• Annual Conference of KIPS
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• 2021.05a
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• pp.553-555
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• 2021

빈혈의 유병률은 매년 증가하고 있으나 이를 가벼운 질병으로 인식해 치료 시기를 놓치는 환자들이 존재한다. 빈혈의 발생원인으로 혈액 내 헤모글로빈 및 헤모글로빈 내 철 부족이 있으며, 헤모글로빈 측정기술의 경우 채혈 이외에 사람의 신체 및 건강 정보를 적용한 사례는 찾아보기 어렵다. 본 논문에서는 신체(키, 몸무게 및 허리둘레) 및 건강 정보(혈청지오티, 이완기 혈압 및 감마지티피 등)가 포함된 건강검진 빅데이터를 이용하여 단일 특징에 대해 선형회귀분석을 수행하고, 다중 특징에 대해 다중회귀분석을 수행하여 회귀분석 식을 산출, 산출된 회귀분석 식을 통해 헤모글로빈을 추정하여 실제 헤모글로빈값과 오차율을 계산하고 비교한다. 실험 결과, 선형회귀분석 식을 통해 헤모글로빈을 추정하였을 때 평균 8.124%의 오차율이 계산되었으며, 다중회귀분석의 경우 선형회귀분석보다 낮은 6.767%의 오차율이 계산되었다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.11
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• pp.157-163
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• 2019

This study determines the difference in prevalence of anemia and hemoglobin concentration between chronic obstructive pulmonary disease (COPD) and control groups in the elderly. Moreover, this study also examines the prevalence of anemia and hemoglobin concentration according to the severity of COPD in the elderly. Medical records of 8150 participants who answered the 7th National Health and Nutritional Survey conducted in 2016 were reviewed, and a total of 694 participants was included in the analysis. Participants were classified into two groups: COPD and control groups. Laboratory studies on hemoglobin, hematocrit, red blood cell concentration and prevalence of anemia were collected. Subgroup analysis was also conducted according to the severity of COPD. No significant differences were determined for the prevalence of anemia and hemoglobin concentration between both groups. Hemoglobin concentration was significantly higher in the COPD group. Although not statistically significant, there was a tendency for decrease in the prevalence of anemia and increase in the hemoglobin concentration as the severity of COPD increased. Our findings present specific data about the prevalence of anemia and hemoglobin concentration in elderly patients with COPD. Hence, we propose that occurrence of anemia in elderly patients with COPD requires further evaluation of the causes.

• Korean Journal of Psychosomatic Medicine
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• v.24 no.1
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• pp.94-101
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• 2016

Objectives : Anemia is a common problem in the management of elderly patients. Recent studies reported that anemia was associated with cognitive impairment and Alzheimer's disease. This study was aimed to analyze the differences of hemoglobin levels in Korean patients with Alzheimer's disease(AD) dementia, mild cognitive impairment(MCI), and healthy controls. Furthermore, the study also examined if any association between hemoglobin levels and cognitive functions existed. Methods : A total of 116 Korean elderly adults were participated in this study(mean age 74.67 years ; 60.3% female). The Korean version of the Mini-Mental State Examination(MMSE-K), Clinical Dementia Rating(CDR) and Global Deterioration Scale(GDS) were applied to all subjects. Hematological and related blood chemistry values were investigated. Results : We found that patients with AD dementia had significantly lower hemoglobin and hematocrit levels than MCI subjects and healthy control group. The hemoglobin levels showed a positive correlation with MMSE-K and negative correlation with CDR, GDS. Conclusions : Among Korean elderly, low hemoglobin level is associated with a cognitive impairment. This study indicates that AD is associated with anemia, and low hemoglobin levels may contribute to potentially useful clinical markers of AD. The risk factor for dementia needs to be confirmed by prospective longitudinal studies in a larger group of patients.

• Clinical and Experimental Pediatrics
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• v.52 no.3
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• pp.385-388
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• 2009

An 8-year-old girl visited the emergency room with perioral cyanosis and dyspnea, which had developed 20 hrs prior to the hospital visit. She had taken a Chinese herbal medication for 3 days prior to the onset of the symptoms. A co-oximeter examination revealed a methemoglobin level of 23.7%. An intravenous infusion of methylene blue was administered. Chemical analysis of the herbal medication revealed an ammonia (NH$_{3}$) level of 239.41 mg/L. More studies are needed on the correlation between methemoglobinemia and the components of Chinese herbal medicines.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2011.11a
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• pp.373-377
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• 2011

Fire patterns have been used to determine the origin and cause of fires in every setting imaginable. However, it is very difficult to identify fire patterns from the fire-damaged remains of a devastated structure. If someone was killed by the fire, it is possible to identify fire patterns by analyzing the concentration of carbon monoxide-hemoglobin in the body of deceased as well as the pace of the fire. For example, a low level of carbon monoxide-hemoglobin in the body of the dead indicates a rapid fire with accelerants and the death was caused by severe heat and thick toxic fumes. However, a high level of carbon monoxide-hemoglobin in the body of the dead demonstrates that the fire was slow and/or there was a flameless form of combustion. Thus, this study identifies fire patterns through analyzing the level of carbon monoxide-hemoglobin concentration on the dead from the fire.

• Analytical Science and Technology
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• v.14 no.6
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• pp.522-529
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• 2001

Carbon monoxide was generated when the saccharides which contained aldehyde group were added to alkali solution (NaOH solution) at $25^{\circ}C$ or $40^{\circ}C$. When the milk was added to 1.0 M NaOH solution at $25^{\circ}C$ and to 0.01 M NaOH solution at $40^{\circ}C$, carbon monoxide was generated. The carbon monoxide gas which was generated by 20 mL of 0.1 M lactose or 0.1 M xylose and 2 mL of 1.0 M NaOH solution at $50^{\circ}C$ for 2days was bubbled through 2 mL of fresh blood. The carboxyhemoglobin concentrations of both conditions were 31%. However, when the carbon monoxide gas which was generated by 30 mL of milk and 2 mL of 1.0 M NaOH at $50^{\circ}C$ for 2days or 3days was bubbled through 2 mL of fresh blood, the carboxyhemoglobin concentration was 32% or 42% respectively.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2006.05a
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• pp.322-326
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• 2006

본 논문에서는 내시경 영상에 대해 위암 영역을 자동으로 추출하는 방법을 제안한다. 본 논문에서는 내시경 영상을 획득하는 과정에서 발생하는 조명에 의한 잡음과 굴곡에 의해 발생하는 그림자에 의한 잡음 부분을 해결하기 위해서 HSI의 채도와 밝기 값을 이용하여 잡음 영역을 제거한다. 그리고 헤모글로빈 색소 정보를 나타내는 IHb값을 이용하여 전자 내시경 영상에서 유사한 헤모글로빈 색소 정보를 가지는 영역으로 분할한다. 분할된 영역들 중에서 RGB의 각 채널과 헤모글로빈 색소가 높게 나타나면 후보 영역으로 설정한다. 설정된 후보 영역 중에서 위암 영역의 형태학적인 특징 정보를 이용하여 위암 영역을 추출한다. 실제 전문의가 제공한 20개의 내시경 영상을 대상으로 실험한 결과, 제안된 위암 추출 방법으로 17개가 정확히 추출되었고 3개의 내시경 영상에서는 위암 영역이 정확히 추출되지 않았다.

• 건강소식
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• v.15 no.1 s.146
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• pp.46-47
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• 1991

• 건강소식
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• v.9 no.2 s.75
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• pp.44-45
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• 1985

• KIPS Transactions on Software and Data Engineering
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• v.11 no.1
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• pp.41-50
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• 2022

In this paper, a method to directly calculate the major elements of skin color such as melanin and hemoglobin from the RGB signal of the camera is proposed. The main elements of skin color typically measure spectral reflectance using specific equipment, and reconfigure the values at some wavelengths of the measured light. The values calculated by this method include such things as melanin index and erythema index, and require special equipment such as a spectral reflectance measuring device or a multi-spectral camera. It is difficult to find a direct calculation method for such component elements from a general digital camera, and a method of indirectly calculating the concentration of melanin and hemoglobin using independent component analysis has been proposed. This method targets a region of a certain RGB image, extracts characteristic vectors of melanin and hemoglobin, and calculates the concentration in a manner similar to that of Principal Component Analysis. The disadvantage of this method is that it is difficult to directly calculate the pixel unit because a group of pixels in a certain area is used as an input, and since the extracted feature vector is implemented by an optimization method, it tends to be calculated with a different value each time it is executed. The final calculation is determined in the form of an image representing the components of melanin and hemoglobin by converting it back to the RGB coordinate system without using the feature vector itself. In order to improve the disadvantages of this method, the proposed method is to calculate the component values of melanin and hemoglobin in a feature space rather than an RGB coordinate system using a feature vector, and calculate the spectral reflectance corresponding to the skin color using a general digital camera. Methods and methods of calculating detailed components constituting skin pigments such as melanin, oxidized hemoglobin, deoxidized hemoglobin, and carotenoid using spectral reflectance. The proposed method does not require special equipment such as a spectral reflectance measuring device or a multi-spectral camera, and unlike the existing method, direct calculation of the pixel unit is possible, and the same characteristics can be obtained even in repeated execution. The standard diviation of density for melanin and hemoglobin of proposed method was 15% compared to conventional and therefore gives 6 times stable.