• 대한예방한의학회지
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• 제24권3호
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• pp.49-56
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• 2020

Objectives : The purpose of this study is to evaluate students' recognitions and satisfaction with education in traditional Korean medicine. Furthermore, we would like to provide basic data to help set the direction for future Korean medicine education. Methods : The questionnaires were developed referring to previous study and distributed to Korean medicine students asking students' satisfaction about education, satisfaction level by subjects, dissatisfaction reason about education. 424 cases were collected, and responses were analyzed statistically. Results : The score of overall satisfaction of students was 2.83 on average. There was statistically meaningful difference in satisfaction depending on respondents' characteristics such as gender, academic year, admission type and other major experience. Clinical Korean medicine and Western basic medicine were both found to be high in satisfaction, necessity, and necessity of expanding the number of classes. 'Curriculum which makes clinical treatment difficult after graduation' was most pointed out as the cause of dissatisfaction with the curriculum. Conclusions : To solve students' dissatisfaction with education, It's necessary to omni-directionally improve the quality of education. Also, it is demanded to improve the environment by gathering and reflecting the students' opinions continuously.

• 대한융합한의학회지
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• 제6권1호
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• pp.29-36
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• 2024

Objectives: Psoriasis is a common chronic inflammatory skin disease characterized by keratinocyte hyperproliferation and an excessive inflammatory response. Agents that can attenuate keratinocyte hyperproliferation and excessive inflammatory responses are considered potentially useful for the treatment of psoriasis. Daehwangmokdanpitang (DHMDPT) exhibits a broad range of bioactivities, including anti-proliferative and anti-inflammatory effects. This study aims to evaluate the anti-psoriatic potential of DHMDPT in vitro. Methods: HaCaT keratinocytes were stimulated with a mixture of IL-17A, IL-22, oncostatin M, IL-1α, and TNF-α (M5) to establish an in vitro psoriatic keratinocyte model. Cell viability was measured using the MTT assay. Quantitative real-time PCR (qRT-PCR) was performed to measure the mRNA levels of the hyperproliferative marker gene keratin 6 (KRT6) and inflammatory factors such as IL-6, TNF-α, and IL-23A. Additionally, chemokines including CCL5, CCL2, CCL20, and CXCL1 were measured by qRT-PCR. Results: DHMDPT attenuated M5-induced hyperproliferation, as indicated by a reduction in KRT6 expression in HaCaT keratinocytes. M5 stimulation significantly upregulated the mRNA levels of IL-6, TNF-α, and IL-23A. However, DHMDPT treatment attenuated the upregulation of IL-6 but not TNF-α or IL-23A. Additionally, DHMDPT inhibited the expression of CCL5, CCL2, and CXCL1, but not CCL20. Conclusion: DHMDPT effectively attenuated the M5-induced proliferation and inflammatory response in HaCaT keratinocytes. Therefore, DHMDPT could be an attractive candidate for future development as an anti-psoriatic agent.

• 한방비만학회지
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• 제6권1호
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• pp.117-132
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• 2006

비만은 단순한 신체적 원인 뿐 아니라 심리적, 사회적, 문화적 문제가 복합되어 있다. 따라서, 의료적 측면에 있어서도 전인적 접근이 강조되어야 하나 서양의 치료는 주로 신체적인 문제에 집중한다. 한의학은 몸과 마음을 따로 보지 않는 전인적인 의학이며 비만과 같은 질환을 접근하는데 강점을 갖는다. 지금까지 비만환자를 위한 한의학의 전인적 접근, 즉 신체 뿐아니라 체계적으로 심리적인 접근을 하려는 노력은 많았으나 보고된 연구 성과가 드물었다. 양성치료는 동양철학과 한의학에 근거하여 비만환자를 위해 개발된 전인적 상담프로그램이다. 기존에 발표된 양성치료에 관한 두 논문에서는 이론적 배경과 임상적 효과에 대한 보고를 하였다면, 본 논문에서는 실제 환자의 사례를 통해 실제 치료의 전개와 역동을 서술하였다.

• 대한한의진단학회지
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• 제24권1호
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• pp.29-52
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• 2020

Objectives In this study, we tried to analyze the expression status and diagnostic application of the disease according to the characteristics of Six Qi. Methods Suwenxuanjiyuanbingshi (Exploration to Mysterious Pathogenesis and Etiology Based on the Plain Questions, 1152), Shoushibaoyuan (Longevity and Life Preservation, 1615), Dongeuibogam (Treasured Mirror of Eastern Medicine, 1613) and two modern works on Six Qi were analyzed for this study. Results Some substrate characteristics presenting Six Qi were extracted from original literatures. Also, we found that the characteristics of Six Qi can be applied to clinical trials by presenting them as three criteria as wind, humidity, and temperature. Conclusions This study suggests.

• 대한한의학원전학회지
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• 제35권4호
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• pp.1-9
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• 2022

Objectives : This study aims to increase efficiency of the prescription similarity analysis method that uses drug composition ratio. Methods : The controlled experiment compared result generation time, generated data quantity, and accuracy of results between previous and new analysis method on the 12,598 formulas and 61 prescription groups. Results : The control group took 346 seconds on average and generated 768,478 results, while the test group took 24 seconds and generated 241,739 results. The test group adopted a selective calculation method that only used overlapping data between two formulas instead of analyzing all number of cases. It simplified the data processing process, reducing the quantity of data that is required to be processed, leading to better system speed, as fast as 14.47 times more than previous analysis method with equal results. Conclusions : Efficiency for similarity analysis could be improved by reducing data span and simplifying the calculation processes.

• 대한본초학회지
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• 제32권5호
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• pp.47-55
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• 2017

Objectives : Obesity is caused by the excess accumulation of fat in the body due to energy imbalance, and it causes various diseases. The aim of this study was to investigate an anti-obesity efficacy and an antioxidant activity of water from herbal mixture extract (SM17). Methods : The antioxidant activities were evaluated through radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals. To evaluated anti-obesity effect of SM17, we used a high fat diet fed mouse model. The SM17 (150 mg/kg body weight/day, p.o.) was treated every day for 6 weeks to C57BL/6 mice. Body weight and food intake were measured every day. The changes of reactive oxygen species (ROS), alanine aminotransferanse (ALT), aspartate aminotransferase (AST), triglycerids (TG) and total cholesterol (TC) in serum were analyzed after experiment. Also, expression of lipid metabolism related proteins were investigated by western blot analysis. Results : It was effective in antioxidant measurements, SM17 administration inhibited the biomarkers of lipid metaboism in serum and tissues. The administration of SM17 showed a significant reduction of body and tissue weight. Morever, it decreased ROS, ALT, AST, TG and TC in serum, compared with those of the obese mice. Adipogenesis-related protein expressions increased in obese mice compared to normal mice. However, SM17 group exhibited the down-expression of these proteins. Conclusion : A SM17 aqueous extract has a great effect on the stimulation (AMPK) activation, and may have a benefit to reduce a fatty acid metabolism through inhibition of lipid accumulation.

• 대한본초학회지
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• 제32권4호
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• pp.1-8
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• 2017

Objectives : Silkworm is known as immunomodulatory substances and contain various bioactive compounds such as serine, tyrosine and alanine. The aim of this study was to investigated the immunopotentiating activity of combine extract that silkworm and food materials (Eucommia ulmoides, Angelica gigas, Acanthopanax, Allium hookeri, Cinnamomum cassia, Liriope platyphylla, Curcuma longa, Achyranthes japonica, Alpinia oxyphylla, Adenophora triphylla). Methods : Among 10 kinds of food materials, to select food materials with the effect of enhancing the immune function mouse splenocyte proliferation ability was measured by 3-[4,5-dimethylthiazol-2-y]-2,5-diphenyl terazolium bromide (MTT) assay. Then, combine extract of silkworm and food materials were evaluated that mouse splenocyte proliferation ability by EZ-cytox cell viability assay. Morever, cytokines production such as IL-2, IL-4, IL10, IL12, $IFN-{\gamma}$ on mouse T lymphocyte stimulated with concanavalin A (ConA) was measured. Results : Eucommia ulmoides, Acanthopanax, Allium hookeri, Cinnamomum cassia, Liriope platyphylla has high proliferation ability of mouse splenocyte compared with Curcuma longa, Achyranthes japonica, Alpinia oxyphylla, Adenophora triphylla. The silkworm and food material combined extract has a relatively high proliferation ability of mouse splenocyte proliferation when the silkworm and food materials are used as a single material. In particularly, combined extract of silkworm and Cinnamomum cassia was stimulate cytokine production on T lymphocyte such as IL12, $IFN-{\gamma}$. Combined extract of silkworm and Liriope platyphylla was stimulate cytokine production on T lymphocyte such as IL2, IL4, IL10. Conclusion : In conclusion, the combined extract of the silkworm and Cinnamomum cassia or Liriope platyphylla may enhance immune function by regulating mouse splenocyte proliferation and stimulating cytokine production.

• 대한중풍순환신경학회지
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• 제8권1호
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• pp.17-21
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• 2007

Objectives : This study was done to investigate the relationship of drinking and Dampness-Phlegm pattern in acute stroke patients. Methods : In the time of period Mar. 2007 to Jun. 2007, 103 patients with stroke admitted in the department of Internal Medicine of Kyungwon University Seoul Oriental Medical Hospital, Kyungwon University Incheon Oriental Medical Hospital, Kyunghee University Oriental Medical Hospital, Dongguk Il-san Oriental Medical Hospital were included. Patients were hospitalized within a month after the onset of stroke. Stroke patients were interviewed by residents who studied standard operation procedures in Fundamental Study for Standardization and Objectification of Differentiation and Pattern Identification of Syndrome of Oriental Medicine for Stroke. A questionnaire was completed by a question-and-answer form between patients and residents after explanation details to patients and the agreement of patients. Results : Drinking subjects have tendency of Dampness-Phlegm Pattern(p=0.096), but don't have statistical significance(p<0.05). Conclusions : In this study, we found the relationship of drinking and Dampness-Phlegm Pattern. To acquire more concrete conclusion on this theme, we need more research.

• 대한중풍순환신경학회지
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• 제8권1호
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• pp.12-16
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• 2007

Objectives : This study was done to investigate the relationship between Sasang constitution and the facial skin in acute stroke patients Methods : In the time of period Mar. 2007 to Jun. 2007, 103 patients with stroke admitted in the department of Internal Medicine of Kyungwon University Seoul Oriental Medical Hospital, Kyungwon University Incheon Oriental Medical Hospital, Kyunghee University Oriental Medical Hospital, Dongguk Il-san Oriental Medical Hospital were included. We assessed the type of Sasang constitution, and the type of Sasang constitution of 51 patients were confirmed. We investigated general characteristics, stroke type and the relationship between Sasang constitution and the facial skin. Results : The color of face have no significant differences by Sasang constitution. But So-yang have blue and purple colored lips than So-eum and Tae-eum have. Conclusions : In this study, we found the relationship between Sasang constitution and the facial skin in acute stroke patients. But it seems necessary to investigate more cases to concrete conclusion on this theme.

• 대한중풍순환신경학회지
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• 제11권1호
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• pp.70-75
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• 2010

Objective : This study is aimed to investigate the present status in acute stroke patients in Koran medicine hospital. Method : We used the Korean medicine stroke database. We collected data from 4 Korean medicine hospital from Feb. 2010 to Aug. 2010. We surveyed past history, motive, diseases, diagnostic machines, the day from onset to admission in acute stroke patients. Results : 1. In Korean medicine hospital, it has been grown up the portion of cerebral infarction and age. 2. In Korean medicine hospital, the patients within 1 day from onset to admission were 63case(34.60%) 3. In Korean medicine hospital, the diagnotic machine has been well used, but MRA utilzation was low. 4. Acute stroke patients were not well known the risk factor, and the patients cerebral infarction didn't know that they had hyperlipidemia. Conclusions : In this study, we know the present status in acute stroke patients. It seems necessary to investigate more further study.