• Title/Summary/Keyword: 쿠마린

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Extractives from the bark of domestic Fraxinus species (국내산 몰푸레나무속 수종 수피의 추출성분)

  • 이상극;배영수
    • Journal of Korea Foresty Energy
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    • v.20 no.1
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    • pp.42-52
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    • 2001
  • The barks of Fraxinus rhynchophylla, Fraxinus sieboldiana and Fraxinus mandshurica, ash trees grown in domestic, were collected, extracted with acetone-H$_2$O(7:3, v/v) and freeze dried to give some dark brown powder. A portion of the freeze dried powder was chromatographed on a Sephadex LH-20 and a TSK 40F column using a series of aqueous methanol, ethanol and ethanol-hexane mixture as eluents Some spectrometric analyses such as NMR and FAB-MS including TLC were performed to identify the structures of the isolated compounds. The bark extractives contained a large amount of coumarin derivatives in addition to a small amount of ester compounds.

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Biological Activity of Natural Coumarins (천연(天然)쿠마린의 생리활성(生理活性))

  • Shin, Kuk-Hyun;Chi, Hyung-Joon
    • Korean Journal of Pharmacognosy
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    • v.10 no.1
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    • pp.1-8
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    • 1979
  • The naturally occurring coumarins are likely to be a large and important group of plant products which are not only metabolic products of the living cells but possess varied physiological and pharmacological actions. Investigations concerning various biological activities of natural coumarins have been undertaken by many investigators in continuing effort. The authors describe on experimental results of biological activities of coumarin derivatives with particular emphasis on 10 different activities that are considered to be of importance in view of the development of new drugs from natural resources.

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Coumarins from the Roots of Angelica decursiva-albiflora (개바디 뿌리의 쿠마린성분)

  • Jung, Nam-Il;Yook, Chang-Soo;Lee, Hyeong-Kyu
    • Korean Journal of Pharmacognosy
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    • v.25 no.4 s.99
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    • pp.311-318
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    • 1994
  • From the root of Angelica decursiva-albiflora Yook, which has been used as a folk medicine for a sedative, analgesic and expectorant, four free coumarins, e.g., decursidin(I), decursin(II), umbelliferone(III) and nodakenetin(IV), and two coumarin glycosides, e.g., nodakenin(V) and decuroside I(VI) were isolate. The cytotoxicity of nodakenin(V) against L-1210 leukemia cells was less effective than cisplatin, but in the nephrotoxicity against rabbit kidney proximal tubular cell nodakenin(V) showed remarkably less nephrotoxicant than cisplatin.

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Synthesis and Fluorescence Properties of New Rhodamine 6G Derivarives Containing Hydroxy Coumarin Moiety (새로운 로다민 6G 하이드록시 쿠마린 유도체의 합성과 형광특성)

  • Park, Seong Ho;Chang, Seung Hyun
    • Journal of Environmental Science International
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    • v.25 no.9
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    • pp.1283-1288
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    • 2016
  • In this study, we synthesized fluorescent sensors from rhodamine 6G derivatives and hydroxy coumarin. The synthetic routes to the rhodamine 6G derivatives containing hydroxy coumarin are shown in Fig. 1. Two derivatives were synthesized through Schiff base reactions. The structures of the new compounds were confirmed by melting point, $^1H$-NMR, and GC-MS analyses. The compounds were found to selectively bind to tin ($Sn^{2+}$) ion by fluorescence titration using various metal cations. Longer carbon chains gave more sensitivity. $Sn^{2+}$ ions exhibited the strongest fluorescence among the nime ions. The binding analysis using Job plots suggested that compounds form 1:1 complexes with the $Sn^{2+}$ ions.