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http://dx.doi.org/10.5352/JLS.2003.13.6.943

Syntheses and Antibacterial Activities of New Quinolones Containing cis- or trans-3-Amino-4-methylthiomethylpyrrolidino Moiety  

Lee, Jae-Wook (Department of Chemistry, Dong-A University)
Lim, Gui-Taek (Department of Chemistry, Dong-A University)
Publication Information
Journal of Life Science / v.13, no.6, 2003 , pp. 943-949 More about this Journal
Abstract
New quinolone derivatives of 7-(cis- or trans-3-amino-4-mehtylthiomethylpyrrolidinyl) quinolone-3-carboxylic acids were synthesized by condensation of 7-halo substituted quinolone-3-carboxylic acids with cis- or trans-3-amino-4-mehtylthiomethylpyrrolidine. Some of these compounds showed broad spectra of antibacterial activities against Gram-positive and Gram-negative organisms except Pseudomonas aeruginosa, and exhibited much stronger activity against MRSA.
Keywords
antibacterial agents; antibacterial activities; pyrrolidine; quinolone;
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