• Journal of Life Science
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• v.13 no.6
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• pp.943-949
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• 2003

New quinolone derivatives of 7-(cis- or trans-3-amino-4-mehtylthiomethylpyrrolidinyl) quinolone-3-carboxylic acids were synthesized by condensation of 7-halo substituted quinolone-3-carboxylic acids with cis- or trans-3-amino-4-mehtylthiomethylpyrrolidine. Some of these compounds showed broad spectra of antibacterial activities against Gram-positive and Gram-negative organisms except Pseudomonas aeruginosa, and exhibited much stronger activity against MRSA.

• Journal of the Korean Chemical Society
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• v.51 no.1
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• pp.106-110
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• 2007

• Journal of the Korean Electrochemical Society
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• v.13 no.1
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• pp.63-69
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• 2010

Electrochemical behavior of fluoroquinolone antibacterial agents on carbon paste electrode (CPE) were investigated by cyclic voltammetry and square wave adsorptive stripping voltammetry. The fluoroquinolone antibacterial agents tested in this study were Enrofloxacin (ENR), Norfloxacin (NOR), Ciprofloxacin (CIP), Ofloxacin (OFL) and Levofloxacin (LEV). In acetate buffer at pH 4.5, the oxidation peak potentials of the fluoroquinolone antibacterial agents of ENR, NOR, CIP, OFL, and LEV were 0.952 V, 1.052 V, 1.055 V, 0.983 V, and 0.990 V (vs. Ag/AgCl), respectively. And their oxidation peak currents from square wave adsorptive stripping voltammograms are proportional to the concentration of each antibacterial agent over the range from $0.2\;{\mu}M$ to $1\;{\mu}M$.

• Journal of the korean veterinary medical association
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• v.28 no.10
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• pp.615-629
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• 1992

• Journal of the korean veterinary medical association
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• v.43 no.10
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• pp.935-946
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• 2007

• Proceedings of the Zoological Society Korea Conference
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• 1994.10a
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• pp.202.1-202
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• 1994

• Journal of Life Science
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• v.23 no.5
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• pp.703-709
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• 2013

The aim of this study was to investigate the prevalence of Extended-spectrum ${\beta}$-lactamase (ESBL) gene and quinolone resistance determinant (qnr) and the pattern of antibiotic resistance in the ESBL-producing Escherichia coli clinical isolates. The 42 ESBL-producing strains from total 274 isolates were detected using a double disk synergy test. They were isolated from various specimens, such as urine (28 strains), sputum (6 strains), pus (3 strains), wound (2 strains), blood (2 strains), and tissue (1 strain). Using the PCR with the specific primers ESBL, ESBL and qnr gene types were determined. Thirty-five strains possessed one or two ESBL genes. CTX-M-1 type was the most abundant followed by CTX-M-9 type and TEM, but SHV, CTX-M-2, and CTX-M-8 gene types were not detected. qnr gene types were detected from ten isolates in the order of qnrB4, qnrB1, and qnrS. Coexistence of ESBL and qnr genes was found. ESBL-producing isolates showed high resistance against some antibiotics, such as cefotaxmie (80.0%), levofloxacin (82.9%), and ampicillin (100%). Neither a synergy effect from the coexistence of ESBL and qnr genes on antibiotic resistance nor a correlation between the production of qnr gene and quinolone resistance were found.

• 동물약계
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• no.85
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• pp.3-4
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• 2002

[ $\cdot$ ]배합사료제조용 동물용의약품등 사용기준 개정 관련 협의회 참석 $\cdot$동물약사감시 행정처분 결과 홍보 $\cdot$협회 제4차 이사회 개최 $\cdot$제5차 이사회 개최 $\cdot$플루오로퀴놀론제제 허가사항 재설정 안내 $\cdot$제조물책임법 대비 품목허가 주의사항 변경 $\cdot$소독약품의 올바른 사용을 위한 일제 정비 $\cdot$2003년도 병역지정업체 선정 신청 $\cdot$동물약품 PL 단체보험 세미나 개최 $\cdot$동물약품 PL 단체보험 가입 안내 $\cdot$동물약품제조용 양허관세적용 유당 변경 배정

• Journal of the Korean Chemical Society
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• v.47 no.5
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• pp.530-532
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• 2003

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.227-227
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• 1994

퀴놀론계 항균제란 퀴놀린 이나 나프티리딘 핵을 갖고 있는 화합물로써 항균효과를 나타내는 물질을 의미한다. 이러한 퀴놀론계 항균제의 구조적 특성에 따라 항균활성의 영향은 ASAR에 의하여 이미 구조적 제한성을 가지고 있다고 보고 되어있다. 본 연구에서는 Drug-Enzyme inleraetion domain을 변화시킴으로서 보다 강력한 항균제를 찾아낼수 있을 것으로 판단하고, 기존 항균제가 C-7에 piperazine이 있으므로 piperazine의 chemical isoster 또는 bioisoster의 개념하에서 C-7에 도입한 아민류를 분자설계하고 합성하여 새로운 퀴놀론계 항균제를 만들어 내고자 하였으며 target molecule은 다음 그림과 같다.