• Journal of Science and Technology Studies
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• v.15 no.2
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• pp.229-262
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• 2015

Toxic tort cases have increased dramatically since the 1970s, as large technological systems, such as nuclear power plants and chemical factories, or mass-produced, high-tech products, had exposed citizens and consumers to dangerous substances. It was, however, difficult to establish causal connection between exposure and the alleged harms in many of the environmental, pollution, and product liability cases under the framework of tort law conception of causation and responsibility. Science and law was called upon to resolve such 'late modern' legal cases where true causes are hard to find, where no single explanatory factor is sufficient for explaining diseases like cancer. This article examines how plaintiffs in the Korean tobacco litigation mobilized such late modern tools in science and law, such as epidemiology and the allocation of the burden of proof, in the context of the global circulation of science and law. It further shows how a set of the scientific theories and legal arguments developed in order to cope with late modern risk played a central role in establishing a causation between smoking and cancer in 2011. This article suggests that STS scholars can fruitfully examine the interaction between science and law as a way to understand and engage with social and legal issues engendered by late modern risk.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.128-128
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• 2011

본 연구에서는 자동유량측정시설에 의하여 실시간으로 생산되는 자동유량측정 자료의 정상성 여부를 판단하는데 중요한 적정 측정 신뢰구간을 실시간으로 예측할 수 있는 기술을 개발하였다. 전세계적으로, 현대적인 유량측정이 시작된 이래 연속유량 산정을 위한 방법은 수위-유량관계곡선을 이용하는 방법 외에 실무적으로 활용 가능한 방법은 거의 전무한 실정이다. 수위-유량관계곡선을 이용하는 방법은 연속수위를 계측하여 이에 해당하는 연속유량을 산정하는 방법으로 수위와 유량간에 일정한 관계를 가지는 정상적인 흐름을 보이는 자연하천의 경우에 정확도가 매우 높다. 그러나 감조나 구조물 등에 의해 유량이 조절되는 경우에 유량산정의 정확도는 현저히 떨어지게 된다. 따라서 수위에서 유량을 환산하는 방법이 아닌 유량을 직접 연속으로 측정하는 방법이 꾸준히 연구되어 왔고, 이 중 가장 대표적인 방법이 자동유량측정 방법이다. 그러나 자동유량측정 방법은 유량을 연속으로 측정할 수 있다는 장점에 반해 측정된 유량의 정확도를 높이기가 매우 어렵다는 단점도 가지고 있다. 계측 자체의 기술적 한계는 주로 계측기기적인 문제로 이는 전자기, 통신 기술 등 첨단 기술의 발전과 함께 다양한 현장 시험을 통해 폭넓은 개선이 이루어지고 있다. 그러나 아직 기술적 완성도가 완전하지 못한 현실에서, 현재 설치되어 있는 자동유량측정 유량자료의 신뢰도를 높이기 위해서는 각각의 계측 시점에서 자료가 정상적으로 산정되고 있는지에 대한 검정이 필요하고, 이는 자동유량측정 자료의 정확도 확보에 매우 중요한 관건으로 작용할 수밖에 없다. 이러한 배경에서 본 연구에서는 조석성분과 유출성분을 분리하여 예측하는 방법을 새롭게 개발 적용하였다. 자료는 자료의 시간해상도 증감에 따른 실제 예측의 정확도 증감을 고려하여 가장 적절하다고 판단되는 시자료를 사용하였으며, 자료간 상관을 분석하여 주 입력 자료로 팔당댐 방류량, 한강대교 지점 수위, 전류 수위를 이용하였다. 모형의 예측 능력을 극대화하기 위하여 조석 영향을 받는 자료의 경우는 웨이블릿 변환(wavelet transform)을 이용하여 순수 유출성분과 조위성분을 분리하여 별도로 적용하였다. 그리고 예측을 위한 모형은 실시간 자료기반 모형으로 그 안정성이 인정된 서포트벡터머신(support vector machine)을 이용하였다. 이러한 과정을 통해 한강대교 지점의 순수 유출성분과 조위성분의 유량을 각각 예측한 후 두 결과를 합성하여 최종 한강 대교 지점의 유량을 산정하였다. 조석성분을 분리하여 한강대교 지점의 유량을 예측한 결과 대부분의 예측치가 95% 예측구간에 포함되었다. 그리고 조석성분을 분리하지 않은 모형과 조석성분을 분리한 모형의 예측 능력을 비교한 결과, 조석성분을 분리한 모형이 예측이 정확도가 높았다. RMSE의 경우 분리하지 않은 모형대비 23%의 예측오차가 감소하였고, NSC의 경우 0.92에서 0.95로 예측의 정확도가 증가하였다.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.4 s.54
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• pp.311-321
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• 2005

Tea (Camellia sinenis) is a popular beverage consumed worldwide. Since green tea, mainly consumed in Asia, has various biological activities, green tea components became one of the most favorite candidates as a functional materials for cosmetics and functional foods. The biological activities of green tea for skin cue have been ranged from protection of epidermal cells to the stimulation of extracellular matrix (ECM) biosynthesis. Green tea polyphenols (GTPs), which are active ingredients of green tea, possess anti-inflammatory, anti-carcinogenic and immune potentiation properties as well as antioxidant. They also modulate intracellular signal transduction pathways. GTPs decrease ultraviolet (UV)-induced oxidative stress, thus suppress mitogen-activated protein kinase (MAPK) pathway and apoptosis in keratinocytes. In addition, GTPs prevent the Induction of inflammatory mediators, such as cyclooxygenase-2 (COX-2), interleukin-8 (IL-8), and vascular endothelial growth factor (VEGF) by tumor necrosis factor alpha $(TNF{\alpha})$ or chemical treatment in keratinocytes. GTPs treatment protects from chemical-or UV-induced skin tumor incidence in animal experiment. Besides, GTPs stimulate keratinocyte differentiation and proliferation of normal and aged epidermal cells, resectively, and suppress matrix metalloproteinases (MMPs) release. According to the progress of formulation study, green tea components will be guaranteed materials for the more effective skin cue products.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.41 no.4
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• pp.351-359
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• 2015

Acute and chronic ultraviolet (UV) irradiation triggers severe skin photoaging processes, which directly disrupt the normal three-dimensional integrity of skin. UV light stimulates the expression of matrix metalloproteinases (MMPs) which degrade constituents of extracellular matrix (ECM) proteins. These MMPs reduce collagen synthesis and decrease skin elasticity and integrity, resulting in wrinkle formation. In this study, we identified Rosa multiflora hip extract (RME) as an effective anti-photoaging ingredient. First, cell proliferation activity of RME was verified using Hs68 human dermal fibroblast cell line. RME downregulated MMPs expression through the inhibition of activator protein (AP)-1. In addition, type I and IV collagen expressions were increased with RME treatment and UVB-induced inflammatory responses were also reduced after RME treatment. In conclusion, R. multiflora hip extract may effectively improve UVB-induced skin aging and wrinkle formation which may provide as an anti-aging, anti-wrinkle, and anti-inflammation ingredient in cosmetic industry.

• Food Science and Preservation
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• v.14 no.2
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• pp.170-176
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• 2007

In this study, extract of Ailanthus altissimawere prepared using hot water under high pressure. The extract were examined for election donating ability (EDA), superoxide dismuase (SOD)-like activity, nitrite scavenging ability (NSA), xanthine oxidase inhibition levels, and tyrosinase inhibition ability. The EDA, using the 1,1-diphenyl-2-picrylhydrazyl method of root extract was 91.25% at 1.0mg/mL. The SOD-like activity of leaf extract was highest at 49.07% and the NSA was 93.33% at pH 1.2, and 85.40% at pH 3.0. The xanthine oxidase inhibitory levels of extracts of A. altissima roots, stems, and leaves were 92.09 97.44% when the extract were tested at 2.0mg/mL. The highest tyrosinase inhibition levels obtained from loot extract were 67.38% at 2.0mg/mL and 63.97% at 0.1mg/mL.

• Korean Journal of Plant Resources
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• v.31 no.4
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• pp.330-341
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• 2018

This study was performed to investigate and measure the antimicrobial activity of evergreen woody species extracts on Trichophyton mentagrophytes. To do this, leaves and stems were collected from Wando and Jeju islands, and were used for the extraction with different solvents (i.e., distilled water, 80% ethanol, and 100% methanol), and at different ultrasonic extracting times (i.e., 15, 30, and 45 minutes). The experiment was conducted by using the agar diffusion method. The clear zone was measured after incubating the paper disc containing the plant extract in a bacterial culture medium. The controls were synthetic antimicrobials, methylparaben and phenoxyethanol, at concentrations of 0.4, 1, 2, and 4 mg/disc. Altogether, extracts of 56 out of 64 species used in this study had inhibitory activity, which confirmed their antimicrobial activity against Athlete's foot. Among them, the crude ethanolic extract of Elaeocarpus sylvestris in 45 min showed a zone of inhibition < 20.2 mm, while the clear zone of Actinodaphne lancifolia ethanolic extraction for 30 min was 23.5 mm. Also, Quercus acuta, Dendropanax morbiferus and Daphne odora showed clear zones of 28.0 mm (45 minutes ethanolic extraction), 20.5 mm (45 minutes crude methanolic extraction) and 19.7 mm (45 minutes methanolic extraction), respectively. Thus, these results confirm that the extracts of evergreen woody species have therapeutic potential against Athlete's foot, and suggest that in order to extract adequate amounts of antimicrobial substance from the plant sources, ideal extraction condition has to be considered.

• Korean Chemical Engineering Research
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• v.59 no.2
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• pp.281-295
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• 2021

In this study, the direct amination of ethanol was performed over impregnated Ni on SiO2-Al2O3 mixed oxide catalysts prepared by varying Si/(Si + Al) molar ratio to 30 mol%. To characterize the physico-chemical properties of the catalysts used, X-ray diffraction (XRD), N2-physisorption, temperature-programmed desorption of iso-propyl alcohol (IPA-TPD), temperature-programmed desorption of ethanol (EtOH-TPD), temperature-programmed reduction with H2 (H2-TPR), H2-chemisorption and transmission electron microscopy (TEM) were used. The acidic property was continuously increased until Si/(Si + Al) = 30 mol% in SiO2-Al2O3 mixed oxides used. The dispersion of Ni metal and surface area, acid characteristics of the supported Ni catalyst have a complex effect on the catalytic reaction activity. The low reduction temperature of nickel oxide and acidic properties were beneficial to the formation of acetonitrile. In terms of conversion of ethanol, Ni/SiO2-Al2O3 catalyst with a molar ratio of 10 mol% Si/(Si+Al) showed the highest activity and a volcanic curve based on it. The tendency of results were consistent in the metal dispersion and catalytic activity.

• Korean Chemical Engineering Research
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• v.57 no.1
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• pp.118-123
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• 2019

In this study, the electrochemical characteristics of Graphite/Silicon/Pitch anode composites were analyzed to improve the low theoretical capacity of graphite as a lithium ion battery. The Graphite/Silica composites were synthesized by bonding silica onto polyvinylpyrrolidone coated graphite. The surface of used silica was treated with (3-Aminopropyl)triethoxysilane(APTES). Graphite/Silicon/Pitch composites were prepared by carbonization of petroleum pitch, the fabrication processes including the magnesiothermic reduction of nano silica to obtain silicon and varying the mass ratio of silica. The Graphite/Silicon/Pitch composites were analysed by XRD, SEM and XRD. Also the electrochemical performances of Graphite/Silicon/Pitch composite as the anode of lithium ion battery were investigated by constant current charge/discharge, rate performance, cyclic voltammetry and electrochemical impedance tests in the electrolyte of $LiPF_6$ dissolved in organic solvents (EC:DMC:EMC=1:1:1 vol%). The Graphite/Silicon/Pitch anode composite (silica 28.5 in weight) has better capacity (537 mAh/g). The cycle performance has an excellent capacity retention to 30th cycle of 95% and the retention rate capability of 98% in 0.1 C/0.2 C.

• Journal of Life Science
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• v.29 no.7
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• pp.755-761
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• 2019

Kojic acid (KA) is produced by Aspergillus oryzae-sort of like mushrooms, which is commonly called as koji in Japan. KA is used as a chelation agent and a preservative preventing oxidative browning of fruits. KA also shows antibacterial and antifungal properties. Because KA stops the production of melanin by inhibiting tyrosinase in the biosynthetic pathway from tyrosine to melanin in skin, it has been applied as a skin lightening ingredient in cosmetics. Since some animal studies have shown that high amounts of KA had side effects such as in liver, kidney, reproductive, cardiovascular, gastrointestinal, respiratory, brain, and nervous system, more efficient KA derivatives are needed to be developed in order to safely apply as a skin lightening ingredient. A series of KA derivatives via conjugated with triazole by click reaction were synthesized and their in vitro tyrosinase inhibitory activities were evaluated. Most of all KA derivatives have shown in moderate tyrosinase inhibitory activities. In case of KA-hybrid compound, 1~3 have shown tyrosinase inhibitory activities about 50~10,000 times more effective tyrosinase inhibitor compared to KA itself. Specifically, the $IC_{50}$ value of KA-hybrid compound, 2 was $0.0044{\pm}0.74{\mu}M$ against tyrosinase. It is about 10,000 times more effective tyrosinase inhibitor compared to KA itself ($IC_{50}=45.2{\pm}4.6{\mu}M$).

• Membrane Journal
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• v.29 no.4
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• pp.223-230
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• 2019

In this paper, we develop a polymeric blend membrane based on $CO_2$-philic poly(2-[3-(2H-benzotriazol-2-yl)-4-hydroxyphenyl] ethyl methacrylate)-poly(oxyethylene methacrylate) (PBEM-POEM) comb copolymer, which was synthesized by facile free radical polymerization. The PBEM-POEM (PBE) comb copolymer was blended with a commercial oligomer, low-molecular-weight poly(ethylene glycol) (PEG, $M_w=200gmol^{-1}$) with various ratios to prepare $CO_2/N_2$ separation membranes. From the result of $CO_2/N_2$ separation test of the PBE/PEG blend membranes with the various PEG contents, we could conclude that with increasing PEG content, the $CO_2/N_2$ selectivity significantly increased while the CO2 permeability decreased showing trade-off relationship. However, when comparing the performance of the PBE/PEG (9 : 1) with the PBE/PEG (7 : 3) membrane, the $CO_2$ permeance decreased by only 8.3%, while the $N_2$ permeance decreased by 69.1%. Therefore, the $CO_2/N_2$ selectivity dramatically increased from 33.8 to 100.3. This could be because the POEM chains, which account for 80% of the PBE copolymer, favorably interact with PEG and lead to a more compact chain structure, which was confirmed by FT-IR, XRD and SEM analysis. The PBE/PEG (7 : 3) blend membrane had the most optimal gas separation performance, showing a $CO_2$ permeance of 170.5 GPU and $CO_2/N_2$ selectivity of 100.3.