Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Neuroprotective Effects of Multi-vitamin Therapy in Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

근위축성측삭경화증의 유전자 이식 마우스 모델에서 비타민 복합요법의 신경보호효과

  • Min, Ju-Hong (Department of Neurology, Seoul National University Hospital, Seoul National University) ;
  • Park, Jong-Ha (Clinical Research Institute of Seoul National University Hospital) ;
  • Cho, Ae-shin (Clinical Research Institute of Seoul National University Hospital) ;
  • Kim, Mi-Yeon (Clinical Research Institute of Seoul National University Hospital) ;
  • Hong, Yoon-Ho (Department of Neurology, Seoul Municipal Boramae Hospital, Seoul National University) ;
  • Sung, Jung-Joon (Department of Neurology, Seoul National University Hospital, Seoul National University) ;
  • Park, Kyung-Seok (Department of Neurology, Seoul Bundang Hospital, Seoul National University) ;
  • Lee, Kwang-Woo (Department of Neurology, Seoul National University Hospital, Seoul National University)
  • 민주홍 (서울대학교 의과대학 서울대병원 신경과) ;
  • 박종하 (서울대학교 의과대학 뇌신경과학교실) ;
  • 조애신 (서울대학교 의과대학 뇌신경과학교실) ;
  • 김미연 (서울대학교 의과대학 뇌신경과학교실) ;
  • 홍윤호 (서울대학교 보라매병원 신경과) ;
  • 성정준 (서울대학교 의과대학 서울대병원 신경과) ;
  • 박경석 (서울대학교 분당병원 신경과) ;
  • 이광우 (서울대학교 의과대학 서울대병원 신경과)
  • Published : 2005.12.30
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Abstract

Background: There is no currently effective treatment for amyotrophic lateral sclerosis (ALS), although this disorder is a progressive neurodegenerative disease resulting in death within several years. Because recent evidence suggests that homocysteine (HC) is highly related to neurodegenerative disorders with aging, we tried to elucidate the effects of multi-vitamin therapy on G93A SOD1 transgenic mice. Methods: We treated this murine model of ALS with multi-vitamin (folic acid 1.97 mg/day, pyridoxine 0.98 mg/day, cyanocobalamin 0.1 mg/day) from 45 days of age, per oral. We performed the rotarod test from postnatal $10^{th}$ week, weekly. Results: We found that multi-vitamin reinforcement significantly prolonged average lifespan and delayed disease onset with improvement of motor performance. However, it did not significantly slow disease progression and statistical differences of weight loss were not observed between in transgenic mice and controls. Conclusions: These results suggest that multi-vitamin can be a potent therapeutic strategy for familial forms of ALS.

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