• Journal of Korean Medicine for Obesity Research
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• v.24 no.1
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• pp.25-40
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• 2024

Objectives: In the present study, we investigated the effects of clean-diabetes mellitus 3 (C-DM3), a herbal formula with Trichosanthis Radix, Coptidis Rhizoma, Crataegi Fructus, and Cinnamomi Cortex, on the pathological and serological symptoms of diabetes and its related molecular mechanisms in diet-induced obese mice. Methods: We prepared an obese mouse model using a high-fat diet for 8 weeks and then administered the C-DM3 extract for 4 weeks. The changes of pathological and serological biomarkers for diabetes assessment were measured in the mice and histological changes were observed in the liver and pancreas tissues. We also identified the main compounds in the C-DM3 extract using high pressure liquid chromatography (HPLC) and analyzed the molecular mechanism of the disease condition by network pharmacological analysis. Results: In the in vivo, the administration of C-DM extract to obese mice significantly reduced body weight gain, fatty liver symptoms, and muscle loss, and decreased the levels of fasting blood glucose, insulin, aspertate aminotransferase, triglycerides, and low-density lipoprotein-cholesterol. In addition, C-DM extract significantly increased the phosphorylation of insulin receptor substrate 1, protein kinase b (AKT), phosphoinositide 3-kinase (PI3K), adenosine monophosphate-activated protein kinase, and glucose transporter 4 in all pancreatic and liver tissues, with inhibition of histopathological changes in obese mice. HPLC analysis identified hyperoside, berberine, epiberberine, columbamin, coptisine, coumarin, jatrorrhizine, and citric acid as the main compounds. In the network pharmacological analysis, the molecular targets of C-DM3 extract on obesity and diabetes were shown as the insulin, AKT, PI3K, and mitogen-activated protein kinase pathways with the regulation of inflammatory molecules interleukin 6 (IL-6), jun proto-oncogene, and IL-1β, which matched our in vivo targets. Conclusions: Based on these results, C-DM3 extract is expected to be effective in improving obesity and preventing diabetic progression.

• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.1
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• pp.149-154
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• 2003

The immunomodulatory activity of PJ-P, a polysaccharide fraction extracted from Paeonia japonica, were reported in our previous paper. In the present study, we investigated that PJ-P inhibited cancer growth through activation of macrophages. The activities of peritoneal macrophage to induce tumor necrosis factor (TNF)-$\alpha$, interleukin-1 (IL-1)$\beta$, interleukin-6 (IL-6) and interleukin-12 (IL-12) as well as to ingest fluorescence-latex microbeads were enhanced by treatment of PJ-P. Direct cytocidal activity of PJ-P against cancer cells was not shown. However, in vitro, peritoneal macrophages treated with PJ-P had an activity to kill cancer cells. Furthermore, PJ-P significantly prolonged the survival of mice implanted intraperitoneally with B16F0 mel-anoma cells. These results suggest that PJ-P could be a useful immunomodulator and assistant of anti-tumor agent.

• The Journal of Internal Korean Medicine
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• v.38 no.2
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• pp.284-288
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• 2017

The patient presented to the clinic with the complaint of severe fatigue. The patient had been diagnosed with chronic hepatitis B a number of years earlier. Although he had used entecavir, an antiviral agent, for over two years, his HBV-DNA level had not dropped below undetectable levels. The fatigue seemed to be associated with chronic hepatitis B. Traditional Korean medicine (TKM) therapy for chronic hepatitis B was administered in conjunction with entecavir and at the same dose. The excessive fatigue gradually decreased following the treatment. On the 28th day, laboratory tests revealed that the patient's bilirubin level was slightly lower and that his HBV-DNA level had dropped below undetectable levels. The addition of TKM therapy may have contributed to the HBV-DNA clearance. No similar cases have been reported in Korea. Herein, we summarize the patient's progress.

• The Journal of Korean Medicine
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• v.16 no.1 s.29
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• pp.227-249
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• 1995

Pursuant to the Medical Product Safety Administration Guidelines for safety assessment of Korean bee vonom for herb-acupuncture, rabbits were used for skin, eye balls, subcutaneous and muscle irritation test. The results were as follows; 1. The skin irritation test of bee venom for herb-acupuncture did not produce any irritation reactions, when the skin was covered with bee venom. 2. The eye irritation test produced moderate to severe stimulating reactions, once the eye mucous membrane was contacted with bee venom. 3. The subcutaneous and muscle irritation test of bee venom showed such local inflammatory reactions as death of cells, infiltration of inflamed cells, dropsical swelling, and congestion, once injected under the skin and in the muscle. As the results of the study on bee venom for herb-acupuncture indicate that severe reactions in such tests as eye balls, subcutancous and muscle irritation exist in the laboratory, more professional caution should be taken in clinical application of the therapy. In addition, further study on subacute, chronic toxicity and allergy reactions should be pursued.

• Herbal Formula Science
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• v.22 no.1
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• pp.193-200
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• 2014

Objective : The purpose of this study is to report that patient diagnosed as drug-induced liver injury treated with herbal and western medicine improve liver function test. Methods : We treated the patient diagnosed as drug-induced liver injury caused by antibiotics with Hepatotonics and Cheonggan-tang Gagam(淸肝湯加減). Then, We followed up the result of liver function test. After the result of liver function test improved, we diagnosed the patient with Korean medical methods, and evaluated the symptom of Cerebral infarction and liver function test treating the patient with Jihwangumja (地黃飮子). Result : After our treatment, Liver function test and symptoms of Cerebral infarction result improved. Conclusion : Use of Western medicine with herbal medicine can improved liver function test of drug-induced liver injury effectively and herbal medicine do not disturb the liver function.

• Journal of Korean Medical classics
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• v.19 no.3
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• pp.255-259
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• 2006

음양오행학설시한의리론적근간(陰陽五行學說是韓醫理論的根幹), 소이기의의최중요(所以其意義最重要), 야유허다적함의(也有許多的含意). 특별시오행유불단적상생상극지관계(特別是五行由不斷的相生相克之關系), 병가이순환(幷可以循環). 단재(但在) ${\ulcorner}$황제내경(黃帝內經)${\lrcorner}$ 등의서중(等醫書中), 유관우오행적내용(有關于五行的內容), 허다의가혹불료해기문적함의(許多醫家或不了解其文的含意), 지용오행상생상극적관계이해석(只用五行相生相克的關系而解釋). 대우(對于) ${\ulcorner}$소간 보명전형론(素間.寶命全形論)${\lrcorner}$ 적오행상극적내용(的五行相克的內容), 허다의가야지이오행상극적관계이석지(許多醫家也只以五行相克的關系而釋之), 소이(所以)'사득목이달(士得木而達)'적의난이해명(的意難以解明), 이차불가이유지일관적해석(而且不可以維持一貫的解釋). 소이아고찰료차편대우오행상극지관계(所以我考察了此篇對于五行相克之關系), 이득료여하결론(而得了如下結論). 모일시(某一是), 본편적오행상극지의(本篇的五行相克之意), 불지유극해적의사(不只有克害的意思), 환유요용상극지기거억제기항성적기(還有要用相克之氣去抑制其亢盛的氣), 저양재가이유지오행상호적균형지의(這樣才可以維持五行相互的均衡之意). 기이시(其二是), '토득목이달(土得木而達)'적달자지의(的達字之意), 불요구어자의이석지(不要拘於字意而釋之), 약이달자지의의해석본문(若以達字之意義解釋本文), 실일관적해석이불가이발명본문적의의(失一貫的解釋而不可以發明本文的意義). 기삼시(其三是), '토득목이달(土得木而達)'적의의(的意義), 시토기항성이과우응취적상태(是土氣亢盛而過于凝聚的狀態), 용목적소설효능거소통토기(用木的疏泄效能去疏通土氣). 여차설명법(如此說明法), 병가이설명별적사행지상극관계(幷可以說明別的四行之相克關系).

• Journal of Korean Medical classics
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• v.18 no.1 s.28
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• pp.94-120
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• 2005

통과연구진사탁적현존팔종의서(通過硏究陳士鐸的現存八種醫書), 득출이하결론(得出以下結論): 인위석실비록시화타소저청낭서적복원본(認爲石室秘?是華?所著靑囊書的復原本), 이기백전급진사탁적시장중경보충설명완성적서적(而岐伯傳給陳士鐸的是張仲景補充說明完成的書籍). 본초신편재약271종(本草新篇載藥271種), 기술료종기백(記述了從岐伯), 장중경(張仲景), 편작소전수적내용(扁鵲所傳授的內容), 단재범예급서문중(但在範例及序文中), 견불도여편작상관적내용(見不到與扁鵲相關的內容). 변증기문여변증녹기술료기호상동적내용(辨證奇聞與辨證錄記述了幾乎相同的內容), 단무유관병인(但無有關病因), 맥진(脈診), 설진등방면적내용(舌診等方面的內容), 제외감이외(除外感以外), 대잡병병리기호도시이오장오행이론위의거진행료설명(對雜病病理幾乎都是以五臟五行理論爲依據進行了說明). 변증옥함기호미재세간류전(辨證玉函幾乎未在世間流傳), 근류전유일종판본(僅流傳有一種版本), 차파음양(且把陰陽), 허실(虛實), 상하(上下), 진가작위기구별질병적강요(眞假作爲其區別疾病的綱要). 맥결천미거설시귀여구소전(脈訣闡微據說是鬼與區所傳), 인기내용교소미단독간행(因其內容較少未單獨刊行), 근부어변증녹지후보충료변증방면적불족지처(僅符於辨?錄之後補充了辨證方面的不足之處). 거인위외경미언시진사탁종선사소수전적서중최위기리적서적(據認爲外經微言是陳士鐸從先師所授傳的書中最爲奇異的書籍), 시일본집진사탁의학사상지대성적전저(是一本集陳士鐸醫學思想之大成的專著). 동천오지시진사탁적외과전저(洞天奧旨是陳士鐸的外科專著), 재림상극소응용도침지법(在臨床極少應用刀針之法), 이책용료이중제위대보내소법(而策用了以重劑爲大補內消法), 계승료사전급가전적비방(繼承了師傳及家傳的秘方), 이차종합료력대외과저작적내용(而且綜合了曆代外科著作的內容).

• Journal of Korean Medical classics
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• v.19 no.3
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• pp.33-46
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• 2006

통과대약물적(通過對藥物的)'승강부심(升降浮沈)'이론화기재방제학적운용방면적연구득출여하결론(理論和其在方劑學的運用方面的硏究得出如下結論): 1. 대약물적(對藥物的)'승강부심(升降浮沈)'대래영향적인소유(帶來影響的因素有), 기미후박지음양(氣味厚薄之陰陽), 한열온경지사기(寒熱溫京之四氣), 산고감신함지오미(酸苦甘辛鹹之五味), 이급약용부위(以及藥用部位), 약물적재질(藥物的材質), 약물적생숙등(藥物的生熟等). 2. 재약성작용상가구분위(在藥性作用上可區分爲), 승부적약성구유소풍(升浮的藥性具有疏風), 산한(散寒), 선폐(宣肺), 투진(透疹), 승양(升陽), 통비(通痺), 최토(催吐), 개궁등작용(開窮等作用), 이침강약성구유통편(而沈降藥性具有通便), 사화(瀉火), 이수(利水), 진정안신(鎭靜安神), 평간개탕(平肝漑湯), 평단(平端), 강역(降逆), 고정(固精), 삽장(澁腸), 지대등자용(止帶等作用). 3. 근거재(根據在), ${\ulcorner}$의학입문(醫學入門) 본초(本草)${\lrcorner}$ 중장결고등인적이론(中張潔古等人的理論), 치풍문적약가귀납위'승'적작용(治風門的藥可歸納爲'升'的作用), 치열문적약가귀납위'심'적작용(治熱門的藥可歸納爲'沈'的作用), 치조문적약가귀납위'강'적작용(治操門的藥可歸納爲'降'的作用), 치한문적약가귀납위'부'적작용(治寒門的藥可歸納爲'浮'的作用), 단시실제상부동적'승강부심'작용시상혼재일기적(但是實際上不同的'升降浮沈'作用是相混在一起的). 4. 재(在) ${\ulcorner}$의학입문(醫學入門)${\lrcorner}$, ${\ulcorner}$의방집해(醫方集解)${\lrcorner}$, ${\ulcorner}$의방고(醫方考)${\lrcorner}$ 중구체응용등약물적승강부심이론(中具體應用等藥物的升降浮沈理論), 내설명료방제적조성원리(來說明了方劑的組成原理), 저일점적용어소유처방(這一點適用於所有處方), 단시주요국한어중기적허약혹심현부교(但是主要局限於中氣的虛弱或心賢不交), 음허화왕등(陰虛火旺等).

• The Journal of Korean Medicine
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• v.35 no.1
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• pp.99-113
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• 2014

Objectives: To provide theoretical basis for the classification of medicinal moxibustion(藥灸劑) in Health Insurance Medical Benefit in Korea through investigating trend of judicial precedents on indirect moxibustion and usage of medicinal moxibustion in "Donguibogam". Methods: We analyzed statistical data of moxibustion from Health Insurance Review & Assessment Service and National Health Insurance Statistical Yearbook. We investigated major judicial precedents on indirect moxibustion to find out some trend and we searched the usages of medicinal moxibustion in "ZhenJiuDaCheng" and "Donguibogam". Results: According to recent judicial precedents, indirect moxibustion with equipment is no loner regarded as Korean Medical Procedure. In composition of 'Oriental Health Treatment', amount for acupuncture has gradually decreased instead, amount for moxibustion has increased steadily for 5 years. Medicinal moxibustion(藥灸劑) is often used as a form of indirect medicinal moxibustion with moxa in "Donguibogam". Argyi Folium, Moschus, Natrii Chloridium, Radix Preparata, Realgar and Olibanum are most frequently used for medicinal moxibustion in "Donguibogam". Medicinal moxibustions are composed of simple prescription or herb-pair or multiple prescription in "Donguibogam". Conclusions: In Health Insurance Medical Benefit in Korea, under the division of moxibustion, direct medicinal moxibustion and indirect medicinal moxibustion should be classified in addition.

• The Journal of Internal Korean Medicine
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• v.38 no.4
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• pp.501-508
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• 2017

Objective: This study evaluated the effects of traditional Korean medicine on a patient with hyperthyroidism, who could not use antithyroid medication due to an adverse reaction to methimazole. Methods: Herbal medicine was administered and acupuncture was carried out. A thyroid function test was used to evaluate the effects of the treatment. Results: After treatment with traditional Korean medicine and therapy, the patient showed significant improvements in symptoms and FT4 levels. Conclusion: This case proved that traditional Korean medicine can be used for patients who have adverse reactions to antithyroid medication; however, studies of larger populations are required in the future.