• Journal of Oral Medicine and Pain
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• v.36 no.1
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• pp.21-24
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• 2011

Xerostomia is subjective feeling of dry mouth, a symptom that may or may not be accompanied by hyposalivation, an objective decrease in salivary flow. There are many causes induced xerostomia like drugs, salivary gland diseases, radiation therapy to the head and neck region, Sjogren syndrome, emotional stress etc. Insufficient salivary flow creates complications with oral candidiasis, dental caries, periodontitis, halitosis, dysgeusia. So finally, these complications lead to an overall decline in quality of life. Managements of xerostomia are eliminating or alterating the etiologic factors, relieving symptoms, preventing or correcting the consequences of salivary dysfunction, treating underlying disease and stimulating salivation. One of the salivation stimulation agents studied to treat xerostomia was the pilocarpine muscarinic agonist. Pilocarpine is one of salivation stimulants, a parasympathomimetic drug and non-selective muscarinic receptor agonist. Systemic pilocarpine has been used to stimulate salivary secretion. But systemic administration of pilocarpine has limitations such as increased risk of side effects and contraindications. Side effects of systemic pilocarpine administration are sweating, urinary and gastrointestinal disturbance, risk of cardiovascular and pulmonary disorders. This drug must be used carefully by patients with controlled asthma, chronic bronchitis, pulmonary or cardiac disease. Patient with acute asthma, narrow angle glaucoma, iritis should not use pilocarpine. Like this, systemic pilocarpine has many limitations. So, many investigators also have looked at the effectiveness of topical pilocarpine. Here we present patients with xerostomia which was relieved by pilocarpine mouthwash.

• Journal of Korean society of Dental Hygiene
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• v.7 no.4
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• pp.553-567
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• 2007

Migrant Worker are rapidly increasing in Korea since 1990. They are nowadays main sources of laborer groups engaging in medium-sized factories. The purpose of this study is to provide the basic information to establish proper oral health policy. Dental caries and periodontal disese are the most common disease that occur in the mouth. Periodontal disease is the most common disease in humans and the biggest reason for the loss of the teeth in the adult population. The CPITIN has been developed jontly by the international Dental Federation and the World Health Organization. CPITN is now an established index of level, of periodontal condition in populations for which specific intervention might be considered. This study was conducted to obtain the information regarding to CPITN of migrant workers located in Daegu, Questionaire survey was carried out for 289 workers from July 9 to August 8, 2006. Total survey was 289, 224 males and 65 females. The result was as follows: First, The number of nationality was 14. The first majority was China as 31.8% Among 14 nationalities were Cambodia 18.0%, Vietnam 12.8%, Sri Lanka 12.1%, Indonesia 7.3%, Nepal 4.2%, the other 13.8%, those who are aged from 20 to 29 were 43.9%, and salary from 1,000,000 won to 1,490,000 won 51.2%.(as for their residence, those who resided) over 3 years were 42.6% and not insured reached 68.5%. Second, more than 93.4% of the subjects need periodontal treatment, only 4.9% of non-smoker was health periodontal states, four times frequency of tooth brushing per a day was 16.7%. Third, 28.7% of migrant workers had experienced visit of dental clinic, and 22.9% had received treatment of decayed tooth. Fourth, It is difficult for them 65.1% of them to visit dental clinic in korea, the First was a communication problem and the second was time. Fifth, Most of them didn't have a oral health education but 85.1% of them said that they wish they attend oral health education. We conclude that the situation of migrant workers was very bad considering their working conditions, circumstances, and health condition. According to this study, more than 93.4% of the people need periodontal treatment. Besides they didn't have accurate knowledge about prevention of periodontal disease. Therefor our considering these facts, the policy of dental health by government should be established for migrant workers.

• The Journal of the Korea Contents Association
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• v.11 no.10
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• pp.370-379
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• 2011

This study was carried out in order to offer basic data available for forming the better oral health habit by closely examining a cause for industrial workers' tooth loss. It analyzed correlation in missing teeth with general characteristics, subjective oral health recognition, habit related to oral health, and oral symptom targeting 6,976 of production workers and office workers who work at 49 industrial places where are located in Gumi city of Gyeongsangbuk-do Province from June 1, 2009 to December 31, thereby having obtained the following conclusions. 1. The higher age group led to the higher ratio of missing teeth. The ratio of missing teeth was lower in a case of having been removed plaque than having not been removed plaque. 2. The ratio of missing teeth was high in a case of having dental caries and periodontal disease. The ratio of missing teeth was high in a case of having smoked in the past or in a case of smoking now. 3. The ratio of missing teeth was high in a case of having less toothbrushing frequency and in a case of not using dental floss or interdental brush. 4. The ratio of missing teeth was high when a tooth is throbbing and when tongue and cheek are throbbing in addition to pain and bleeding in gum. 5. The ratio of missing teeth was high in a case of having unpleasant bad breath. The above results are expected to be likely conducive to offering basic data necessary for developing the oral health educational program for industrial places that can promote and maintain workers' oral health, and for improving oral health program and system available for promoting and maintaining workers' oral health hereafter.

• Journal of dental hygiene science
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• v.2 no.2
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• pp.63-67
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• 2002

The purpose of this study was to develop more effective dental health education program and to reduce the occurrence of dental diseases among industrial men-workers in Korea. The questionaire and dental examination were given to 782 industrial men-workers who visited Asan Medical Center for the purpose of health examinations in 2000. The obtained results were as follows; 1. According to the results of logistic regression analysis, both ages (especially under 30's: P=0.027) and monthly incomes (especially under 1,000,000 won: P=0.000) show negative relationships with the occurrence of dental caries. 2. As the results of logistic regression analysis, ages shows positive relationship and monthly incomes shows negative relationship (only under 1,000,000 won: P=0.059) with the occurrence of missing teeth. 3. According to the results of logistic regression analysis of periodontal disease, the model shows no significance (P=0.117). 4. As the results of logistic regression analysis, both monthly incomes and ages show positive relationships with the occurrence of abrasion.

• Journal of dental hygiene science
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• v.8 no.4
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• pp.225-231
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• 2008

The purpose of this study was to examine the relationship between oral health habits and oral diseases in an attempt to raise awareness of the need for prolonged dental checkup projects and lay the foundation for oral health education and sustained oral health care projects. The subjects in this study were 2,643 workers from 76 workplaces in Siwha Industrial Complex in the city of Ansan, Gyeonggi province, who were at the age of 20 and up. The findings of the study were as follows: 1. Concerning the experience of visiting a dental clinic over the past year, 760 male workers (37.4%) and 237 females (38.9%) visited dental clinics in the past year. By age group, those who were in their 50s (54.0%) visited dental clinics the most, and the workers in their 30s (67.9%) paid a visit the least. The gap between the age groups was statistically significant (p < 0.001). 2. In regard to the time for toothbrushing by age group, the workers in their 20s (64.6%) made up the largest group that brushed their teeth before breakfast, and those who were in their 60s and up constituted the greatest group that did toothbrushing after breakfast. The workers in their 20s brushed their teeth the least, as the rates of the workers of this age group who did toothbrushing after breakfast and dinner respectively stood at 64.0 percent and 54.5 percent. The disparities between the age groups were statistically significant (p < 0.001). 3. As for scaling experience for the past year, 302(46.0%) out of the workers who got their teeth scaled in the past year had periodontal diseases, and 1,600(80.6%) out of those who didn't suffered from periodontal diseases. The gap between them was statistically significant (p < 0.001). 4. Regarding the relationship of subjective oral health state to dental caries among the workers without dental caries, the largest group that numbered 327(54.1%) considered themselves to be in good oral health. In the event of the workers with dental caries, the greatest group that numbered 708(75.5%) found themselves to have one or more carious tooth(teeth). The disparity between them was statistically significant (p < 0.001). 5. As for connections between dietary habits and dental caries, those who had dental caries (2.29) showed a greater preference for snack than the others who hadn't (2.21). The preference for snack made a bigger statistically significant difference to dental caries than the other dietary habits (p < 0.05).

• Journal of Periodontal and Implant Science
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• v.28 no.4
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• pp.703-721
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• 1998

In order to observe the effects of Nicotine and NNK on cultured human gingival fibroblast, several factors were examined including mutagenicity, the number of cells attached culture plate surface through MTT test, the abundance of collagen & collagenase in mRNA level and collagenolytic activity in extracellular matrix. The results were as follows; 1. Regardless of the co-existence of S9, Nicotine did not show the mutagenicity by itself and NNK by itself showd the same result; However, dose related mutagenicity was shown in NNK with S9. 2. The number of fibroblasts attached cultured plate surface was measured by MTT procedure. The number of cells in Non-smokers increased at all time periods as compared to those of smoker. 3. Non-smoker's fibroblast treated by NNK or Nicotine was dosedependently dosedependently decreased in the number of cells when compared to untreated control. In higher dose, Nicotine showed the cellular toxicity, but NNK did not. 4. No change in the abundance of mRNA for pro${\alpha}1$ and pro${\alpha}2$ was shown in Nicotine treated group but in gingival fibroblasts following treatment with NNK, the abundance of mRNA for pro${\alpha}1$, but not pro${\alpha}2$ collagen was decreased. 5. The abundance of mRNA for collagenase was decreased when NNK was treated but no change occurred in Nicotine treated group. 6. The effect of NNK and Nicotine in collagenolytic activity showed that, collagenase activity exclusively react to type I collagen, was increased in both group, but gelatinase exclusively react to type IV collagen was not influenced at all. Collagenase activity of smoker's fibroblast was also increased as much as Nicotine and NNK group. The findings suggest that both of Nicotine and NNK lead gingival fibroblast to decrease in the abundance of collagen. And it seems to be that Nicotine and NNK have independent pathway toward the gingival fibroblast.

• Journal of dental hygiene science
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• v.2 no.2
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• pp.95-103
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• 2002

This study was carried out to investigate recognition level and practical application status of oral hygiene devices through making a survey of Seoul inhabitants. And survey was implemented in order to propose oral hygiene device for household health care activities. The following results were obtained by analyzing personal interviews of 347 commuting patients at two university hospitals and seven dental clinics. 1) The average length of toothbrush head was estimated as 22.3 mm and average changing cycle was 2.3 months. The user ratio of flat-headed brush was estimated as 51.9% and 46.7% were using fluoridated toothpaste. 2) Generally the ratio of toothpick users was higher than other device users. But the user ratio of dental floss was higher than toothpick in case of patients under orthodontic treatment. 3) The patients under orthodontic treatment were not familiar with handling orthodontic toothbrush. Though 45.8% among orthodontic patients recognized this type of toothbrush, only 25.4% of them knew how exactly to use it. 4) It was shown very low user ratio of oral hygiene devices that the patients who had periodontal problem, hypersensitive trouble, halitosis, implant or denture 5) The patients who had halitosis showed the highest user ratio of toothpick. The patients who had separation of teeth showed the highest user ratio of dental floss. The patients who're under orthodontic treatment showed the highest user ratio of interproximal brush and motorized brush. 6) In response to the most interesting dental disease, it's surveyed as follows; 60.3% of dental caries, 24.0% of periodontal disease, 14.8% of false occlusion and 0.9% of oral cancer. 7) Regarding the motivation of using those oral hygiene devices, 45% responded that it was because of recommendation by dental clinics. Among the negative answers, 38.6% responded that it was because of no selection guidance. 31.3% answered that they didn't use hygiene device because it's inconvenient. 12.0% answered that it's difficult to buy and expensive. 7.8% responded that they didn't feel significant improvement. 4.8% answered that dental hospitals and clinics didn't even introduce those hygiene devices. Therefore efficient campaign for those hygiene devices over all Korea nation should be developed and education program must be prepared for each case of patients in every dental hospitals and clinics.

• Journal of Periodontal and Implant Science
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• v.35 no.1
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• pp.133-152
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• 2005

1. 목적 Prostaglandin은 치주질환과 관련된 국소적 골 대사에 중요한 역할을 한다. ${\Delta}^{12}PGJ_2$는 생체 내에서 혈장의 존재 하에 형성되는 천연 $PGD_2$ 대사산물이며 peroxisome- proliferator에 의해 활성화되는 감마 수용체 (PPAR ${\Gamma}$)에 대해 높은 친화성을 갖는 리간드로서 핵 수용체군에 속하는 전사조절인자이다. 이 연구의 목적은 골화 과정에서 ${\Delta}^{12}PGJ_2$의 역할을 규명하기 위해, 조골세포주의 증식과 분화에 미치는 영향과 그에 관련된 세포기전을 조사하는 데에 있다. 2. 방법 인간 골육종세포주인 Saos-2 (ATCC.HTB 85)와 쥐의 조골세포주 (MC3T3-E1)를 배양한 후 실험군에 농도가 각각 $10^{-5}$, $10^{-6}$, $10^{-7}$, $10^{-8}$, $10^{-9}$ 몰인 ${\Delta}^{12}PGJ_2$와 ciglitazone (합성 PPAR 감마 길항체)를 첨가하였다. 조골세포에서 PPAR 감마의 발현을 관찰하기 위해 역전사효소-중합효소연쇄반응(RT-PCR)을 특정한 primer를 이용하여 시행하였다. 세포 증식은 1일, 2일, 3 일째에 MIT 분석법으로 측정하였고, 2 일째에 알칼리성 인산효소 (ALPase) 생산을 측정하였다. 위의 결과에서 얻은 적정한 농도에서 다양한 조골세포 분화의 표지자들-제 1 형 교원질, 알칼리성 인산효소, osteopontin 및 bone sialoprotein-에 대한 간이 정량적 역전사효소-중합효소연쇄반응 (semiquantitative RT-PCR)을 실시하였으며 골결절 형성에 대한 효과를 알아보고자 석회화 분석도 시행하였다. 3. 결과 ${\Delta}^{12}PGJ_2$와 ciglitazone 모두 Saos-2 세포주의 증식을 촉진시켰다 .$10^{-8}$ 몰의 ${\Delta}^{12}PGJ_2$와 $10^{-6}$몰의 ciglitazone을 첨가한 실험군을 대조군과 비교했을 때, 시간에 비례하여 세포 증식률이 증가되었다. 알칼리성 인산효소의 활성화 검사에서도 증식률에서와 유사한 결과를 보여주었다. 간이 정량적 RT-PCR에서는 ${\Delta}^{12}PGJ_2$로 처리한 군의 경우 제 1 형 교원질, 알칼리성 인산효소, osteopontin, 그리고 bone sialoprotein의 상대적 mRNA 수준이 유의하게 높았다. 석회화 분석에서는 MC3T3-E1 세포를 $10^{-6}$ 몰의 ${\Delta}^{12}PGJ_2$로 처리한 군과 $10^{-5}$ 몰의 ciglitazone으로 처리한 군에서 현저한 골결절 형성을 보였다. 이러한 결과들은 ${\Delta}^{12}PGJ_2$가 유용한 골 유도물질이 될 수 있으며 또한 그 작용기전이 PPAR 감마-의존형 경로와 연관되어 있음을 보여준다.

• Journal of Korean society of Dental Hygiene
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• v.11 no.5
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• pp.773-782
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• 2011

Objectives : The purpose of the study was to investigate self-reported oral health attitudes and behaviors among patients receiving scaling services and provide guidelines for developing preventive programs for dental disease. Methods : The survey was administered to a sample of 462 receiving voluntary scaling service in the practice lab in the department of dental hygiene at J health college. Results : 1. Of all participants, 261(56.5%) reported that they received scaling services in the past. 134 of the women (62.6%) and 127 of the men (51.2%) received scaling services 2. Analysis of the regular scaling attendance rates showed that only 16.2% of all participants received routine scaling. 13.7% of the male participants and 19.2% of the female participants received scaling on a regular basis. 3. Participants commonly reported "self-motivation" and "suggestion by others" (37.9% and 34.1%, respectively) as the main reasons for obtaining scaling services. 4. The main reasons for not obtaining scaling services were "I did not know about scaling" (39.3%), "I don't feel it is necessary" (27.4%) and "because I am scared" (20.9%). More men (42.1%) than women (35%) reported that they did not know about scaling. 5. Of the total participants, 41.6% reported that they were concerned about oral health at a moderate level, and 30.3% reported that they were concerned about oral health at a high level. 6. Of the participants who responded "very concerned about oral health" and "extremely concerned about oral health", the majority obtained scaling service (70.2% and 84.2%, respectively). Conclusions : The study suggested that researchers and national health authorities should develop routine scaling, preventive dental care, and oral health programs for oral health promotion and disease prevention.

• Journal of Periodontal and Implant Science
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• v.35 no.3
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• pp.731-745
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• 2005

Cyclosproin A(CsA)는 세포 이식거부방지를 위한 면역 억제제 및 자가 면역질환 치료제로 널리 사용되어 왔다. CsA는 매양된 사람 치은섬유아세포를 증식시킴이 알려져 있지만 CsA에 의한 세포증식기전에 대한 세포사멸기전 및 Bcl-2의 역할은 연구되어 있지 않다. 이번 연구는 사람 섬유아세포에서 CsA에 의한 세포증삭기전에 세포고사기전 및 Bcl-2 family가 관여하는지 밝히는 데에 목적이 있다. 세포 생장력은 MTT 방법으로 측정하였다. Bcl-2 family와 Fas 발현 정도는 RT-PCR 방법이나 western blot으로 확인하였다. Caspase-3 및 -9의 활성은 ELISER reader로, reactive oxygen species(ROS)는 fluorescence spectrometer에 의해 측정되었다. 미토콘드리아에서 세포질로 분비된 cytochrome c는 Western blot으로 조사하였다. CsA는 $0.1{\sim}10\;{\mu}M$에서 사람 섬유아세포의 생존률을 시간과 농도 의존적으로 증가시켰으며, 50 ${\mu}M$ CsA에서는 오히려 세포가 죽였다. 또한, CsA 처리로 미토콘드리아에서 세포질로 유리되는 cytochrome c 양과 VDAC 1 및 3 발현량이 감소되었고, caspase-9과 caspase-3의 활성도도 감소되었다. 한편, CsA 처리한 섬유아세포에서 death receptor 구성요소인 Fas 발현이 감소되었다. Bcl-2 family에 대한 RT-PCR, western blot 분석결과, 세포고사를 억제하는 Bel-2 발현은 증가되었으나 세포고사를 자극하는 Bax와 Bid의 발현은 감소되었다. 이러한 결과들은 사람 섬유아세포에서 CsA유도 세포증식에 Bcl-2 family와 ROS가 매개하는 미토콘드리아 의존 및 death receptor 의존 세포고사기전이 관여함을 시사하였다.