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http://dx.doi.org/10.22246/jikm.2022.43.4.680

A Review of Research Trends in Traditional Korean Medicine for Nonalcoholic Fatty Liver Disease  

Kim, Na-yeon (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Yoon, Mi-jung (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Choi, Hong-sik (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Kim, Seung-mo (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Kim, Sang-chan (Dept. of Herbal Formulation, College of Korean Medicine, Daegu Haany University)
Kim, Kyung-soon (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Publication Information
The Journal of Internal Korean Medicine / v.43, no.4, 2022 , pp. 680-719 More about this Journal
Abstract
Objectives: The aim of this study was to investigate the trends in research on non-alcoholic fatty liver disease (NAFLD) using Korean traditional medicine. Methods: This review included studies related to the treatment of NAFLD, irrespective of the year of publication. The search terms were "nonalcoholic fatty liver disease", "non-alcoholic fatty liver", "nonalcoholic hepatitis", "herb", "herbal medicine", "acupuncture", and "traditional medicine". The studies were analyzed according to the type of research. Results: After screening, 179 studies were selected from the 592 identified by the search. The types of studies were 151 in vivo or in vitro studies, 5 randomized controlled trials, 12 case reports, 2 unspecified clinical studies, 8 review articles, and 1 article that was difficult to classify. Conclusion: Analysis of the trends in Korean traditional medicine treatment by reviewing the studies on NAFLD revealed a focus on experimental studies rather than clinical studies. Therefore, multifaceted and well-designed studies are needed.
Keywords
nonalcoholic fatty liver disease; Korean traditional medicine; review;
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Times Cited By KSCI : 23  (Citation Analysis)
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114 Goyale A, Jain A, Smith C, Papatheodoridi M, Misas MG, Roccarina D, et al. Assessment of non-alcoholic fatty liver disease (NAFLD) severity with novel serum-based markers: A pilot study. Strnad P, editor. PLoS ONE 2021 Nov 23;16(11):e0260313.   DOI
115 Diep Nguyen T. Adiponectin: Role in physiology and pathophysiology. Int J Prev Med 2020;11(1):136.   DOI
116 Woo HJ, Lee JH, Kim YC, Kim GS, Son CK, Jo JH. Oriental Internal Medicine on Hepatobiliary System, Hematology and Toxicology 6th. Seoul: Nado; 2016, p. 307-12.
117 Hwang YJ, Wi HR, Kim HR, Park KW, Hwang KA. Pinus densiflora Sieb. et Zucc. Alleviates Lipogenesis and Oxidative Stress during Oleic Acid-Induced Steatosis in HepG2 Cells. Nutrients 2014 Jul 23;6(7):2956-72.   DOI
118 Lee GH, Peng C, Park SA, Hoang TH, Lee HY, Kim JH, et al. Citrus Peel Extract Ameliorates High-Fat Diet-Induced NAFLD via Activation of AMPK Signaling. Nutrients 2020 Mar 1;12(3):673.
119 Lee MR, Park KI, Ma JY. Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet. Nutrients 2017 Dec 25;10(1):20.   DOI
120 Kim HG. Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model. World J Gastroenterol 2014;20(42):15703-14.   DOI
121 Canbay A, Kalsch J, Neumann U, Rau M, Hohenester S, Baba HA, et al. Non-invasive assessment of NAFLD as systemic disease-A machine learning perspective. Strnad P, editor. PLoS ONE 2019 Mar 26;14(3):e0214436.   DOI
122 Kim MJ, Bae HS, Park SS. Study on Liver Function Test and Liver Disorders under the Ultrasonography for each of the Sasang Constitutional Types. J Sasang Constitut Med 2013 Sep 30;25(3):195-207.   DOI
123 Choi JY, Lee KH, Lee SM, Yoo SH, Hwang SG, Choi JY, et al. Efficacy and Safety of Human Pla-cental Extract for Alcoholic and Nonalcoholic Steatohepatitis: An Open-Label, Randomized, Comparative Study. Biological & Pharmaceutical Bulletin 2014;37(12):1853-9.   DOI
124 Lee HI, Kim YK, Lim HC, Lee DE, Kim EJ, Moon YH. Effects of Agastachis Herba Extract and Lysimachiae Herba Extract on the Experimental Cellular Model of NFLDs Induced by Palmitic Acid. J Int Korean Med 2018 Jun 30;39(3):302-12.   DOI
125 Seo EH, Oh YS, Jun HS. Psoralea corylifolia L. Seed Extract Attenuates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice. Nutrients 2016 Feb 6;8(2):83.   DOI
126 Song YO, Lee SJ, Jang SH, Ha JH, Song YM, Ko YG, et al. Sasa borealis Stem Extract Attenuates Hepatic Steatosis in High-Fat Diet-induced Obese Rats. Nutrients 2014 Jun 5;6(6):2179-95.   DOI
127 Han CW, Joo MS, Lee JH. Comparison of the therapeutic efficacy of rhizoma alismatis, fructus crataegi, fructus lycii, radix curcumae, radix salviae miltiorrhizae, herba artemisiae scopariae on the experimental cellular model of nonalcoholic fatty liver disease. J Int Korean Med 2012;33(4):533-42.
128 Kim EY, Lee JH. The effect of alisma orientale extract on free fatty acid-induced lipoapoptosis in HepG2 cells. J Int Korean Med 2014;35(2):184-94.
129 Kim SY, Kwon JN, Lee I, Hong JW, Choi JY, Park SH, et al. Research on anti-lipogenic effect and underlying mechanism of Laminaria japonica on experimental cellular model of non-alcoholic fatty liver disease. J Int Korean Med 2014;35(2):175-83.
130 Lee JW, Choi CW, Jeon SY, Han CW, Ha YJ. Effect of Jungmanbunso-hwan extract on HepG2 cell model of nonalcoholic fatty liver disease caused by palmitate. J Int Korean Med 2016;37(3):442-52.
131 Yun KS, Woo HJ, Lee JH, Kim YC. Effect of Injinchunggan-tang & Injinsaryung-san on NASH induced by MCD-diet in A/J mice. J Int Korean Med 2009;30(2):410-21.
132 Choi EY, Choi JO, Park CY, Kim SH, Kim DH. Water Extract of Artemisia annua L. Exhibits Hepatoprotective Effects Through Improvement of Lipid Accumulation and Oxidative Stress-Induced Cytotoxicity. J Med Food 2020 Dec 1;23(12):1312-22.   DOI
133 Riazi K, Azhari H, Charette JH, Underwood FE, King JA, Afshar EE, et al. The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2022 Sep;7(9):851-61.   DOI
134 Mun JE, Kim ST, Yoon HG, You YH, Kim OK, Choi KC, et al. Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty Liver Disease. Nutrients 2019 Oct 21;11(10):2536.   DOI
135 Tran NKS, Kim GT, Park SH, Lee DY, Shim SM, Park TS. Fermented Cordyceps militaris Extract Prevents Hepatosteatosis and Adipocyte Hypertrophy in High Fat Diet-Fed Mice. Nutrients 2019 May 6;11(5):1015.   DOI
136 Chang BY, Kim DS, Kim SY. Improvement in Menopause-Associated Hepatic Lipid Metabolic Disorders by Herbal Formula HPC03 on Ovariectomized Rats. Evid Based Complement Alternat Med 2020 Jul 20;2020:1409376.
137 Choi DJ, Kim SC, Park GE, Choi BR, Lee DY, Lee YS, et al. Protective Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract against Hepatic Steatosis in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mice. Evid Based Complement Alternat Med 2020 Mar 19;2020:1-11
138 Kang SH, Lee HW, Yoo JJ, Cho YR, Kim SU, Lee TH, et al. KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease. Clin Mol Hepatol 2021;27(3):363-401.   DOI
139 Armandi A, Bugianesi E, Valenti L. Natural history of NASH. Liver Int 2021 Jun;41(S1):78-82.   DOI
140 Estes C, Chan HLY, Chien RN, Chuang WL, Fung J, Goh GBB, et al. Modelling NAFLD disease burden in four Asian regions-2019-2030. Aliment Pharmacol Ther 2020 Apr;51(8):801-11.   DOI
141 Hyun J, Lee JB, Kim SY, Han CW. Clinical Effectiveness of Acupuncture in the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review. J Int Korean Med 2018 Dec 30;39(6):1206-24.   DOI
142 Choi JY, Kwon EY, Choi MS. Elucidation of the Metabolic and Transcriptional Responses of an Oriental Herbal Medicine, Bangpungtongseong-san, to Nonalcoholic Fatty Liver Disease in DietInduced Obese Mice. J Med Food 2019 Sep 1;22(9):928-36.   DOI