• Journal of the Korean Applied Science and Technology
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• v.33 no.4
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• pp.693-697
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• 2016

In this study, the electron donating ability(EDA) and total polyphenol content of herbal wine were examined. The herbal wine was obtained from extract concentration to evaluate its functional properties. The herbal wine were screened for their potential antioxidant activities using test such as electron donating ability(EDA) and total polyphenol content. The electron donating ability(EDA) were $21.81{\pm}0.56$ in herbal wine 15% and $40.45{\pm}1.60$ in herbal wine 35%. As the extract concentration was increased the electron donating ability(EDA) were significantly increased(p<0.05). The total polyphenol contents were measures $113.89{\pm}1.79{\mu}g\;GAE/m{\ell}$ in herbal wine 15%, $274.24{\pm}0.71{\mu}g\;GAE/m{\ell}$ in herbal wine 35%. As the extract concentration was increased the total polyphenol contents were significantly increased(p<0.05). Also, the total polyphenol contents were measures $61.75{\mu}g\;GAE/m{\ell}$ in herbal wine, the higher.

• Journal of Life Science
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• v.32 no.5
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• pp.355-361
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• 2022

Melanin pigments are the main cause of skin color. They are produced in melanocytes and then transferred to keratinocytes, which eventually gives the skin surface a variety of colors. Although many skin-lightening or depigmenting agents have been developed, the demand for materials to reduce pig- mentation is still increasing. Here, we tried to find materials for skin-lightening or depigmentation using natural compounds and found that mistletoe (Viscum album var. coloratum) extracts (ME) had an inhibitory effect on tyrosinase activity. As a result, ME significantly reduced pigmentation in human primary melanocytes. In addition, a promoter reporter assay revealed that ME inhibited the transcription of microphthalmia-associated transcription factor (MITF), melanophilin (MLPH), tyrosinase-related protein-2 (TRP-2), and tyrosinase (TYR) genes in HM3KO melanoma cells. In addition, ME decreased the protein level for pigmentation-related molecules, such as TYR and TRP-1. Furthermore, it markedly inhibited the melanogenesis of zebrafish embryos, an in vivo evaluation model for pigmentation. To elucidate the action mechanism of ME, we investigated its effects on intracellular signaling. Eventually, the ME dramatically decreased the phosphorylation of the cAMP responsive element binding protein (CREB), AKT, and ERK. The data suggest that ME may inhibit the melanogenesis pathway by regulating the signaling pathway related to pigmentation. Taken together, these data propose that ME can be developed as a depigmenting or skin-lightening agent.

• Food Science and Preservation
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• v.20 no.2
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• pp.272-277
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• 2013

The physicochemical and sensory properties of herb samgyetang, ginseng chicken soup added with medicinal herbs were investigated to determine the optimum addition level of medicinal herbs. The pH of herb samgyetang decreased with increasing addition level of the Acorus gramineus addition level, and the soluble solid content increased as the Codonopsis lanceolata addition level increased. The herb samgyetang with the highest Codonopsis lanceolata addition level had the lowest $L^*$ and $b^*$ value. In contrast, the $a^*$ value increased with increasing Codonopsis lanceolata addition level. In sensory evaluation, the highest color, taste, and overall acceptability scores were obtained by the herb samgyetang with the highest Codonopsis lanceolata addition level. In conclusion, the optimum addition levels of medicinal herbs for herb Samgyetang are as follows: Platycodon grandiflorum 4 g, Acorus gramineus 4 g, Codonopsis lanceolata 12 g, Schizandra chinensis 6 g, Atractylodeslancea 4 g, Glycyrrhiza uralensis 4 g, and Zizyphus jujube 4 g.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.16 no.2
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• pp.249-254
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• 2003

Dyshidrotic eczema is a chronic vesicular skin disease due to stress, sweating and nickel dermatitis. It has the characteristic symptoms of a cluster of vesicles and frequent recurrence. We diagnosed a 63-year old male patient case with hyperkeratosis, itching and vesicles at his right foot as dyshidrotic eczema and treated him with application of herbal medicine(bo-jung-ik-ki-tang) and acupunture at Dong-su Oriental-medicine hospital in 2003. We had a good result, so we report this case.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.17 no.3
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• pp.114-119
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• 2004

Background: Atopic dermatitis is chronic exzemaous dermatosis characterized by severe itching, licalized eruption and chronic relapsing progress and has familu history of atopic diseases and hereditary disposition. This Study is attempted in order to estimate of possibility of oriental treatment on atopic dermatitis. Objective: We studied 24 years old women with atopic dermatitis from June 2004 to July 2004 Method: We treated her with herb medication and used three index to assess the severity of atopic dermatitis. Results: Each index show us about 50-60$\%$ of improvement Conclusion: On the basis of this study, It should be considered that treatment of atopic dermatitis should be focused on fever of yang-ming.

• The Journal of Korean Obstetrics and Gynecology
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• v.35 no.2
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• pp.87-105
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• 2022

Objectives: The purpose of this study is to analysis the Clinical Study Trends on Korean Medicine Treatment for Polycystic Ovary Syndrome. Methods: The key words such as 'polycystic ovary syndrome', 'polycystic ovarian syndrome', 'korean medicine', 'herbal medicine', 'acupuncture' are used for the research through 'OASIS', 'KCI', 'KISS', 'RISS'. Results: Ten clinical studies with 73 patients were selected. All studies were the noncomparative studies, and 8 case reports, 1 case series, 1 retrospective chart review. Symptoms accompanied by PCOS were oligomenorrhea, amenorrhea, irregular menstruation, hirsutism, acne, obesity etc. The most used treatment was herbal medicine in all studies with 72 patients (98.6%). The most frequently used acupuncture and moxibustion point was respectively 合谷 (LI4) and 關元 (CV4). The duration of treatment was between 3 months and 10 months, the average 159 days. Outcome measurements were Recovery of menstrual cycle (97.6%), Hormone test (23.8%), Sonogram (61.9%), Indexes of obesity (23.8%). In terms of menstrual recovery, 35 patients (85.4%) have recovered from menstruation in 8 studies with 41 patients. In hormone tests, all 10 patients have decrease of LH/FSH ratio and LH in 3 studies with 10 patients. Through sonogram, Ovulation menstruation was confirmed in all 6 patients. In all 10 patients of 3 studies evaluating weight before and after treatment, weight was reduced. Conclusions: The effect on Korean Medicine treatment for Polycystic Ovary Syndrome had mostly positive results. However, Further large, well-designed clinical trials are needed to establish the foundation of Korean Medicine treatment for Polycystic Ovary Syndrome.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.34 no.3
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• pp.80-91
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• 2021

Objective : The purpose of this study is to discriminate the vestibular schwannoma misdiagnosed as Idiopathic Sudden Sensorineural Hearing Loss. Methods : A 46-year-old female patient who was suffering left sudden sensorineural hearing loss(SSNHL), visited after diagnosed as Idiopathic SSNHL by previous hospital. For diagnosing the vestibular schwannoma, we conducted the Puretone audiometry, auditory brainstem response threshold test and magnetic resonance imaging(MRI) for temporal bone with enhancement. Result : Auditory Brainstem Response threshold test was abnormal and in enhanced MRI, the vestibular schwannoma in left side was detected. The patient was discharged from the hospital for tertiary hospital care. Conclusions : When the patient with SSNHL visits a hospital even if after diagnosed as Idiopathic SSNHL by previous hospital, a doctor should keep in mind the possibility of vestibular schwannoma.

• Journal of Korean Medicine Rehabilitation
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• v.32 no.1
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• pp.37-49
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• 2022

Objectives The purpose of this study is to present evidence by analyzing the research trends in acupuncture treatment in the last 10 years for thromboangiitis obliterans. Methods Randomized controlled trials about acupuncture on thromboangiitis obliterans were searched China National Knowledge Infrastructure (CNKI), PubMed, EMBASE, Cochrane Library, Oriental Medicine Advanced Searching Integrated System (OASIS), ScienceON, Koreanstudies Information Service System (KISS) and Research Information Sharing Service (RISS) from January 1, 2011 to November 13, 2021. Only randomized controlled trials were selected and we assessed the risk of bias (RoB) according to the revised Cochrane RoB2 criteria. Results A total of 5 randomized controlled trials (RCTs) were selected in this review and all were conducted in China. A total of 326 participants were in 5 RCTs. SP10, ST36, GB34 was the most commonly used treatment point. There were four types of acupuncture used: manual acupuncture, embedding acupuncture, pharmacopuncture, electroacupuncture. The most commonly used indicator for evaluation was the total efficacy rate, and all five studies were significantly higher. Conclusions All selected studies showed the group treated with acupuncture treatments on thromboangiitis obliterans were statistically more effective than the control group. However, the number of studies is too small and the interpretation of the results is limited due to the inclusion of subjective evaluation. So more objective and systematic studies should be conducted continuously.

• The Journal of Korean Obstetrics and Gynecology
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• v.37 no.3
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• pp.1-19
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• 2024

Objectives: The purpose of this study is to analysis the clinical study trends on Korean Medicine treatment for Bell's palsy during pregnancy. Methods: Key words such as 'facial palsy', 'Bell's palsy, 'Korean medicine', 'herbal medicine', 'acupuncture', 'pregnancy' were searched through the 'RISS', 'OASIS', 'KISS', 'PubMed' and 'CNKI' databases. Results: Ten clinical studies with 107 patients were selected, and 1 randomized controlled trial and 9 case reports were included as the target studies. In the 9 case reports, the gestational age at the onset of facial palsy was most common in the third trimester (29-42 weeks) in 38 cases (56.7%). The most commonly used Korean medicine interventions were acupuncture, with the most frequently used acupoints being ST4, ST2, ST6, BL2, TE23, LI20, GB1, GB14, SI18, and CV24. The herbal medicine treatment most commonly utilized was Geumgwedanggwi-san (金匱當歸散), which is related to the principles of clearing heat, nourishing blood, and stabilizing the fetus (淸熱養血安胎). Among the 65 participants evaluated using the House-Brackmann facial nerve grading system, 81.5% showed complete recovery to grade 1, while 6% remained at grade 4 with no effect, indicating the efficacy of Korean medicine treatment for facial palsy during pregnancy. All the selected studies reported no abnormalities in the mothers or fetal growth, and all participants who had the reported delivery had full-term childbirth. Conclusions: The effect on Korean Medicine treatment for Bell's palsy during pregnancy had mostly positive results. However, further large, well-designed clinical trials are needed to establish the foundation of Korean Medicine treatment for Bell's palsy during pregnancy.

• 대한한약신문
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• s.117
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• pp.1-8
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• 2007

2006년도 긴급 정책위원회-한.미 FTA 협상관련 대책 등 논의/한의사시장 개방 여파 '갈수록 태산'/'세계전통의약의 날' 제정 추진/수입약재(의약품) 반입량 크게 감소/건강기능식품 구입시 가격보다는 '기능성'/중국산 한약재 한국 수출액 급증/한의계 한미FTA 대처 '이율배반'/2006년도 연도말이사회/지부탐방-지부장에게 듣는다/칼럼-민간약/병증 이야기/명칭이 비슷하여 감별하기 어려운 한약재/성약과 패륜아-패륜아에게는 성약이 존재하지 않아/우리 약초를 찾아서-자란/한방과 항문질환/하고초에 대한 소고