• Archives of design research
• /
• v.15 no.2
• /
• pp.147-156
• /
• 2002

As our country holds 2002 Korea-Japan FIFA World Cup, more foreigners are visiting Korea, making the tourist industry more profitable. Under these circumstances, we should pay attention to the restroom as a public facility, and inspire the awareness in the Korean people to improve the public restrooms. However, according to KNTO(Korea National Tourist Organization), it has turned out that foreign tourists are still dissatisfied with dirty restrooms and poor signposting when they visit Korea, Though the number of restrooms has been increased, they are not properly managed being a public nuisance due to negligence of administration and straggling facilities. To make it worse, poor design of restrooms and insufficient consideration of handicapped person bring disgrace on Koreas tourist administration. While studies on restrooms began from the 1980s, it has placed too much emphasis on the space arrangement and facility plan, so we need to pay attention to the traditional design and environment aspect of restrooms. This study is 1 haute looked into the problems and actual conditions of restrooms, and based on these data, applied Korean Buddhist architecture style to restrooms to create a comfortable circumstance in restrooms.

• The Korean Journal of Nuclear Medicine
• /
• v.28 no.3
• /
• pp.331-337
• /
• 1994

In order to develop a $^{18}F$-labelled myocardial perfusion agent(flow tracer) for PET, $^{18}F$-labelled organic ammonium cations were synthesized and evaluated in relation to their biodistribution. Five quaternary organic ammonium compounds were labelled with $^{18}F$ in a side chain with moderate to good yields by direct introduction of $^{18}F$-fluoride. Radiochemical yields have been achieved in 30-40min by the precursors (tosylates) in dimethylsulfoxide 15-60% (decay corrected). The reaction was found to be autocatalyzed. A remote controlled procedure was developed in these synthesis. $^{18}F$-Labelling and HPLC-purification of com-pounds needed about 60 min(Yield; 7-20%). Up to now the two compounds N-4-[$^{18}F$]fluorobutyl-pyridinium cation(1) and N, N dibenzyl-4(2-[$^{18}F$]fluoroethyl)piperidinium cation(2) were investigated in relation to their biodistribution in mice. Compound 1 showed at 1 min post injection the high uptake of 19.22% ID/g organ in the myocardium but a following fast decline to 1.12% ID/g organ after 40min. Uptake of compound 2 was after 1min in the heart 5.90% ID/g organ but after 40min at the relative high value of 4.33% ID/g organ. Heart:blood ratio for compound(1) at 1 min was 8.3, at 40 min 2.6 for compound II 2.0(1min) and 15.0(40 min). As data of compound 2 showed greater heart uptake, slower myocardial release, and higher heart: blood ratios, compound 2 is a good candidate for further evaluation.

• Journal of Digital Convergence
• /
• v.9 no.5
• /
• pp.55-63
• /
• 2011

The purpose of this study is analyzes the violate behavior the Parking Area for the handicapped and monitor the management problem, therefore presents the improvement alternatives of it. We use the field interview survey method by visiting the government office of cities of 16, commercial facility, housings, medical centers, cultural and sports facilities, express highway rest area. We visited the 50 places and interviewed the 227 violating persons. As a result, violate behavior is divided into the not attachment of sticker on parking possibility and not accompaniment with walking disabled person. We presented the improvement alternatives for the lawful usage of the parking area for the handicapped. First, We have to magnify a recognition and a advertisement about the parking area for the handicapped. Second, We have to improve a management of expense, manpower and civil complains, etc. We have to prepare the legal revision which strengthens the concrete punishment for a violate behavior improvement.

• The Korean Journal of Mycology
• /
• v.39 no.3
• /
• pp.249-253
• /
• 2011

Cetecol has been known as a component of melanin in teliospores of the corn smut fungus Ustilago maydis. Its metabolic precursor has been assumed to be benzoic acid but it has not been proven yet. This study was carried out to verify the synthesis of benzoic acid and to chase its metabolic origin in U. maydis. For this aim, the catabolic process of phenylalanine was investigated by culturing the fungus in the complete medium containing L-$^{14}C$-phenylalanine and $^{14}C$-trans-cinnamic acid. We detected trans-cinnamic acid, benzoic acid, 4-hydroxybenzoic acid and hydroxybenzoic acid derivatives from the extracts of the fungus cells and cultural filtrates by thin layered chromatography analysis. We also observed that the fungus could completely catabolize L-$^{14}C$-phenylalanine and produce $^{14}CO_2$ in the air. Conclusively, this study provided an evidence that U. maydis could produce benzoic acid through catabolic process of phenylalanine.

• Fire Science and Engineering
• /
• v.30 no.5
• /
• pp.36-45
• /
• 2016

Integral fire shutters are installed indiscriminately, regardless of evacuation. There is always the risk of an accident because integral shutters are applied mainly to corridors, passages, and stairs of schools This study evaluated the problem of integral shutter's entrance, evacuation, construction management, and maintenance control through a fire shutter accident case, including present condition of fire shutter installed at school of Okgil, Bucheon and Dongtan, Hwaseong. The results suggest that emergency lighting or signs for passage be set up to check location of entrance easily and install obstruction sensors at fire shutter to reduce life damage. In addition, the number of efficiency tests of fire shutters should be increased by running a trial test monthly or weekly to maintain the performance of fire shutter. Schools need to install a fire shutter- applied sprinkler at the entire floor.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.39C no.6
• /
• pp.466-475
• /
• 2014

The IVEF service is the draft standard designed for exchange of information on sea traffic between the vessel traffic systems and between the vessels. Standardization of this service is under way as a part of the next-generation navigation system, called e-Navigation. The International Association of Lighthouse Authorities (IALA) suggests, on its recommendation V-145, the IVEF service model and the protocol for provisioning of this service. But the detailed configuration of this service must be designed by the users. This study suggests, based on the basic service model and protocol provided in the recommendation V-145, the implementation of the J-VTS middleware which will facilitate exchange of information on sea traffic. The J-VTS middleware consists of various components for providing the IVEF service and for processing the IVEF message protocols. The vessel traffic systems and the vessels corresponding to upper-layer applications may use the IVEF service with the functions provided by the J-VTS middleware, and the services are designed to be accessed according to the security level of users.

• Investigative Magnetic Resonance Imaging
• /
• v.14 no.2
• /
• pp.139-144
• /
• 2010

Enteric duplications associated with the pancreas are especially uncommon, and the differential diagnosis of pancreatic duplication cysts is often difficult, and may be confused with various cystic lesions of the pancreas. We report a case of pancreatic duplication cyst; present the images and laboratory findings including cyst fluid tumor markers. MR and MRS findings enabled the detection of the location, contour, characteristics of cystic fluid and definition of tissue planes between the lesion and adjacent structures, providing useful information for an accurate surgical approach.

• YAKHAK HOEJI
• /
• v.52 no.5
• /
• pp.331-344
• /
• 2008

Recently, the FDA (Food and Drug Administration) of the United States and many advanced countries remark biomarkers and surrogate endpoints as a critical path tool on model based drug development. Economic, technical and social profit on model based drug development like a reduction of the length of research and development have been achieved. Therefore we summarize previous studies about biomarkers and surrogate endpoints and suggest a development direction of therapeutic agents. In diabetes mellitus (DM) and osteoporosis, there are remarkable increases in number of patients and most of patients take medicine during their whole lifetime. For this reason, many patients with DM and osteoporosis have a tolerance on their medicine. We expect that research and development on biomarkers and surrogate endpoints will contribute to new drug development on DM and osteoporosis. Biomarkers for DM are blood levels of glucose, insulin, ${HbA}_{1c}$, CRP, alpha-glucosidase, adiponectin and DPP-4. Among these, validated surrogate endpoints for DM are blood levels of glucose, insulin and ${HbA}_{1c}$ Biomarkers for osteoporosis are BMD, BMC, trabecular volume, ICTP, DPD, osteocalcin, the activity of osteoclast and production of osteoblast. The validated surrogate endpoints for osteoporosis are BMD only. This review summarizes all suggested biomarkers and surrogate endpoints in DM and osteoporosis. The biomarkers are classified by drugs, and the method of validation for surrogate endpoints is suggested. This information would contribute to suggest a direction of DM and osteoporosis therapeutic agent development.

• YAKHAK HOEJI
• /
• v.54 no.2
• /
• pp.75-90
• /
• 2010

Biomarkers are likely to be important in the study of various pulmonary diseases for many reasons. Research efforts in developing biomarkers and surrogate endpoints of lung diseases have resulted in the identification of new risk factors and novel drug targets, as well as the establishment of treatment guidelines. Government agencies, academic research institutions, diagnostic industries, and pharmaceutical companies all recognize the importance of biomarkers in new drug development and advancing therapies to improve public health. In drug development, biomarkers are used to evaluate early signals of efficacy and safety, to select dose, and to identify the target population. Identification of suitable end points not only would help investigators design appropriate clinical trials but would assist clinicians in caring for this patient population. Though the area of pulmonology has received much attention in the past decades, it still lags behind with regard to the development of biomarkers, particularly those of health effects and susceptibility. This review critically summarized several biomarker researches such as Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study with objectives of identifying the parameters that predict disease progression of COPD, as well as biomarkers that may serve as surrogate end-points.

• Journal of Gastric Cancer
• /
• v.3 no.2
• /
• pp.104-111
• /
• 2003

Purpose: The prognostic significance of peri-operative serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA)19-9 determination in patients with gastric cancer has been controversial. This study was performed to evaluate the significance of CEA and CA19-9 as clinical predictors of prognosis. Materials and Methods: The correlations between peri-operative serum CEA/CA19-9 levels and clinicopathologic factors were evaluated retrospectively in gastric cancer patients who had undergone curative surgery during the period from January 1995 to December 1998 at the Department of Surgery, Yonsei University College of Medicine. Results: The positive rates for CEA and CA19-9 were $17.9\%$ and $18.4\%$, respectively. The CEA positivity was related to the depth of invasion (P=0.040), lymph-node metastasis (P=0.000), and stage (P=0.001). The CA19-9 positivity was significantly related to the depth of invasion (P=0.000), lymph-node status (P=0.000), and stage (P=0.000). The positive rate of combined assay of pre-operative CEA and CA19-9 was $30.0\%$ There were statistically significant correlations with stage, depth of invasion, or degree of lymphnode metastasis in the combined assay. The survival rates according to the positivity of CEA and to the positivity of CA19-9 were clearly different (P=0.000). Conclusion: It should be stressed that even a simple blood test prior to surgery could be useful in establishing the depth of invasion, the status of lymph-node involvement, and the prognosis. For improved survival, an aggressive lymphadenectomy and adjuvant chemotherapy should be considered for patients with positive levels of pre-operative CA19- 9.