• 건강소식
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• v.17 no.8 s.177
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• pp.48-50
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• 1993

• 건강소식
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• v.27 no.7 s.296
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• pp.12-13
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• 2003

• 건강소식
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• v.20 no.8 s.213
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• pp.16-17
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• 1996

• 건강소식
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• v.2 no.9 s.12
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• pp.18-19
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• 1974

• 건강소식
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• v.25 no.12 s.277
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• pp.36-37
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• 2001

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.4
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• pp.447-453
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• 2018

Acetyl hexapeptide 8 (AH8) is a synthetic peptide for anti-wrinkle cosmetics ingredient. It was developed as a mimetic of botox, patternd after N -terminal end of the protein synatosomal-associated protein 25 (SNAP25), a substrate of botulinum toxin. While AH8 has good efficacy and safety profiles, the permeation through the skin is poor. Therefore, we tried to enhance the transdermal delivery of AH8 by using of hyaluonic acid (HA), a linear polysaccharide of N-acetyl glucosamine and glucuronic acid. To investigate the effect of HA on AH8 penetration, we analyzed paraffin sections of $Micropig^{(R)}$ skin. Fluorescence labeled AH8 was applied to micropig skin with or without HA. The absorption of AH8 was limited to the stratum corneum (SC) without HA. On the other hand, AH8 penetrated to the dermis with HA. Especially, low molecular weight HA (5 kDa) was most efficient compared to 500 kDa HA and 2000 kDa HA. Experiments using fourier-transform infrared (FTIR) spectroscopy revealed that lower molecular weight HA had a tendency to increase the fluidity of the SC lipids more, which means enhancing the skin penetration. Therefore, HA could be expected to enhance the anti-wrinkle effect of AH8.

• 건강소식
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• v.22 no.11 s.240
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• pp.19-19
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• 1998

• 건강소식
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• v.4 no.12 s.38
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• pp.42-44
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• 1976

• Proceedings of the Korean Society for Food Science of Animal Resources Conference
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• 1999.06a
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• pp.171-183
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• 1999

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.158-165
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• 2017

The purpose of this study is to provide basic data for increased understanding of detailed customer needs by age group, and also to improve customer satisfaction. The survey was conducted from August $30^{th}$ to September $15^{th}$, 2017. The poll was conducted with 302 persons aged from 20's to 50's by using convenience-sampling method and self-administration method for survey. The results were analyzed by frequencies, independent sample t-test, Pearson correlations, and through multiple regression analysis. The study results are briefly summarized as follows. First, the overall age group's interest of hand's health was robustly high. Second, in the 20s and 30s age groups hand care interest and self-hand care (r=.284, p<.01) increased with improved hand health condition. In the 40s and 50s age groups there were positive correlations between hand health condition and Information recognition(${\beta}=.246$, p<.1), Product use(${\beta}=.312$, p<.05), and Professional Hand Care(${\beta}=.354$, p<.000). This study indicates that hand care concern and management behaviors change with age. Therefore, further research and more specific follow-up are required for improvement of the awareness of healthy hands.