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Anti-wrinkle Activity of Lindera obtusiloba Extract  

Park, Keum-Ju (R&D Center, Jung San Biotechnology Co., Ltd.)
Park, Seung-Hee (R&D Center, Jung San Biotechnology Co., Ltd.)
Kim, Jae-Ki (R&D Center, Jung San Biotechnology Co., Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.35, no.4, 2009 , pp. 317-323 More about this Journal
Abstract
Chronic exposure of solar ultraviolet (UV) light to human skin results in photoaging with wrinkle formation. This study was performed to investigate anti-wrinkle effects of Lindera obtusiloba extract (LO) on UVB-induced wrinkle formation. We first measured cell proliferation and type I pN collagen synthesis activities in normal human dermal fibroblasts. Cell proliferation and type I pN collagen synthesis were increased by 33.8 % and 91.8 %, respectively, compared with no treatment control. SKH-1 hairless mice were topically applied 5 % LO solution for 10 weeks with UVB irradiation three times a week. After 10 weeks, a visual assessment and replica assay were performed on each mouse. According to visual assessment of close-up photos and skin replica, application of 5 % LO solution inhibited UV-induced wrinkle formation in mouse skin as compared to the vehicle-applied control mice. These results indicated that LO could protect skin wrinkle formation caused by chronic photo-irradiation in hairless mice.
Keywords
Lindera obtus; loba extract; anti-wrinkle; ultra violet; free radical;
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Times Cited By KSCI : 5  (Citation Analysis)
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