• Proceedings of the Korea Information Processing Society Conference
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• 2010.11a
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• pp.697-700
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• 2010

피부 이미지의 여러 가지 특징들 중 주름은 피부의 상태를 판단하는 중요한 요소이다. 따라서 주름을 추적하기 위해 확대경으로 촬영된 원본 이미지에서 질감 대비 증가, 노이즈 제거 등의 전처리 과정을 수행한 후 Watershed 알고리즘을 이용하여 주름을 선분으로 표현하였다. 이렇게 생성된 주름의 깊이, 너비, 길이 등은 피부 분석 시 특징 정보로 이용할 수 있다. 또한 주름과 주름이 연결되어 이루는 다각형을 논문에서는 셀(Cell)이라고 정의하는데 그것의 크기나 개수 같은 정보도 추출할 수 있게 된다. 그러나 주름으로 만들어진 셀들은 실제와 다르게 과분할 되는 경향을 보인다. 과분할 된 셀들은 잘못된 정보를 제공하기 때문에 피부 상태를 판단하는 결과의 정확도를 떨어뜨린다. 본 논문에서는 이러한 문제점을 인지하고 차후 정확한 셀 정보를 획득하기 위한 확장성 측면에서 각 셀들을 개체화시키고 과분할 된 셀을 검출하는 방법을 제안한다.

• Journal of Advanced Navigation Technology
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• v.24 no.2
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• pp.148-154
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• 2020

Wrinkles are one of the main features of skin aging. Conventional image processing-based wrinkle detection is difficult to effectively cope with various skin images. In particular, Wrinkle extraction performance is significantly decreased when the wrinkles are not strong and similar to the surrounding skin. In this paper, deep learning is applied to extract wrinkles from microscopic skin images. In general, the microscope image is equipped with a wide-angle lens, so the brightness at the boundary area of the image is dark. In this paper, to solve this problem, the brightness of the skin image is estimated and corrected. In addition, We apply the structure of semantic segmentation network suitable for wrinkle extraction. The proposed method obtained an accuracy of 99.6% in test experiments on skin images collected in our laboratory.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.32 no.2 s.57
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• pp.123-127
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• 2006

In this study, we evaluated the crow's fret of 95 Korean female by using mechanical assessments; Skin-Visiometer SV 600 and Dermascan C. Transparency profilometry (Skin Visiometer) were using a very thin skin print which allowed parallel light to pass through and was analysed immediately after production. High-frequency (20 MHz) ultrasonography (Dermascan C) enabled non-invasive evaluation in skin thickness and echodensity. We found a correlation between skin roughness and dermal density. Particularly, we showed a significant correlation between skin roughness (R2) and dermal thickness. Also, we demostrated a significant negative correlation between dermal density and dermal thickness (p < 0.05). Therefore, the ultrasonography system might be considered a very useful method in wrinkle evaluation with the transparency profilometry. Further study will be required.

• Proceedings of the Korean Society of Computer Information Conference
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• 2023.01a
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• pp.365-368
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• 2023

본 논문에서는 타블렛을 이용해 사용자로부터 주름 스케치를 입력받아 피부 패턴을 고려한 사실적인 얼굴 주름을 생성 할 수 있는 인터페이스를 제안한다. 주름을 생성하고 싶은 모델의 normal map에 간단한 스케치를 하면 해당 모델의 피부 패턴을 고려해 스케치를 주름으로 생성해준다. 또한, 얼굴 부위별 주름 형태를 분석하여 부위별 생성되는 주름의 형태가 다르고, 나이 설정을 통해 나이에 맞는 잔주름 및 주름 형태를 변형 한다. 본 논문에서 제안하는 방법을 이용한 주름 생성 방식은 주름에 대한 자세한 지식이 없는 사용자라도 간단한 스케치만 한다면 자동 계산을 통해 실시간으로 주름을 생성해주며, 얼굴 패턴에 따른 사실적인 주름이 생성되는 결과를 보여준다.

• Applied Microscopy
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• v.41 no.2
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• pp.129-137
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• 2011

The aim of this study was to evaluate the inhibitory effect of nude pack containing black tea water extract (NPBT) on skin wrinkle formation in hairless mice. Skin wrinkles were induced by UVB irradiation to the backs of hairless mice for 5 weeks. And at the same time, NPBT was applied topically. Wrinkle formation, histological changes, expression of matrix metalloproteinase-3 (MMP-3) and protein activities of MMP-2 and MMP-9 were observed or analyzed. Wrinkles for the control group were formed as a pattern of deep furrows and thick crests. Whereas wrinkles for the NPBT treated group were formed as a pattern of shallow furrows and thin crests, and their wrinkle areas were significantly (p<0.001) lower than the control group. Collagen fibers were arranged irregularly and sparse in density and some elastic fibers were degenerated in the control group, while they were almost intact in the NPBT treated group. MMP-3 mRNA expression in the control group was significantly (p<0.001) higher than the normal group, and that of NPBT treated group was significantly (p<0.001) lower than the control group. The NPBT treated group showed remarkably lower protein activities of MMP-2 and MMP-9 than the control group. NPBT could have a considerable inhibitory effect on skin wrinkle formation in hairless mice.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.35 no.4
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• pp.317-323
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• 2009

Chronic exposure of solar ultraviolet (UV) light to human skin results in photoaging with wrinkle formation. This study was performed to investigate anti-wrinkle effects of Lindera obtusiloba extract (LO) on UVB-induced wrinkle formation. We first measured cell proliferation and type I pN collagen synthesis activities in normal human dermal fibroblasts. Cell proliferation and type I pN collagen synthesis were increased by 33.8 % and 91.8 %, respectively, compared with no treatment control. SKH-1 hairless mice were topically applied 5 % LO solution for 10 weeks with UVB irradiation three times a week. After 10 weeks, a visual assessment and replica assay were performed on each mouse. According to visual assessment of close-up photos and skin replica, application of 5 % LO solution inhibited UV-induced wrinkle formation in mouse skin as compared to the vehicle-applied control mice. These results indicated that LO could protect skin wrinkle formation caused by chronic photo-irradiation in hairless mice.

• The Korean Journal of Food And Nutrition
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• v.28 no.6
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• pp.941-946
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• 2015

Photoaging is the main extrinsic aging factor that is induced due to UVB. Many studies have revealed that application of hyaluronic acid to the skin is effective in healing photoaging. However, the effect of hyaluronic acid through oral administration is unclear. The aim of this research was to investigate the effect on skin photoaging after oral administration of hyaluronic acid. During a ten week study, hyaluronic acid was fed to hairless mice, which were illuminated by UV radiation. After ten weeks, wrinkle indicator and histological changes were determined. Compared with the control group, the sample group had a decrease in wrinkle depth, thickness, and number. Especially, the HA 160 mg/kg group had a similar value of wrinkle depth ($19.44{\pm}0.75{\mu}m$), number ($654.00{\pm}98.34$), and thickness ($1.35{\pm}0.08mm$), when compared with the RA (retinoic acid) group ($19.28{\pm}0.95{\mu}m$, $653.57{\pm}83.54$, and $1.34{\pm}0.07mm$ respectively). Also, the treated group showed improved elastosis and decreased collagen degradation resulting from UV irradiation. Thus, we can conclude that hyaluronic acid has a positive effect in improving skin photoaging induced by UV radiation. Hyaluronic acid therefore has the potential to be an ingredient in skin health function foods.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.34 no.4
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• pp.303-309
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• 2008

Deficiency of collagen regeneration, denaturalization of elastic fibers, and promotion of reactive oxygen species formation are important factors for deterioration of skin function. They induce wrinckle formation and decrease skin elasticity. Vitamin C and its derivatives have been used as cosmetic ingredients for anti-aging effects but their chemical instability has been a major problem. In an attempt to develop a novel anti-aging agent with a improved stability and bioactivity, the anti-wrinkle effect of 3-O-cetyl-L-ascorbic acid (VCCE), a new vitamin C derivative, was investigated in this study. VCCE increased procollagen type-1 synthesis in a dose-dependent manner (149% at 0.002%) in cultured fiboroblasts. Its potent anti-wrinkle effect was confirmed in vivo by analyzing human skin replica by a visiometer and the PRIMOS system. It did not cause any irritation in human patch test. Taken together, our findings suggest that the VCCE has potential benefits applicable to cosmetics for anti-wrinkle effects.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.3
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• pp.259-266
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• 2018

In today's society, where people look younger than their chronological age due to improvements in the quality of life, there is a gaining interest in anti-aging and how people compare to those in the same age group. We evaluated the wrinkle index, which is the most important attribute amongst skin parameters, to evaluate external age (wrinkle age). The wrinkles of the whole face were scored by divided 8 areas (forehead, glabella, nasal root, upper eyelid, lower eyelid, crow's feet, nasolabial groove and perioral skin) and analyzed the correlation between chronological age and skin parameters. 206 subjects (Korean female, n = 105 and Mongolians female, n = 101) were enrolled. Subjects were divided into four groups by ages: 20s, 30s, 40s, and 50s. Wrinkle scores of 8 areas were evaluated and developed a calculation formula based on the wrinkle scores. Skin characteristic parameters were measured about skin elasticity, pore, wrinkle, sebum secretion. There was no difference between the calculated ages and the chronological ages in Korean women. On the other hand, Mongolian looked older than chronological age by 9 years. The correlation between the facial wrinkle ages and skin physiology parameters was presented in the order of skin elasticity > pore or crow's feet > skin tone > sebum secretion in both countries. Skin elasticity represented the most related parameter with the facial wrinkle ages. This study identified the skin wrinkle patterns of Korean and Mongolian women and the wrinkle age calculation formula developed from this study can be used as a tool for calculating the facial wrinkle ages in cosmetic studies.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2021.04a
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• pp.12-12
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• 2021

최근 길어진 여름 및 이상고온 현상이 지속됨에 따라 심화되는 광노화 피부의 특징으로는 건조, 굵고 깊은 주름, 탄력저하 및 불균일한 색소침착 등이 나타나게 됨. 화장품 소재는 기존 광노화 관련 화학물질인 Retinol 등을 대체하기 위해 자연 유래 성분을 적용한 신소재 연구를 진행하고 있음. 흰목이버섯(Tremella fuciformis)은 흰목이목에 속하는 버섯류로 자실체는 한천질로서, 주름이 되어 갈라져 있거나 또는 귓불 모양을 이루고 있으며, 크기는 10 cm 정도이다. 중국에서는 보양식의 주재료로 쓰일 만큼 탁월한 항노화 효능이 알려져 있다. 본 연구에서는 흰목이버섯의 자실체에서 추출하여 정제한 β-Glucan의 성분 확인, in vitro 수준의 피부 항노화 효과, 동물대체 독성 시험을 통한 피부독성 확인 및 인체 피부유효성 평가를 통한 항노화 효과를 확인하였다. 흰목이에서 추출, 정제 후 Bio-LC를 통한 유리당 분석 결과 Mannose, Fucose, Glucose를 확인하였으며, Human Keratinocyte에 UVB를 조사하여 광노화를 유발한 피부세포에 피부 자극 및 탄력저하 인자인 IL-6, TNFa 및 MMP-1을 평가한 결과 농도 의존적으로 현저히 개선됨을 확인하였다. 또한 보습 및 피부장벽 개선 인자인 Filaggrin과 Involucrin 생성효능을 평가한 결과 매우 높이 생성됨을 확인하였다. 본 연구결과를 토대로 광독성, 피부감작성 및 안점막 동물대체 독성시험을 실시한 결과 무독성임을 확인하여 피부에 안전하면서 효능이 우수한 것을 in vitro 수준에서 확인하였고, 피부 홍반완화, 주름개선, 탄력개선 및 보습증가 등 광노화 예방효과를 인체를 대상으로 평가한 결과 유의적인 홍반완화, 주름개선, 탄력 및 보습증가효과를 확인하였다. 본 연구결과를 종합하여 볼 때 흰목이버섯에서 추출, 정제한 β-Glucan은 in vitro 수준에서 자외선으로 인한 피부 트러블 완화, 탄력 및 보습개선을 확인하였고 독성시험을 통해 무자극임을 판정하였으며, 인체유효성 평가를 통해 광노화 예방효과를 확인하였으며 본 결과를 통해 아시아 및 글로벌 시장으로 천연유래 항노화 소재로 확장하고자 한다.