• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.6
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• pp.362-371
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• 2020

In order to find out the relationship between the Eight Principle Pattern Identification of Yin-Yang, Exterior-Interior and the Sasang constitution, we analyzed the clinical data from 500 women with menstrual pain and women without menstrual pain. In the previous study, the subject's information of Typology Complexion Pulse and Symptom was collected, and Eight Principle Pattern Identification was executed based on this. Later, The relationship between the Sasang constitution and the Eight Principle Pattern Identification was statistically analyzed. The obvious difference between the experimental group and the control group in the patterns of Yin-Yang and Exterior-Interior is that patients who complain of menstrual pain do not maintain harmony with the yin-yang ratio, it can be said that the patterns of Yin-Yang and Exterior-Interior can be a identification standard that significantly obscures the condition of the disease. There was a significant difference between the Sasang constitution and the Eight Principle Pattern Identification of Yin-Yang. There was no significant difference between the Sasang constitution and the Eight Principle Pattern Identification of Exterior-Interior. It is assumed that the relationship between the Eight Principle Pattern Identification and the Sasang constitution has changed depending on the difference a view of emotional Qi and pathogenic Qi.

• The Korea Journal of Herbology
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• v.39 no.4
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• pp.19-28
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• 2024

Objectives : Ephedrae Herba has been used in the East Asian traditional medicine, for treatment of asthma, cold and influenza. Silymarin is an effective antioxidant and its anti-fibrogenic, anti-inflammatory, and hepatoprotective properties have been reported. This study was performed to explore an anti-fibrogenic potential of Ephedrae Herba extract (EHE) + silymarin on immortalized human hepatic stellate cell line, LX-2 cells. Methods : We studied the anti-fibrogenic effects of EHE + silymarin on transforming growth factor β1 (TGF-β1) signaling pathway in LX-2 cells. Cell viability was measured using the MTT assay. mRNA levels were detected by real-time PCR. TGF-β1 signaling-related proteins expression were detected by Western blot. Results : Silymarin 30 ㎍/mL and EHE 100 ㎍/mL showed cytotoxicity on LX-2 cells. Therefore, the concentrations of silymarin and EHE were studied at 10 ㎍/mL, respectively. Silymarin significantly reduced PAI-1 protein expression, Smad binding element (SBE) luciferase activity, and mRNA (PAI-1, MMP2 and 9) expression compared to TGF-β1. EHE significantly reduced SBE luciferase activity and mRNA (PAI-1, MMP2 and 9) expression compared to TGF-β1. More importantly, EHE + silymarin significantly reduced all parameters compared to TGF-β1, and also significantly reduced compared to EHE alone and silymarin alone. Conclusion : The results indicate that EHE + silymarin has anti-fibrogenic effect in LX-2 cells induced by TGF-β1. Additionally, EHE + silymarin shows more effective anti-fibrogenic effect than EHE alone and silymarin alone.

• Journal of the Korean Applied Science and Technology
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• v.40 no.1
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• pp.88-94
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• 2023

Sericin is a protein extracted from the cocoon and has many health benefits. This study was conducted to evaluate the anti-wrinkle and anti-inflammatory activity of sericin derived from cocoon as a cosmetic material. The antioxidant activity of sericin was measured by DPPH and ABTS assays. In addition, cell viability was confirmed in Raw 264.7 cells, which are macrophages, and the anti-inflammatory effect of sericin was investigated using the inflammatory response induced using lipopolysaccharide (LPS). It shows that sericin has antioxidant activity and can be an excellent material for anti-aging and anti-inflammatory cosmetics.

• Herbal Formula Science
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• v.32 no.1
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• pp.63-82
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• 2024

Objective : Saengkankunbi-tang (SKT) is used as a traditional Korean herbal formula for treatment of liver diseases. We investigated the hepatoprotective effects of SKT plus Epimedium koreanum Nakai (EKE) against arachidonic acid (AA) + iron-mediated cytotoxicity in HepG2 cells and carbon tetrachloride (CCl₄)-mediated acute liver damage in mice. Methods : The cyto-protective effects of SKT + EKE were determined by MTT assay, western blot and fluorescence activated cell sorting analysis. In mice, blood biochemistry and western blot were assessed in CCl₄-induced acute hepatic damage. The animal groups included vehicle-treated control, CCl₄, SKT (200 mg/kg/day), EKE (100 mg/kg/day), SKT (200 mg/kg/day) + EKE (100 mg/kg/day) and silymarin (200 mg/kg/day). Results : In HepG2 cells, pretreatment with SKT + EKE significantly suppressed cytotoxicity induced by AA + iron and reduced the expression of proteins related to apoptosis. In addition, pretreatment with SKT + EKE significantly prevented the increase in H₂O₂ production, GSH depletion, and lower mitochondrial membrane potential induced by AA + iron. In CCl₄-induced liver damage mice, the administration of SKT + EKE prevented the liver damage by inhibition of hepatocyte damage and expression of apoptosis proteins in liver. More importantly, in vitro and in vivo assay, SKT + EKE showed significant effect compare with SKT alone or EKE alone in all parameters. Conclusions : These results indicated that SKT + EKE could protect against oxidative stress-induced liver damage, and SKT + EKE is more effective than SKT alone or EKE alone.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.05a
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• pp.123-126
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• 2008

한의학의 대중화 및 선호도 향상을 위해 가장 시급하고 중요한 일이 임상의들의 직관을 정량화 및 객관화 하는 일이다. 특히 병색을 살피는 망진(望診)의 경우 임상 현장뿐 아니라 u-헬스에 기반이 될 수 있는 진단법인 관계로 더욱 망진에 대한 정량화 작업이 시급하며 중요한 부분을 차지하고 있다. 이와 같이 망진의 공학적 융합을 통한 시스템화를 위해서는 디지털 기기의 특성상 일어날 수 있는 색 정보의 손실을 최소화 하여야 하며 색 분석을 위한 기준을 만들어 주어야 한다. 이를 위해 본 논문에서는 한의학의 찰색을 시스템 하기 위한 실험 환경 및 조건 등에 대한 기준을 제안하고, 또한 질병에 따른 특정 부위의 색상을 살피기 위해 가장 효율적인 디지털 색 체계가 무엇인지를 다양한 실험을 통해 분석한 자료를 제시하고자 한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2007.11a
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• pp.59-62
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• 2007

태어나면서부터 건강에 대한 욕구는 현대 사회에서 많은 부분을 차지하게 된다. 물론 어려서부터의 건강관리가 건강 수명 연장은 물론 가장 기본적인 행복한 삶의 추구까지도 보장되고 있는 실정이다. 이를 위해 본 논문에서는 한의학에서 환자의 질병을 진단하기 위해 사용되고 있는 망진(望診)과 청진(聽診)의 이론적 근거를 바탕으로 소아 감기 질환에 대한 진단 시스템을 개발하고자 한다. 특히 소아감기는 일반적으로 제일 발병률이 높은 질환으로 얼굴 부위에 열을 동반한다는 것과 울음소리가 인체의 모든 조음기관과 연관되어 있다는 한의학적 이론을 기반으로 소아의 생체신호를 분석하여 소아 감기와의 상관성을 분석하고자 한다. 이를 위해 소아 감기 환자에 대한 1차 실험으로 얼굴 영상에서의 열 관련 여부에 대한 색상 분석을 행하였으며 2차 실험으로는 조음기관에 대한 성분음을 추출하는 스펙트럼 분석을 수행하였다. 이를 통해 정상 소아와 감기 질환을 앓고 있는 소아 환자간의 차이점을 추출하고자 한다.

• Korean Journal of Acupuncture
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• v.40 no.3
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• pp.109-127
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• 2023

Objectives : It was conducted to experimentally analyze the effects of acupuncture treatment at CV12, ST25, and ST36 on weight, FBCS, fat metabolism, microbiome, and metabolome changes in the general diet rat and the high-fat diet rat. Methods : It was classified into four groups: general diet & non-treatment group (ND), general diet & acupuncture treatment group (ND+AT), high-fat diet & non-treatment group (HFD), and high-fat diet & acupuncture treatment group (HFD-AT). After acupuncture treatment was performed on CV12, ST25, and ST36, changes in body weight, FBCS, fat metabolism, microbiome, and metabolome were analyzed. Results : Compared to the ND group, acupuncture treatment performed on CV12, ST25, and ST36 in the ND+AT group had no significant effect. Compared to the HFD group, CV12, ST25, and ST36 acupuncture in the HFD+AT group reduced weight, fat weight, inflammatory cytokine IL-6 expression, and lipid droplet accumulation in liver tissue. Acupuncture can promote fat metabolism and relieve inflammatory conditions. Differences in diversity between ND and HFD groups were clear in changes in microbiome, fecal metabolites, and serum metabolites. As a result of some microbiome and metabolites involved in fat decomposition, intestinal lipid absorption, and blood lipid concentration control, such as Intestinimonas, Ruminococcus 1, pyroglutamic acid, tryptophan, and inositol, it was observed that the acupuncture treatment effect was evident in the disease-induced imbalance. Conclusions : Acupuncture treatment performed on CV12, ST25, ST36 clearly observed various regulatory actions on obesity induced by high-fat diet, confirming that the action of acupuncture treatment mainly plays a role in controlling an unbalanced state.

• Korean Journal of Veterinary Research
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• v.62 no.3
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• pp.25.1-25.9
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• 2022

Canine cognitive dysfunction syndrome (CDS) is a neurodegenerative disease that causes cognitive and behavioral disorders and reduces the quality of life in dogs and their guardians. This study reviewed the complementary and alternative medicine (CAM) for CDS and compared the diagnosis and therapy of CAM between CDS in canines and dementia in humans. The evaluation tools for the diagnosis of CDS and dementia were similar in the neurological and neuropsychiatric examinations, daily life activity, cognitive tests, and neuroimaging, but the evaluation for dementia was further subdivided. In CAM, pattern identification is a diagnostic method for accurate, personalized treatment, such as herbal medicine. For herbal medicine treatment of cognitive impairment in canines and humans, a similar pattern identification classified as deficiency (Qi, blood, and Yin) and Excess (phlegm, Qi stagnation, and blood stasis) is being used. However, the veterinary clinical basis for verifying the efficacy and safety of CAM therapies for CDS is limited. Therefore, based on CAM evidence in dementia, it is necessary to establish CDS-targeted CAM diagnostic methods and therapeutic techniques considering the anatomical, physiological, and pathological characteristics of dogs.

• Journal of Korea Technology Innovation Society
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• v.18 no.4
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• pp.667-692
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• 2015

The study examined the Korean medicine industry from the perspective of the innovation system theory of each business, while it concentrated on the conflict between traditional Korean medicine and Western medicine, which have a major influence on the innovation system of Korean medicine industry, rather than the innovation system itself. The Korean healthcare system is a dual system of Western and Korean medicine, yet the definitions of Western medical practices and Korean medical practices are ambiguous. Thus the distinction of dual system depends on judicial precedents, and the innovation of Korean medicine has been inhibited due to the excessive emphasis placed on the Western medical practice in both healthcare system and pharmaceutical system. First of all, the usage of most medical devices derived from the development of modern medical engineering is not permitted in the Korean medicine industry, on the basis that most of the medical devices were originated from the Western medicine field. Secondly, new drugs using natural substances, once approved by the drug administration, cannot be prescribed by the Korean medicine industry although they are developed based on Korean medicine. Thirdly, the major safety issues on herbal medicine are about hazardous materials in medicinal herbs and liver toxicity of prescribed herbal medicine. The problem of hazardous materials can be solved by appropriate quality and safety tests in the cultivation and importation process. Whereas the Korean medicine circles points out that the liver toxicity issue is only a unilateral condemnation by the Western medicine circles.

• Annual Conference on Human and Language Technology
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• 1990.11a
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• pp.65-72
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• 1990