• Tuberculosis and Respiratory Diseases
• /
• v.65 no.2
• /
• pp.137-141
• /
• 2008

We treated synchronous double primary lung cancers, where one site resulted from CIS disease, with lobectomy and argon plasma coagulation (APC) in a patient who couldn't tolerate pneumonectomy, which resulted in a reduction of the extent of surgery. APC could be a reasonable alternative for CIS disease of lung in inoperable patients.

• Tuberculosis and Respiratory Diseases
• /
• v.46 no.5
• /
• pp.674-684
• /
• 1999

Background : It has been generally known that the incidence of lung cancer is higher in the patients with idopathic pumonary fibrosis (IPF) than those in general population. The reported incidence was variable from 4.8 to 43.2%. There were controversies on the most frequent cell type (squamous cell carcinoma vs. adenocarcinoma) and no study was done about the real concordance of cancer and the fibrotic lesion. And the pulmonary fibrosis may influence not only the development of cancer but also the treatment and prognosis of the cancer, but there was no report on that point. Method : Total 63 patients ($66.8{\pm}7.8$ year, M : F=61 : 2) were diagnosed as IPF combined with lung cancer (IFF-CA) at Asan Medical Center. A retrospective analysis was done about the risk factors of the lung cancer, pulmonary function test, the site of cancer(especially the relationship of the cancer with the fibrotic lesion), the histologic types, and the stage of cancer. The histologic types were compared with those of 2,660 patients with lung cancer who were diagnosed at the same institute for the same period. The effect of IPF on the treatment of the cancer was evaluated with the survival time after the detection of lung cancer. Results : The lung cancer was found in 63(22.9%) out of 281 patients with IPF. But in most of them(45 patients), lung cancer was detected at the same time with IPF and only in 18 patients, the cancer was diagnosed during the follow-up($25.2{\pm}17.7$ months) of IPF. So in our study, 6.7% of patients with IPF developed lung cancer during the course of the disease. The age ($66.8{\pm}7.84$ vs. $63.4{\pm}11.1$ years), percentage of smoker (88.9 vs. 67.2%), and the male gender (96.8 vs. 67.6%) were significantly higher in IPF-CA compared with lone IPF (p<0.05). The odds ratio of smoking was 4.7 compared with non smoking IPF controls. The lung cancer was located more frequently in the upper lobe and 55.5% was in the periphery of lung. The cancer was developed in the fibrotic lesion in 23 patients (35.9%), and in the majority of the patients, the cancer was separated from the fibrosis. The cell type of the lung cancer in IPF-CA was squamous cell carcinoma 34.9%, adenocarcinoma 30.2%, small cell carcinoma 19.0%, large cell undifferenciated carcinoma 6.3%, and others 9.5%. No significant difference in the distribution of histologic type of the lung cancer was found between IPF-CA and lone lung cancer. There was no significant difference in demographic features, cell types, location and the stage of the cancer between the group with concurrent IPF-CA and the group with cancer diagnosed during the follow up of IPF. There was a tendency (but statistically not significant : p=0.081) of higher incidence of adenocarcinoma among the cancers developed in the fibrotic area(43.5%) (F-CA) than in the cancers in non-fibrotic area (22.5%) (NF-CA). The prognosis of the patients with F-CA was poor (median survival : 4 months) compared with the patients with NF-CA (7 months, p=0.013), partly because the prevalence of severe IPF (the extent of fibrosis in HRCT 50%) was higher in F-CA group. Conclusion : These data suggest that the lung cancer in the patients with IPF has similar features to the ordinary lung cancer.

• Journal of Bio-Environment Control
• /
• v.16 no.1
• /
• pp.27-31
• /
• 2007

The experiment has investigated the effects of blending rate of waste rockwool in nursery media on growth of Marygold 'Yellow boy' plug seedlings. A commercial plug medium containing 10% zeolite, 10% vermiculite, 5% perlite, 10% peatmoss and 65% cocopeat was used as the control, and the other media compounded with 10% of zeolite, vermiculite, perlite and peatmoss and 10, 30, and 50% of waste rock-wool. There was not significant difference in germination rate ot Marygold between treatments. Plant height, number of leaves, stem diameter and leaf area were higher in commercial plug medium and compound nursery media containing 50% of waste rockwool than 30 or 10% of waste rockwool. Fresh weight and dry weight of shoot and root increased in the treatment of commercial plug medium and the medium of 50% waste rockwool than 10 and 30% of waste rockwool. These results suggested the possibility of utilization of waste rockwool for medium components of plug seedlings.

• Journal of Chest Surgery
• /
• v.36 no.7
• /
• pp.535-538
• /
• 2003

Spontaneous pneumothorax accompanying primary lung cancer is rare and its occurrence as an initial sign of primary lung cancer is much rarer. A few articles on spontaneous pneumothorax accompanying lung cancer have been published in Korea so far. Lung cancers, diagnosed after spontaneous pneumothorax, are usually in advanced stage, so that conservative treatment modalities such as closed tube thoracostomy, chemotherapy, or radiotherapy are the mainstream of the treatment. We experienced a case of local recurrence of primary lung cancer in six months after radical resection and radiotherapy of neoplasm performed immediately after the diagnosis by excisional biopsy of bulla, for which resection and pleurodesis had been done under the impression of spontaneous pneumothorax. In this paper, we report the case and follow-up observation of the patient.

• Journal of Chest Surgery
• /
• v.34 no.5
• /
• pp.377-385
• /
• 2001

배경: Cisplain과 같은 세포돗성 약제에 대한 내성은 폐암 치료 실패의 중요한 원인이다. 이러한 항암제에 대한 내성의 발생기전은 복잡하고 아직 완전히 알려져 있지 않지만 불량한 예후의 원인으로 생각된다. 특히 약제 내성이 발생한 환자의 경우 기존의 종양의 급속한 성장뿐 아니라 새로운 전이 병소가 급속히 발생 및 진단됨은 약제 내성을 가진 종양이 전이에의 용이성을 획득하는게 아닌가 의심케한다. 이를 규명하기 위해 Cisplatin에 내성을 지닌 비소세포폐암 세포주 H460/CISm이 전이 능력을 Cisplatin에 민감한 비소세포폐암 세로주 H460과 비교하고자 한다. 대상 및 방법: 약제 내성 세포주를 확보하기 위하여 H460세포에 cisplatin을 점차적으로 증가시켜 처리한 후 배양하였다. H460 세포와 H460/CIS 세로에서의 혈관신생인자와 성장관련인 자의 발현양상, gelatin zymography 분석 그리고 in vivo 실험으로 nude 마우스에서의 자발적 전이 능력의 차이를 비교하였다. 결과: H460 세포를 이식한 마우스에 폐에서는 종양이 형성되지 않았으나 H460/CIS세포를 이식한 마우스 10마리중 8마리에서 종양이 형성되었다. 또한 H460/CIS 세포주에서 전이 관련 유전자로 알려진 angiopoietin-1, vascular endothelial growth factor, basic fibroblast growth factor, matrix metalloproteinase 2 등이 더 발현되었고, 전이의 침습성을 유발하는 gelatinase의 활성이 증가된 것을 확인할 수 있었다. 결론: 본 여구 결과를 통해 cisplatin에 내성을 가진 비소세포폐암세포에서 전이 능력이 증가될 수 있다고 여겨지며 이러한 사실을 토대로 초기 비소세포폐암 환자의 수술 전 항암약물요법의 타당성에 대해서 이야기 하기 위해서는 많은 임상적 연구가 필요하리라 생각된다.

• Horticultural Science & Technology
• /
• v.18 no.1
• /
• pp.33-38
• /
• 2000

This study was conducted in an effort to meet the need for domestic production of hydroponic media and for medium development using recycled hydroponic rockwool slabs. Two experiments were conducted to evaluate the growth of plug seedlings of petunia 'Romeo' in various mixtures including particles of used rockwool slabs (rockwool particles) and wood chips. In the first experiment, seedlings were grown in plugs filled with mixtures of steam- sterilized rockwool particles and chestnut wood chips, which had been weathered for six months and screened through either 2.8 mm or 5.6 mm sieve, at the mixing ratio of 100:0, 75:25, 50:50, 25:75, or 0:100 (v/v). In the second experiment, seedlings were grown in plugs filled with twenty different mixtures of steam-sterilized particles of used hydroponic rockwool slabs with 4 mm chestnut or pine wood chips, coir, peatmoss, or perlite. In the first experiment seedling growth was not affected by particle size of chestnut wood chips, was superior in the control (commercial plug medium) and in 100% rockwool particles, but was suppressed as mixing ratio of chestnut wood chips increased. In the second experiment, leaf length, and shoot fresh and dry weights were the greatest in rockwool particles+peatmoss+coir treatment, followed by rockwool particles+peatmoss treatment. Leaf length was suppressed as ratio of wood chips increased, especially of chestnut wood chips. Root development was the greatest in rockwool particles+peatmoss+perlite treatment, followed by the control, and rockwool particles+peatmoss+coir treatment. The growth was suppressed as the mixing ratio of rockwool particles, peatmoss, or coir decreased.

• The Korean Chronic Disease News
• /
• no.320
• /
• pp.1-17
• /
• 2007

전국 지자체 보건사업 종합평가/"생활습관병 퇴치 정책도입 필요"/고혈압.당뇨병환자 직접 등록관리/'방문건강관리'로 고혈압 관리율 향상/세계폐암학회, 담배 판매 금지 촉구/"폐암 진단 기준 세분화된다"/세계폐암학회 2007년 담배규제선언문/서울대병원, 브랜드 경쟁력 1위/세브란스병원 국제적으로 인증/충남도청 이전지에 '건양대학병원' 설립/55세 이상 남성... 5%가 전립선암/"순한 담배가 선암성 폐암 일으킨다"/골다공증 척추골절, 직접성형 96% 만족/건강투자전략의이해/"살기 좋은 웰빙 도봉"-도봉구보건소/"생각이 바뀌면 운명이 달라진다"

• Proceedings of the Korean Society of Computer Information Conference
• /
• 2020.01a
• /
• pp.27-28
• /
• 2020

본 논문에서는 초음파 영상의 통계적 특징벡터를 활용하여 폐암 분류를 제안한다. 폐암의 초음파 사진들을 비교 분석하여 각각의 label에 맞는 feature vector를 선별한다. 선택된 feature vector는 SVM을 이용하여 훈련 시킨 후, 최종적으로 폐암을 구별한다.

• Tuberculosis and Respiratory Diseases
• /
• v.56 no.6
• /
• pp.646-656
• /
• 2004

Background : The aim of this study was to elucidate the mediastinal lymphatic drainage of nonsmall- cell lung cancer (NSCLC). Methods : We retrospectively analyzed the frequency of enlarged mediastinal lymph node (LN) in 256 NSCLC patients with N2 or N3 diseases on CT scan, especially with respect to the location of primary tumor. Results : In 57 patients with right upper lobe (RUL) tumors, right lower paratracheal LN (89.5%) was the most commonly enlarged, followed by subcarinal LN (54.4%). In 61 patients with left upper lobe (LUL) tumors, left lower paratracheal (70.5%) and subaortic LNs (52.5%) were commonly enlarged. Subcarinal LN enlargement without ipsilateral superior mediastinal LN enlargement was rarely found in both upper lobe tumors; RUL 8.8%, LUL 6.6%. In patients with right or left lower lobe (RLL or LLL) tumors, the most commonly enlarged LN was subcarinal; 88.2%, 65.7%, respectively. In RLL tumors with both subcarinal and superior mediastinal LN enlargements, the frequency of ipsilateral superior mediastinal LN involvement was similar to that of bilateral superior mediastinal involvement. In LLL tumors with both subcarinal and superior mediastinal LN enlargements, bilateral superior mediastinal involvement was more frequent than ipsilateral superior mediastinal involvement. Conclusion : The results of this study suggest that both upper lobe tumors are mainly drained directly to ipsilateral superior mediastinal LNs, and that both lower lobe lesions are drained to superior mediastinal LN via subcarinal LNs.

• Journal of Chest Surgery
• /
• v.42 no.6
• /
• pp.725-731
• /
• 2009

Background: Lobectomy and more extended anatomic resection are regarded as standard treatment for stage Ia non-small cell lung cancer, but approximately 15~40% of patients suffer from treatment failures such as cancer recurrence or death. The authors analyzed types and causes of treatment failures in surgically treated cases of stage Ia non small cell lung cancer. Material and Method: We retrospectively reviewed the medical records of 156 patients who had undergone complete resection for stage Ia NSCLC between Jan 1992 and Aug 2005. Patients were divided into two different treatment failure groups: cancer-related deaths and non-cancer-related deaths. Risk factors were analyzed in each group by the Kaplan-Meyer survival method and the Cox proportional hazard model. Result: Among the 156 patients, 93 were males; the mean age was 61. The median follow-up period was 33.8 months. The 5 year survival rate was 87.6%. Microscopic lympho-vascular permeation was reported in 10 patients. Recurrence was reported in 19 patients and 12 patients died due to recurrent lung cancer. Noncancer related deaths occurred in 16 patients. Risk factors for cancer recurrence and cancer related death were microscopic lympho-vascular permeation (HR=6.81, p=0.007, HR=7.81, p<0.001); for non-cancer related death, risk factors were pneumonectomy (HR=25.92, p=0.001) and postoperative cardiopulmonary complications (HR=29.67, p=0.002). Conclusion: After complete resection of stage Ia non small cell lung cancer patients, mortality includes not only cancer related deaths but also cancer unrelated deaths. Adjuvant chemotherapy is advised for patients who show microscopic lympho-vascular permeation, which is a risk factor for recurrence and for cancer related death. Patients who had pneumonectomy or who suffered from cardiac or respiratory complications need meticulous care in order to reduce comorbidity-induced death.