• 대한한의학방제학회지
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• 제8권1호
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• pp.87-97
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• 2000

• 한국컴퓨터정보학회논문지
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• 제28권10호
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• pp.113-121
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• 2023

한의학 및 중의학 분야에서 네트워크 약리학은 계산학적인 방법을 통해 한약의 분자생물학적인 기전을 연구하기 위해 널리 활용된다. 개별 연구를 위해 사용되는 데이터베이스, 분석기법, 분석기준 등은 다양하나, 대부분의 한의학 네트워크 약리학 연구들은 약재-성분 네트워크 구축, 성분-표적 네트워크 구축, 표적의 해석이라는 유사한 단계로 수행된다. 효율적이고 일관성있는 한의학 네트워크 약리학 분석을 위해서, 우리는 일반적으로 적용할 수 있는 한의학 네트워크 분석 파이프라인 시스템을 설계하고 구현하였다. 우리는 이 시스템의 신뢰성을 약재의 네트워크 약리학 분석을 위해 널리 사용되는 데이터베이스를 활용해서 확인하였다. 제안된 시스템은 다양한 한약에 대한 네트워크 약리학적 분석을 용이하게 하고, 일관성 있는 분석을 도울 것이다.

• 한국문헌정보학회지
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• 제53권2호
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• pp.223-246
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• 2019

본 연구에서는 한의학 연구 데이터 관리 및 공유를 위한 메타데이터 요소를 설계하고 한국한의학연구원에서 생산되는 연구 데이터를 대상으로 요소검증을 수행하였다. TTAK.K0-10.0976 표준과 DataCite 메타데이터 스키마, 한국과학기술정보연구원의 국가 연구 데이터플랫폼 스키마를 대상으로 메타데이터 요소를 도출하였다. 최상위 요소로서 Identifier를 포함한 27개 요소가 도출되었으며, 필수요소 29개, 권고요소 13개, 선택요소 31개를 도출하였다. 한의학 관련 분야별 전문가 6인을 대상으로 도출요소에 대한 필요성 정도를 조사하였으며, 추가적인 메타데이터 요소를 제안 받아 검토하였다. 한의학 연구 데이터 주제 분류를 제안하였으며, 최종 제안하는 메타데이터 요소로 현재 운영 중인 시스템의 메타데이터 수용여부를 검증하였다. 본 연구결과는 향후 한국한의학연구원에 구축되는 데이터 리포지터리에 아이템과 파일을 기술하기 위한 메타데이터 스키마로 활용될 수 있다.

• 대한본초학회지
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• 제28권1호
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• pp.91-96
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• 2013

Objectives : Obesity is a chronic metabolic disease caused by disorder of energy balance and lipid metabolism. This study was conducted by histopathology and histomorphometry to investigate the anti-obesity effects of mixed water extract of Plantaginis Semen & Poria (CJB) on liver, epididymal fat pads and pancreas zymogen granules in obese rats induced with high fat diet. Method : Male Sprague-Dawley rats to be divided four groups were fed into four different treatments: normal (NOR) diet, high-fat (HF) diet, HF diet+CJB (100 mg/kg and 300 mg/kg, P.O.) for 8 weeks. The weekly body weights were measured in four experimental groups, respectively. Also histopathological and histomorphometrical changes of liver, epididymal fat pads and pancreas zymogen granules were observed in normal control and obese rats, respectively. Results : Adminstration of CJB significantly reduced body weights compared to those of HF group for experimental period. After 8 weeks, liver weights in the CJB groups were lower than those of HF group. In addition, HF diet related steatohepatitis, adipocyte hypertrophy, exocrine disturbances (decreases of pancreatic zymogen granules) were also dose-dependently inhibited by treatment of test material, CJB 100 and CJB 300 as compared with HF group, respectively. Conclusion : Based on the results, it is considered that CJB will be showed hepatoprotective and anti-obese effects, may be directly and/or indirectly mediated by pancreatic zymogen granules because they dose-dependently inhibited steatohepatitis, hypertrophy of adipocytes and decreases of pancreatic zymogen granules induced by HF diet supply, respectively.

• 대한한의학방제학회지
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• 제26권4호
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• pp.307-318
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• 2018

Objectives : Endoplasmic reticulum (ER) stress designates cellular responses to the accumulation of misfolded and unfolded proteins in ER, which is related to a variety of liver diseases. Present study investigated the inhibitory effects of Litsea japonica flesh water extract (LJE) aganist ER stress. Methods : After HepG2 cells were pretreated with LJE and subsequently exposed to tunicamycin (Tm) or thapsigargin (Tg), expression of C/EBP homologous protein (CHOP), glucose regulated protein 78 kDa (GRP78), asparagine synthetase (ASNS), and endoplasmic reticulum DnaJ homologue 4 (ERDJ4) were determined by immunoblot and real-time PCR analysis. Three canonical signaling pathways in response to ER stress were examined to explore molecular mechanisms involved. Results : Pretreatment of 1 mg/mL LJE inhibited Tm- or Tg-induced CHOP expression, while L. japonica fruit water extract did not. In addition, LJE decreased the levels of GRP78, ASNS, and ERDJ4 mRNA by Tm. Moreover, phosphorylations of eukaryotic translation initiation factor $2{\alpha}$ and inositol-requiring enzyme 1, expression of nuclear form of activating transcription factor $6{\alpha}$, and transactivation of ER stress response element- and unfolded protein response element-harboring luciferase activities were inhibited by LJE pretreatment. Conclusions : Present results suggest that LJE would be a candidate to prevent or treat ER stress-mediated liver injuries.

• 혜화의학회지
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• 제17권2호
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• pp.33-49
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• 2008

韓醫學的現代化, 並不意味著在自然科學方法論的框框限制下實現韓醫學的現代化, 而是使傳統韓醫學的理論和醫療技術與現代社會及文化得以圓滿溝通, 開發新理論和新醫療技術, 從而在現有的保健醫療體系內更有效的發揮韓醫學的醫療技術. 韓醫學理論的現代化當保持傳統韓醫學理論的長處, 並著眼現代之角度彌補不足之處, 從而進一步完善理論之體系. 同時, 還應提示在現代醫療體制下能夠創造出新的醫療技術的理論, 並與包括西醫學在內的所有學科和政治經濟社會文化等領域做到圓滿溝通. 韓醫學現代化應當按照以下順序來進行, 首先, 以經釋經或應用醫史學的硏究方法整備傳統韓醫學理論, 其次, 當對韓醫學理論的概念和關系, 采用現代科學的語言重新進行描繪和解釋, 然後與現代的其他學問和理論進行學科間的合作研究. 再其次, 在臨床方面, 當以現代科學的測定儀器代替人的感覺器官, 或者根據傳統韓醫學的診斷方法, 開發新的診斷儀器以實現更爲客觀的診斷, 尤其需要結合和利用電腦來進行辯證分析, 至少應以電腦爲輔助, 從而得以確立韓醫學的新的醫療形式. 最後, 創出有關韓醫學及醫學, 醫療技術等各各方面適用可能的理論.

• 동의생리병리학회지
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• 제33권2호
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• pp.158-162
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• 2019

This study is to show the clinical effect of additional CP Pharmacopuncture on hypoesthesia of lower limb which was occurred by laminectomy. The patients were treated using CP Pharmacopuncture, and other treatments including acupunture, moxibustion and herbal medication. The effect of treatment was measured by Numeric Rating Scale(NRS) and American Spinal Injury Association(ASIA) scale. After treatment, NRS was gradully reduced and ASIA scale's score was incresed. These results suggest that CP Pharmacopuncture might be a possible therapeutic option for hypoesthesia of lower limb which was occurred by laminectomy.

• 한국의사학회지
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• 제36권1호
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• pp.89-98
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• 2023

This study aimed to review trends in Korean medical education research from 2003 to 2022. A total of 60 studies were identified, with an increasing trend in publication numbers. The research topics covered various aspects of Korean medicine education, including curriculum, basic science, clinical science, teaching methods, history, and international comparisons. Text mining analysis revealed "Curriculum", "Satisfaction" and "Clinical" to be frequent terms. The study suggests that Korean medicine education research should continue to develop, given its broad scope and growing interest.

• 대한중풍순환신경학회지
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• 제11권1호
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• pp.76-81
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• 2010

Background : Currently, the absence of a unified terminology and proper translation about Traditional Korean Medicine is a problem that should be solved. Although Traditional Korean Medicine has undergone steady growth in popularity during the past years, the Westerner's poor access to information has been drawback to its reception in the West. Objective : This research is aimed to seek system for standardization of stroke terminology and proper translation into English. Conclusion : We proposed the method of making unified terminology and translation about stroke in Traditional Korean Medicine.

• 대한한방내과학회지
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• 제43권4호
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• pp.680-719
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• 2022

Objectives: The aim of this study was to investigate the trends in research on non-alcoholic fatty liver disease (NAFLD) using Korean traditional medicine. Methods: This review included studies related to the treatment of NAFLD, irrespective of the year of publication. The search terms were "nonalcoholic fatty liver disease", "non-alcoholic fatty liver", "nonalcoholic hepatitis", "herb", "herbal medicine", "acupuncture", and "traditional medicine". The studies were analyzed according to the type of research. Results: After screening, 179 studies were selected from the 592 identified by the search. The types of studies were 151 in vivo or in vitro studies, 5 randomized controlled trials, 12 case reports, 2 unspecified clinical studies, 8 review articles, and 1 article that was difficult to classify. Conclusion: Analysis of the trends in Korean traditional medicine treatment by reviewing the studies on NAFLD revealed a focus on experimental studies rather than clinical studies. Therefore, multifaceted and well-designed studies are needed.