• The Journal of Internal Korean Medicine
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• v.25 no.4
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• pp.260-273
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• 2004

Backgrounds : In recent years, asthma has become recognized as a chronic inflammatory disease associated pathologically with airway epithelial inflammation and airway remodeling. Objectives : To evaluate the different effects of Hirudo depending upon pharmaceutical manufactures on the expression and the activities of IL-6 and GM-CSF in airway epithelial cells, samples of Hirudo(水蛭), Hirudo toasted with Talcum(水蛭滑石炒) and Hirudo toasted with Ephedrae Herba(水蛭麻黃炒) were tested. Methods : After inducing enhanced messenger RNA(mRNA) expression and secretion of each cytokine by tumor necrosis factor-alpha(10 ng/ml) treatment, cultured human bronchial epithelial cell line BEAS-2B was added to each sample$(l,\;10,\;100\;&\;1000\;{\mu}g/ml)$. Subsequently, DNA activities were analyzed. Specifically mRNA expression and culture supernatants(protein levels) of IL-6 and GM-CSF from BEAS-2B cells, were analyzed using luciferase reporter gene assay, reverse transcription-polymerase chain reaction(RT-PCR) analysis and enzyme-linked immunosorbent assay. Results : Hirudo toasted with Ephedrae Herba(水蛭麻黃炒) and Hirudo(水蛭) inhibited IL-6 activities in BEAS-2B cells remarkably, and inhibited mRNA expression levels and protein levels in supernatant of IL-6 and GM-CSF at various concentrations, significantly(p<0.05). However, Hirudo toasted with Talcum(水蛭滑石炒) had no effect on mRNA expression levels and showed a slight inhibitory effect on GM-CSF protein levels in supernatant of culture medium. Conclusions : These results strongly suggest that Hirudo toasted with Ephedrae Herba(水蛭麻黃炒) and Hirudo(水蛭) would be serve as effective medicaments in the treatment of airway inflammation and remodeling of asthmatic patients.

• The Journal of Internal Korean Medicine
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• v.28 no.3
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• pp.570-585
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• 2007

A clinical study of 106 cases of $Henoch-Sch{\ddot{o}}nlein$ purpura was made. The author analyzed the result of Korean traditional medical therapy. It was observed more frequently in female at the sex ratio of 1:1.3. The most prevalent age group was $4{\sim}9$ years(56.6%). In seasonal incidence, the cases were frequent during spring(50%), and the main specific history was upper respiratory tract infection(48.1%). The duration of contraction was $420.9{\pm}1079.3$ days. The adults were more chronic than children (p<0.05), The clinical manifestation showed in the skin (100%), the gastrointestinal tract(62.3%), the joints(64.2%), the kidney(25.3%), genitourinary system(11.3%), headache(6.6%), and scalp edema(4.7%) respectively. The first outbreak of symptoms was showing of skin purpura in 77 cases(72.6%) the highest frequency. and the gastrointestinal tract and joints were 16(15.1%) and 12 cases(11.3%) respectively. Of all patients, 22 cases(20.8%) experienced recurrences and 47 patients(44.3%) experienced hospitalization treatment. In the patients group which were recurrence experiences, the recurrence rate was high with patients(63.2%) who usually enjoyed meats and convenience foods and in patients(84%) who treated URI with chemical drugs(p<0.05). The patients group(68.9%) that took steroids also experienced a relatively high recurrence rate. Out of the patients(68.9%) who took treatment with steroids, 46.6% experienced side effects, in orders moon face(100%), weight gain(47.1%), appetite increase(52.9%), and acne. alopecia(11.8%), etc. There was a statistically significant relationship between the period of taking the steroid and the side effects(p<0.05), As the result of the herbal medicine treatment(treatment period: $6.7{\pm}6.2$ weeks, a follow-up survey during $15{\sim}24$ months), 67 patients(91.8%) among the 73 patients(68.9%) under 18 years old recovered completely but 3 cases(4.5%) recurred. 23 patients(69.7%) among the 33 patients(31.3%) above 19 years recovered completely but 5 cases(21.7%) recurred.

• Journal of the Korean association of regional geographers
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• v.2 no.2
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• pp.103-111
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• 1996

I followed the results of Lee and Min(1996) for classification of the months of cold and warm winter. The winter of 1992 and 1984 recorded extraordinary cold and warm. Study of the Synoptic Climatology on the January's cold and warm winter is below: (1) Climatology's characteristic. Temperature of extremely high temperature month is higher compared with extremely low temperature month. Also precipitation is more than over low temperature month compared with extremely high temperature month. (2) In circulation of 500hPa surface. (1) Extremely high temperature month At 500hPa, negative geopotential height anomalies in high latitude, three trough developed over eastern Canada. In midlatitude, a deep trough persisted in the central North Pacific and conspicuous positive height anomalies showed over northwestern Europe, Where a blocking anticyclone developed. It had been warmer than normal since last year in Korea due mainly to positive height anomalies stretched from central Siberia (2) Extremely low temperature month Appeared the strong meridional circulation and negative height anomalies showed from Far East to the Mid-Pacific and appeared ridge in the west of the North America and Atlantic. Alutien Low shows negative deviation during 1984. In northern hemisphere shows negative deviation. Therefore, we can show that the surface pressure distribution and height distribution of 500hPa level are closely connected with each other as parts of general circulation. (3) The characteristics of the general circulation pattern of the 500hPa (1) Extremely high temperature month is high than extremely low temperature month1984 in Zonal index (2) The majority type is S type in 500hPa level circulation of extremely high temperature month but extremely high temperature month is M type (3) The wave number in 500hPa all shows 3 wave. So can not distinguished by only predominant wave number pattern.

• Journal of Engineering Education Research
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• v.16 no.2
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• pp.3-10
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• 2013

This paper aims to present the model of engineering design education workshop for appropriate technologies. Since 2008 Handong Innovation Center for Engineering Education and a Non-Profit Organization, Sharing and Technology, held engineering design workshop during every summer break. We present the contents of the workshop and analyze the educational effects of the program. The workshop is entitled "Engineering Design Academy for the other 90%" because we take it serious that most of the research and development efforts of the science and technologies in the world is just focused on the rich people while the other 90% people in the world are unreachable from the benefits of the modern technologies. By the workshop we tries to provide the college students the perspectives on the worldwide poverty problems and to encourage them to serve the 3rd world people in need through their specialties in the field of engineering profession. The evaluation results by participants are very positive. Especially, we began invite the 3rd world people to the workshop as design problem clients from 2010 summer workshop. The evaluation from them are also very positive. The analysis results on the educational effects of the workshop show that the workshop improves the students skills required by the ABEEK (Acreditation Board of Engineering Education of Korea) including not only design capability but also team work, communication skill, understanding the social impacts of engineering design, engineering ethics, and globalization.

• The Journal of Engineering Geology
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• v.18 no.3
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• pp.331-338
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• 2008

A new ground water sampler was developed and evaluated for target depth sampling under most rigorous field conditions. This new concept sampler comprises an air-cylinder, a hypodermic needle and a sampling bottle. Pressurized air or nitrogen gas can be used as a mechanical power source to operate the sampler. The air-cylinder is used to jab the hypodermic needle into the rubber cap of the sampling bottle. The hypodermic needle functions as a pathway to inject groundwater into the sampling bottle. Field test was conducted in a seawater intrusion monitoring well located at Handong district of Jeju Island. Water qualities in this well are periodically changed from the effects of sea water. Water sampling fir the same target depth in this well were tried at various times, and variations in electrical conductivity and pressure at the inside and outside of the sampler were measured using CTD divers. We found that the device could collect water samples only when it was actuated, and the pattern and range of variations in electrical conductivities and pressures measured at the inside and outside of the sampler were nearly identical. These results indicate that water samples using the sampler presented in this study represent correctly water qualities in which the samplings were made at a specific target depth in a well.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.30 no.3
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• pp.295-303
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• 2012

Clarify wind energy productivity depends on three factors: the wind probability density function(PDF), the turbine's power curve, and the air density. The wind PDF gives the probability that a variable will take on the wind speed value. Wind shear refers to the change in wind speed with height above ground. The wind speed tends to increase with the height above ground. also, Wind PDF refers to the change with height above ground. Wind analysts typically use the Weibull distribution to characterize the breadth of the distribution of wind speeds. The Weibull distribution has the two-parameter: the scale factor c and the shape factor k. We can use a linear least squares algorithm(or Ln-least method) and moment method to fit a Weibull distribution to measured wind speed data which data was located same site and different height. In this study, find that the scale factor is related to the average wind speed than the shape factor. and also different types of terrain are characterized by different the scale factor slop with height above ground. The gross turbine power output (before accounting for losses) was caculated the power curve whose corresponding air density is closest to the air density. and air desity was choose two way. one is the pressure of the International Standard Atmosphere up to an elevation, the other is the measured air pressure and temperature to calculate the air density. and then each power output was compared.

• Economic and Environmental Geology
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• v.38 no.1
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• pp.79-89
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• 2005

Groundwater level changes in coastal aquifers occur due to oceanic tides, where the properties of oceanic tides can be applied to estimate hyadraulic parameters. Hydraulic parameters of coastal aquifers located in eastern part of Jeju island were estimated using the tidal response technique. Groundwater level data from a saltwater intrusion monitoring well system was used which showed tidal effects from 3 to 5 km. The hydraulic gradient was assessed by utilizing the filtering method from 71 consecutive hourly water-level observations. Calculated hydraulic diffusivity ranged from 2.94${\times}10^7m^2d^{-1}$ to 4.36${\times}10^7m^2d^{-1}$ . The hydraulic gradient of the coastal aquifer area was found to be ~$10^{-4}$, whereas the gradient of the area between wells Handong-1 and 2 was found to be ~$10^{-6}$, which is very low comparatively. Analysis of groundwater monitoring data showed that groundwater levels are periodically higher near coastal areas compared to that of inner land areas due to oceanic tide influences. When assessing groundwater flow direction in coastal aquifers it is important to consider tidal fluctuation.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.14 no.5
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• pp.1-11
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• 2019

Financing plays an important role in the survival and growth of startups. This study investigates key factors that improve startup financing performance. To this end, we analyze the relationship between the proportion of intellectual property and the financing performance. In addition, this study also examine the impact of the founder's education level on the financing of startups, and the moderating effect of the founder's education level on the relationship between intellectual property proportion and financing. Based on the survey data of 331 startups, this study found that the proportion of intellectual property and the financing performance have an inverted U-shaped nonlinear relationship. While the founder's education level has a positive impact on the financing performance, it negatively moderate the relationship between the intellectual property proportion and the financing performance. Through these findings, this study suggests that it is necessary to maintain an adequate proportion of intellectual property in order to maximize startup financing performance. The higher education level of founder enhances the startup financing. Since the founder's education level weaken the effect of intellectual proporty's effect on startup financing, however, startups need to control the proportion of intellectual property to improving financing according to the founder's education level. Based on signal theory, this study proposes a new strategy of intellectual property to enhance startup financing performance.

• Journal of Digital Convergence
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• v.19 no.5
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• pp.175-186
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• 2021

The roles and functions of domestic public libraries are diversifying, but various problems have emerged due to internally biased book lending. In addition, due to the 4th Industrial Revolution, public libraries have introduced a book recommendation system focusing on popular books, but the variety of books that users can access is limited. Therefore, in this study, the public library unborrowed book recommendation system was implemented limiting its spatial scope to Duryu Library in Daegu City to enhance the satisfaction of public library users, by using the loan records data (213,093 cases), user information (35,561 people), etc. and utilizing methods like cluster analysis, topic modeling, content-based filtering recommendation algorithm, and conducted a survey on actual users' satisfaction to present the possibility and implications of the unborrowed book recommendation system. As a result of the analysis, the majority of users responded with high satisfaction, and was able to find the satisfaction was relatively high in the class classified by specific gender, age, occupation, and usual reading. Through the results of this study, it is expected that some problems such as biased book lending and reduced operational efficiency of public libraries can be improved, and limitations of the study was also presented.

• Journal of Technology Innovation
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• v.29 no.4
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• pp.161-196
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• 2021

This study presents a new methodology for developing AI-based products. It identifies the distinctive attributes of AI innovation that are different from existing methods, and presents a product design process and methodology reflecting these attributes. This study emphasizes that AI product development should be oriented toward an ambidexterity approach. This study proposes a design process and specific development method for AI-based products that including steps such as technology push oriented idea generation with morphological approach, market pull oriented consumer requirements analysis, product design refinement, etc. In order to verify the practical applicability of this methodology, an AI-based car infotainment system development strategy is derived as a case study. 13 innovative ideas were generated by the morphological approach and expert review based on technological possibility, and a total of 6 quality requirements were derived as new product development strategies through the analysis of consumer requirements by combining Kano and TOPSIS. The methodology proposed in this research paper can be usefully utilized for companies to pioneer new markets through AI-based products or to expand the market by upgrading existing products or services.