• The Science & Technology
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• v.32 no.10 s.365
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• pp.30-31
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• 1999

SK케미칼 생명과학연구실은 9년동안의 연구 끝에 국내 최초로 백금착체 항암제인 '선플라'를 개발해 지난 7월 식품의약품안전청으로부터 발매 허가를 받았다. 81억원의 연구비를 투자하여 선플라를 개발한 이 연구실은 앞으로 1백억원 이상을 더 투자하여 임상실험을 계속키로 했으며 이미 30여국에 특허를 출원하여 22개국에서 특허를 완료했다.

• The Science & Technology
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• no.11 s.414
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• pp.6-7
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• 2003

암 · 뇌졸중, 세포로 치료한다/ 연구목적외 체세포 복제 금지/ 삼성전자, 70㎚ 4G 메모리 세계 첫 개발/ 100% 생분해성 일회용기 개발/ 원자까지 보는 전자현미경 본격 가동/ 한국, 정보통신분야 종합점수 세계 6위/ 정통부 중소 · 벤처기업 컨설팅 비용지원 대폭 향상/ 종근당 항암제 '캄토벨주'신약 허가

• 대한두경부종양학회:학술대회논문집
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• 1985.11a
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• pp.10.2-12
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• 1985

• 대한두경부종양학회:학술대회논문집
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• 2004.11a
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• pp.261-261
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• 2004

• Journal of the korean veterinary medical association
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• v.26 no.3
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• pp.169-173
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• 1990

• Journal of Life Science
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• v.27 no.9
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• pp.1059-1063
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• 2017

Angiogenesis is an essential step in tumoral growth and metastasis and is regulated by a balance between stimulators and inhibitors. Recently, antiangiogenic target therapy has shown promise as a new type of chemotherapy. Natural products have attracted widespread attention worldwide as a useful source of novel therapeutic compounds. The balloon-flower has long been used as a traditional medicinal material and food in Asia. In this study, we investigated whether extract of balloon-flower would inhibit in vitro angiogenesis and vascular-like network formation in human umbilical vein endothelial cells (HUVECs). The extract of Balloon-flower did not affect the viability of HUVECs. However, treatment with the Balloon-flower extract suppressed tube formation of HUVECs. In addition, after treatment with the Balloon-flower extract, cell migration decreased about 80%, and cell invasion was almost completely inhibited. Taken together, these results suggest that extract of Balloon-flower may have potential as an angiogenic inhibitor and that it could be developed as an anticancer agent.

• Asian Oncology Nursing
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• v.4 no.2
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• pp.154-165
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• 2004

Purpose : To provide basic data for establishing the policy of safe handling of cytotoxic drugs and for building training materials and clinical guidelines for nurses handling cytotoxic drugs. Methods: 255 nurses in Seoul and 257 nurses in D metropolitan area participated in the study. Questionnaires were based on the safe handling guideline for cytotoxic drugs issued by OSHA and ONA. Results: Nurses in Seoul scored higher in the cognition for safe handling guidelines of cytotoxic drugs in preparation, administration. as well as total score compared with nurses in D metropolitan area. The practical score also showed higher in nurses in Seoul in administration, disposal and total score. But both groups showed low level of practical score. The answers why they could not follow the guideline for cytotoxic drugs were "don't have", "busy", and "don't know", etc Conclusion: Handling of the cytotoxic drug is very common and important. The study findings suggest that hospitals especially in D metropolitan area should educate the nurses and supply equipments for safe handling of cytotoxic drugs. Thus, repetitive and continual education of all nurses including experts is needed. In addition, it is necessary to supply enough protective equipment for preventing exposure to the cytotoxic drugs.

• Microbiology and Biotechnology Letters
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• v.9 no.4
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• pp.231-236
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• 1981

Studies were made on the optimal conditions of sterilization for Streptococcus pyogenes treated with heat. The results were as follows: The optimal temperature on growth of Streptococcus pyogenes was 37$^{\circ}C$ and mean generation time was 20 minutes in the logarithmic growth phase. The suspension of Streptococcus pyogenes, adjusted to pH 6-9 and treated with heat at 5$0^{\circ}C$, showed logarithmic death rate. Specific death rate constant(k) values at pH 6-9 were 0.1448, 0.1194. 0.1273 and 0.1707 minute$^{-1}$ , respectively.

• Asian Oncology Nursing
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• v.6 no.1
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• pp.47-53
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• 2006

Purpose: The present study explored the effects of education for safe handling of cytotoxic drugs on knowledge and practice in nurses. Method: Data were collected using a single group with pre and posttest design from 59 nurses at medical and surgical wards in C university hospital from April to June 2005. Questionnaires on the knowledge and practice of the guidelines for safe handling of cytotoxic drugs were asked to complete before and after the education. Result: The education improved nurses' knowledge and practice of the guidelines for safe handling of cytotoxic drugs. The knowledge and practice had a significant positive correlation. Conclusion: These findings show that the education for safe handling of cytotoxic drugs improved the knowledge and practice of nurses. As the knowledge of the guidelines for safe handling of cytotoxic drugs makes a positive association with the practice, it is thought to be required to enhance the education program for nurses.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.25 no.4
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• pp.293-300
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• 2018

Purpose: This study was done to identify the relationship between nurses' compliance with safety guidelines for the use of antineoplastic agents, observable symptoms, and stress from occupational exposure. Methods: The participants were 172 nurses from six general hospitals in a metropolitan area. They had administered antineoplastic agents at least three months prior to the study. Data were collected using self-report questionnaires, and then analyzed using SPSS/WIN 23.0 for descriptive statistics, t-test, one-way ANOVA, $Scheff\acute{e}$ method, and Pearson correlation coefficient. Results: The average score on the guideline for safety compliance was 87.75 points out of a total of 100. The average score for observable symptoms of exposure to antineoplastic agents was 30.12 (28~56) points, and that for mean stress was 33.52 (15~60) points. Observable symptoms and stress from occupational exposure showed a statistically significant positive correlation (r=0.34, p<.001). Conclusion: To increase the degree of compliance with safety guidelines for antineoplastic agents, hospitals should lower the chance of exposure to antineoplastic agents, as well as minimize the observable symptoms and stress from occupational exposure. Periodic education and policy support are needed to improve compliance with safety guidelines for antineoplastic agent use.