• Journal of Sasang Constitutional Medicine
• /
• v.31 no.1
• /
• pp.102-112
• /
• 2019

Objectives The purpose of this case study was to report that cold hypersensitivity caused by hypothyroidism was alleviated by diagnosing and treating as Greater Yang Disease Reverting Yin Pattern. Methods The patient was administered Insamosuyu-tang and Sammisamyu-tang and treated with acupuncture. Global Assessment Scale (GAS) and Digital Infrared Thermal Imaging (DITI) was used to assess the improvements of symptoms. Results and Conclusions Cold hypersensitivity of hands and feet was improved to GAS 20, and hours of sleep were increased from one to six. On DITI, the increase of the temperature were 1-3 degree celsius on the chest and the abdomen, 0.2-1 degree on the forearms and the hands, 1-2 degree on the thighs, and 0.2-0.5 degree on the shins and the feet.

• The Journal of Pediatrics of Korean Medicine
• /
• v.35 no.3
• /
• pp.53-66
• /
• 2021

Objective The purpose of this study is to evaluate whether herbal bath shortens the duration of pediatric fever. Methods Databases, such as Medline, EMBASE, Cochrane library, OASIS, KISS, KMBASE, CNKI, Wanfang Med Online were used to search randomized controlled trials. Those trials that included children younger than 18-year-old were evaluated for the clinical efficacy of herbal bath in fever by analyzing 'body temperature (BT) drop start time' and 'time to return to normal BT'. Results 12 studies or 1306 participants were analyzed in the study. When applying herbal bath in combination with the controlled treatment, 'BT drop start time' was decreased by 0.11 hours, and 'time to return to normal BT' was decreased by 10.94 hours compared to the controlled group. When comparing herbal bath with tepid bath, 'time to return to normal BT' was reduced by 8.19 hours in herbal bath group. In regards to safety, 3 studies out of 12 studies mentioned about its adverse events: 2 studies did not have any adverse events, and a minor needle-shaped bleeding had occurred in one of the studies. Conclusion Use of herbal bath as a treatment of fever in children was associated with shortened duration of fever. However, cautious interpretation is necessary due to its limited safety data.

• Journal of Oriental Neuropsychiatry
• /
• v.30 no.3
• /
• pp.199-207
• /
• 2019

Objectives: The purpose of this study was to evaluate the neuroprotective effects of donepezil and 33 kinds of herbal extract combinations in SH-SY5Y cells with $A{\beta}_{25-35}$ treatment. Methods: MTT assay was performed to measure the cell viability of each herbal extract combined with donepezil against $A{\beta}$-induced neurotoxicity. The most active extracts were then subjected to assess the effects on CREB phosphorylation and COX-2 expressions through the western blot analysis. Results: There were eight herbal extracts representing significant increase on the cell viability: 1) Erycibe obtusifolia, 2) Polygonum multiflorum, 3) Polygala tenuifolia, 4) Illicium verum, 5) Santalum album, 6) Loranthus parasticus, 7) Platycladus orientalis, and 8) Zanthoxylum piperitum. Especially, when Santalum album and donepezil were treated together, the phosphorylation of CREB significantly increased and COX-2 protein expression was significantly inhibited. Conclusions: Among the screened herbal extracts, combination treatment of each of the eight herbs and donepezil showed neuroprotective effects in SH-SY5Y cells. Additionally, the combination of Santalum album and donepezil suggested cognitive improvement by up-regulation of p-CREB and down-regulation of COX-2.

• Journal of Korean Medicine Rehabilitation
• /
• v.31 no.1
• /
• pp.47-57
• /
• 2021

Objectives This study was conducted to confirm the possibility of Clostridium difficile infection (CDI) treatment through natural herbal medicines. Methods After screening a total of 77 herbal medicines through the paper disc agar diffusion method, we selected the herbal medicines that showed a effectiveness compared to the positive control vancomycin. Afterwards, drugs that showed inhibitory effects compared to C. difficile without inhibition of Bifidobacterium bifidum and Lactobacillus plantarum, known as beneficial bacteria, were selected and minimal inhibitory concentration (MIC) was confirmed by applying the Broth microdilution method. Results The Coptidis Rhizoma, well known for its antimicrobial effect, was found to have antimicrobial effects on C. difficile, but also had inhibitory effects on the beneficial bacterium B. bifidum. 30% ethanol extraction Crataegi fructus, Corni fructus and Mume fructus had antimicrobial effects on C. difficile without inhibiting the beneficial bacteria B. bifidum and L. plantarum. The MIC values of 30% ethanol extraction Crataegi fructus, Corni fructus and Mume fructus were found to be 10 mg/mL, 20 mg/mL and 5 mg/mL, respectively. Conclusions Crataegi fructus, Corni fructus and Mume fructus were identified as candidate medicines for C. difficile. Further researchs will need to be done in vivo, and to find an optimal extraction method accompanied by economic evaluation.

• Proceedings of the Plant Resources Society of Korea Conference
• /
• 2018.10a
• /
• pp.34-34
• /
• 2018

천연물 산업은 과학적 기술력이 요구되는 고부가가치 산업으로 건강기능식품 등의 원료 산업으로 각광받고 있다. 최근 친환경, 지속가능성에 대한 관심 증가로 천연물 제품에 대한 수요가 증가되고 있으며 고령화 사회 진입과 건강에 대한 의식 수준 상승으로 전세계 건강기능 식품 시장 확대 추세에 있다. 생물자원의 70%이상을 수입에 의존하고 있는 우리나라는 천연물 산업의 경쟁력 확보와 고부가가치화 실현을 위해 천연물 산업 육성 촉진이 필요하다. 또한 지역 균형발전 측면에서 신성장동력 마련 및 국가 차원의 형평성을 고려한 전략적 투자가 필요한 시점에서 천연물 관련 산업의 신성장동력화를 통해 지역의 한계점 등을 개선하고, 새로운 먹거리 발굴과 함께 지역 전략산업으로 육성이 필요하다. 제천의 특화산업업인 한방천연물산업의 고도화와 활성화를 위해 영세한 스타트업 및 중소기업의 연구 및 제품개발을 지원하기 위한 인프라와 산업 클러스터 조성이 요구되고 있다. 제천은 풍부한 한약재 생산지를 보유하고 있어 전체 면적의 50% 이상이 석회암 지대로 알칼리성 토양이 넓게 분포되어 있고, 토양의 양분이 풍부하며 해발고도 250m 이상의 준산간 지역에서 주로 재배가 이루어지고 있어, 배수가 양호하고 병충해가 적어 한약재의 친환경 재배 및 다년생 한약재 재배가 가능한 지역이다. 이러한 천연물 산업을 육성하기 위하여 산업통상자원부, 충청북도, 제천시, (재)충북테크노파크는 180억원의 사업비로 '글로벌 천연물 원료제조거점시설'을 구축하여 규격화된 천연물 원료공급 시스템을 갖추었으며 150억원을 투자하여 '천연물 조직배양 상용화 시설'을 건립 중에 있다. 또한 향후에는 천연물 클러스터 가치 사슬의 완성형으로 160억 상당의 '천연물 제제개발 생산시설' 사업을 기획하고 있어 장차 대한민국의 천연물 산업을 앞장서 견인할 것으로 예상 된다.

• The Hankook-Saengyark Bo
• /
• no.250
• /
• pp.2-2
• /
• 2002

인삼 국제식품규격 제정 초안제출(인삼규격화 진행을 위한 후속조치 일환 - 올 약령시 축제 5월 7$\~$12일 열려(약썰기대회 약초꽃등산 조성등 행사 다양) - 토종 홍화씨 무료보급 - 옻나무 재배단지 조성(옥천군) - '식품부적합' 생각 한약재로 둔갑 - 수입약재 검사기관서 제외(한국인삼연초연구원)

• The Hankook-Saengyark Bo
• /
• no.236
• /
• pp.2-2
• /
• 1999

야생화 생태공원 조성된다(진천군, 진천읍에 13만5천본 야생식물 식재) - 홍삼은 천연 '비아그라'(발기부전 효과 탁월$\cdots$부작용 없어) - 남원시, 지리산 자락 옻나무 집중 재배 - '전주 약령시' 60년만에 부할(11월17$\~$21일 거리재현, 한방 무료진료) - 당귀포럼 개최 한국약용작물학회 - 산초나무 농가소득 주목(평창군, 재배지원 확대)

• The Hankook-Saengyark Bo
• /
• no.259
• /
• pp.2-2
• /
• 2004

지황. 시호 등 약재 수입물량 재검토 - 적작약, 창출, 하수오 3개 품목 제외(복지부 한약재 수급 관리규정 입안예고) - 수입한약재 국산보다 잔류농약, 중금속 비율 높아 - 중국산 종자서 외래해충 발견

• Journal of the Korean Wood Science and Technology
• /
• v.44 no.3
• /
• pp.430-439
• /
• 2016

Medicine herb residues boards were manufactured by using medicine herb residues, and emission properties of volatile compounds from boards were examined under various temperature conditions. The volatile compounds were identified with analysis of TD GC/MS by absorbing their flavor components in Tenax tubes. Total 88 volatile compounds were identified from the board. The number of identified compounds at temperature conditions of $25^{\circ}C$, $35^{\circ}C$, and $45^{\circ}C$ were 44, 55, and 65 kinds, respectively. The number of volatile compounds and the total peak area tended to increase with an increase in the temperature. The number of the flavor components detected in all temperature conditions were 34 kinds. Hydrocarbon compounds showed 93% of the detected flavor compounds at $25^{\circ}C$, 92% at $35^{\circ}C$, and 90% at $45^{\circ}C$. Ether compounds accounted for 4% and ketone, aldehyde, and acid-type compounds were detected in a small quantity. The hydrocarbons were composed of 17 kinds of monoterpenes and 39 kinds of sesquiterpenes, which accounted for 11% and 80%, respectively. The most detected compound of monoterpene was limonene, and the major flavor components of sesquiterpenes were ${\alpha}-curcumene$, zingiberene, ${\beta}-elemene$, ${\beta}-selinene$, ${\alpha}-amorphene$, and ${\alpha}-copaene$. Anethole (3.26%) known for ether compounds was detected considerably in all temperature conditions. The results suggest that the manufactured medicine herb residues board include various types of flavor compounds and the flavor compounds might be useful for the manufacture of various products.

• Korean Journal of Food Science and Technology
• /
• v.38 no.1
• /
• pp.75-81
• /
• 2006

Effects of medicinal herbs and bee propolis on pork quality were assessed using formulae A (control), B (boiling water extraction with propolis), and C (boiling water extraction without propolis). Seasoning sauce was made with medicinal herb, spices, total flavonoid, and soy sauce with/without 0.4% propolis (21.8 mg/g), mixed with pork, and stored at low temperature $(4{\pm}1^{\circ}C)$ for 20 days. In formula B peroxide value and thiobarbituric acid content increased with increasing storage period. Formula B showed highest Volatile Basic Nitrogen (VBN) and lowest microbial counts, followed by formulae C and A, receiving higher scores for taste and fragrance.