• Journal of the Society of Cosmetic Scientists of Korea
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• v.23 no.1
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• pp.57-74
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• 1997

나이, 자외선 등 내외적인 여러 가지 스트레스에 의해 일어나는 피부노화 현상은 피부두께의 변화오 함께 세포수 감소 및 피부 신진대사 저하, 생체결합수 손실을 비롯하여 콜라겐, 엘라스틴 등을 세포간물질 감소로 인해 피부속이 바람 빠진 공처럼 함몰되고 골이 생겨 결국 주름지고 거칠은 피부표면의 형태로 나타난다. 피부 노화 현상에 대한 여러 가지 기능적, 구조적 변화를 살피고 피부노화를 억제하기 위한 화장품의 역할과 연구 동향을 살펴 본다.

• Korean Journal of Ichthyology
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• v.20 no.2
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• pp.90-96
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• 2008

The histological morphology on the skin of Misgurnus anguillicaudatus was described in the three regions such as dorsal, lateral, occiput and subsequently morphological variations of the skin were monthly observed for a year. The skin consisted of epidermis having epithelial cell, club cell and mucus cell, and dermis of mainly connective tissue fiber, embedded scale and blood capillary. Unicellular mucus cells situated at the epidermis underwent seasonal change in its size, as well as number and amounts of mucus-secreting materials, which they greatly increased in winter, but did not in summer. As it is getting cold, the mucus cells' shape changed from initial spherical to oval or elongated form. Such considerable changes in the mucus cell were particularly most evident in the occiput during winter. Moreover, the dermis largely thickened about 2~3 times in winter than in summer. Based on these results, we discussed function for the mucus on what it mainly acts in nature and information on whether mucus cells' seasonal variations affect on hibernation and cutaneous respiration.

• The Journal of the Convergence on Culture Technology
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• v.3 no.3
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• pp.31-36
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• 2017

We are made up to the variation of the structure modeling of the stratum corneum by the skin on the hydration. The given skin structure is consist of the control level of the intercellular route and transcellular route, and is confirmed to the variation of the modeling for algorithm. Hydration condition is consisted to modeling by the size, form and combination, that skin impedance is appeared to result the value of measurement by the several layer such as forms of ${\xi}-R-SC-RH$, ${\xi}-R-SL-RH$, ${\xi}-R-SG-RH$, ${\xi}-R-SS-RH$ and ${\xi}-R-SB-RH$. Hydration condition is showed to the alteration difference value of S-Corneum, S-Lucidum, S-Granulosum, S-Spinosum and S-Basale. And, composition condition was constructed with the alteration modeling that was established to separate the division parts for conversion system. We will be possible to progress the improvement effectiveness of the skin and to consist of the continuous hydration control system for functional on the skin. We will be possible to progress the improvement effectiveness of the skin and to consist of the continuous penetration control system for functional energy on the skin.

• Proceedings of the SCSK Conference
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• 1996.07a
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• pp.52-67
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• 1996

새로운 노화방지 물질로 개발한 3-APPA가 노화에 의해 야기되는 여러 변화들, 특히 세포 증식, 유전자 수준 및 단백질 수준에서의 collagen의 생합성 변화, 면역조직화학염색을 이용한 collagen 생합성의 변화등을 세포배양 및 동물실험을 통하여 측정하였다. MTT assay를 이용한 인체 피부 섬유아세포의 증식 실험에서 3-APPA는 무처치군에 비교해서 최고 2배의 섬유아세포 증식 효능을 나타내었으며, $^3$[H]-proline incorporation 방법을 이용한 단층세포 배양 및 3차원 dermal equivalent 섬유아세포 배양에서 무처치군 및 vitamin C 처리군에 비해 최고 1.5배의 collagen 생합성 증가를 나타내었다. 그러나 type I alpha-procollagen mRNA expression에는 영향을 미치지 않는 것으로 나타났다. H&E 염색을 이용한 hairless mice의 피부에 대한 형태학적 변화 및 type I pM procollagen antibody를 이용한 면역조직화학염색에서, 3-APPA는 collagen 생합성을 증가시키는 것으로 나타났다. 이상의 결과에서 3-APPA는 섬유아세포 배양 및 hairless mouse를 이용한 실험에서 피부 섬유아세포 증식을 촉진시키며 collagen 생합성을 증가시켜 피부노화를 억제 할 수 있는 물질임을 밝혔다.

• Journal of Convergence for Information Technology
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• v.9 no.6
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• pp.211-217
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• 2019

In this study, the change of skin condition was analyzed by skin analysis equipment using scrub cosmetics, and the morphological characteristics of microbead were observed by dermascope and scanning electron microscope. In the dermascope observation, during the process of cleansing, the microbeads attached to the skin existed in close contact with each other or dispersed. The skin after scrubbing was clean and smooth and the fine wrinkles between epidermal keratinocytes were reduced. In the scanning electron microscopic observation, the microbead surface did not have severe bending or rough surface. The skin moisture and oil content were higher than the scrub skin before the scrub, and there was no significant difference in the pH.

• The Journal of the Convergence on Culture Technology
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• v.3 no.3
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• pp.37-42
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• 2017

We are designed to control the lipoid variation of the structure system with the stratum corneum on the skin. The skin structure is consisted of a morphology how to use the lipoid component, and the given skin structure is consisted of the mechanical shapes of the intercellular route and transcellular route, and is confirmed to control the variation state of the structure capacity. The skin impedance is appeared to result the value of measurement such as shapes of ${\lambda}-Lip-RSC$, ${\lambda}-Lip-RSL$, ${\lambda}-Lip-CSG$, ${\lambda}-Lip-CSS$ and ${\lambda}-Lip-RSB$. The condition is showed to the alteration difference value of the intercellular route and transcellular route. And, composition condition is established to separate the division parts for conversion system that is constructed with the alteration modeling. We will be possible to progress the improvement effectiveness of the continuous skin control system on the skin.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2000.05a
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• pp.387-388
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• 2000

어류는 엷은 피부를 경계로 하여 체액과 삼투압의 차가 있는 수중에서 생활하고 있다. 다른 척추동물과 달리 표피의 살아있는 세포가 직접 외부 환경과 접촉하고 있으며(Hawkes, 1974), 그로 인해 겪게 되는 삼투압의 불균형과 환경적인 유해성분 등에 직면하게 되기 때문에 여러 가지 형태의 특이한 구조를 갖고 있다. 어류 피부계의 미세구조에 대한 연구로는 Brown and Wetting(1970), Zaccone(1983), Jeong and Moon(1994), Lee and Kim(1999) 등의 보고를 들 수 있다. 본 연구는 저서 정착성 어류인 넙치 피부 상피층의 조직학적 관찰을 통하여 추후 이들 어류의 생활환경 및 생리적 변화와 관련된 피부계의 변화양상에 관한 연구의 기초자료를 제공하고자 하였다. (중략)

• The Journal of Dong Guk Oriental Medicine
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• v.6 no.1
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• pp.117-128
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• 1997

Abdominal skin tissues of ICR mouse painted with Dinitrochlorobenzene (DNCB) were observed to investigate the delayed type hypersensitivity of skin by chemical allergen as hapten. The abdominal skin tissues were obtained at hour 48 after secondary DNCB sensitization that were stained by Luna's method for mast cell, and immunohistochemical stain method for IL-2 receptor. The superficial perivascular lymphocytic aggregation were shown in basement membrane after DNCB secondary painting and the large size capillaries in dermis were appeared. The infiltration of lymphocyte to epithelium, the vacuolation of epithelial cell and intercellular space were increased. The number of mast cell in dermis was increased and these shape is degranulation type. The number of IL-2 receptor positive cell was increased in dermis. As results indicated that the hypersensitivy of immune system were induced by DNCB, subsequently to damage evoke inflammation in skin.

• 한국패션뷰티학회:학술대회논문집
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• 2005.05a
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• pp.17-18
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• 2005

• Korean Journal of Ichthyology
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• v.21 no.2
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• pp.87-92
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• 2009

Histological investigation of seasonal changes of the mucus cells of ricefield-dwelling mud loach Misgurnus mizolepis was carried out on the skin in three regions of the fish: dorsal, lateral, and occipital. Although there were no significant differences in general morphology, the mucus cells of the epidermis showed a severe change in size and number by skin region. The density of the mucus cells was generally the highest in winter and the lowest in summer in all three skin regions. In particular, during two distinct periods, March to April when water is supplied to the ricefields, and August to September when the ricefields become dry after harvest, showed that the change in density and distribution of the mucus cells in both lateral and occipital regions is greater than during any other period. Moreover, the mucus cells for the dorsal and occipital regions temporally increased in size in June during the period of the highest water temperature of the year. Therefore, we may consider these seasonal changes as part of a protective adaptation to overcome extreme environmental conditions and to increase uptake of oxygen by cutaneous respiration.