• Herbal Formula Science
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• v.8 no.1
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• pp.87-97
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• 2000

• Journal of the Korea Society of Computer and Information
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• v.28 no.10
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• pp.113-121
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• 2023

Network pharmacology in traditional Korean and Chinese medicine studies the molecular and biological aspects of herbal medicine using computational methods. Despite variations in databases, techniques, and criteria, most studies follow similar steps: constructing herb-compound networks, compound-target networks, and target interpretation. To ensure efficient and consistent analysis in herbal medicine network pharmacology, we designed and implemented a common analysis pipeline. We showed its reliability with existing databases. The proposed system has a potential to facilitate network pharmacology analysis in traditional medicine, ensuring consistent analysis of various herbal medicines.

• Journal of the Korean Society for Library and Information Science
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• v.53 no.2
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• pp.223-246
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• 2019

This research makes the metadata element design for Korean medicine research data management and re-use. Derived metadata elements are verified in research data of Korea Institute of Oriental Medicine. TTAK.K0-10.0976 Standard, DataCite metadata Schema and National Research Data Platform of KISTI were analyzed to derive the metadata elements. Including Identifier, 27 elements were derived as top-level elements with 29 mandatory elements, 13 recommended elements and 31 optional elements. The degree of elements' necessity and new metadata elements were investigated and suggested in the survey by six domain experts in korean medicine field. In this study subject classification for the korean medicine research data are suggested. The final version of metadata schema was tested and verified by comparing with the legacy metadata fields. The research results can be used to describe the Korean medicine research data: items and files.

• The Korea Journal of Herbology
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• v.28 no.1
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• pp.91-96
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• 2013

Objectives : Obesity is a chronic metabolic disease caused by disorder of energy balance and lipid metabolism. This study was conducted by histopathology and histomorphometry to investigate the anti-obesity effects of mixed water extract of Plantaginis Semen & Poria (CJB) on liver, epididymal fat pads and pancreas zymogen granules in obese rats induced with high fat diet. Method : Male Sprague-Dawley rats to be divided four groups were fed into four different treatments: normal (NOR) diet, high-fat (HF) diet, HF diet+CJB (100 mg/kg and 300 mg/kg, P.O.) for 8 weeks. The weekly body weights were measured in four experimental groups, respectively. Also histopathological and histomorphometrical changes of liver, epididymal fat pads and pancreas zymogen granules were observed in normal control and obese rats, respectively. Results : Adminstration of CJB significantly reduced body weights compared to those of HF group for experimental period. After 8 weeks, liver weights in the CJB groups were lower than those of HF group. In addition, HF diet related steatohepatitis, adipocyte hypertrophy, exocrine disturbances (decreases of pancreatic zymogen granules) were also dose-dependently inhibited by treatment of test material, CJB 100 and CJB 300 as compared with HF group, respectively. Conclusion : Based on the results, it is considered that CJB will be showed hepatoprotective and anti-obese effects, may be directly and/or indirectly mediated by pancreatic zymogen granules because they dose-dependently inhibited steatohepatitis, hypertrophy of adipocytes and decreases of pancreatic zymogen granules induced by HF diet supply, respectively.

• Herbal Formula Science
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• v.26 no.4
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• pp.307-318
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• 2018

Objectives : Endoplasmic reticulum (ER) stress designates cellular responses to the accumulation of misfolded and unfolded proteins in ER, which is related to a variety of liver diseases. Present study investigated the inhibitory effects of Litsea japonica flesh water extract (LJE) aganist ER stress. Methods : After HepG2 cells were pretreated with LJE and subsequently exposed to tunicamycin (Tm) or thapsigargin (Tg), expression of C/EBP homologous protein (CHOP), glucose regulated protein 78 kDa (GRP78), asparagine synthetase (ASNS), and endoplasmic reticulum DnaJ homologue 4 (ERDJ4) were determined by immunoblot and real-time PCR analysis. Three canonical signaling pathways in response to ER stress were examined to explore molecular mechanisms involved. Results : Pretreatment of 1 mg/mL LJE inhibited Tm- or Tg-induced CHOP expression, while L. japonica fruit water extract did not. In addition, LJE decreased the levels of GRP78, ASNS, and ERDJ4 mRNA by Tm. Moreover, phosphorylations of eukaryotic translation initiation factor $2{\alpha}$ and inositol-requiring enzyme 1, expression of nuclear form of activating transcription factor $6{\alpha}$, and transactivation of ER stress response element- and unfolded protein response element-harboring luciferase activities were inhibited by LJE pretreatment. Conclusions : Present results suggest that LJE would be a candidate to prevent or treat ER stress-mediated liver injuries.

• Journal of Haehwa Medicine
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• v.17 no.2
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• pp.33-49
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• 2008

韓醫學的現代化, 並不意味著在自然科學方法論的框框限制下實現韓醫學的現代化, 而是使傳統韓醫學的理論和醫療技術與現代社會及文化得以圓滿溝通, 開發新理論和新醫療技術, 從而在現有的保健醫療體系內更有效的發揮韓醫學的醫療技術. 韓醫學理論的現代化當保持傳統韓醫學理論的長處, 並著眼現代之角度彌補不足之處, 從而進一步完善理論之體系. 同時, 還應提示在現代醫療體制下能夠創造出新的醫療技術的理論, 並與包括西醫學在內的所有學科和政治經濟社會文化等領域做到圓滿溝通. 韓醫學現代化應當按照以下順序來進行, 首先, 以經釋經或應用醫史學的硏究方法整備傳統韓醫學理論, 其次, 當對韓醫學理論的概念和關系, 采用現代科學的語言重新進行描繪和解釋, 然後與現代的其他學問和理論進行學科間的合作研究. 再其次, 在臨床方面, 當以現代科學的測定儀器代替人的感覺器官, 或者根據傳統韓醫學的診斷方法, 開發新的診斷儀器以實現更爲客觀的診斷, 尤其需要結合和利用電腦來進行辯證分析, 至少應以電腦爲輔助, 從而得以確立韓醫學的新的醫療形式. 最後, 創出有關韓醫學及醫學, 醫療技術等各各方面適用可能的理論.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.2
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• pp.158-162
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• 2019

This study is to show the clinical effect of additional CP Pharmacopuncture on hypoesthesia of lower limb which was occurred by laminectomy. The patients were treated using CP Pharmacopuncture, and other treatments including acupunture, moxibustion and herbal medication. The effect of treatment was measured by Numeric Rating Scale(NRS) and American Spinal Injury Association(ASIA) scale. After treatment, NRS was gradully reduced and ASIA scale's score was incresed. These results suggest that CP Pharmacopuncture might be a possible therapeutic option for hypoesthesia of lower limb which was occurred by laminectomy.

• The Journal of Korean Medical History
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• v.36 no.1
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• pp.89-98
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• 2023

This study aimed to review trends in Korean medical education research from 2003 to 2022. A total of 60 studies were identified, with an increasing trend in publication numbers. The research topics covered various aspects of Korean medicine education, including curriculum, basic science, clinical science, teaching methods, history, and international comparisons. Text mining analysis revealed "Curriculum", "Satisfaction" and "Clinical" to be frequent terms. The study suggests that Korean medicine education research should continue to develop, given its broad scope and growing interest.

• The Journal of the Society of Stroke on Korean Medicine
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• v.11 no.1
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• pp.76-81
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• 2010

Background : Currently, the absence of a unified terminology and proper translation about Traditional Korean Medicine is a problem that should be solved. Although Traditional Korean Medicine has undergone steady growth in popularity during the past years, the Westerner's poor access to information has been drawback to its reception in the West. Objective : This research is aimed to seek system for standardization of stroke terminology and proper translation into English. Conclusion : We proposed the method of making unified terminology and translation about stroke in Traditional Korean Medicine.

• The Journal of Internal Korean Medicine
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• v.43 no.4
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• pp.680-719
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• 2022

Objectives: The aim of this study was to investigate the trends in research on non-alcoholic fatty liver disease (NAFLD) using Korean traditional medicine. Methods: This review included studies related to the treatment of NAFLD, irrespective of the year of publication. The search terms were "nonalcoholic fatty liver disease", "non-alcoholic fatty liver", "nonalcoholic hepatitis", "herb", "herbal medicine", "acupuncture", and "traditional medicine". The studies were analyzed according to the type of research. Results: After screening, 179 studies were selected from the 592 identified by the search. The types of studies were 151 in vivo or in vitro studies, 5 randomized controlled trials, 12 case reports, 2 unspecified clinical studies, 8 review articles, and 1 article that was difficult to classify. Conclusion: Analysis of the trends in Korean traditional medicine treatment by reviewing the studies on NAFLD revealed a focus on experimental studies rather than clinical studies. Therefore, multifaceted and well-designed studies are needed.