• Journal of Acupuncture Research
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• 제31권3호
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• pp.67-73
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• 2014

Objectives : Amyotrophic lateral sclerosis(ALS) is a progressive neurodegenerative disorder characterized by a selective death of motor neuron, leading to respiratory insufficiency. The purpose of this study was to assess the long term respiratory management of ALS patient with respiratory failure. Methods : One ALS patient applying a non-invasive BIPAP ventilator as well as Korean medical treatment such as acupuncture, pharmacopuncture and herbal medicine was measured on $SpO_2$, $EtCO_2$, Vte(expiratorytidalvolume) for 2 years 7 months. Results : The $SpO_2$, $EtCO_2$ of ALS patient were maintained in the normal range for 2 years 7 months. The Vte of ALS patient also wasn't worse in this study. Conclusions : In this study, the long term respiration management, combined administration of Korean medical treatment and non-invasive BIPAP ventilator, could be effective in ALS patient with respiratory failure.

• 복식문화연구
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• 제21권2호
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• pp.151-166
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• 2013

This study aims to shed light on the diversity and complexity of design represented through modern fashion and to identify growth opportunities for globalizing and modernizing traditional clothing designs. To this end, formative trends and aesthetic characteristics of $21^{st}$ century fashion were analyzed, with an emphasis on Japanism reflected in the works of Western designers. The research methodology consisted of an analysis as well as a literature review. A total of 217 designs with Japanism characteristics were identified from the 2001 S/S collection to the 2011 S/S collection in Paris, Milano, New York, and London, and these were analyzed in terms of image, color details, pattern, and accessories. The research findings with regard to the characteristics of modern fashion designs that reflect Japanism were as follows. First, sensuality was projected by highlighting the erotic elements of Japanese clothing. Second, the underlying principles, styles, and elements of Japan's traditional clothing were embodied in a cross-cultural and eclectic manner that blurred the boundaries between styles by mix-and- matching the traditional and the contemporary, the East and the West, and different styles. Third, a variety of patterns, colors, accessories, and design techniques associated with Japanese traditional clothing played a critical role in creating flamboyant and decorative images in contemporary fashion. Fourth, the overlapping of the kimono style, the flat design that accentuates body curves, and the layered style has created a beautifully free-form fashion that demonstrates non-structural features.

• Annals of Clinical Neurophysiology
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• 제5권1호
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• pp.21-26
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• 2003

Background & Objectives: Hyperexcitablity of motor system is a well-established characteristic pathophysiologic finding of amyotrophic lateral sclerosis (ALS). Whereas little is known about the source of excitability according to the progression of the disease. We evaluated the excitability and its source in advanced ALS patients using transcranial magnetic stimulation (TMS). Meterial & Methods: Motor evoked potentials (MEP) by TMS were recorded for abductor pollicis brevis muscles in 20 patients, 11 men and 9 women, with ALS. Mean age was $54.2{\pm}12.1years$, and mean disease duration was $13.9{\pm}13.4years$. Serial magnetic stimulations were applied to get the parameters; excitability threshold (ET), amplitude and latency of MEP. We also had a facilitated MEP (fMEP). Results: The parameters were analyzed according to the clinical settings. ET was higher in ALS(mean $63.5{\pm}18.1$) than normal control (mean $46.0{\pm}8.4$, p<0.01). Amplitudes of MEP were reduced in ALS ($2.6{\pm}3.6mV$; control $6.5{\pm}3.1mV$, p<0.01). Duration of the disease and ET showed significant inverse correlation (Spearson correlation coefficient = -0.57, p<0.01). Duration of the disease and fMEP/MEP ratio showed less but also significant inverse correlation (Spearson correlation coefficient, r = -0.52, p < 0.05). Conclusions: Lower ET in advanced ALS patients, in spite of decreased fMEP/MEP ratio, may indicate the hyperexcitability of lower motor neurons in these patients. This study suggests that lower motor neurons is hyperexcitable due to upper motor neuron dysfunction at advanced stage.

• Annals of Clinical Neurophysiology
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• 제15권2호
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• pp.53-58
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• 2013

Background: The autophagy is the major route for lysosomal degradation of misfolded protein aggregates and oxidative cell components. We hypothesized that rapamycin (autophagy enhancer) would prolong the survival of motor neuron and suppress the disease progression in amyotrophic lateral sclerosis (ALS). Methods: A total of 24 transgenic mice harboring the human G93A mutated SOD1 gene were used. The clinical status involving rotarod test and survival, and biochemical study of ALS mice model were evaluated. Results: The onset of symptoms was significantly delayed in the rapamycin administration group compared with the control group. However, after the clinical symptom developed, the rapamycin exacerbated the disease progression and shortened the survival of ALS mice model, and apoptosis signals were up-regulated compared with control group. Conclusions: Even though further detailed studies on the relevancy between autophagy and ALS will be needed, our results revealed that the rapamycin administration was not effective for being novel promising therapeutic strategy in ALS transgenic mice and exacerbated the apoptosis.

• 대한족부족관절학회지
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• 제7권2호
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• pp.151-156
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• 2003

Purpose: Proximal crescentic metatarsal osteotomy(PMO) is one of the most common procedures for correcting moderate to severe degree hallux valgus deformity. Although screw fixation is used for osteotomy site stability, loss of reduction can occur. The purpose of this study is to compare the sagittal plane stability of the conventional crescentic PMO fixed with a single screw with that of the crescentic PMO fixed with 1 screw and 2 supplemental K -wires. Material and Methods: Ten matched pairs of cadaveric foot specimens were used for the proximal crescentic metatarsal osteotomy. For one foot specimen of each pair, crescentic osteotomy was fixed with 4mm long threaded cannulated screw, while the matched pair was prepared by adding two axial 1.6mm K-wires to the conventionally fixed 4mm screw. The extensometer was used to measure the osteotomy gap as the metatarsal head was loaded continuously until failure using a servohydraulic MTS Mini Bionix test frame. The strength of fixation was normalized with the bone mineral density (BMD) of the paired specimen $(N{\times}cm^{2}/gm)$, Result: The average strength of the crescentic PMO with axial K-wire fixation ($458.8cm^{2}/gm$, S.D. 434.3) was significantly higher than the standard crescentic PMO ($367.5cm^{2}/gm$, S.D. 397,9) (p=0.05). Conclusion: Supplemental fixation with two axial K-wires can be added to the crescentic PMO to enhance the initial fixation stability to prevent the loss of reduction or dorsal malunion.

• Korean Chemical Engineering Research
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• 제50권2호
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• pp.334-342
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• 2012

새로 개발된 '고액분리 통합이론'의 핵심 개념인 '케이크 첫 입자층이 받는 압력 $p_d$'의 역할을 인식하기 위해, 고압축성 케이크에 대해 다음과 같은 세 가지 고액분리 분야를 새로운 개념으로 분석하였다. 첫째, 침전된 플럭의 케이크 여과에서 여과 대상이 되는 침전 플럭의 두께 계산에서 $p_d$의 역할과, 케이크의 형성 두께 계산에서의 $p_d$의 역할. 둘째, 압착 과정에서의 $p_d$의 역할, 그리고 마지막으로 간섭침전 결과 쌓이는 높이에 미치는 $p_d$의 역할과 간섭침전 과정에서의 $p_d$의 중요성을 보였다. 이로써 고액분리 통합이론의 적용 가능성과, 그에 있어 $p_d$의 중요성을 밝힐 수 있었다. 이 과정을 통하여 케이크 여과, 압착, 간섭침전의 이론적인 새로운 정의가 가능해졌다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 춘계학술대회
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• pp.156-161
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• 2004

To predict the direction of the fatigue crack initiated from a hole under various types of biaxial fatigue loads with different phase difference and biaxiality, fatigue parameters were investigated. Axial and torsional biaxial fatigue loads were selected with the respective combination of five different phase differences of 0, 45, 90, 145 and 180 degrees and five biaxialities of 0, $1/{\sqrt{3}}$, 1, ${\sqrt{3}}$, ${\infty}$. Directions of the fatigue crack initiation around the hole were found to approach to the circumferential direction of the specimen with increment of the phase difference for fatigue tests with phase differences less than $90^{\circ}$. Whereas directions for tests with phase differences greater than $90^{\circ}$ went away from the circumferential direction and those were symmetric to the directions for tests with phase difference less than $90^{\circ}$. With increase of biaxilities, the fatigue crack initiated more apart from the circumferential direction of the specimen. These crack initiation direction were predicted using maximum tangential stress range and maximum shear stress range obtained at far-field and around the hole. Comparing these two stress parameters, The crack initiation direction can be successfully explained by using the direction of the maximum tangential stress range obtained around the hole and at far-field.

• Annals of Clinical Neurophysiology
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• 제7권2호
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• pp.101-106
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• 2005

Background: There is no currently effective treatment for amyotrophic lateral sclerosis (ALS), although this disorder is a progressive neurodegenerative disease resulting in death within several years. Because recent evidence suggests that homocysteine (HC) is highly related to neurodegenerative disorders with aging, we tried to elucidate the effects of multi-vitamin therapy on G93A SOD1 transgenic mice. Methods: We treated this murine model of ALS with multi-vitamin (folic acid 1.97 mg/day, pyridoxine 0.98 mg/day, cyanocobalamin 0.1 mg/day) from 45 days of age, per oral. We performed the rotarod test from postnatal $10^{th}$ week, weekly. Results: We found that multi-vitamin reinforcement significantly prolonged average lifespan and delayed disease onset with improvement of motor performance. However, it did not significantly slow disease progression and statistical differences of weight loss were not observed between in transgenic mice and controls. Conclusions: These results suggest that multi-vitamin can be a potent therapeutic strategy for familial forms of ALS.

• Annals of Clinical Neurophysiology
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• 제13권2호
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• pp.71-79
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• 2011

Geographical differences in the incidence of amyotrophic lateral sclerosis (ALS) have been reported, and there are still many unresolved problems. The incidence as well as epidemiologic data of ALS is not known in Korea. Web-based multicenter registry of ALS, the Korean ALS registry, was established at January, 2011. The aim of "the Korean ALS registry" is the following: (1) to establish a database for the prospective collection of epidemiological information; (2) to assess the incidence and prevalence; (3) to find the temporal and geographic trends in the disease; (4) to define the full clinical spectrum of the disease; (5) to develop treatment guideline based on the database.

• 지능정보연구
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• 제20권1호
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• pp.103-119
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• 2014

본 논문은 주식 시장 참가자들의 여러 기업 공시에 대한 다양한 지능적인 반응의 차이점과 거래 행동에 영향을 미치는 주요 정보를 분석하였다. 본 연구는 2000년01월부터 2012년 09월까지 코스닥 시장에 신규 상장을 된 기업과 3가지 공시를(무상증자, 유상증자, 신규 시설 투자) 한 기업들을 대상으로 하였다. 시장 참가자들이 무상증자와 유상증자 공시일 경우에 긍정적으로 반응하고 신규 시설 투자일 경우에 부정적으로 반응하다는 연구 결과가 나왔다. 시장 거래량은 긍정적인 사건 전에 급격히 증가하며 모든 그룹의 참가자들의 매수가 활발히 이루어진다. 부정적인 사건일 경우에 기관 참가자들만 활발한 매수 행동을 보여준다. 종합적으로, 기관들은 모멘텀 전략을 보여주며, 개인과 외국인들은 반대투자전략을 보여준다. 본 논문의 합축성도 논의했다.