• The Korean Journal of Applied Statistics
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• v.26 no.4
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• pp.581-594
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• 2013

A group sequential design can end a clinical trial early if a confirmed efficacy or a futility of study medication is found during clinical trials. Adaptation can adjust the design of clinical trials based on accumulated data. The key to this methodology is considered to control the overall type 1 error rate while maintaining the integrity of clinical trials. The estimation would be more complex and the sample size calculation will be more difficult if the clinical trials have repeated measurement data. Lee et al. (2002) suggested a repeated observation case by using the independent increments properties of the interim test statistics and investigated the properties of the proposed confidence interval based on the stage-wise ordering. This study extend Lee et al. (2002) to adaptive group sequential design. We suggest test statistics for the adaptation as redesigning the second stage of clinical trials and induce the stage-wise confidence interval of parameter of interests. The simulation will help to confirm the suggested method.

• Journal of the Korean Geotechnical Society
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• v.16 no.5
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• pp.93-105
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• 2000

일정변형률압밀사시험의 효율성 및 적용성을 구체화하기 위해 인공시료 또는 한정된 지역에서 채취한 불교란 점성토 시료가 아닌 광범위한 지역에서 채취한 불교란 점성토 시료에 대해 시험을 실시하였다. 시료채취의 대상지역은 우리나라의 서해안에서 동해안에 이르는 13개 지역이며, 29개의 불교란 자연시료를 채취하여 일정변형률압밀시험을 113회 실시하였다. 또한, 비교하기 위해 표준압밀시험도 병행하였다. 시험결과로부터 얻어진 압밀정수에 대한 공학적 특성을 고찰하였고, 회기분석을 통해 통계식을 제안하였다. 두 시험법에 의해 산출된 압밀정수를 비교 분석한 결과 수압비가 20% 이내인 범위에서는 일정변형률압밀시험의 변형률 속도가 압밀시험의 정수에 미치는 영향은 거의 없는 것으로 나타났다. 압축지수 및 압밀계수는 일정면형률시험의 결과 값이 표준압밀시험의 결과 값보다 크게 산출되었으나 일관성을 보였다. 또한, 선행압밀압력에 있어서는 두 시험법에 Cassagrande의 방법을 적용할 경우 서로 일치하는 것으로 나타났다. 본 연구로부터 일정변형률압밀시험을 사용하여 표준압밀시험에 상용하는 상호관계식 개발의 타당성을 확인할 수 있었다.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.6
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• pp.3-8
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• 2014

Recently, a spectrum sensing technique employing the maximum value of a received power spectrum as a test statistic has been presented in the literature for the purpose of detecting a wireless microphone signal in TV bands This detects the presence of a primary user by comparing the test statistic with some threshold, which depends on the background noise power level as well as a target false alarm rate. Therefore its performance may deteriorate when the noise power uncertainty occurs. As a means to mitigate this difficulty, we present a spectrum sensing strategy adopting the ratio of the maximum and the minimum value of the power spectrum as a test statistic and analyze its performance of spectrum sensing.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.11
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• pp.1099-1108
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• 2017

Data points obtained by conducting repetitive experiments under identical environmental conditions are, theoretically, required to correspond. However, experimental data often display variations due to generated errors or noise resulting from various factors and inherent uncertainties. In this study, an algorithm aiming to determine valid bounds of input variables, representing uncertainties, was developed using probabilistic and statistical methods. Furthermore, a reliability assessment was performed to verify and validate applications of this algorithm using bolt-fastening friction coefficient data in a sample application.

• Communications for Statistical Applications and Methods
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• v.17 no.3
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• pp.327-335
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• 2010

Item response theory provides a fixed results about students, regardless of the item difficulty and discrimina-tion and it is also a kind of item analysis methods which provides the same proper competence scores to students in spite of them taking different test repeatedly. In this paper, we researched item difficulty and item discrimina-tion and analyzed items in the national academic aptitude test which were given from 2000 to 2009 in the past 10 years through item response theory, especially, in connection with given items about statistical unit. As a result, we found that about 60 percents of the items were too difficult for high school students to solve, however, item discrimination proved to be great.

• The Korean Journal of Applied Statistics
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• v.33 no.2
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• pp.137-145
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• 2020

Phase I clinical trials (Dose Finding Studies) are the first step in administering new drugs developed through animal experiments or in vitro experiments to humans. An important area of interest in designing Phase I clinical trials is determining the dose that provides the greatest efficacy and acceptable safe dose to the patient. In this paper, we propose a method to determine the maximum tolerated dose considering efficacy and safety using Biased coin design and stopping rule. The proposed method is compared with existing methods through simulation.

• The Korean Journal of Applied Statistics
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• v.14 no.2
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• pp.345-355
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• 2001

동일한 유효성분을 가지면서 용량 혹은 형식 만이 다른 제제의 개발이 증가되고 이에 따른 두 제제 이상의 생물학적 동등성시험의 필요성이 제기되었다. 이에 이용주 등(1998)은 온단세트론 제제에 대한 생물학적 동등시험에서 3$\times$3 교차설계법을 적용하였다. 그러나 3$\times$3 교차설계법에서 각 순서에 피험자의 수가 다르거나 실험중에 결락(dropout)되는 피험자가 발생하는 경우에는 일반적인 통계적 방법은 적용할 수 없었다. 본 연구에서는 이러한 경우에 제제효과의 추론에 대한 통계적 방법과 생물학적 동등성 시험 방법을 제안하고 모의실험을 통하여 생물학적 동등성평가의 정도를 측정하였다.

• Journal of the Korean Data and Information Science Society
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• v.7 no.1
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• pp.37-46
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• 1996

In this paper, we introduce the goodness of fit test procedure for lifetime distribution using step stress accelerated lifetime data. Using the nonpapametric estimate of acceleration factor, we prove the strong consistence of empirical distribution function under null hypothesis. The critical vailues of Kolmogorov-Smirnov, Anderson-Darling, Cramer-von Mises statistics are computed when the lifetime distibution is assumed to be exponential and Weibull. The power of test statistics are compared through Monte-Cairo simulation study.

• The Korean Journal of Applied Statistics
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• v.13 no.2
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• pp.563-573
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• 2000

In this paper, we propose three estimators of Kullback-Leibler Information functions using the data from accelerated life tesb. This acceleration model is assumed to be a tampered random variable model. Some asymptotic properties of proposed estimators are proved. Simulations are performed for comparing the small sample properties of the proposed estimators under use condition of accelerated life test.

• The Korean Journal of Applied Statistics
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• v.29 no.3
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• pp.539-547
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• 2016

We discussed how to handle missing binary data clinical trials. Patterns of occurring missing data are discussed and introduce missing binary data imputation methods that include the modified method. A simulation is performed by modifying actual data for each method. The condition of this simulation is controlled by a response rate and a missing value rate. We list the simulation results for each method and discussed them at the end of this paper.