• Microbiology and Biotechnology Letters
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• v.39 no.3
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• pp.224-237
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• 2011

For establishing the efficacy against breast cancer occurrence, women's mammographic breast density and hot flush remission related to pre and post-menopausal symptoms were selected as biomarkers. Meta analysis applied the final selection of 40 papers from Medline to assess the efficacy of isoflavone-rich soy or supplements versus placebo under randomized controlled trials. Interestingly, the exposure to the purified isoflavones was more effective than the exposure to the crude extract of soy isoflavones for hot flush suppression. The length and the amount of dosage dependency is the most appropriately suggested to be one year long with 50~100 mg/day of isoflavone-rich soy or supplements. Funnel plots was used to interpret the results, overall effect of isoflavones on breast density in post-menopausal women was revealed to be less effect [effect size: 0.062, 95% confidence interval (CI): 0.005 to 0.12], than that of pre-menopausal women (effect size: 0.101, CI: -0.003 to 0.205). The reason why breast density was found higher among the pre-menopausal than the post-menopausal women is that the phytoestrogens of dietary isoflavones were antagonized against estrogen by the basis of estrogen receptor binding affinity. Overall, the Meta analysis reported that isoflavone had limited influence on breast density by suppressing the expansion by only 2%, while it was more effective to suppressing the hot flush, showing a dramatic decrease of 23%.

• KSBB Journal
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• v.19 no.1
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• pp.83-87
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• 2004

This research was designed to investigate the effects of Estromon including FGF271 (Female Growth Factor 271) which was developed as a phytoestrogen for post- and pre-menopausal syndrome (PMS). The oral administration of two capsules of Estromon twice a day for 3 months significantly improved PMS (Post-/Premenopausal Syndrome) about 5 times more than placebo group (OR=5.04, 95% C.1. 1.40-18.14). In the group of 24 patients having taken Estromon, the concentration of alkaline phosphatase asn the bone marker decreased by -9.3${\pm}$9.5 IU/L after 3 months with a statistic significance. Since the concentration of osteocalcin as the other bone marker also decreased in more patients in Estromon group than in placebo group, the bone density might be expected to be improved in long-term treatment. Serum human growth hormone level increased in 17 out of 24 patients. Triglycerides decreased by -8.0${\pm}$40 (mg%) after 1 month and by -4.4${\pm}$36 (mg%) after 3 months in Estomon group while triglycerides increased in both cases in placebo group (p.0.01). Therefore, PMS patients might benefit from Estromon as a phytoestrogen supplement without any serious side effects.

• Journal of Korean Academy of Nursing
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• v.39 no.6
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• pp.868-877
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• 2009

Purpose: The purpose of this study was to examine the effects of Koryo Hand Therapy (KHT) on menopausal symptoms and hormone levels (Follicle Stimulating Hormone [FSH], Luteinizing Hormone [LH], and estradiol [$E_2$]) in climacteric women. Methods: The research design was a nonequivalent control group pretest-posttest design. Data were collected from November 28, 2005 to February 28, 2006. The 45 participants were assigned to either the experimental group (23) or control group (22). KHT was applied three times a week, for a total of 8 weeks to the women in the experimental group. Results: There was a statistically significant decrease in menopausal symptoms (F=42.49, p=.000), FSH level (F=26.98, p=.000) and LH level (F=5.31, p=.026) between the experimental and control groups. There was an increase of the estradiol level in the experimental group but the difference between the two groups was not statistically significant. Conclusion: KHT can be applied as a supportive nursing intervention to climacteric women. KHT is expected to be a complementary alternative intervention for health management of the climacteric women.

• Women's Health Nursing
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• v.12 no.1
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• pp.29-36
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• 2006

Purpose: The purpose of this study was to investigate postmenopausal women's risk factors and subjective symptoms of coronary artery disease, their knowledge about the risk factors and their performance of health behaviors. Method: The subjects were 285 women aged between 50~60 who had naturally reached menopause. We interviewed them using a questionnaire on the subjects' risk factors of coronary artery disease, their knowledge about the risk factors and their performance of preventive health behaviors. Collected data was analyzed through t-test, ANOVA & Duncan test. Results: Risk factors of coronary artery disease observed in the subjects were diabetes (10.9%), hypertension (22.8%) and hyperlipidemia (14.7%). Symptoms of coronary artery disease were experienced more by those who had diabetes, smoked, had a history of coronary artery disease, and thought that they might have coronary artery disease. With regard to the subjects' knowledge about the risk factors of coronary artery disease, the average score was 13.88 out of 20 points. Conclusion: The results of this study suggest that postmenopausal women have several risk factors of coronary arterial disease but they did not have sufficient knowledge about the risk factors and did not manage the factors appropriately.

• Women's Health Nursing
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• v.12 no.4
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• pp.291-300
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• 2006

Objectives: The purpose of this study was to examine the effects of Koryo Hand Therapy(KHT) on menopausal symptoms and lipid levels in middle-aged women. Methods: The design of this study was a nonequivalent control-group pretest-posttest design. There were 32 subjects, 40-60 years of age, and assigned to two group. There were 16 members in the experimental group and 16 members in the control group. KHT was applied three times a week, for a total of 8weeks to the experimental group. The instruments used in this study to measure the effects of KHT were the menopausal symptoms scale and clinical laboratory testing(Blood Lipid Levels). Data was analyzed by Fisher's Exact Test, Mann-Whitney U-test, and ANCOVA, using SPSS/Win PC 13.0. Results: There was a statistically significant decrease in the menopausal symptoms, and levels of the total cholesterol and LDL cholesterol in the experimental group compared to the control group. Conclusions: KHT was effective in decreasing menopausal symptoms in middle-aged women. Therefore KHT is recommended as a nursing intervention strategy for middle-aged women.

• Journal of the East Asian Society of Dietary Life
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• v.16 no.5
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• pp.533-541
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• 2006

The purpose of this study was to investigate the relation between climacteric symptoms and intakes of various nutrients, phytoestrogens and foods in postmenopausal women. We conducted anthropometric measurements, questionnaire interview and 24hr dietary recall for 3 days in 128 postmenopausal women aged $49{\sim}64$. The subjects were divided into the two groups, NCMS(non climacteric symptoms group) and CMS(climacteric symptoms group), according to the severity of the climacteric symptoms. There were no significant difference in anthropometric measurements, maternal factors(menarche age, menopause age), subjective health status, frequency of exercise, smoking and drinking status between the two groups. The Mg and lignan precusor intakes of the NCMS group were significantly higher than those of the CMS group. Mg, lignan precusor, pulse and seed intakes had negative correlations with the severity of climacteric symptoms. From this study results, Mg, phytoestrogen(especially some lignan) and some food groups like as pulse and seeds may prevent and reduce climacteric symptoms in postmenopausal women.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.1
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• pp.73-84
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• 2015

Purpose: The purpose of this study is to analyze the characteristics of the pulse energy in women who complain of climacteric and menopausal symptoms. Methods: We analyzed the values of pulse energy on 45 climacteric and menopausal women. The patients' symptoms were assessed by Kupperman's index and Menopause Rating Scale (MRS). Statistical analysis was performed using SPSS 18.0 for window program, one way ANOVA, pearson correlation coefficient. Results: The results were as follows. 1. The pulse energy of the Left Chon was significantly largest and Left Cheok was comparatively smallest. 2. There was no statistically significant correlation in the pulse energy of Left Chon minus Left Cheok, Kupperman's index, MRS total sum score. Conclusions: The results suggest that the pulse energy of the Left Chon tends to be increased and Left Cheok decreased in climacteric and menopausal women.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.3
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• pp.269-278
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• 2008

Purpose: The purpose of this study is to report the effect of Traditional Korean Medicine therapy on climacteric symptoms in premature ovarian failure patient. Methods: The patient in this case was 32 years old female. She had a history of the right side ovariectomy and antituberculous chemoteraphy caused by pelvic tuberculosis. And she was diagnosed with premature ovarian failure in October, 2007. She had a climacteric symptoms when she admitted to the OBGY department of Se-Myung University in Je-Cheon. She received Korean Medicine therapies such as herbal medicine, moxibustion, acupuncture. We evaluated patient's health status by Kupperman's index and VAS. Results: After the treatment, the climacteric symptoms in premature ovarian failure patient was improved. Conclusion: This case study shows that Korean Medicine therapies have significant effect on climacteric symptoms in premature ovarian failure.

• Journal of Korean Clinical Nursing Research
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• v.25 no.1
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• pp.15-24
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• 2019

Purpose: The purpose of this study was to investigate relationships among menopausal symptoms, functional status, and distress and to identify factors influencing distress in premenopausal breast cancer patients who had been on endocrine therapy. Methods: A descriptive correlational study was conducted. Data were collected using questionnaires from 140 patients with breast cancer undergoing endocrine therapy at a general hospital. Data were analyzed using descriptive statistics, t-test, ANOVA, Tukey HSD test, Pearson's correlation analysis and hierarchical regression analysis. Results: The mean scores for menopausal symptom, functional status, and distress were $19.65{\pm}7.86$, $2.67{\pm}0.33$ and $3.69{\pm}2.19$, respectively. The menopausal symptoms and distress were positively correlated (r=.76, p<.001). The menopausal symptoms and functional status (r=-.43, p<.001) and functional status and distress (r=-.31, p<.001) were negatively correlated. The most influential factor for distress was menopausal symptoms (${\beta}=.79$, p<.001). Conclusion: Based on the findings of this study, developing nursing intervention programs focusing on decreasing menopausal symptoms and distress are recommended.

• Journal of dental hygiene science
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• v.12 no.2
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• pp.171-179
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• 2012

The aim of this study was to analyze the factors related to whole saliva flow and the xerostomia for the ground use of the materials in developing oral health improvement program and life quality improvement program. So, this study performed a questionnaire survey, targeting at 160 adults, older than 40 years, living in Gyeonggi and Incheon provinces from January to February 2011 and measured unstimulated salivary flow rate and stimulated salivary flow rate. The results are as followings. The group of participants who took gums and candies to relieve oral dryness had low stimulated whole saliva flow. The group of participants who graduated from middle schools, who separated by death, who were not healthy with menopause, and who recognized periodontal disease symptoms and tongue burning sensation recognized more symptoms of dry mouth than others. In addition, the group of participants who were not satisfied with life so much, who couldn't feel the meaning of life, and who recognized negative feelings frequently recognized symptoms of dry mouth more. Women, the group of participants who graduated from middle schools, who suffered from depressive symptoms, and who recognized halitosis had low unstimulated whole saliva flow. The group of participants who graduated from middle schools, who were not satisfied with life so much, who couldn't feel the meaning of life, and who were not satisfied with themselves had low stimulated saliva flow.