• 사상체질의학회지
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• 제17권2호
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• pp.121-128
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• 2005

1. Objectives In the western Medicine, UTI generally bring on fever, and treated by antibotics. In the traditional way of korean Medicine, our predecessors used the herb for the febrile disease that has the property of coldness. However, Lee Je-ma tried to make the Yang ascend with the herb, considering thar the febrile illness in Soeumin is made by the Exterior Heat not ascending. In the aspect of the Sasang Consititutional Medicine(SCM), Hwanggigyeji-tang(황지계지탕(黃芷桂技場)) & Palmoolgunja-tang (팔물군자탕(八物君子湯)) belongs to the kind of the warm medication. This study is reported to evaluate rhe effected of Hwanggigyeji-tang(황지계지탕(黃芷桂技場)), Palmulgoonja tang(팔물군자탕(八物君子湯)) to the febrile patient. 2. methods To heal the febrile patient who was diagnosed as UTI & Soeumin exterior disease, we used soeumin Hwanggigyeji-tang(황지계지탕(黃芷桂技場)), Palmulgoonja tang(팔물군자탕(八物君子湯)). 3. Results This parient's main symptoms are fever, sweating impotently feeling, anorexia. So we treated the patient with Hwanggigyeji-tang(황지계지탕(黃芷桂技場)), (팔물군자탕(八物君子湯)) in ${\ulcorner}$Dongyi Suse Bowon(동의수세보원(東醫壽世保元))${\lrcorner}$ and improved the patient?s symptoms. 4. Conclusions We suggest that Soeumin Hwanggigyeji-tang(황지계지탕(黃芷桂技場)), (팔물군자탕(八物君子湯)) are effective significantly to the patient with febrile illness, bur then we consider that the studies on the case like this are more needed to convince that Hwanggigyeji-tang(황지계지탕(黃芷桂技場)), (팔물군자탕(八物君子湯))are very much effective.

• 사상체질의학회지
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• 제32권2호
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• pp.80-95
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• 2020

Introduction This study is the first case report to observe a significant improvement of clinical symptoms of both Recurrent Aphthous Stomatitis(RAS) and pompholyx treating with modified Palmulgunja-tang for Soeum-type. Case presentation A 37-year-old female patient complained of pain by ulcers on her mouth and tongue, and of itching caused by vesicles on her palms and soles was diagnosed with RAS, pompholyx, and, especially moderate pattern of 'Congestive Hyperpsychotic symptomatology' according to the theory of Sasang Constitutional Medicine(SCM). During inpatient and outpatient treatment, she took modified Palmulgunja-tang, and was treated with acupuncture, moxibustion, and cupping therapy. The effectiveness of these therapies was assessed with subjective Neumeral Rating Scale(NRS) and Dyshidotic Eczema Area and Severity Index(DASI). Conclusion After the treatment according to the theory of SCM, NRS, and DASI score about RAS and pompoholyx was decreased, and the general condition of the patient also has improved.

• 사상체질의학회지
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• 제11권2호
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• pp.377-383
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• 1999

임상에서 가장 빈번하게 당면하는 빈혈의 하나로 여러종류의 만성적 원질환에 동반되는 빈혈이 있다. 이에 본 증례에서 소뇌 출혈이후의 합병증인 폐렴으로 인해 만성 염증성 빈혈이 발생한 환자에서 한방치료에 의해 전신상태 호전과 함께 빈혈이 교정된 증례가 있어 이에 보고하고자 한다. 75세의 여환으로 뇌출혈 후유증으로 인한 두통과 현훈, 보행장애, 연하장애, 전신무력감으로 본원 내원하였으며. 내원당시 혈액학 검사상 normocytic normochromic anemia 소견을 보이고 있었다. 이를 소음인 울광증으로 변증하고 승양익기의 치법에 준하여 팔물군자탕을 투여한 결과 전신증상의 호전과 빈혈의 치료를 확인하였다.

• 대한한방부인과학회지
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• 제23권4호
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• pp.20-34
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• 2010

Purpose: These experiments were undertaken to evaluate the effect of administration of Palmulgunjatang gamibang on ovarian functions in female mice. Methods: We administered the Palmulgunjatang gamibang to 6-week-old female CF-1 mice for 4, 8, or 12 days. After administration of Palmulgunjatang gamibang with different concentration, the female mice were injected PMSG and hCG for ovarian hyperstimulation. The mice were divided into 3 different groups for each experiment. To compare the differences, we set a control group treated with plain water at the same volume by the same way. Results: In case of 4-day, 8-day, 12-day administration of Palmulgunjatang gamibang, the mean number of total ovulated oocytes and the number of morphologically normal oocytes were increased compared with control group. We were also examined the embryonic developmental competence in vitro. In case of 4-day administration of Palmulgunjatang gamibang, the rates of blastocyst formation from 2-cell stages were higher than control group. Conclusion: From our results suggested that the medication of Palmulgunjatang gamibang has beneficial effect on reproductive functions of female mice via promotion of cell proliferation.

• 사상체질의학회지
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• 제17권2호
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• pp.64-73
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• 2005

1. Objectives The purpose of this study was to investigate the effects of the enzyme activity of Palmulgunja-tang with administered orally solution on cytochrome P450 isozyme 2. Methods This study was carried on through following methods. We treated the rat with the {3-naphthoflavone (${\beta}NF$) of 80mg/kg for 3 days i.p injection. Firstable, microsomal protein was separated and total intracellular protein test was done. Then GOT and GPT were measured and assay of cytochrome P450 IAI/2 enzyme activity was performed according to the method of EROD and MROD. (Ethoxyresorufin-O-deethylase(EROD) activity was used to measure cytochrome P450 lAI activity and methoxyresorufin O-demethylase(MROD) activity was used to measure cytochrome P450 lA2 activity. ) 3. Results and Conclusions 1) PGT recovered the liver damage on ${\beta}NF$ inducible CYP IAI/2 by pre-post and high-low condition. 2) At concentration of post-treated 50mg!kg of PGT, the inhibiting of $\betaNF$ metabolites to liver of rat cytochrome P450 lAl was inhibited by 53.0% respectively. 3) PGT showed 36.0% inhibition of ${\beta}NF$-induced lA2 activity at the concentration post-treated 50mg/kg.

• 사상체질의학회지
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• 제22권4호
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• pp.1-9
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• 2010

1. Objectives This paper investigates the origin, the progressive changes and the constructive principles of Palmulgunja-tang (八物君子湯). 2. Methods Palmulgunja-tang and other related prescriptions were analyzed in terms of their pathological indications, based on previous literature including "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)", "Donguisusebowon Gabobon (東醫壽世保元 甲午本)", "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" and "Dongmuyugo (東武遺稿)". 3. Results and Conclusions 1) The Palmulgunja-tang most likely originates from Paljin-tang introduced in "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)". Paljin-tang progressively transformed into Seungyangpalmul-tang ("Donguisusebowon Gabobon (東醫壽世保元 甲午本)") and ultimately into Palmulgunja-tang ("Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)"), a prescription appropriate for usage in the Ulgwang symptomatology (鬱狂證). Also, Seungyangikgi-tang in "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" can be presumed to have been affected by Seungyangpalmul-tang. 2) The variational prescriptions (變方) of Palmulgunja-tang shows increasing Seungyang (升陽) effect in order of Baekhaogunja-tang, Sipjeondaebo-tang, Palmulgunja-tang, and Doksampalmul-tang. 3) Palmulgunja-tang is composed of 8 herbs. Of these, Paeoniae Radix Alba (白芍藥), Glycyrrhizae Radix(甘草), Angelicae gigantis Radix (當歸), and Cnidii Rhizoma (川芎) fortify the Soeumin Spleen Element (脾元). Ginseng Radix (人蔘) and Astragali Radix (黃芪) support the ascension of Yang, whereas Atractlodis Rhizoma White (白朮) and Citrus unshiu (陳皮) encourage the descension of Yin.

• 사상체질의학회지
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• 제28권2호
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• pp.132-146
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• 2016

Objectives This study's object was to observe the comparative effects of Yangkyuksanhwa-tang, Palmulgunja-tang and Cheongpyesagan-tang on the chronic LT4(levothyroxine) induced hyperthyroidism in rats.Methods Six groups, each of 8 rats in group, were used in this study. Saline and distilled water treated rats are intact control group. Hyperthyroidism was induced by daily subcutaneous LT4 300 μg/kg treatment for 27 days(LT4 control). Since 12th LT4 treatment PTU(propylthiouracil) 10 mg/kg was intraperitoneal injected(PTU group) and aqueous extracts of Yangkyuksanhwa-tang, Palmulgunja-tang and Cheongpyesagan-tang(YS, PG and CS) 500 mg/kg were orally administrated(YS, PG, CS group), once a day for 15 days. The differences in the body, thyroid gland and epididymal fat pad weights, serum T3(tri-iodothyronine), T4(thyroxine), TSH(thyroid-stimulating hormone), thyroid gland and epididymal fat pad histopathology, liver weight, AST(asparte aminotransferase), ALT(alanine aminotransferase) concentrations, hepatic lipid peroxidation, GSH(glutathione), SOD(superoxide dismutase), CAT(catalase) activities, liver histopathology were observed to evaluate effects on hyperthyroidism, liver damages and antioxidant effects.Results As results of LT4 treatment, hyperthyroidism and related liver damages such as lower body, thyroid weights, higher serum T3, T4, AST, ALT levels, thinner follicular lining epithelium in thyroid glands were observed. However, these symptoms were inhibited by oral treatment of YS, PG and CS. As compared with PTU treatment, these herbal prescriptions showed lower overall efficacy on the hyperthyroidism, but YS showed more favorable effects on the hepatic antioxidant defense systems.Conclusions This results suggest that YS, PG and CS favorably control the LT4 induced hyperthyroidism and related liver damages in rats through modulation of the hepatic antioxidative defense systems.

• 사상체질의학회지
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• 제11권1호
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• pp.201-220
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• 1999

1. 목적 대부분의 사상처방(四象處方)은 기존 처방을 기본 모델로 하여 가감(加減)의 형식을 취하면서 발전하였음을 알 수 있다. 특히 소음인(少陰人)은 다른 체질에 비해 기존 한의학에서 이미 병증(病證)과 약리(藥理)가 비교적 자세히 밝혀졌다고 하였는바 소음인(少陰人)의 병증(病證)과 약리(藥理)가 다른 체질에 비해 기존 한의학에서 많은 영향을 받았을 것으로 유추해 볼 수 있다. 이러한 점에서 사상처방(四象處方)형성이 기존 한의학에서 어떻게 발전되는가 하는 문제에 쉽게 접근할 수 있을 것이라고 판단된다. 이에 저자(著者)는 소음인(少陰人) 의 기본 모델링이 된 처방(處方)중에서 가장 핵심적인 처방(處方)이라 할 수 있는 계기장(桂技場)이 소음인병증(少陰人病證)에서 어떻게 이해되었으며 병증(病證)에 따라 어떻게 변용(變用)되는가를 고찰(考察)해 봄으로써 소음인(少陰人)의 병증약리(病證藥理)에 대한이해의 폭을 넓히고자 하였다. 2. 연구방법 1) 소음인(少陰人)의 병증(病證)을 표상(表喪) 병증(病證)으로 구분하고 병증(病證) 약리(藥理) 용약(用藥)을 정리하였다. 2) 기존(旣存) 한의학(韓醫學)에서의 계기장(桂技場)에 대한 해석(解釋)과 방해(方解)를 상한론(傷寒論)을 중심으로 살펴보고 동의수세본원(東醫壽世保元)에서의 계기장증(桂技場證)에 대한 해석과의 차이점을 비교하였다. 3) 계기장(桂技楊)의 운계방(運系方)을 구분하는 기준으로는 계주(桂技), 작약(芍藥), 생강(生薑)이 모두 들어있으며 그 처방 자체가 계기장(桂技楊)의 정신이 들어있는 것으로 하였다. 4) 동의수세보원(東醫壽世保元)의 소음인(少陰人) 처방 중 계기장(桂技楊)의 연계방(連系方)을 상한론(傷寒論) 경험방(經驗方), 후세방중(後世方中) 소음인병(少陰人病) 에 경험(經驗)한 요방중(要方中) 계기장(桂技楊)의 연계방(連系方), 그리고 소음인(少陰人) 신정처방(新定處方)중 표병증(表病證)과 이병증(裏病證)에 사용하는 연계방(連系方)중에 계기장(桂技楊) 연계방(連系方)들을 각각 나누어 분석하였다. 5) 이 외에 계기장(桂技楊)의 연계장(連系方)은 아니지만 각각의 단계에서 이와 유사한 정신이 들어 있는 처방들을 분류하였다. 3. 결론 신정처방(新定處方)중 계지탕 연계방은 표병(表病)에 7방(方)이 있고 이병(裏病)에 2방(方)이 있는데 표병증에는 천궁계지탕, 황기계지탕, 숭양익기탕, 승양익기부자탕, 황기 계지부자탕, 인삼계지부자탕, 인삼관계부자탕 등이, 이병증에는 계지반하생강탕, 산밀탕 등이 계지탕에서 변용(變用)된 처방으로 해석되며, 표병에서는 양기의 진퇴강약에 따라 이병에서는 냉기의 취산경중에 따라 병증구분과 처방의 내용이 변화됨을 알 수 있다. 또한 곽향정기산, 향소산, 궁귀향소산, 팔물군자탕 등은 계지탕의 변방(變方)은 아니지만 각각의 병증(病證) 단계에 있어서 계기장(桂技場) 변방(變方)과 같은 정신으로 제시되고 있음을 알 수 있다. 소음인(少陰人)에서 병증(病證)이 명확히 구분되지만 서로 다른 병증에 사용되는 처방이 내용상 유사한 점을 보이는데, 이는 보명지주(保命之主)인 양원지기(陽援之氣)를 유지한다는 동일한 목표에서 승강창념(升降廠念)의 치법이 운용되기 때문으로 파악 된다.

• 대한한방내과학회지
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• 제43권5호
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• pp.980-988
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• 2022

The most common definition of postherpetic neuralgia is the presence of pain more than a month after the onset of the eruption of zoster. This case report suggests the effect of Korean medicine on postherpetic neuralgia. An 85-year-old male patient with postherpetic neuralgia was treated with a combination of Korean medical remedies. Kyung Hee Gongjin-dan and Hyangbujapalmul-tang-gagam were applied for 23 days. The Numerical Rating Scale was used to measure pain intensity. The Barthel Index and Beck Depression Inventory were used for the functional assessment and depression evaluation, respectively. After treatment, the patient's pain intensity decreased. Additionally, the patient's independence increased during activity, and the severity of their depression decreased. Thus, this case suggests that a combination of Korean medicine treatments might be effective for postherpetic neuralgia. In particular, it shows that Kyung Hee Gongjin-dan and Hyangbujapalmul-tang-gagam can be therapeutic options in the treatment of postherpetic neuralgia.

• 대한약침학회지
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• 제6권3호
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• pp.23-37
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• 2003

The purpose of this research was to investigate the correlation Among Sasang Constitutional Disease and Examination of the pulse. I have gone over literatures of mainly ${\ulcorner}$Dongyi Soose Bowon${\lrcorner}$ and the others Oriental Medical book was studied about the Pulse Diagnosis. And then I came to get some conclusion as follows. 1. Soeumin(소음인) the initial-stage symptoms of wulkwang disease(울광증) ; when the Superficial Pulse and the Superficial+ Moderate Pulse is made a diagnosis, Ceongunggyegitang(천궁계지탕) and Gunggyuhyangsosan(궁귀향소산) can be used. 2. Soeumin(소음인) the initial-stage blood disease symptoms of wulkwang disease(울광증) ; when the Minute+deep Pulse is made a diagnosis, Palmulgnnjatang(팔물군자탕) and Guakhyanggeonggisan(곽향정기산) can be used. 3. Soeumin(소음인) the initial-stage symptoms of mangyang disease(망양증) ; when the Yang region Superficial Pulse and the Yin region Weak Pulse is made a diagnosis, Hwanggigyegitang(황기계지탕), Bojungikgitang(보증익기탕) and Sengyangikgitang(승양익기탕) can be used. 4. Soeumin(소음인) the symptoms of taeum disease(태음증) ; when the Minute Pulse and Deep+Thin Pulse is made a diagnosis, Sasang Prescription can be used. 5. Soeumin(소음인) the symptoms of soeum disease(소음증) ; when the Minute+Thin Pulse, Deep Pulse and Thin+Deep+Rapid Pulse is made a diagnosis, Sasang Prescription can be used. 6. Soyangin(소양인) Wind of soyang disease(소양상풍증) ; when the Superficial+Tight Pulse is made a diagnosis, Hungbangpaedogsan(형방패독산) can be used. And when the Deep+Full with strong power Pulse is made a diagnosis, Hyungbangdojeoksan(형방도적산) can be used. 7. Soyangin(소양인) the symptoms of mangyeum disease(망음증) ; when the Superficial+Large+Rapid Pulse and Flood+Large Pulse is made a diagnosis, Hungbangsabaeksan(형방사백산) can be used. And when the Wiry+Thin Pulse is made a diagnosis, Hungbanggiwhangtang(형방지황탕) can be used. 8. Soyangin(소양인) the chest-phrenic fever syndrome(흉격열증) ; when the Superficial Pulse, Flood+Full+Rapid Pulse and Flood+Large Pulse is made a diagnosis, Sasang Prescription can be used. 9. Soyangin(소양인) the after fever syndrome(음허오열증) ; when the Empty+Soft+Rapid Pulse is made a diagnosis, Sasang Prescription can be used. 10. Taeumin(태음인) the upper neck exterior disease caused by Cold(배추표병) ; when the Superficial and Superficial+Tight Pulse is made a diagnosis, Mawhangbalpoytang(마황발표탕) can be used, And when the Superficial and Superficial+Tight with strong power on left hand Pulse is made a diagnosis, Ungdamsan(웅담산) and Handayulsotang(한다열소탕) can be used. 11. Taeumin(태음인) the Coldness syndrome in esophagus(위완한증) ; when the Superficial+Tight Pulse with weak power on left hand Pulse is made a diagnosis, Taeumjowetang(태음조위탕) can be used. 12. Taeumin(태음인) the Dryness-Heat syndrome(조열증) ; when the Flood+Large Pulse, Long Pulse and Long+Large Pulse is made a diagnosis, Galgeunhaegitang(갈근해기탕) can be used. And when the Tight+Full+Rapid Pulse with deep region is made a diagnosis, Yuldahansotang(열다한소탕) can be used. And when the Superficial+Slippery Pulse is made a diagnosis, Chungsimyunjatang(청심연자탕) can be used. 13. Taeumin(태음인) the symptoms of Yin-blood Exhaustion(음혈모갈증) ; when the Superficial with weak power Pulse is made a diagnosis, Nokyongdaebotang(녹용대보탕) can be used. And when the Deep with weak power Pulse is made a diagnosis, Gongjinheukwondan(공진흑원단) can be used. 14. Taeyangin(태양인) a slight Lumbar vertebrae disease(외감경증) ; when the Superficial+Hollow Pulse is made a diagnosis, Gunshitang(건시탕) can be used. 15. Taeyangin(태양인) the Generalized and Fatigue syndrome(해역증) ; when the Moderate+Choppy Pulse with left hand chi region(척맥) is made a diagnosis, Ogapijangchuktang(오가피장척탕) can be used. 16. Taeyangin(태양인) a slight Small Intestine disease(내촉경증)