, and HRmax 70% for the 9th to 12th week. Each session took 60 minutes. The result is as follows. First, as a result of participating in the boxing aerobics program, body weight, body fat percentage, and muscle showed significant differences depending on the measuring period and the interacting term of the group and measuring period(p<.001), and the result of t-test on the sample matched to each group's measuring time also showed the significant increase or decrease in the exercising group(p<.001). Second, as a result of participating in the boxing aerobics program, the exercising group's TC, TG, HDL-C, and LDL-C, all showed significant differences in accordance with each group, measuring time, and the interaction term between groups and measuring time(p<.01, p<.001), and the result of t-test on each group's samples matched to the measuring time also shows significant increase or decrease in the exercising group(p<.01). Third, as a result of participating in the boxing aerobics programs, the vascular compliance of right hand, left hand, right hand, and left hand showed significant differences in accordance with each group, measuring time, and the interacting term between the measuring time and the group(p<.001), the t-test results of the samples matched to the each group's measuring time also showed significant differences in the exercising group(p<.001). To summarize the results above, it is suggested that the 12-week boxing aerobics program can improve body composition, blood constituents, and the blood circulation, which may prevent or enhance relevant diseases such as cardiovascular disorders.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.1-6
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• 2017

Stents are widely used as the most common method of treating coronary artery disease with implants in the form of a metal mesh. The blood flow is normalized by inserting a stent into the narrowed or clogged areas of the human body. In this study, the mechanical characteristics of a stent are investigated according to the variations of its design parameters by the Taguchi method and finite element analysis. A stent model of the Palmaz-Schatz type was used for the analysis. In the analysis, an elasto-plastic material model was adopted for the stent and a hyper-elastic model was used for the balloon. The main interest of this study is to investigate the effects of the design parameters which reduce the possibility of restenosis by adjusting the recoil amount. A Taguchi orthogonal array was constructed on the model of the stent. The thickness and length and angle of the slot were selected as the design parameters. The amounts of radial recoil and longitudinal recoil were calculated by finite element analysis. The statistical analysis using the Taguchi method showed that optimizing the shape of the stent could reduce the possibility of restenosis. The optimized shape showed improvements of recoil in the radial and longitudinal directions of ~1% and ~0.1%, respectively, compared to the default model.

• Journal of the Korean Society for Precision Engineering
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• v.27 no.6
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• pp.90-97
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• 2010

In order to understand the biomaterial like the blood vessel of artery, there is a need to quantify the biomechanical behavior of the vessel. Using computer-controlled experimental system, the experiment can acquire data such as inner pressure, axial load, diameter and axial gauge length without contacting the specimen. Rubber-liked material which is similar to passive artery was selected as pseudo-biomaterial. Deformations are measured for pressure-diameter curves. The data were collected and stored online to be used in the feedback control of experimental protocols. Finally, the illustrative data obtained from the experimental system were presented and the system shows that strain invariants are controlled to understand the nonlinear elastic behavior of biomaterial which is involved with strain energy function.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.29 no.4 s.235
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• pp.425-434
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• 2005

In order to analyze pulsating flows in elastic blood vessels, a method based on the ALE concept and finite volume method was reformed and modulated to include wall motion of elastic vessels and impedance phase angle(phase difference between wall motion and blood flow). Our study indicated wall shear rates(WSR) were significantly influenced by the wall motion and the impedance phase angle. For larger wall motion more than $5{\%},$ the computed WSR started to deviate from the results of the perturbation theory that assumed smaller wall motion. The study showed that oscillatory shear index increased as the impedance phase angle became more negative like $-70{\circ}\;or\;-80{\circ}$ due to reduced mean WSR and increased amplitude of WSR. This result indicated that hypertensive patients are more vulnerable to atherosclerosis than normal persons because of the role of more negative impedance phase angles usually observed in these patients.

• 한국전산유체공학회:학술대회논문집
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• 2011.05a
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• pp.500-503
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• 2011

Blood flow simulations in an idealized carotid bifurcation model with considering wall compliance were carried out to investigate the effect of wall elasticity on the wall shear stress and wall solid stress. Canonical waveforms of flowrates and pressure in the carotid arteries were imposed for the boundary conditions. Comparing to rigid wall model, generally, we could find an increased recirculation region at the carotid bulb and an overall reduced wall shear stress. Also, there was appreciable change of flowrate and pressure waveform in longitudinal direction. Solid and wall shear stress concentration occurs at the bifurcation apex.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.6
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• pp.840-844
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• 2013

In this study, we try to estimate vascular compliance for management vascular disease. Because It is known the vascular compliance represents the state of the blood vessels. In general, the vascular compliance is estimated using an acceleration photoplethymogram from measured by photoplethymogram-based. The acceleration photoplethymogram is come from second derivative of photoplethymogram. By using the acceleration photoplethymogram, we can estimating vascular compliance, vascular age, vascular state. In this study, for measuring acceleration photoplethymogram we have developed a measurement device having analog filters. It has the advantage of miniaturization, low-power because it is simpler than digital filters. Using the developed device, we have estimated vascular compliance and tested the reliability of our device compare with conventional device having digital filters. As a result.

• Journal of Chest Surgery
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• v.30 no.11
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• pp.1092-1096
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• 1997

Thromboelastography(TEG) enables a global assessment of hemostatic function to be made from a single blood sample, documenting the interaction of platelets with protein coagulation cascade from the time of the initial platelet-fibrin interaction, through platelet aggregation, clot strengthening and fibrin cross linking to eventual clot Iysis. Thirty-five patients(mean age 34$\pm$ 12) undergoing open heart surgery from April 1st, 1996 to August 31th, 1996 were investigated at preoperatively and immediate, one hour, and 24 hours after cessation of cardiopulmonary bypass using TEG. Comparisons were made between classic hematological indices and TEG data. There were statistically significant correlation between maximal amplitude(MA) and platelet count before CPB, activating clotting time(ACT) and TEG date(R time, K time and a angle) at 24-hour after CPB. The data on the predictive accuracy for postoperative bleeding at 24-hour after CPB, the TEG was significantly better than ACT(57%) or the coagulation profiles(43%) as a predictor of postoperative bleeding, with an accuracy rate of 100% (P=0.0043). In conclusion, TEG seems to be easy to use, clinically accurate, cost effective and provides data which can effectively manage a patient's hemostasis.

• Journal of the Korean Society for Nondestructive Testing
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• v.32 no.5
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• pp.484-493
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• 2012

Since the 1980s, there have been many research activities devoted to quantitatively characterizing and imaging human tissues based on sound speed, attenuation coefficient, density, nonlinear B/A parameter, etc., but those efforts have not yet reached the stage of commercialization. However, a new imaging technology termed elastography, which was proposed in the early 1980s, has recently been implemented in commercial clinical ultrasound scanners, and is now being used to diagnose prostates, breasts, thyroids, livers, blood vessels, etc., more quantitatively as a complementary adjunct modality to the conventional B-mode imaging. The purpose of this article is to introduce and review various elastographic algorithms for use in quasistatic or static compression type elasticity imaging modes. Most of the algorithms are based on the crosscorrelation or autocorrelation function methods, and the fundamental difference is that the time shift is estimated by changing the lag variable in the former, while it is directly obtained from the phase shift at a fixed lag in the latter.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.4
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• pp.813-820
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• 2009

This paper describes the realization of ubiquitous healthcare monitoring system using wearable pulse oximeter based on a wireless sensor network. In order to obtain information of oxygen saturation from a patient, a small size and low power consumption wearable pulse oximeter was designed. Information of oxygen saturation collected by wireless sensor node was transmitted wirelessly to a base-station for storage and display purposes via wireless sensor network. Wireless sensor nodes were programmed by TinyOS application to perform data acquisition and transmission. Lab VIEW server program was designed to monitor information of oxygen saturation and process the measured PPG (photo plethysmogram) signals to APG(Accelerated plethysmogram) signals by appling second order derivatives. PPG signals are simple and cost effective technique to measure blood volume change.