• Proceedings of the Korean Society of Computer Information Conference
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• 2019.07a
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• pp.143-144
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• 2019

본 논문은 현대에 신체활동(Physical activity)를 하지 않으면 심혈관계질환, 당뇨, 암, 골다공증 등과 같은 질환의 위험성을 가지고 있음에도 불구하고 공간부족, 시간부족, 날씨 등으로 제약을 받아 신체활동이 부족한 척수장애인의 들을 위한 스마트 휠체어 트레드밀을 개발함이다. 기존의 휠체어 트레드밀은 휠체어를 생활할 때 사용하는 대상자들에게 신체활동을 제공하였다. 스마트 휠체어 트레드밀은 경사(Slope-Incline, Decline)를 조절하여 개별마다 다른 건강체력능력에 운동강도(Exercise intensity)를 다르게 할 수 있다. 또한 스마트 휠체어 트레드밀은 거리측정, 속도측정이 가능한 센서를 부착하여 대상자의 운동량을 알 수 있을 뿐만 아니라 체중측정도 가능하여 대상자의 운동량에 대한 칼로리소모량을 얻을 수 있다. 이러한 스마트 휠체어 트레드밀과 VR(Virtual reality) 프로그램, 게임을 접목시켜 척수장애인들의 신체활동에 흥미를 증진 시킬 수 있다.

• Journal of Life Science
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• v.18 no.9
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• pp.1263-1270
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• 2008

The purpose of this study is to investigate the effect of exercise mode and anti-hypertensive drug responding status on the cardiovascular response and perceived exertion in acute coronary syndrome (ACS) patients. Seventy-five patients who participated in six-week exercise rehabilitation therapy performed a treadmill running and a cycle ergometer exercise at intensities of 60%HRR and 85%HRR respectively. Systolic and diastolic blood pressure, mean arterial blood pressure (MAP), rate pressure production (RPP), and ratings of perceived exertion (RPE) were measured. The results of cardiovascular response by the different exercise modes with moderate and intensive intensity of anti-hypertensive drug responder and nonresponder ACS patients were following: First cycle ergometer exercise induced significantly higher SBP, DBP, MAP, RPP and MAP than treadmill running exercise at the intensities of 60%HRR and 85%HRR in both anti-hypertensive responder and nonresponder ACS patients (p<0.05). Secondly anti-hypertensive nonresponder ACS patients had significantly higher DBP and MAP that anti-hypertensive responder ACS patients at all the exercise modes (p<0.05). Finally there was no difference of RPP between anti-hypertensive responder and nomresponder ACS patients, although anti-hypertensive nonresponder ACS patients showed higher blood pressure and RPP than anti-hypertensive responder ACS patients. In conclusion, cycle ergometer induced increased cardiovascular response at same intensities of treadmill running exercise and anti-hypertensive nonresponder ACS patients had even more increased cardiovascular response than anti-hypertensive responder ACS patients with no difference in perceived exertion during exercise. These results suggested that cycle ergometer exercise should be greatly careful with the risk of higher blood pressure, especially for those who are patients with hypertensive blood pressure.

• Journal of the Korea Convergence Society
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• v.10 no.5
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• pp.79-84
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• 2019

The purpose of this study was to examine the effects of treadmill exercise on the aerobic function of dance majors in their 20s. The subjects consisted of 10 female Korean dance majors in their 20s as an experimental group and 10 normal female college students as a control group, and both groups conducted treadmill gait training. Their heart rate recovery (HRR), maximal oxygen uptake (MOU), maximal voluntary ventilation (MVV), and lactate recovery rate (LRR) were measured before and after the experiment. The comparison of changes in the subjects' aerobic function before and after the experiment showed that the experimental group gained more significant effects on HRR and LRR than the control group. Therefore, treadmill gait training may help Korean dance majors to improve their basic physical strength by enhancing their aerobic function, and the findings of this study are likely to provide basic data to support scientific exercise prescriptions.

• Exercise Science
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• v.21 no.3
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• pp.289-298
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• 2012

In the present study, we investigated the effect of treadmill exercise on apoptotic neuronal cell death in the retinas of streptozotocin-induced diabetic rats. Twenty-eight male Sprague-Dawley rats were used for this study. The animals were divided into four groups(n = 7 in each group):(1) control group, (2) exercise group, (3) diabetes-induced group, (4) diabetes-induced and exercise group. Diabetes mellitus(DM) was induced by intraperitoneal injection of streptozotocin. The rats in the exercise groups were forced to run on the treadmill for 30 minutes once a day, five times per a week, during 12 weeks. In this study, a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL) assay and western blot for the expressions of caspase-3, cytochrome c, Bax, and Bcl-2 in the retinas were conducted for the detection of apoptotic retinal cell death. The present results showed that the number of TUNEL-positive cells was increased in the retinas of the diabetic rats, whereas treadmill exercise suppressed this number. The expressions of pro-apoptotic factors caspase-3, cytochrome c, and Bax were enhanced and the expressions of anti-apoptotic factor Bcl-2 was decreased in the retinas of the diabetic rats. In contrast, treadmill exercise suppressed the expressions of caspase-3, cytochrome c, and Bax and increased the expression of Bcl-2. The present study demonstrated that treadmill exercise suppressed diabetes-induced apoptotic neuronal cell death in the retinas. Based on the present results, treadmill exercise may be effective therapeutic strategy for the alleviating complications of diabetes patients.

• Journal of Digital Convergence
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• v.14 no.9
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• pp.553-561
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• 2016

The purpose of this study was to compare cardiopulmonary function, RPE(Rating of perceived exertion), and blood lactate when examining the GXT(Graded exercise testing) of wheelchair treadmill and arm ergometer. Participants were 11 wheelchair basketball players with non disability. While examining the GXT of wheelchair treadmill and arm ergometer, cardiorespiratory functional capacity was measured by using $Quarkb^2$ and Polar and RPE was measured through Borg Scale. The lactate analyser, YSI-2000 was used to measure blood lactate level when resting, right after exercise, two minutes, four minutes, six minutes, and ten minutes of recovery. Data was analyzed by paired t-test using SPSS 18.0 program and significance for all statistical analysis was fixed at .05 confidence level(p<0.05). The conclusion of this study is below. First, maximal oxygen uptake which is a factor of cardiopulmonary function showed the highest with arm ergometer, the rate of respiratory exchange showed the highest with wheelchair treadmill, and maximal heart rate showed the highest with wheelchair treadmill. Second, subjective exercise intensity showed the highest with arm ergometer at the end point. Third, blood lactate level showed the highest with arm ergometer right after exercise.

• Journal of Korean Medicine Rehabilitation
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• v.19 no.2
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• pp.73-88
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• 2009

Objectives : Neuronal changes that result from treadmill exercise for patients with Parkinson's disease(PD) have not been well documented, although some clinical and laboratory reports suggest that regular exercise may produce a neuroprotective effect and restore dopaminergic and motor functions. However, it is not clear if the improvements are due to neuronal alterations within the affected nigrostriatal region or result from a more general effect of exercise on affect areas and motivation. In this study, we demonstrate that motorized treadmill exercise improves the neuronal outcomes in rodent models of PD. Methods : We used a chronic mouse model of parkinsonism, which was induced by injecting male C57BL/6 mice with 10 doses(Every 12 hour) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (30 mg/kg) and probenecid (20 mg/kg) over 5 days. These mice were able to sustain an exercise training program on a motorized rodent treadmill at a speed of 18 m/min, $0^{\circ}$ of inclination, 40 min/day, 5 days/week for 4 weeks. At the end of exercise training, we extracted the brain and compared their neuronal and neurochemical changes with the control(saline and sedentary) mice groups. Synphilin protein is the substance that manifestly reacts with ${\alpha}$-synuclein. In this study, we used Synphilin as a manifest sign of recovery from neurodegeneration. We analyze the brain stems of the substantia nigra and striatum region using the western blotting technique. Results : There were no expression of synphilin in the saline-induced groups. The addition of MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) greatly accelerated synphilin expression which meant an aggregation of ${\alpha}$-synuclein. But, the MPTP-induced treadmill exercise group showed significantly lower expression than the MPTP-induced sedentary group. This means treadmill exercise has a definite effect on the decrease of ${\alpha}$-synuclein aggregation. Conclusions : In this study, our results suggest that treadmill exercise promoted the removal of the aggregation of ${\alpha}$-synuclein, resulting in protection against disease development and blocks the apoptotic process in the chronic parkinsonian mice brain with severe neurodegeneration.

• Journal of the Korean Applied Science and Technology
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• v.37 no.1
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• pp.91-101
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• 2020

The purpose of this study was to investigate the influence of obesity on the expression of autophagy-related proteins in cardiac muscle. To this end, obesity was induced in rats through 20 weeks of high-fat diet, and the animals were then subjected to 8 weeks of treadmill exercise. Subsequently, the expression of proteins that regulate the induction of autophagy, formation of autophagosome, and fusion of autophagosome and lysosome was confirmed. Obesity was induced in the experimental animals (SD rats) through 20 weeks of high-fat diet (carbohydrate: 20%, fat: 60%, and protein: 20%), and they were subsequently subjected to 8 weeks of treadmill exercise (5 days/week, 30 min/day, 5 minutes; 8m/min, 5 minutes; 11m/min, 20 minutes; 14m/min). The experimental groups comprised the normal diet control group (ND-CON, n=10), high-fat diet comparison group (HFD-CON, n=10), and high-fat exercise group (HFD-TE, n=10). Oral glucose tolerance test was conducted before and after 8 weeks of treadmill exercise, and the area under the curve (AUC) was calculated. Through fasting insulin and fasting glucose levels, HOMA-IR, which is an index of insulin resistance, and abdominal visceral fat/body weight (AVF/BW) were calculated for comparison. Moreover, autophagy-related proteins were analyzed from cardiac tissue to investigate the effects of exercise training. Obesity was successfully induced in the HFD-CON group through long-term high-fat diet, and the HFD-CON group had higher body weight, AUC, HOMA-IR, and AVF/BW compared to the ND-CON group. The HFD-TE group, which underwent 8 weeks of treadmill exercise, showed improvements in AUC, HOMA-IR, and AVF/BW. Although the body weight tended to decrease as well, there was no statistically significant difference. mTOR and AMPK, which are involved in the induction of autophagy, both decreased in obesity but increased upon exercise. Beclin-1, BNIP3, ATG-7, p62, and LC3, which are related to the formation of autophagosomes, all increased in obesity and decreased after exercise. Cathepsin L and LAMP2, which regulate the fusion of autophagosome and lysosome, both decreased in obesity and increased upon exercise. Physical activity, including treadmill exercise, was found to induce normal autophagy and improve pathological phenomena observed in metabolic diseases. Therefore, the findings suggest the need to consider treadmill exercise as a primary means to achieve effective prevention and treatment of cardiac diseases.

• Physical Therapy Korea
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• v.8 no.4
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• pp.17-29
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• 2001

발목에 대한 유착성 테이핑의 적용은 물리치료 분야와 운동 트레이닝 분야에서의 일반적인 치료 접근 방법이라 할 수 있다. 즉 발목 염좌 같은 손상을 예방하기 위한 방법과 재활의 부가적인 치료 형태로 이용될 수 있는 것이다. 본 연구는 발목의 테이핑과 트레드밀에서의 30분간 보행이 수직 착지 동작 동안 하지의 운동 역학적 요소들에 어떠한 영향을 주는지 알아보기 위해 시행되었다. 14명의 신체 건강한 대상자들 (남:10, 여:4)이 본 연구에 참여하였다. 한발로 서있는 동안 40 cm의 높이로 뛰게 하였다. 가자미근, 전경골근, 안쪽넓은근, 넙다리 두갈래근에 근전도 전극이 부착되었다. 테이핑된 신체 부위로 착지하는 동안 근전도와 힘판(force plate) 자료가 500 Hz의 주파수로 수집되었다. 대상자들의 우세쪽 하지 발목에 테이핑을 하였고, 대상자는 한발로 뛰어 내리는 동작을 반복하였다. 트레드밀에서 30분 동안 발목에 테이핑을 한 채로 보행하였고 이후 한발로 뛰어 내리는 동작을 반복하여 수행하였다. 테이핑을 적용한 상태와 테이핑한 채로 30분 동안 트레드밀에서 걷기 운동을 한 조건에서 수직 지면 반발력의 통계학적으로 유의미한 증가가 있었다. 착지 동안에 네 가지 상황에서의 최대 내측 가속도의 유의한 차이가 있었고, 그 차이는 테이핑 전과 테이핑을 한 채로의 운동 조건에서 유의한 차이가 있었다. 테이핑한 상태에서 가자미근은 접촉되는 착지 순간부터 최대 수직 지면 반발력이 나타나는 동안의 평균 근전도의 수치에 있어서 유의한 감소가 있었다. 반면에 다른 근육들에서는 아무런 변화를 보이지 않았다. 비록 발목 테이핑이 발목 손상의 위험을 줄이는데 효과적이라고 일반적으로 인식되고 있으나 이번 실험의 결과는 30분 동안의 트레드밀에서의 보행 후 테이핑은 발목의 움직임을 제한하는 효과는 있지만 한편으로는 가자미근의 활동을 감소시키는 것을 보여주었다. 따라서 이 연구의 결과는 테이핑을 하면 점프와 착지로 이어지는 동작 중에 발목관절 손상 위험을 증가시킬 가능성이 있음을 보여주었다.

• Journal of Life Science
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• v.19 no.11
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• pp.1651-1657
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• 2009

Physical activity and exercise can promote sensorimotor recovery from central nerve injury. It has been suggested that the functional recovery promoted by exercise training after spinal cord injury might be associated with insulin-like growth factor-I in the inflicted muscle. To investigate morphological and biochemical change of the soleus muscle after spinal cord injury, all tissues were used for H&E, immunofluorescence staining and Western blot. Also, BBB-test was used to evaluate behavioral improvement after spinal cord contusion. Thirty male Sprague-Dawley rats ($230{\pm}10\;g$; 7week in age) were assigned equally to three different groups; Normal (n=10), SCI (n=10), SCI+TMT (n=10). Every rat in SCI and SCI+TMT groups underwent laminectomy at T9 level and then contusion on the exposed spinal cord site in anesthetized condition. After one week-recovery from contusion, every rat in the SCI+TMT group exercised on a motorized treadmill for 30min/d, 5d/wk for 7wks. TMT followed by injury increased IGF-I induction levels in the soleus muscle and inhibited muscle atrophy. Behavioral scales for 4 and 8 weeks after spinal cord injury were improved in the SCI+TMT group compared to the SCI group. These results suggest that treadmill exercise after spinal cord injury might promote functional recovery along with muscle regrowth through the up-regulation of IGF-1 in muscle tissue.

• 한국체육학회지인문사회과학편
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• v.51 no.3
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• pp.363-372
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• 2012

One of the major ocular complications of diabetes mellitus(DM) is retinopathy, which is characterized by increased neovascularization and neural degeneration in the retina. In the present study, we investigated the effects of treadmill exercise on retinopathy in the rats with DM. Thirty-two male Sprague-Dawley rats were divided into four groups(n = 8 in each group): control group, exercise group, DM-induction group, and DM-induction and exercise group. DM was induced by intraperitoneal injection of streptozotocin. The rats in the exercise groups were made to run on the treadmill for 30 min five times per a week, during 12 weeks. The expressions of phosphoinositide 3-kinase(PI3K), phospho-protein kinase B(pAkt), hypoxia inducible factor-1α(HIF-1α), and vascular endothelial growth factor(VEGF) in the retina were determined using western blot analysis and immunohistochemistry. In the present results, the expressions of PI3K, pAkt, HIF-1α, and VEGF in the retina of the diabetic rats were increased. Treadmill exercise suppressed HIF-1α and VEGF expressions through inhibition of PI3K/pAkt pathway in the diabetic rats. These results suggest that treadmill exercise may ameliorate the progression of diabetes-induced retinopathy by inhibiting neovascularization in the retina.