• The Monthly Diabetes
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• s.210
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• pp.17-18
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• 2007

당뇨병성 족부병변은 당뇨병성 신경증, 허혈증, 그리고 골관절병 등에 의해서 감염, 궤양 등 하지의 조직이 파괴된 상태로 당뇨병환자의 하지절단, 사망률 등을 높이는 중요한 원인이다. 전세계적으로 하지절단의 가장 많은 원인이 당뇨병성 족부병변이며, 당뇨병환자는 정상인에 비해 하지절단의 위험이 약 15배 가량 높다. 또한 5$\sim$15% 정도의 당뇨병환자가 일생 동안 하지절단에 직면하게 된다고 하고, 한쪽 다리를 절단하면 다른 한쪽도 절단할 확률이 1$\sim$3년 이내에 40%, 3$\sim$5년 사이에 58% 정도이며, 일단 하지절단 후에는 3년 생존률이 50%에 이른다는 보고도 있다.

• Bulletin of Korea Environmental Preservation Association
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• s.388
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• pp.10-13
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• 2010

불행하게도 우리 국토는 기후 재난을 막을 수 있는 물 관리 여건이 매우 취약하다. 장마철에는 폭우로 인해 물난리를 겪고, 가뭄에는 물 한 방울이 아쉽다. 여기에 대형 자연호가 전무하여 장마에 집중되는 비를 모아둘 물그릇이 크게 부족하다. 한반도에 도래하는 기후변화는 이처럼 취약한 우리의 물 관리 여건을 더욱 심각한 상태로 몰아가고 있다. 폭우와 가뭄은 점점 강해지고 있으며, 그 피해는 연간 수조원에 달하고 있다. 역사와 전통을 가진 가뭄과 홍수의 나라이자 태생적 물그릇 부족국가에서 다가오는 기후 변화는 결코 방치될 수 없는 시급한 현안이다. 물그릇을 키우고 국토의 혈관이나 다름없는 강의 기능을 살려 기후재난을 최소화하는 물관리의 대변화가 절실하다. 이 글에서 4대강 살리기의 필요성과 찬반 논란의 핵심 쟁점에 관해 논의하고자 한다.

• Journal of Chest Surgery
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• v.40 no.4 s.273
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• pp.264-272
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• 2007

Background: Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis, including stimulating the proliferation and migration of vascular smooth muscle cells (VSMCs). It has been known that diabetes is associated with accelerated cellular proliferation via VEGF, as compared to that under a normal glucose concentration. We investigated the effects of selective blockade of a VEGF receptor by using anti-Flt-1 peptide on the formation and hyperplasia of the neointima in balloon injured-carotid arteries of OLETF rats and also on the in vitro VSMCS' migration under high glucose conditions. Material and Method: The balloon-injury method was employed to induce neointima formation by VEGF. For f4 days beginning 2 days before the ballon injury, placebo or vascular endothelial growth factor receptor-1 (VEGFR-1) specific peptide (anti-Flt-1 peptide), was injected at a dose of 0.5mg/kg daily into the OLETF rats. At 14 days after balloon injury, the neointimal proliferation and vascular luminal stenosis were measured, and cellular proliferation was assessed by counting the proliferative cell nuclear antigen (PCNA) stained cells. To analyze the effect of VEGF and anti-Flt-1 peptide on the migration of VSMCs under a high glucose condition, transwell assay with a matrigel filter was performed. And finally, to determine the underlying mechanism of the effect of anti-Flt-1 peptide on the VEGF-induced VSMC migration in vitro, the expression of matrix metalloproteinase (MMP) was observed by performing reverse transcription-polymerase chain reaction (RT-PCR). Result: Both the neointimal area and luminal stenosis associated with neointimal proliferation were significantly decreased in the anti-Flt-1 peptide injected rats, ($0.15{\pm}0.04 mm^2$ and $ 36.03{\pm}3.78%$ compared to $0.24{\pm}0.03mm^2\;and\;61.85{\pm}5.11%$, respectively, in the placebo-injected rats (p<0.01, respectively). The ratio of PCNA(+) cells to the entire neointimal cells was also significantly decreased from $52.82{\pm}4.20%\;to\;38.11{\pm}6.89%$, by the injected anti-Flt-1 peptide (p<0.05). On the VSMC migration assay, anti-Flt-1 peptide significantly reduced the VEGF-induced VMSC migration by about 40% (p<0.01). Consistent with the effect of anti-Flt-1 peptide on VSMC migration, it also obviously attenuated the induction of the MMP-3 and MMP-9 mRNA expressions via VEGF in the VSMCS. Conclusion: Anti-Flt-1 peptide inhibits the formation and hyperplasia of the neointima in a balloon-injured carotid artery model of OLETF rats. Anti-Flt-1 peptide also inhibits the VSMCs' migration and the expressions of MMP-3 and MMP-9 mRNA induced by VEGF under a high glucose condition. Therefore, these results suggest that specific blockade of VEGFR-1 by anti-Flt-1 peptide may have therapeutic potential against the arterial stenosis of diabetes mellitus patients or that occurring under a high glucose condition.

• Journal of Chest Surgery
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• v.30 no.3
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• pp.326-329
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• 1997

Coronary artery bypass grafting(CABG) without cardiopulmonary bypass(CPB) is now an accepted technique of myocardial revascularization in selective cases of coronary arterial occlusive disease. The lesion was total(100%) occlusion of proximal right coronary artery(RCA) without any evidence of dis,Base in the rest of coronary arteries. Percutaneous transluminal angioplasty(PTCA) was tried but unsuccessful. We herein report a case of successful CABG to right coronary artery without CPB on a patient with complete occlusion of RCA and symptomatic wit minimal activity.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.10a
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• pp.235-239
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• 2008

일상생활 중 지속적인 심장의 활동상태 모니터링을 통해 건강관리 및 응급상황에 대처하기 위한 많은 관련 연구들이 수행되고 있다. 심전도신호를 모니터링하기 위해서는 필수적으로 전극을 신체에 부착해야만 하며 피검자로 하여금 불편함을 초래한다. 본 연구에서는 가정 또는 사무실에서 무구속(non- restrained)적인 방법으로 심장의 활동상태를 모니터링하기 위하여 심탄도(ballistocardiogram, BCG)를 계측하고자 하였다. 심탄도는 심장의 수축과 이완에 따라 심장과 혈관에서의 혈류변화에 따른 탄도를 계측한 신호를 의미하며, 심탄도를 계측하기 위하여 로드셀을 이용한 의자형 무구속 심탄도 측정시스템을 구현하였다. 그리고 심탄도 신호로부터 건강정보의 추출을 위해 웨이브렛 변환과 템플릿 매칭(template maching)기법을 이용한 신호처리기법을 제안하였다. 구현된 시스템 및 신호처리기법의 타당성을 검토하기 위해 심전도와 동시에 심탄도를 측정하였으며, 상호 비교를 통해 심탄도 계측시스템의 유용성을 평가하였다.

• Journal of Chest Surgery
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• v.42 no.1
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• pp.104-106
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• 2009

Extra-anatomic graft bypass is frequently performed instead of standard infrarenal aorto-iliac reconstruction in patients with Leriche syndrome in whom the thrombus extends to the level of the renal arteries. However, many different surgical options are still being attempted due to the unsatisfying long-term graft patency. We performed a descending thoracic aorto-bifemoral bypass graft with 14 and 14-7-7 mm artificial vessels through a posterolateral thoracotomy, a median laparotomy, and a longitudinal inguinal incision in a 48-year-old male who suffered from claudication with Leriche syndrome. After surgery, the patient recovered well and was discharged. The patient walked well without any symptoms during the 6 month follow-up period in the outpatient department. We have concluded that descending thoracic aorto-bifemoral bypass grafting could be considered as an alternative method for patients with Leriche syndrome in whom standard infrarenal aorto-iliac reconstruction is unsuitable.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.10
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• pp.178-184
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• 2017

This study was performed on 16 patients diagnosed with tsutsugamushi disease and cerebral infarction from January 2007 to December 2015. An acute cerebral infarction was diagnosed by brain MRI and MRA. Tsutsugamushi disease was diagnosed using a polymerase chain reaction. To distinguish the difference between the generalized cerebral infarction and infarction with tsutsugamushi disease, the blood pressure and body temperature were measured uponadmission. In general, the blood pressure increases during an acute cerebral infarction. Interestingly, in this study, 12 patients showed a systolic blood pressure less than 130 mmHg uponadmission. The location of the cerebral infarction and whether single or multiple cerebral infarction were examined. Thirteen patients had a cerebral infarction in anterior circulation and 3 patients developed in posterior circulation. To evaluate the coagulation disorders, prothrombin time (PT), activated partial thromboplastin time (aPTT), D-dimer, fibrinogen, fibrin degradation product (FDP). D-dimer, which is generally known to increase in an acute cerebral infarction, showed a significant increase in the 13 patients. Fibrin degradation products (FDP) showed a significant increase in 15 patients. The pathophysiological mechanism of tsutsugamushi disease is known as vasculitis, which may result in an endothelial cell injury and proliferation of the endothelial wall, which may lead to a cerebral infarction accompanied by coagulopathy. Without endothelial cell damage and proliferation, a vasospasm caused by vasculitis may cause vasoconstriction and cerebral infarction.

• Journal of Digital Convergence
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• v.18 no.2
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• pp.447-453
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• 2020

This study used a nonequivalent control group pretest-posttest design to develop an information provision program for arteriovenous fistula and angioplasty patients and to examine the effects of the information provision program offered by operating room nurses. The research subjects were selected trough convenience sampling who had come to hospitals to have an arteriovenous fistula and angioplasty surgery, and an experimental group and a control group of 40 persons. The information provision program consisted of two sessions, each conducted on the day of surgery and after surgery. The content included surgery information, pain management after surgery, management of dialysis blood vessels, how to handle emergency, and management of complications. The results of the study showed that the experimental group, which was offered an information provision program by nurses, a decrease in trait and state anxiety and an increase in self-efficacy on a statistically significant level. In conclusion, the information provision program provided by operating room nurses helped to reduce anxiety in arteriovenous fistula and angioplasty patients and increase their self-efficacy. This will improve end-stage renal disease patients' self-management ability after surgery, and thus, contribute to improving the prevention of complications and the level of self-nursing care.

• Journal of Chest Surgery
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• v.39 no.10 s.267
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• pp.782-785
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• 2006

Chronic pulmonary obstructive disease is known to be a significant risk factor for mortality in patients who under-went operation for abdominal aortic aneurysm. To decrease perioperative respiratory complication in these patients, maintenance of self respiration as possible is one of the better method. A seventy-seven year old male patient complained of abdominal pain and he was diagnosed for 9 cm sized abdominal aortic aneurysm. But he had severe chronic obstructive pulmonary disease which was expected to increase surgical mortality. So we introduced epidural anesthesia with maintenance of self respiration and performed surgical resection and graft replacement of abdominal aorta, and he recovered without any complication.

• Journal of Chest Surgery
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• v.37 no.11
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• pp.929-932
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• 2004

The estimated relative incidence of primary pulmonary sarcoma to lung cancer is 0.4%. Furthermore, osteogenic sarcoma of the pulmonary artery is extremely rare. We report a case of a 63-year-old woman who visited our emergency room with the chief complaints of chest pain, dyspnea and dizziness. On echocardiography, right heart failure due to acute pulmonary artery embolism was diagnosed and we performed emergency operation. After opening the main pulmonary artery trunk, we found a mass attached to the arterial wall and massive thrombi around the mass. The mass was diagnosed as primary pulmonary artery osteosarcoma through postoperative evaluation. The patient received chemotherapy and radiotherapy. The patient is alive without specific symptoms 16 months postoperatively.